In the last 12 months, insiders at Ultragenyx Pharmaceutical Inc. ($RARE) filed 237 transactions with the SEC: 0 open-market purchases totaling $0 and 78 sales totaling $24,300,012. Net insider sentiment: net selling.
Ultragenyx Pharmaceutical Inc. operates in the Pharmaceutical preparations industry (Life sciences sector).
Most Active Insiders
- KAKKIS EMIL D (President & CEO) — 26 transactions totaling $15,705,929
- Kassberg Thomas Richard (CBO & EVP) — 17 transactions totaling $2,744,080
- Parschauer Karah Herdman (EVP and Chief Legal Officer) — 21 transactions totaling $2,122,434
- Harris Erik (EVP & Chief Commercial Officer) — 16 transactions totaling $1,540,710
- Pinion John Richard (See Remarks) — 18 transactions totaling $1,519,226
View all SEC Filings for Ultragenyx Pharmaceutical Inc. (RARE).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| April 1, 2026 | Horn Howard | Chief Financial Officer | S | Common Stock | 4683 | $20.97 | 80,351.0000 | 98,600,000 | 5.51% | 0.00% |
| March 6, 2026 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 6018 | $21.40 | 70,328.0000 | 98,600,000 | 7.88% | 0.01% |
| March 10, 2026 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 3508 | $22.67 | 66,820.0000 | 98,600,000 | 4.99% | 0.00% |
| March 2, 2026 | Horn Howard | Chief Financial Officer | S | Common Stock | 5290 | $22.80 | 89,788.0000 | 98,600,000 | 5.56% | 0.01% |
| March 1, 2026 | Horn Howard | Chief Financial Officer | A | Common Stock | 6143 | $0.00 | 95,078.0000 | 98,600,000 | 6.91% | 0.01% |
| March 2, 2026 | Crombez Eric | EVP and Chief Medical Officer | S | Common Stock | 7029 | $22.80 | 76,301.0000 | 98,600,000 | 8.44% | 0.01% |
| March 3, 2026 | Horn Howard | Chief Financial Officer | S | Common Stock | 1635 | $22.40 | 85,034.0000 | 98,600,000 | 1.89% | 0.00% |
| March 2, 2026 | Horn Howard | Chief Financial Officer | S | Common Stock | 3119 | $22.54 | 86,669.0000 | 98,600,000 | 3.47% | 0.00% |
| March 2, 2026 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 1632 | $22.80 | 48,670.0000 | 98,600,000 | 3.24% | 0.00% |
| March 2, 2026 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | F | Common Stock | 148 | $23.39 | 50,302.0000 | 98,600,000 | 0.29% | 0.00% |
| March 2, 2026 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 8135 | $22.80 | 76,346.0000 | 98,600,000 | 9.63% | 0.01% |
| March 1, 2026 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Common Stock | 11137 | $0.00 | 84,408.0000 | 98,600,000 | 15.20% | 0.01% |
| March 2, 2026 | KAKKIS EMIL D | President & CEO | S | Common Stock | 54404 | $22.80 | 2,817,979.0000 | 98,600,000 | 1.89% | 0.06% |
| March 1, 2026 | KAKKIS EMIL D | President & CEO | A | Common Stock | 71177 | $0.00 | 2,871,893.0000 | 98,600,000 | 2.54% | 0.07% |
| March 2, 2026 | Harris Erik | EVP & Chief Commercial Officer | S | Common Stock | 10539 | $22.80 | 89,515.0000 | 98,600,000 | 10.53% | 0.01% |
| March 1, 2026 | Harris Erik | EVP & Chief Commercial Officer | A | Common Stock | 11643 | $0.00 | 99,498.0000 | 98,600,000 | 13.25% | 0.01% |
| March 2, 2026 | Pinion John Richard | See Remarks | S | Common Stock | 10029 | $22.80 | 110,026.0000 | 98,600,000 | 8.35% | 0.01% |
| March 1, 2026 | Pinion John Richard | See Remarks | A | Common Stock | 11137 | $0.00 | 119,565.0000 | 98,600,000 | 10.27% | 0.01% |
| March 2, 2026 | Huang Dennis Karl | See Remarks | F | Common Stock | 999 | $23.39 | 124,729.0000 | 98,600,000 | 0.79% | 0.00% |
