In the last 12 months, insiders at Jazz Pharmaceuticals plc ($JAZZ) filed 316 transactions with the SEC: 5 open-market purchases totaling $11,428,882 and 104 sales totaling $51,256,081. Net insider sentiment: net selling.
Jazz Pharmaceuticals plc operates in the Pharmaceutical preparations industry (Life sciences sector).
Most Active Insiders
- COZADD BRUCE C (Director) — 27 transactions totaling $38,200,290
- Patil Neena M (EVP & Chief Legal Officer) — 42 transactions totaling $22,584,013
- COZADD BRUCE C (Chairman & CEO) — 26 transactions totaling $14,995,359
- Mulligan Seamus (Director) — 11 transactions totaling $10,627,087
- Carr Patricia (SVP, Chief Accounting Officer) — 41 transactions totaling $6,717,601
View all SEC Filings for Jazz Pharmaceuticals plc (JAZZ).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| April 1, 2026 | COZADD BRUCE C | Director | S | Ordinary Shares | 24 | $191.74 | 384,682.0000 | 61,606,000 | 0.01% | 0.00% |
| April 1, 2026 | COZADD BRUCE C | Director | S | Ordinary Shares | 3684 | $190.22 | 386,998.0000 | 61,606,000 | 0.94% | 0.01% |
| April 1, 2026 | COZADD BRUCE C | Director | S | Ordinary Shares | 2292 | $190.94 | 384,706.0000 | 61,606,000 | 0.59% | 0.00% |
| March 5, 2026 | COZADD BRUCE C | Director | F | Ordinary Shares | 15114 | $188.69 | 390,682.0000 | 61,606,000 | 3.72% | 0.02% |
| March 5, 2026 | Johnson Philip L | EVP & Chief Financial Officer | F | Ordinary Shares | 2615 | $188.69 | 59,608.0000 | 61,606,000 | 4.20% | 0.00% |
| March 5, 2026 | Henderson Mary Elizabeth | SVP, Technical Operations | F | Ordinary Shares | 1394 | $186.75 | 27,334.0000 | 61,606,000 | 4.85% | 0.00% |
| March 5, 2026 | Pearce Samantha | EVP, Chief Commercial Officer | F | Ordinary Shares | 2503 | $188.69 | 50,272.0000 | 61,606,000 | 4.74% | 0.00% |
| March 5, 2026 | Iannone Robert | EVP, Global Head of R&D & CMO | F | Ordinary Shares | 6209 | $188.69 | 88,871.0000 | 61,606,000 | 6.53% | 0.01% |
| March 5, 2026 | Carr Patricia | SVP, Chief Accounting Officer | F | Ordinary Shares | 1436 | $186.77 | 7,799.0000 | 61,606,000 | 15.55% | 0.00% |
| March 9, 2026 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 1287 | $182.94 | 6,512.0000 | 61,606,000 | 16.50% | 0.00% |
| March 5, 2026 | GALA RENEE D | President & CEO | F | Ordinary Shares | 7065 | $188.69 | 152,630.0000 | 61,606,000 | 4.42% | 0.01% |
| March 5, 2026 | Patil Neena M | EVP & Chief Legal Officer | F | Ordinary Shares | 5000 | $188.69 | 53,818.0000 | 61,606,000 | 8.50% | 0.01% |
| March 3, 2026 | COZADD BRUCE C | Director | S | Ordinary Shares | 2608 | $186.73 | 406,029.0000 | 61,606,000 | 0.64% | 0.00% |
| March 3, 2026 | COZADD BRUCE C | Director | S | Ordinary Shares | 3159 | $186.09 | 408,637.0000 | 61,606,000 | 0.77% | 0.01% |
| March 3, 2026 | COZADD BRUCE C | Director | S | Ordinary Shares | 233 | $187.84 | 405,796.0000 | 61,606,000 | 0.06% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 1784 | $191.88 | 60,024.0000 | 61,606,000 | 2.89% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | M | Ordinary Shares | 27084 | $137.12 | 83,946.0000 | 61,606,000 | 47.63% | 0.04% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 15555 | $190.28 | 68,391.0000 | 61,606,000 | 18.53% | 0.03% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | M | Ordinary Shares | 2916 | $137.12 | 71,307.0000 | 61,606,000 | 4.26% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 2916 | $189.81 | 68,391.0000 | 61,606,000 | 4.09% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | A | Ordinary Shares | 10079 | $0.00 | 78,470.0000 | 61,606,000 | 14.74% | 0.02% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 11529 | $191.65 | 66,941.0000 | 61,606,000 | 14.69% | 0.02% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 3523 | $193.58 | 63,418.0000 | 61,606,000 | 5.26% | 0.01% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 1061 | $190.00 | 62,357.0000 | 61,606,000 | 1.67% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 549 | $190.80 | 61,808.0000 | 61,606,000 | 0.88% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | M | Non-Qualified Stock Option (right to buy) | 20125 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.03% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 1009 | $192.79 | 59,015.0000 | 61,606,000 | 1.68% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 197 | $193.60 | 58,818.0000 | 61,606,000 | 0.33% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | M | Incentive Stock Option (right to buy) | 875 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | M | Incentive Stock Option (right to buy) | 2916 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.00% |
| Feb. 27, 2026 | RIEDEL NORBERT G | Director | M | Non-Qualified Stock Option (right to buy) | 3415 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.01% |
| Feb. 27, 2026 | RIEDEL NORBERT G | Director | S | Ordinary Shares | 3415 | $192.00 | 17,654.0000 | 61,606,000 | 16.21% | 0.01% |
| Feb. 27, 2026 | RIEDEL NORBERT G | Director | M | Ordinary Shares | 3415 | $138.08 | 21,069.0000 | 61,606,000 | 19.34% | 0.01% |
| Feb. 26, 2026 | Henderson Mary Elizabeth | SVP, Technical Operations | S | Ordinary Shares | 5343 | $194.49 | 28,728.0000 | 61,606,000 | 15.68% | 0.01% |
| Feb. 26, 2026 | Henderson Mary Elizabeth | SVP, Technical Operations | A | Ordinary Shares | 4447 | $0.00 | 34,071.0000 | 61,606,000 | 15.01% | 0.01% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | M | Non-Qualified Stock Option (right to buy) | 27084 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.04% |