| March 1, 2026 | Huang Dennis Karl | See Remarks | A | Common Stock | 11137 | $0.00 | 125,728.0000 | 98,600,000 | 9.72% | 0.01% |
| March 1, 2026 | Crombez Eric | EVP and Chief Medical Officer | A | Common Stock | 11643 | $0.00 | 83,173.0000 | 98,600,000 | 16.28% | 0.01% |
| Feb. 2, 2026 | Horn Howard | Chief Financial Officer | S | Common Stock | 3061 | $23.56 | 88,935.0000 | 98,600,000 | 3.33% | 0.00% |
| Jan. 2, 2026 | Horn Howard | Chief Financial Officer | S | Common Stock | 3150 | $22.84 | 91,996.0000 | 98,600,000 | 3.31% | 0.00% |
| Dec. 29, 2025 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 85 | $34.38 | 50,450.0000 | 99,771,297 | 0.17% | 0.00% |
| Dec. 10, 2025 | Horn Howard | Chief Financial Officer | S | Common Stock | 3081 | $36.38 | 95,146.0000 | 99,771,297 | 3.14% | 0.00% |
| Oct. 13, 2025 | Horn Howard | Chief Financial Officer | S | Common Stock | 7942 | $31.51 | 98,227.0000 | 99,771,297 | 7.48% | 0.01% |
| Sept. 18, 2025 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 64 | $29.17 | 50,242.0000 | 90,538,118 | 0.13% | 0.00% |
| Sept. 12, 2025 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 2450 | $31.17 | 73,271.0000 | 90,538,118 | 3.24% | 0.00% |
| Sept. 5, 2025 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 84 | $31.39 | 50,306.0000 | 90,538,118 | 0.17% | 0.00% |
| June 20, 2025 | Sanders Corazon (Corsee) D. | Not found | S | Common Stock | 2405 | $37.39 | 15,344.0000 | 90,538,118 | 13.55% | 0.00% |
| May 15, 2025 | SULIMAN SHEHNAAZ | Not found | A | Stock Option (Right to Buy) | 10787 | $0.00 | 10,787.0000 | 90,538,118 | 9999.99% | 0.01% |
| May 15, 2025 | WELCH DANIEL G | Not found | A | Stock Option (Right to Buy) | 10787 | $0.00 | 10,787.0000 | 90,538,118 | 9999.99% | 0.01% |
| May 15, 2025 | WELCH DANIEL G | Not found | A | Common Stock | 5740 | $0.00 | 32,690.0000 | 90,538,118 | 21.30% | 0.01% |
| May 15, 2025 | SULIMAN SHEHNAAZ | Not found | A | Common Stock | 5740 | $0.00 | 25,940.0000 | 90,538,118 | 28.42% | 0.01% |
| May 15, 2025 | Ray Amrit | Not found | A | Stock Option (Right to Buy) | 10787 | $0.00 | 10,787.0000 | 90,538,118 | 9999.99% | 0.01% |
| May 15, 2025 | Ray Amrit | Not found | A | Common Stock | 5740 | $0.00 | 23,365.0000 | 90,538,118 | 32.57% | 0.01% |
| May 15, 2025 | Dunsire Deborah | Not found | A | Stock Option (Right to Buy) | 10787 | $0.00 | 10,787.0000 | 90,538,118 | 9999.99% | 0.01% |
| May 15, 2025 | Dunsire Deborah | Not found | A | Common Stock | 5740 | $0.00 | 30,815.0000 | 90,538,118 | 22.89% | 0.01% |
| May 15, 2025 | Fust Matthew K | Not found | A | Stock Option (Right to Buy) | 10787 | $0.00 | 10,787.0000 | 90,538,118 | 9999.99% | 0.01% |
| May 15, 2025 | Fust Matthew K | Not found | A | Common Stock | 5740 | $0.00 | 25,945.0000 | 90,538,118 | 28.41% | 0.01% |
| May 15, 2025 | NARACHI MICHAEL | Not found | A | Stock Option (Right to Buy) | 10787 | $0.00 | 10,787.0000 | 90,538,118 | 9999.99% | 0.01% |
| May 15, 2025 | NARACHI MICHAEL | Not found | A | Common Stock | 5740 | $0.00 | 32,690.0000 | 90,538,118 | 21.30% | 0.01% |
| May 15, 2025 | Sanders Corazon (Corsee) D. | Not found | A | Stock Option (Right to Buy) | 10787 | $0.00 | 10,787.0000 | 90,538,118 | 9999.99% | 0.01% |
| May 15, 2025 | Sanders Corazon (Corsee) D. | Not found | A | Common Stock | 5740 | $0.00 | 17,749.0000 | 90,538,118 | 47.80% | 0.01% |
| May 5, 2025 | Crombez Eric | EVP and Chief Medical Officer | S | Common Stock | 520 | $39.24 | 71,530.0000 | 90,538,118 | 0.72% | 0.00% |