| Feb. 26, 2026 | Johnson Philip L | EVP & Chief Financial Officer | A | Ordinary Shares | 11857 | $0.00 | 62,223.0000 | 61,606,000 | 23.54% | 0.02% |
| Feb. 26, 2026 | Pearce Samantha | EVP, Chief Commercial Officer | A | Ordinary Shares | 9782 | $0.00 | 52,775.0000 | 61,606,000 | 22.75% | 0.02% |
| Feb. 26, 2026 | Iannone Robert | EVP, Global Head of R&D & CMO | A | Ordinary Shares | 14822 | $0.00 | 95,080.0000 | 61,606,000 | 18.47% | 0.02% |
| Feb. 26, 2026 | Carr Patricia | SVP, Chief Accounting Officer | A | Ordinary Shares | 2223 | $0.00 | 11,605.0000 | 61,606,000 | 23.69% | 0.00% |
| Feb. 26, 2026 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 1253 | $194.11 | 10,352.0000 | 61,606,000 | 10.80% | 0.00% |
| Feb. 27, 2026 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 1117 | $190.91 | 9,235.0000 | 61,606,000 | 10.79% | 0.00% |
| Feb. 26, 2026 | GALA RENEE D | President & CEO | A | Ordinary Shares | 44465 | $0.00 | 159,695.0000 | 61,606,000 | 38.59% | 0.07% |
| Feb. 26, 2026 | LOVE TED W | Director | A | Ordinary Shares | 1527 | $0.00 | 1,527.0000 | 61,606,000 | 9999.99% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | M | Ordinary Shares | 20125 | $113.10 | 73,464.0000 | 61,606,000 | 37.73% | 0.03% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 16602 | $192.53 | 56,862.0000 | 61,606,000 | 22.60% | 0.03% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | M | Ordinary Shares | 875 | $113.10 | 57,737.0000 | 61,606,000 | 1.54% | 0.00% |
| Feb. 26, 2026 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 875 | $192.07 | 56,862.0000 | 61,606,000 | 1.52% | 0.00% |
| Jan. 16, 2026 | Pearce Samantha | EVP, Chief Commercial Officer | F | Ordinary Shares | 1599 | $171.16 | 42,993.0000 | 61,606,000 | 3.59% | 0.00% |
| Jan. 16, 2026 | Iannone Robert | EVP, Global Head of R&D & CMO | A | Ordinary Shares | 11699 | $0.00 | 84,398.0000 | 61,606,000 | 16.09% | 0.02% |
| Jan. 16, 2026 | Iannone Robert | EVP, Global Head of R&D & CMO | F | Ordinary Shares | 4140 | $171.16 | 80,258.0000 | 61,606,000 | 4.91% | 0.01% |
| Jan. 16, 2026 | GALA RENEE D | President & CEO | A | Ordinary Shares | 12741 | $0.00 | 120,601.0000 | 61,606,000 | 11.81% | 0.02% |
| Jan. 16, 2026 | GALA RENEE D | President & CEO | F | Ordinary Shares | 5371 | $171.16 | 115,230.0000 | 61,606,000 | 4.45% | 0.01% |
| Jan. 16, 2026 | Henderson Mary Elizabeth | SVP, Technical Operations | A | Ordinary Shares | 10116 | $0.00 | 29,624.0000 | 61,606,000 | 51.86% | 0.02% |
| Jan. 16, 2026 | COZADD BRUCE C | Director | F | Ordinary Shares | 17453 | $171.16 | 411,796.0000 | 61,606,000 | 4.07% | 0.03% |
| Jan. 16, 2026 | COZADD BRUCE C | Director | A | Ordinary Shares | 35917 | $0.00 | 429,249.0000 | 61,606,000 | 9.13% | 0.06% |
| Jan. 16, 2026 | Pearce Samantha | EVP, Chief Commercial Officer | A | Ordinary Shares | 3637 | $0.00 | 44,592.0000 | 61,606,000 | 8.88% | 0.01% |
| Jan. 16, 2026 | Patil Neena M | EVP & Chief Legal Officer | D | Ordinary Shares | 3275 | $171.16 | 53,339.0000 | 61,606,000 | 5.78% | 0.01% |
| Jan. 16, 2026 | Patil Neena M | EVP & Chief Legal Officer | A | Ordinary Shares | 8852 | $0.00 | 56,614.0000 | 61,606,000 | 18.53% | 0.01% |
| Jan. 16, 2026 | Carr Patricia | SVP, Chief Accounting Officer | A | Ordinary Shares | 2370 | $0.00 | 9,382.0000 | 61,606,000 | 33.80% | 0.00% |
| Aug. 18, 2025 | ENRIGHT PATRICK G | Director | J | Ordinary Shares | 5000 | $0.00 | 21,379.0000 | 66,007,000 | 18.95% | 0.01% |
| Dec. 9, 2025 | Henderson Mary Elizabeth | SVP, Technical Operations | S | Ordinary Shares | 2238 | $169.51 | 19,508.0000 | 61,606,000 | 10.29% | 0.00% |
| Dec. 5, 2025 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 160 | $171.11 | 7,012.0000 | 61,606,000 | 2.23% | 0.00% |
| Dec. 5, 2025 | Carr Patricia | SVP, Chief Accounting Officer | M | Non-Qualified Stock Option (right to buy) | 4500 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.01% |
| Dec. 5, 2025 | Carr Patricia | SVP, Chief Accounting Officer | M | Ordinary Shares | 4500 | $140.67 | 11,512.0000 | 61,606,000 | 64.18% | 0.01% |
| Dec. 5, 2025 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 4500 | $171.20 | 7,012.0000 | 61,606,000 | 39.09% | 0.01% |
| Dec. 5, 2025 | GALA RENEE D | President & CEO | F | Ordinary Shares | 80 | $166.91 | 107,860.0000 | 61,606,000 | 0.07% | 0.00% |
| Dec. 2, 2025 | O'Keefe Kenneth W | Director | F | Ordinary Shares | 603 | $173.07 | 30,256.0000 | 61,606,000 | 1.95% | 0.00% |
| Nov. 26, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 507 | $179.79 | 431,458.0000 | 61,606,000 | 0.12% | 0.00% |
| Nov. 26, 2025 | COZADD BRUCE C | Director | M | Non-Qualified Stock Option (right to buy) | 76689 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.12% |
| Nov. 26, 2025 | COZADD BRUCE C | Director | M | Incentive Stock Option (right to buy) | 811 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.00% |
| Nov. 26, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 38126 | $177.27 | 393,332.0000 | 61,606,000 | 8.84% | 0.06% |
| Nov. 26, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 8380 | $179.23 | 431,965.0000 | 61,606,000 | 1.90% | 0.01% |
| Nov. 26, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 30487 | $178.06 | 440,345.0000 | 61,606,000 | 6.48% | 0.05% |
| Nov. 26, 2025 | COZADD BRUCE C | Director | M | Ordinary Shares | 811 | $123.36 | 470,832.0000 | 61,606,000 | 0.17% | 0.00% |
| Nov. 26, 2025 | COZADD BRUCE C | Director | M | Ordinary Shares | 76689 | $123.36 | 470,021.0000 | 61,606,000 | 19.50% | 0.12% |
| Nov. 20, 2025 | McSharry Heather Ann | Director | M | Ordinary Shares | 3415 | $138.08 | 23,864.0000 | 61,606,000 | 16.70% | 0.01% |
| Nov. 20, 2025 | McSharry Heather Ann | Director | S | Ordinary Shares | 3415 | $177.78 | 20,449.0000 | 61,606,000 | 14.31% | 0.01% |
| Nov. 20, 2025 | McSharry Heather Ann | Director | M | Non-Qualified Stock Option (right to buy) | 3415 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.01% |
| Nov. 19, 2025 | Henderson Mary Elizabeth | SVP, Technical Operations | D | Ordinary Shares | 1331 | $180.40 | 21,746.0000 | 61,606,000 | 5.77% | 0.00% |
| Nov. 18, 2025 | Carr Patricia | SVP, Chief Accounting Officer | M | Non-Qualified Stock Option (right to buy) | 5250 | $0.00 | 0.0000 | 61,606,000 | 100.00% | 0.01% |
| Nov. 18, 2025 | Winningham Rick E | Director | S | Ordinary Shares | 5500 | $180.86 | 8,893.0000 | 61,606,000 | 38.21% | 0.01% |
| Nov. 18, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 3384 | $180.09 | 405,442.0000 | 61,606,000 | 0.83% | 0.01% |
| Nov. 18, 2025 | Carr Patricia | SVP, Chief Accounting Officer | M | Ordinary Shares | 5250 | $136.18 | 12,262.0000 | 61,606,000 | 74.87% | 0.01% |
| Nov. 18, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 8382 | $180.88 | 397,060.0000 | 61,606,000 | 2.07% | 0.01% |
| Nov. 18, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 5517 | $181.81 | 391,543.0000 | 61,606,000 | 1.39% | 0.01% |
| Nov. 18, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 717 | $182.60 | 390,826.0000 | 61,606,000 | 0.18% | 0.00% |
| Nov. 18, 2025 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 69 | $181.66 | 7,012.0000 | 61,606,000 | 0.97% | 0.00% |
| Nov. 20, 2025 | COZADD BRUCE C | Director | A | Ordinary Shares | 2506 | $0.00 | 393,332.0000 | 61,606,000 | 0.64% | 0.00% |
| Nov. 18, 2025 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 5250 | $182.07 | 7,012.0000 | 61,606,000 | 42.82% | 0.01% |
| Nov. 17, 2025 | Iannone Robert | EVP, Global Head of R&D & CMO | S | Ordinary Shares | 7159 | $168.26 | 72,628.0000 | 61,606,000 | 8.97% | 0.01% |
| Oct. 1, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 2000 | $131.78 | 412,326.0000 | 61,606,000 | 0.48% | 0.00% |
| Oct. 3, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 3500 | $140.00 | 408,826.0000 | 61,606,000 | 0.85% | 0.01% |
| Sept. 14, 2025 | COZADD BRUCE C | Director | F | Ordinary Shares | 15647 | $126.16 | 414,326.0000 | 66,007,000 | 3.64% | 0.02% |
| Sept. 2, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 3000 | $127.23 | 432,973.0000 | 66,007,000 | 0.69% | 0.00% |
| Sept. 2, 2025 | COZADD BRUCE C | Director | S | Ordinary Shares | 3000 | $130.00 | 429,973.0000 | 66,007,000 | 0.69% | 0.00% |
| Aug. 7, 2025 | McSharry Heather Ann | Director | A | Ordinary Shares | 3507 | $0.00 | 22,408.0000 | 66,007,000 | 18.55% | 0.01% |
| Aug. 7, 2025 | GALA RENEE D | President & CEO | A | Ordinary Shares | 18808 | $0.00 | 107,869.0000 | 66,007,000 | 21.12% | 0.03% |
| Aug. 7, 2025 | Mulligan Seamus | Director | A | Ordinary Shares | 3507 | $0.00 | 1,281,234.0000 | 66,007,000 | 0.27% | 0.01% |
| Aug. 8, 2025 | Winningham Rick E | Director | F | Ordinary Shares | 1805 | $111.25 | 14,393.0000 | 66,007,000 | 11.14% | 0.00% |
| Aug. 7, 2025 | Winningham Rick E | Director | A | Ordinary Shares | 3507 | $0.00 | 16,198.0000 | 66,007,000 | 27.63% | 0.01% |
| Aug. 8, 2025 | Smith Mark Douglas | Director | F | Ordinary Shares | 1805 | $111.25 | 10,837.0000 | 66,007,000 | 14.28% | 0.00% |
| Aug. 7, 2025 | Smith Mark Douglas | Director | A | Ordinary Shares | 3507 | $0.00 | 12,642.0000 | 66,007,000 | 38.39% | 0.01% |
| Aug. 8, 2025 | RIEDEL NORBERT G | Director | F | Ordinary Shares | 1805 | $111.25 | 17,654.0000 | 66,007,000 | 9.28% | 0.00% |
| Aug. 7, 2025 | RIEDEL NORBERT G | Director | A | Ordinary Shares | 3507 | $0.00 | 19,459.0000 | 66,007,000 | 21.98% | 0.01% |
| Aug. 8, 2025 | ORiordan Anne | Director | F | Ordinary Shares | 1805 | $111.25 | 16,500.0000 | 66,007,000 | 9.86% | 0.00% |
| Aug. 7, 2025 | ORiordan Anne | Director | A | Ordinary Shares | 3507 | $0.00 | 18,305.0000 | 66,007,000 | 23.70% | 0.01% |
| Aug. 8, 2025 | McSharry Heather Ann | Director | F | Ordinary Shares | 1959 | $111.25 | 20,449.0000 | 66,007,000 | 8.74% | 0.00% |
| Aug. 7, 2025 | O'Keefe Kenneth W | Director | A | Ordinary Shares | 3507 | $0.00 | 34,922.0000 | 66,007,000 | 11.16% | 0.01% |
| Aug. 8, 2025 | Kennedy Patrick | Director | F | Ordinary Shares | 1959 | $111.25 | 6,702.0000 | 66,007,000 | 22.62% | 0.00% |
| Aug. 7, 2025 | Kennedy Patrick | Director | A | Ordinary Shares | 3507 | $0.00 | 8,661.0000 | 66,007,000 | 68.04% | 0.01% |
| Aug. 8, 2025 | Hamill Laura | Director | F | Ordinary Shares | 1805 | $111.25 | 6,933.0000 | 66,007,000 | 20.66% | 0.00% |
| Aug. 7, 2025 | Hamill Laura | Director | A | Ordinary Shares | 3507 | $0.00 | 8,738.0000 | 66,007,000 | 67.04% | 0.01% |
| Aug. 8, 2025 | ENRIGHT PATRICK G | Director | F | Ordinary Shares | 1805 | $111.25 | 26,379.0000 | 66,007,000 | 6.40% | 0.00% |
| Aug. 7, 2025 | ENRIGHT PATRICK G | Director | A | Ordinary Shares | 3507 | $0.00 | 28,184.0000 | 66,007,000 | 14.21% | 0.01% |
| Aug. 8, 2025 | Cook Jennifer E. | Director | F | Ordinary Shares | 1805 | $111.25 | 10,837.0000 | 66,007,000 | 14.28% | 0.00% |
| Aug. 7, 2025 | Cook Jennifer E. | Director | A | Ordinary Shares | 3507 | $0.00 | 12,642.0000 | 66,007,000 | 38.39% | 0.01% |
| Aug. 8, 2025 | O'Keefe Kenneth W | Director | F | Ordinary Shares | 1805 | $111.25 | 33,117.0000 | 66,007,000 | 5.17% | 0.00% |
| Aug. 5, 2025 | Pearce Samantha | EVP, Chief Commercial Officer | F | Ordinary Shares | 577 | $116.10 | 40,815.0000 | 66,007,000 | 1.39% | 0.00% |
| Aug. 1, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 1000 | $113.21 | 435,973.0000 | 66,007,000 | 0.23% | 0.00% |
| July 1, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 500 | $105.26 | 437,473.0000 | 66,007,000 | 0.11% | 0.00% |
| July 1, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 500 | $110.00 | 436,973.0000 | 66,007,000 | 0.11% | 0.00% |
| June 3, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 500 | $110.00 | 437,973.0000 | 66,007,000 | 0.11% | 0.00% |
| June 2, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 500 | $107.90 | 438,473.0000 | 66,007,000 | 0.11% | 0.00% |
| May 9, 2025 | Mulligan Seamus | Director | P | Ordinary Shares | 19216 | $98.91 | 1,276,006.0000 | 66,007,000 | 1.53% | 0.03% |
| May 9, 2025 | Mulligan Seamus | Director | P | Ordinary Shares | 100 | $99.71 | 1,276,106.0000 | 66,007,000 | 0.01% | 0.00% |
| May 12, 2025 | Mulligan Seamus | Director | P | Ordinary Shares | 1621 | $103.00 | 1,277,727.0000 | 66,007,000 | 0.13% | 0.00% |
| May 9, 2025 | Mulligan Seamus | Director | P | Ordinary Shares | 80684 | $98.10 | 1,256,790.0000 | 66,007,000 | 6.86% | 0.12% |
| May 2, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 500 | $120.00 | 438,807.0000 | 66,007,000 | 0.11% | 0.00% |
| May 1, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 1000 | $116.35 | 439,307.0000 | 66,007,000 | 0.23% | 0.00% |
| April 1, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 1500 | $123.75 | 440,307.0000 | 66,007,000 | 0.34% | 0.00% |
| March 10, 2025 | Iannone Robert | EVP, Global Head of R&D & CMO | S | Ordinary Shares | 2403 | $138.41 | 79,621.0000 | 66,007,000 | 2.93% | 0.00% |
| March 7, 2025 | Carr Patricia | SVP, Chief Accounting Officer | D | Ordinary Shares | 1333 | $138.23 | 8,152.0000 | 66,007,000 | 14.05% | 0.00% |
| March 7, 2025 | Henderson Mary Elizabeth | SVP, Technical Operations | D | Ordinary Shares | 698 | $138.23 | 23,077.0000 | 66,007,000 | 2.94% | 0.00% |
| March 10, 2025 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 1140 | $137.81 | 7,012.0000 | 66,007,000 | 13.98% | 0.00% |
| March 5, 2025 | Pearce Samantha | EVP, Chief Commercial Officer | D | Ordinary Shares | 1905 | $138.95 | 41,226.0000 | 66,007,000 | 4.42% | 0.00% |
| March 5, 2025 | Patil Neena M | EVP & Chief Legal Officer | D | Ordinary Shares | 4088 | $138.95 | 47,526.0000 | 66,007,000 | 7.92% | 0.01% |
| March 5, 2025 | Johnson Philip L | EVP & Chief Financial Officer | D | Ordinary Shares | 1149 | $138.95 | 50,060.0000 | 66,007,000 | 2.24% | 0.00% |
| March 5, 2025 | Iannone Robert | EVP, Global Head of R&D & CMO | D | Ordinary Shares | 5239 | $138.95 | 89,104.0000 | 66,007,000 | 5.55% | 0.01% |
| March 7, 2025 | Iannone Robert | EVP, Global Head of R&D & CMO | S | Ordinary Shares | 5532 | $138.21 | 83,572.0000 | 66,007,000 | 6.21% | 0.01% |
| March 7, 2025 | Iannone Robert | EVP, Global Head of R&D & CMO | S | Ordinary Shares | 1548 | $140.00 | 82,024.0000 | 66,007,000 | 1.85% | 0.00% |
| March 5, 2025 | GALA RENEE D | President & COO | D | Ordinary Shares | 5704 | $138.95 | 88,895.0000 | 66,007,000 | 6.03% | 0.01% |
| March 5, 2025 | COZADD BRUCE C | Chairman & CEO | D | Ordinary Shares | 22251 | $138.95 | 441,807.0000 | 66,007,000 | 4.79% | 0.03% |
| Feb. 27, 2025 | Patil Neena M | EVP & Chief Legal Officer | A | Ordinary Shares | 12518 | $0.00 | 45,836.0000 | 66,007,000 | 37.57% | 0.02% |
| Feb. 27, 2025 | Henderson Mary Elizabeth | SVP, Technical Operations | A | Ordinary Shares | 3852 | $0.00 | 23,775.0000 | 66,007,000 | 19.33% | 0.01% |
| Feb. 27, 2025 | Pearce Samantha | EVP, Chief Commercial Officer | A | Ordinary Shares | 11941 | $0.00 | 37,353.0000 | 66,007,000 | 46.99% | 0.02% |
| Feb. 27, 2025 | Pearce Samantha | EVP, Chief Commercial Officer | A | Ordinary Shares | 5778 | $0.00 | 43,131.0000 | 66,007,000 | 15.47% | 0.01% |
| Feb. 27, 2025 | GALA RENEE D | President & COO | A | Ordinary Shares | 23111 | $0.00 | 83,044.0000 | 66,007,000 | 38.56% | 0.04% |
| Feb. 27, 2025 | GALA RENEE D | President & COO | A | Ordinary Shares | 11555 | $0.00 | 94,599.0000 | 66,007,000 | 13.91% | 0.02% |
| Feb. 27, 2025 | Johnson Philip L | EVP & Chief Financial Officer | A | Ordinary Shares | 15407 | $0.00 | 43,505.0000 | 66,007,000 | 54.83% | 0.02% |
| Feb. 27, 2025 | Johnson Philip L | EVP & Chief Financial Officer | A | Ordinary Shares | 7704 | $0.00 | 51,209.0000 | 66,007,000 | 17.71% | 0.01% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | M | Ordinary Shares | 4500 | $113.10 | 12,737.0000 | 66,007,000 | 54.63% | 0.01% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 4500 | $144.42 | 8,237.0000 | 66,007,000 | 35.33% | 0.01% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | M | Ordinary Shares | 313 | $123.36 | 8,550.0000 | 66,007,000 | 3.80% | 0.00% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 313 | $144.42 | 8,237.0000 | 66,007,000 | 3.66% | 0.00% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | D | Ordinary Shares | 371 | $142.43 | 7,866.0000 | 66,007,000 | 4.50% | 0.00% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | D | Ordinary Shares | 497 | $142.43 | 7,369.0000 | 66,007,000 | 6.32% | 0.00% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | A | Ordinary Shares | 2889 | $0.00 | 10,258.0000 | 66,007,000 | 39.20% | 0.00% |
| Feb. 28, 2025 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 773 | $143.30 | 9,485.0000 | 66,007,000 | 7.54% | 0.00% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | M | Non-Qualified Stock Option (right to buy) | 4500 | $0.00 | 0.0000 | 66,007,000 | 100.00% | 0.01% |
| Feb. 27, 2025 | Carr Patricia | SVP, Chief Accounting Officer | M | Non-Qualified Stock Option (right to buy) | 313 | $0.00 | 0.0000 | 66,007,000 | 100.00% | 0.00% |
| Feb. 27, 2025 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 3800 | $144.87 | 33,318.0000 | 66,007,000 | 10.24% | 0.01% |
| Feb. 27, 2025 | Patil Neena M | EVP & Chief Legal Officer | A | Ordinary Shares | 5778 | $0.00 | 51,614.0000 | 66,007,000 | 12.61% | 0.01% |
| March 3, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 6500 | $144.25 | 464,058.0000 | 66,007,000 | 1.38% | 0.01% |
| Feb. 27, 2025 | COZADD BRUCE C | Chairman & CEO | A | Ordinary Shares | 30814 | $0.00 | 470,558.0000 | 66,007,000 | 7.01% | 0.05% |
| Feb. 27, 2025 | Iannone Robert | EVP, G R&D and CMO | A | Ordinary Shares | 17718 | $0.00 | 85,484.0000 | 66,007,000 | 26.15% | 0.03% |
| Feb. 27, 2025 | Iannone Robert | EVP, G R&D and CMO | A | Ordinary Shares | 8859 | $0.00 | 94,343.0000 | 66,007,000 | 10.36% | 0.01% |
| Feb. 27, 2025 | Henderson Mary Elizabeth | SVP, Technical Operations | A | Ordinary Shares | 5392 | $0.00 | 19,923.0000 | 66,007,000 | 37.11% | 0.01% |
| Feb. 3, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 1500 | $122.31 | 439,744.0000 | 66,007,000 | 0.34% | 0.00% |
| Jan. 17, 2025 | Patil Neena M | EVP & Chief Legal Officer | F | Ordinary Shares | 1905 | $122.62 | 37,118.0000 | 66,007,000 | 4.88% | 0.00% |
| Jan. 17, 2025 | Carr Patricia | SVP, Chief Accounting Officer | A | Ordinary Shares | 1641 | $0.00 | 8,237.0000 | 66,007,000 | 24.88% | 0.00% |
| Jan. 17, 2025 | GALA RENEE D | President & COO | F | Ordinary Shares | 3300 | $122.62 | 59,933.0000 | 66,007,000 | 5.22% | 0.00% |
| Jan. 17, 2025 | GALA RENEE D | President & COO | A | Ordinary Shares | 7741 | $0.00 | 63,233.0000 | 66,007,000 | 13.95% | 0.01% |
| Jan. 17, 2025 | COZADD BRUCE C | Chairman & CEO | F | Ordinary Shares | 13840 | $122.62 | 441,244.0000 | 66,007,000 | 3.04% | 0.02% |
| Jan. 17, 2025 | COZADD BRUCE C | Chairman & CEO | A | Ordinary Shares | 29559 | $0.00 | 455,084.0000 | 66,007,000 | 6.95% | 0.04% |
| Jan. 17, 2025 | Iannone Robert | EVP, G R&D and CMO | F | Ordinary Shares | 2181 | $122.62 | 67,766.0000 | 66,007,000 | 3.12% | 0.00% |
| Jan. 17, 2025 | Iannone Robert | EVP, G R&D and CMO | A | Ordinary Shares | 7506 | $0.00 | 69,947.0000 | 66,007,000 | 12.02% | 0.01% |
| Jan. 17, 2025 | Pearce Samantha | EVP, Chief Commercial Officer | F | Ordinary Shares | 1365 | $122.62 | 25,412.0000 | 66,007,000 | 5.10% | 0.00% |
| Jan. 17, 2025 | Pearce Samantha | EVP, Chief Commercial Officer | A | Ordinary Shares | 2533 | $0.00 | 26,777.0000 | 66,007,000 | 10.45% | 0.00% |
| Jan. 17, 2025 | Patil Neena M | EVP & Chief Legal Officer | A | Ordinary Shares | 5864 | $0.00 | 39,023.0000 | 66,007,000 | 17.68% | 0.01% |
| Jan. 2, 2025 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 1500 | $123.43 | 425,525.0000 | 66,007,000 | 0.35% | 0.00% |
| Dec. 5, 2024 | GALA RENEE D | President & COO | F | Ordinary Shares | 80 | $123.45 | 55,492.0000 | 67,511,000 | 0.14% | 0.00% |
| Dec. 2, 2024 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 2000 | $121.17 | 427,025.0000 | 67,511,000 | 0.47% | 0.00% |
| Dec. 2, 2024 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 53 | $122.49 | 6,596.0000 | 67,511,000 | 0.80% | 0.00% |
| Nov. 8, 2024 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 3700 | $123.41 | 33,048.0000 | 67,511,000 | 10.07% | 0.01% |
| Nov. 1, 2024 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 1000 | $110.84 | 428,976.0000 | 67,511,000 | 0.23% | 0.00% |
| Sept. 6, 2024 | Henderson Mary Elizabeth | SVP, Technical Operations | S | Ordinary Shares | 1410 | $108.30 | 14,531.0000 | 72,066,000 | 8.85% | 0.00% |
| Aug. 2, 2024 | RIEDEL NORBERT G | Director | A | Ordinary Shares | 3731 | $0.00 | 17,436.0000 | 72,066,000 | 27.22% | 0.01% |
| Aug. 2, 2024 | ENRIGHT PATRICK G | Director | A | Ordinary Shares | 3731 | $0.00 | 24,677.0000 | 72,066,000 | 17.81% | 0.01% |
| Aug. 2, 2024 | Winningham Rick E | Director | A | Ordinary Shares | 3731 | $0.00 | 14,175.0000 | 72,066,000 | 35.72% | 0.01% |
| Aug. 6, 2024 | Winningham Rick E | Director | F | Ordinary Shares | 1484 | $111.35 | 12,691.0000 | 72,066,000 | 10.47% | 0.00% |
| Aug. 2, 2024 | Smith Mark Douglas | Director | A | Ordinary Shares | 3731 | $0.00 | 10,619.0000 | 72,066,000 | 54.17% | 0.01% |
| Aug. 6, 2024 | Smith Mark Douglas | Director | F | Ordinary Shares | 1484 | $111.35 | 9,135.0000 | 72,066,000 | 13.97% | 0.00% |
| Aug. 6, 2024 | RIEDEL NORBERT G | Director | F | Ordinary Shares | 1484 | $111.35 | 15,952.0000 | 72,066,000 | 8.51% | 0.00% |
| Aug. 2, 2024 | ORiordan Anne | Director | A | Ordinary Shares | 3731 | $0.00 | 16,282.0000 | 72,066,000 | 29.73% | 0.01% |
| Aug. 6, 2024 | ORiordan Anne | Director | F | Ordinary Shares | 1484 | $111.35 | 14,798.0000 | 72,066,000 | 9.11% | 0.00% |
| Aug. 2, 2024 | O'Keefe Kenneth W | Director | A | Ordinary Shares | 3731 | $0.00 | 32,899.0000 | 72,066,000 | 12.79% | 0.01% |
| Aug. 6, 2024 | O'Keefe Kenneth W | Director | F | Ordinary Shares | 1484 | $111.35 | 31,415.0000 | 72,066,000 | 4.51% | 0.00% |
| Aug. 2, 2024 | McSharry Heather Ann | Director | A | Ordinary Shares | 3731 | $0.00 | 20,509.0000 | 72,066,000 | 22.24% | 0.01% |
| Aug. 6, 2024 | McSharry Heather Ann | Director | F | Ordinary Shares | 1608 | $111.35 | 18,901.0000 | 72,066,000 | 7.84% | 0.00% |
| Aug. 2, 2024 | Cook Jennifer E. | Director | A | Ordinary Shares | 3731 | $0.00 | 10,619.0000 | 72,066,000 | 54.17% | 0.01% |
| Aug. 6, 2024 | Cook Jennifer E. | Director | F | Ordinary Shares | 1484 | $111.35 | 9,135.0000 | 72,066,000 | 13.97% | 0.00% |
| Aug. 2, 2024 | Pearce Samantha | EVP, Chief Commercial Officer | A | Ordinary Shares | 6996 | $0.00 | 24,078.0000 | 72,066,000 | 40.96% | 0.01% |
| Aug. 2, 2024 | Mulligan Seamus | Director | A | Ordinary Shares | 3731 | $0.00 | 1,176,106.0000 | 72,066,000 | 0.32% | 0.01% |
| Aug. 2, 2024 | Kennedy Patrick | Director | A | Ordinary Shares | 3731 | $0.00 | 5,154.0000 | 72,066,000 | 262.19% | 0.01% |
| Aug. 2, 2024 | Hamill Laura | Director | A | Ordinary Shares | 3731 | $0.00 | 5,231.0000 | 72,066,000 | 248.73% | 0.01% |
| June 7, 2024 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 163 | $108.83 | 6,596.0000 | 72,066,000 | 2.41% | 0.00% |
| May 3, 2024 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 5000 | $109.65 | 36,629.0000 | 72,066,000 | 12.01% | 0.01% |
| April 5, 2024 | GALA RENEE D | President & COO | F | Ordinary Shares | 1736 | $115.21 | 55,357.0000 | 72,066,000 | 3.04% | 0.00% |
| March 6, 2024 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 1236 | $120.85 | 9,064.0000 | 72,066,000 | 12.00% | 0.00% |
| March 6, 2024 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 700 | $117.51 | 8,364.0000 | 72,066,000 | 7.72% | 0.00% |
| March 7, 2024 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 1768 | $116.98 | 6,596.0000 | 72,066,000 | 21.14% | 0.00% |
| March 5, 2024 | COZADD BRUCE C | Chairman & CEO | F | Ordinary Shares | 22436 | $117.53 | 429,809.0000 | 72,066,000 | 4.96% | 0.03% |
| March 5, 2024 | GALA RENEE D | President & COO | F | Ordinary Shares | 3622 | $117.53 | 57,093.0000 | 72,066,000 | 5.97% | 0.01% |
| March 5, 2024 | Pearce Samantha | SVP, Head of Europe & Internat | F | Ordinary Shares | 2474 | $117.53 | 16,922.0000 | 72,066,000 | 12.76% | 0.00% |
| March 5, 2024 | Patil Neena M | EVP & Chief Legal Officer | F | Ordinary Shares | 3432 | $117.53 | 41,629.0000 | 72,066,000 | 7.62% | 0.00% |
| March 5, 2024 | Iannone Robert | EVP, Global Head of R&D | F | Ordinary Shares | 4294 | $117.53 | 62,226.0000 | 72,066,000 | 6.46% | 0.01% |
| March 1, 2024 | COZADD BRUCE C | Chairman & CEO | A | Ordinary Shares | 50187 | $0.00 | 452,245.0000 | 72,066,000 | 12.48% | 0.07% |
| March 1, 2024 | Johnson Philip L | EVP & Chief Financial Officer | A | Ordinary Shares | 15932 | $0.00 | 15,932.0000 | 72,066,000 | 9999.99% | 0.02% |
| March 1, 2024 | Johnson Philip L | EVP & Chief Financial Officer | P | Ordinary Shares | 12000 | $119.65 | 27,932.0000 | 72,066,000 | 75.32% | 0.02% |
| March 1, 2024 | Henderson Mary Elizabeth | SVP, Technical Operations | A | Ordinary Shares | 5178 | $0.00 | 15,941.0000 | 72,066,000 | 48.11% | 0.01% |
| March 1, 2024 | Carr Patricia | SVP, Chief Accounting Officer | A | Ordinary Shares | 2987 | $0.00 | 10,300.0000 | 72,066,000 | 40.85% | 0.00% |
| March 1, 2024 | Kennedy Patrick | Director | A | Common Stock | 1423 | $0.00 | 1,423.0000 | 72,066,000 | 9999.99% | 0.00% |
| March 1, 2024 | Pearce Samantha | SVP, Head of Europe & Internat | A | Ordinary Shares | 5065 | $0.00 | 19,396.0000 | 72,066,000 | 35.34% | 0.01% |
| March 1, 2024 | Patil Neena M | EVP & Chief Legal Officer | A | Ordinary Shares | 12348 | $0.00 | 45,061.0000 | 72,066,000 | 37.75% | 0.02% |
| March 1, 2024 | Iannone Robert | EVP, Global Head of R&D | A | Ordinary Shares | 16928 | $0.00 | 66,520.0000 | 72,066,000 | 34.13% | 0.02% |
| March 1, 2024 | GALA RENEE D | President & COO | A | Ordinary Shares | 19916 | $0.00 | 60,715.0000 | 72,066,000 | 48.81% | 0.03% |
| Dec. 4, 2023 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 50 | $121.39 | 5,986.0000 | 62,539,000 | 0.83% | 0.00% |
| Jan. 17, 2024 | GALA RENEE D | President & COO | A | Ordinary Shares | 7079 | $0.00 | 44,003.0000 | 72,066,000 | 19.17% | 0.01% |
| Jan. 17, 2024 | COZADD BRUCE C | Chairman & CEO | A | Ordinary Shares | 26545 | $0.00 | 414,303.0000 | 72,066,000 | 6.85% | 0.04% |
| Jan. 17, 2024 | Carr Patricia | SVP, Chief Accounting Officer | A | Ordinary Shares | 1327 | $0.00 | 7,363.0000 | 72,066,000 | 21.98% | 0.00% |
| Jan. 17, 2024 | COZADD BRUCE C | Chairman & CEO | F | Ordinary Shares | 12245 | $119.13 | 402,058.0000 | 72,066,000 | 2.96% | 0.02% |
| Jan. 17, 2024 | Pearce Samantha | SVP, Head of Europe & Internat | A | Ordinary Shares | 2210 | $0.00 | 15,369.0000 | 72,066,000 | 16.79% | 0.00% |
| Jan. 17, 2024 | Pearce Samantha | SVP, Head of Europe & Internat | F | Ordinary Shares | 1038 | $119.13 | 14,331.0000 | 72,066,000 | 6.75% | 0.00% |
| Jan. 17, 2024 | Patil Neena M | EVP & Chief Legal Officer | A | Ordinary Shares | 5087 | $0.00 | 34,369.0000 | 72,066,000 | 17.37% | 0.01% |
| Jan. 17, 2024 | Patil Neena M | EVP & Chief Legal Officer | F | Ordinary Shares | 1656 | $119.13 | 32,713.0000 | 72,066,000 | 4.82% | 0.00% |
| Jan. 17, 2024 | Iannone Robert | EVP, Global Head of R&D | A | Ordinary Shares | 5970 | $0.00 | 51,322.0000 | 72,066,000 | 13.16% | 0.01% |
| Jan. 17, 2024 | Iannone Robert | EVP, Global Head of R&D | F | Ordinary Shares | 1730 | $119.13 | 49,592.0000 | 72,066,000 | 3.37% | 0.00% |
| Jan. 17, 2024 | GALA RENEE D | President & COO | F | Ordinary Shares | 3204 | $119.13 | 40,799.0000 | 72,066,000 | 7.28% | 0.00% |
| Dec. 4, 2023 | Cook Jennifer E. | Director | S | Ordinary Shares | 417 | $119.27 | 6,888.0000 | 62,539,000 | 5.71% | 0.00% |
| Dec. 4, 2023 | Smith Mark Douglas | Director | S | Ordinary Shares | 417 | $119.27 | 6,888.0000 | 62,539,000 | 5.71% | 0.00% |
| Nov. 10, 2023 | GALA RENEE D | President & COO | A | Ordinary Shares | 772 | $0.00 | 36,887.0000 | 62,539,000 | 2.14% | 0.00% |
| Sept. 1, 2023 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 1500 | $144.25 | 29,186.0000 | 62,539,000 | 4.89% | 0.00% |
| Aug. 29, 2023 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 142 | $143.47 | 5,986.0000 | 62,539,000 | 2.32% | 0.00% |
| Aug. 15, 2023 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 750 | $139.59 | 30,686.0000 | 62,539,000 | 2.39% | 0.00% |
| Aug. 14, 2023 | O'Keefe Kenneth W | Director | S | Ordinary Shares | 1241 | $138.16 | 29,168.0000 | 62,539,000 | 4.08% | 0.00% |
| Aug. 11, 2023 | Winningham Rick E | Director | A | Ordinary Shares | 3075 | $0.00 | 11,685.0000 | 62,539,000 | 35.71% | 0.00% |
| Aug. 14, 2023 | Winningham Rick E | Director | S | Ordinary Shares | 1241 | $138.16 | 10,444.0000 | 62,539,000 | 10.62% | 0.00% |
| Aug. 11, 2023 | Sohn Catherine A. | Director | A | Ordinary Shares | 3075 | $0.00 | 16,109.0000 | 62,539,000 | 23.59% | 0.00% |
| Aug. 14, 2023 | Sohn Catherine A. | Director | S | Ordinary Shares | 1241 | $138.16 | 14,868.0000 | 62,539,000 | 7.70% | 0.00% |
| Aug. 11, 2023 | Smith Mark Douglas | Director | A | Ordinary Shares | 3075 | $0.00 | 8,546.0000 | 62,539,000 | 56.21% | 0.00% |
| Aug. 14, 2023 | Smith Mark Douglas | Director | S | Ordinary Shares | 1241 | $138.16 | 7,305.0000 | 62,539,000 | 14.52% | 0.00% |
| Aug. 11, 2023 | RIEDEL NORBERT G | Director | A | Ordinary Shares | 3075 | $0.00 | 14,946.0000 | 62,539,000 | 25.90% | 0.00% |
| Aug. 14, 2023 | RIEDEL NORBERT G | Director | S | Ordinary Shares | 1241 | $138.16 | 13,705.0000 | 62,539,000 | 8.30% | 0.00% |
| Aug. 11, 2023 | Mulligan Seamus | Director | A | Ordinary Shares | 3075 | $0.00 | 1,172,375.0000 | 62,539,000 | 0.26% | 0.00% |
| Aug. 11, 2023 | McSharry Heather Ann | Director | A | Ordinary Shares | 3075 | $0.00 | 18,122.0000 | 62,539,000 | 20.44% | 0.00% |
| Aug. 14, 2023 | McSharry Heather Ann | Director | S | Ordinary Shares | 1344 | $138.16 | 16,778.0000 | 62,539,000 | 7.42% | 0.00% |
| Aug. 11, 2023 | Henderson Mary Elizabeth | SVP, Technical Operations | A | Ordinary Shares | 10763 | $0.00 | 10,763.0000 | 62,539,000 | 9999.99% | 0.02% |
| Aug. 11, 2023 | Gray Peter | Director | A | Ordinary Shares | 3075 | $0.00 | 17,309.0000 | 62,539,000 | 21.60% | 0.00% |
| Aug. 14, 2023 | Gray Peter | Director | S | Ordinary Shares | 1241 | $138.16 | 16,068.0000 | 62,539,000 | 7.17% | 0.00% |
| Aug. 11, 2023 | ENRIGHT PATRICK G | Director | A | Ordinary Shares | 3075 | $0.00 | 22,187.0000 | 62,539,000 | 16.09% | 0.00% |
| Aug. 14, 2023 | ENRIGHT PATRICK G | Director | S | Ordinary Shares | 1241 | $138.16 | 20,946.0000 | 62,539,000 | 5.59% | 0.00% |
| Aug. 11, 2023 | Cook Jennifer E. | Director | A | Ordinary Shares | 3075 | $0.00 | 8,546.0000 | 62,539,000 | 56.21% | 0.00% |
| Aug. 14, 2023 | Cook Jennifer E. | Director | S | Ordinary Shares | 1241 | $138.16 | 7,305.0000 | 62,539,000 | 14.52% | 0.00% |
| Aug. 14, 2023 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 158 | $138.16 | 6,128.0000 | 62,539,000 | 2.51% | 0.00% |
| Aug. 11, 2023 | ORiordan Anne | Director | A | Ordinary Shares | 3075 | $0.00 | 13,792.0000 | 62,539,000 | 28.69% | 0.00% |
| Aug. 14, 2023 | ORiordan Anne | Director | S | Ordinary Shares | 1241 | $138.16 | 12,551.0000 | 62,539,000 | 9.00% | 0.00% |
| Aug. 11, 2023 | O'Keefe Kenneth W | Director | A | Ordinary Shares | 3075 | $0.00 | 30,409.0000 | 62,539,000 | 11.25% | 0.00% |
| Aug. 7, 2023 | Patil Neena M | EVP & Chief Legal Officer | D | Ordinary Shares | 1390 | $131.51 | 31,436.0000 | 62,539,000 | 4.23% | 0.00% |
| June 8, 2023 | Mulligan Seamus | Director | M | Non-Qualified Stock Option (right to buy) | 4500 | $0.00 | 0.0000 | 62,539,000 | 100.00% | 0.01% |
| June 8, 2023 | Mulligan Seamus | Director | M | Ordinary Shares | 4500 | $81.76 | 1,169,300.0000 | 62,539,000 | 0.39% | 0.01% |
| June 7, 2023 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 126 | $127.92 | 6,286.0000 | 62,539,000 | 1.97% | 0.00% |
| June 5, 2023 | Iannone Robert | EVP, Global Head of Research a | D | Ordinary Shares | 1311 | $129.73 | 45,315.0000 | 62,539,000 | 2.81% | 0.00% |
| June 5, 2023 | Sablich Kim | EVP, GM of U.S. | D | Ordinary Shares | 2082 | $129.73 | 28,478.0000 | 62,539,000 | 6.81% | 0.00% |
| June 1, 2023 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 1526 | $127.98 | 32,900.0000 | 62,539,000 | 4.43% | 0.00% |
| June 1, 2023 | Patil Neena M | EVP & Chief Legal Officer | S | Ordinary Shares | 74 | $128.02 | 32,826.0000 | 62,539,000 | 0.22% | 0.00% |
| May 18, 2023 | GALA RENEE D | EVP & Chief Financial Officer | S | Ordinary Shares | 6000 | $131.75 | 35,978.0000 | 62,539,000 | 14.29% | 0.01% |
| April 5, 2023 | GALA RENEE D | EVP & Chief Financial Officer | F | Ordinary Shares | 1807 | $145.78 | 41,978.0000 | 62,539,000 | 4.13% | 0.00% |
| March 15, 2023 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 1023 | $133.22 | 6,286.0000 | 62,539,000 | 14.00% | 0.00% |
| March 8, 2023 | Sablich Kim | EVP, GM of U.S., Commercial Ma | S | Ordinary Shares | 1752 | $139.42 | 31,821.0000 | 62,539,000 | 5.22% | 0.00% |
| March 8, 2023 | Sablich Kim | EVP, GM of U.S., Commercial Ma | S | Ordinary Shares | 1261 | $140.19 | 30,560.0000 | 62,539,000 | 3.96% | 0.00% |
| March 7, 2023 | O'Keefe Kenneth W | Director | M | Ordinary Shares | 4500 | $81.76 | 30,024.0000 | 62,539,000 | 17.63% | 0.01% |
| March 7, 2023 | O'Keefe Kenneth W | Director | S | Ordinary Shares | 2690 | $138.39 | 27,334.0000 | 62,539,000 | 8.96% | 0.00% |
| March 7, 2023 | O'Keefe Kenneth W | Director | M | Non-Qualified Stock Option (right to buy) | 4500 | $0.00 | 0.0000 | 62,539,000 | 100.00% | 0.01% |
| March 6, 2023 | Larkin Finbar | SVP, Technical Operations | M | Non-Qualified Stock Option (right to buy) | 1706 | $0.00 | 0.0000 | 62,539,000 | 100.00% | 0.00% |
| March 3, 2023 | Swisher Daniel N JR | President and COO | A | Ordinary Shares | 13456 | $0.00 | 60,440.0000 | 62,539,000 | 28.64% | 0.02% |
| March 5, 2023 | Swisher Daniel N JR | President and COO | F | Ordinary Shares | 5426 | $142.78 | 55,014.0000 | 62,539,000 | 8.98% | 0.01% |
| March 3, 2023 | Iannone Robert | EVP, Global Head of Research a | A | Ordinary Shares | 12447 | $0.00 | 48,763.0000 | 62,539,000 | 34.27% | 0.02% |
| March 5, 2023 | Iannone Robert | EVP, Global Head of Research a | F | Ordinary Shares | 2274 | $142.78 | 46,489.0000 | 62,539,000 | 4.66% | 0.00% |
| March 3, 2023 | Carr Patricia | SVP, Chief Accounting Officer | A | Ordinary Shares | 2523 | $0.00 | 8,457.0000 | 62,539,000 | 42.52% | 0.00% |
| March 5, 2023 | Carr Patricia | SVP, Chief Accounting Officer | S | Ordinary Shares | 1148 | $140.76 | 7,309.0000 | 62,539,000 | 13.57% | 0.00% |
| March 3, 2023 | GALA RENEE D | EVP & Chief Financial Officer | A | Ordinary Shares | 12784 | $0.00 | 45,342.0000 | 62,539,000 | 39.27% | 0.02% |
| March 5, 2023 | GALA RENEE D | EVP & Chief Financial Officer | F | Ordinary Shares | 1557 | $142.78 | 43,785.0000 | 62,539,000 | 3.43% | 0.00% |
| March 3, 2023 | Patil Neena M | EVP & Chief Legal Officer | A | Ordinary Shares | 9419 | $0.00 | 36,262.0000 | 62,539,000 | 35.09% | 0.02% |
| March 5, 2023 | Patil Neena M | EVP & Chief Legal Officer | F | Ordinary Shares | 1923 | $142.78 | 34,339.0000 | 62,539,000 | 5.30% | 0.00% |
| March 3, 2023 | Pearce Samantha | SVP, Head of Europe & Internat | A | Ordinary Shares | 3870 | $0.00 | 15,179.0000 | 62,539,000 | 34.22% | 0.01% |
| March 5, 2023 | Pearce Samantha | SVP, Head of Europe & Internat | F | Ordinary Shares | 2020 | $142.78 | 13,159.0000 | 62,539,000 | 13.31% | 0.00% |
| March 3, 2023 | Sablich Kim | EVP, GM of U.S., Commercial Ma | A | Ordinary Shares | 10429 | $0.00 | 35,183.0000 | 62,539,000 | 42.13% | 0.02% |
| March 5, 2023 | Sablich Kim | EVP, GM of U.S., Commercial Ma | F | Ordinary Shares | 1610 | $142.78 | 33,573.0000 | 62,539,000 | 4.58% | 0.00% |
| March 3, 2023 | COZADD BRUCE C | Chairman & CEO | A | Ordinary Shares | 42388 | $0.00 | 409,466.0000 | 62,539,000 | 11.55% | 0.07% |
| March 5, 2023 | COZADD BRUCE C | Chairman & CEO | F | Ordinary Shares | 21882 | $142.78 | 387,584.0000 | 62,539,000 | 5.34% | 0.03% |
| March 4, 2023 | Mulligan Seamus | Director | M | Non-Qualified Stock Option (right to buy) | 4500 | $0.00 | 0.0000 | 62,539,000 | 100.00% | 0.01% |
| March 4, 2023 | Mulligan Seamus | Director | M | Ordinary Shares | 4500 | $59.13 | 1,164,800.0000 | 62,539,000 | 0.39% | 0.01% |
| March 3, 2023 | Larkin Finbar | SVP, Technical Operations | A | Ordinary Shares | 4373 | $0.00 | 23,854.0000 | 62,539,000 | 22.45% | 0.01% |
| March 6, 2023 | Larkin Finbar | SVP, Technical Operations | M | Ordinary Shares | 1706 | $58.72 | 25,560.0000 | 62,539,000 | 7.15% | 0.00% |
| March 6, 2023 | Larkin Finbar | SVP, Technical Operations | S | Ordinary Shares | 1706 | $143.92 | 23,854.0000 | 62,539,000 | 6.67% | 0.00% |
| March 7, 2023 | Larkin Finbar | SVP, Technical Operations | S | Ordinary Shares | 2075 | $140.76 | 21,779.0000 | 62,539,000 | 8.70% | 0.00% |
| Feb. 2, 2023 | Pearce Samantha | SVP, Head of Europe & Internat | M | Non-Qualified Stock Option (right to buy) | 531 | $0.00 | 6,907.0000 | 62,539,000 | 7.14% | 0.00% |
| Feb. 2, 2023 | Pearce Samantha | SVP, Head of Europe & Internat | M | Ordinary Shares | 531 | $109.45 | 11,840.0000 | 62,539,000 | 4.70% | 0.00% |
| Feb. 2, 2023 | Pearce Samantha | SVP, Head of Europe & Internat | S | Ordinary Shares | 531 | $157.26 | 11,309.0000 | 62,539,000 | 4.48% | 0.00% |
| Feb. 1, 2023 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 1000 | $155.79 | 367,078.0000 | 62,539,000 | 0.27% | 0.00% |
| Jan. 3, 2023 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 1000 | $159.59 | 370,078.0000 | 62,539,000 | 0.27% | 0.00% |
| Jan. 3, 2023 | Pearce Samantha | SVP, Head of Europe & Internat | M | Ordinary Shares | 531 | $109.45 | 11,840.0000 | 62,539,000 | 4.70% | 0.00% |
| Jan. 3, 2023 | Pearce Samantha | SVP, Head of Europe & Internat | S | Ordinary Shares | 531 | $159.59 | 11,309.0000 | 62,539,000 | 4.48% | 0.00% |
| Jan. 3, 2023 | Pearce Samantha | SVP, Head of Europe & Internat | M | Non-Qualified Stock Option (right to buy) | 531 | $0.00 | 7,438.0000 | 62,539,000 | 6.66% | 0.00% |
| Jan. 3, 2023 | COZADD BRUCE C | Chairman & CEO | S | Ordinary Shares | 2000 | $160.00 | 368,078.0000 | 62,539,000 | 0.54% | 0.00% |