| April 21, 2025 | Crombez Eric | EVP and Chief Medical Officer | S | Common Stock | 242 | $35.11 | 71,680.0000 | 90,538,118 | 0.34% | 0.00% |
| March 6, 2025 | Horn Howard | Chief Financial Officer | S | Common Stock | 1785 | $40.40 | 106,169.0000 | 90,538,118 | 1.65% | 0.00% |
| March 1, 2025 | Crombez Eric | EVP and Chief Medical Officer | A | Stock Ooption (Right to Buy) | 30246 | $0.00 | 30,246.0000 | 90,538,118 | 9999.99% | 0.03% |
| March 1, 2025 | Pinion John Richard | See Remarks | A | Common Stock | 18443 | $0.00 | 122,205.0000 | 90,538,118 | 17.77% | 0.02% |
| March 3, 2025 | Pinion John Richard | See Remarks | S | Common Stock | 14439 | $42.10 | 107,766.0000 | 90,538,118 | 11.82% | 0.02% |
| March 3, 2025 | Pinion John Richard | See Remarks | F | Common Stock | 31 | $42.92 | 108,428.0000 | 90,538,118 | 0.03% | 0.00% |
| March 1, 2025 | Pinion John Richard | See Remarks | A | Stock Option (Right to Buy) | 26074 | $0.00 | 26,074.0000 | 90,538,118 | 9999.99% | 0.03% |
| March 1, 2025 | KAKKIS EMIL D | President & CEO | A | Common Stock | 43268 | $0.00 | 2,766,858.0000 | 90,538,118 | 1.59% | 0.05% |
| March 1, 2025 | KAKKIS EMIL D | President & CEO | A | Common Stock | 107292 | $0.00 | 2,874,150.0000 | 90,538,118 | 3.88% | 0.12% |
| March 3, 2025 | KAKKIS EMIL D | President & CEO | S | Common Stock | 73434 | $42.10 | 2,800,716.0000 | 90,538,118 | 2.55% | 0.08% |
| Feb. 28, 2025 | KAKKIS EMIL D | President & CEO | S | Common Stock | 25000 | $42.48 | 2,800,716.0000 | 90,538,118 | 0.88% | 0.03% |
| March 1, 2025 | KAKKIS EMIL D | President & CEO | A | Stock Option (Right to Buy) | 78448 | $0.00 | 78,448.0000 | 90,538,118 | 9999.99% | 0.09% |
| March 1, 2025 | Harris Erik | EVP & Chief Commercial Officer | A | Common Stock | 16813 | $0.00 | 83,976.0000 | 90,538,118 | 25.03% | 0.02% |
| March 1, 2025 | Harris Erik | EVP & Chief Commercial Officer | A | Common Stock | 18443 | $0.00 | 102,419.0000 | 90,538,118 | 21.96% | 0.02% |
| March 3, 2025 | Harris Erik | EVP & Chief Commercial Officer | S | Common Stock | 15103 | $42.10 | 87,855.0000 | 90,538,118 | 14.67% | 0.02% |
| March 1, 2025 | Harris Erik | EVP & Chief Commercial Officer | A | Stock Option (Right to Buy) | 30246 | $0.00 | 30,246.0000 | 90,538,118 | 9999.99% | 0.03% |
| March 1, 2025 | Huang Dennis Karl | See Remarks | A | Common Stock | 14494 | $0.00 | 97,496.0000 | 90,538,118 | 17.46% | 0.02% |
| March 1, 2025 | Huang Dennis Karl | See Remarks | A | Common Stock | 18443 | $0.00 | 115,939.0000 | 90,538,118 | 18.92% | 0.02% |
| March 3, 2025 | Huang Dennis Karl | See Remarks | F | Common Stock | 1348 | $42.92 | 114,591.0000 | 90,538,118 | 1.16% | 0.00% |
| March 1, 2025 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Common Stock | 9392 | $0.00 | 51,232.0000 | 90,538,118 | 22.45% | 0.01% |
| March 3, 2025 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 967 | $42.10 | 50,265.0000 | 90,538,118 | 1.89% | 0.00% |
| March 3, 2025 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | F | Common Stock | 141 | $42.92 | 50,124.0000 | 90,538,118 | 0.28% | 0.00% |
| March 1, 2025 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Stock Option (Right to Buy) | 5632 | $0.00 | 5,632.0000 | 90,538,118 | 9999.99% | 0.01% |
| March 1, 2025 | Horn Howard | Chief Financial Officer | A | Common Stock | 15653 | $0.00 | 107,954.0000 | 90,538,118 | 16.96% | 0.02% |
| March 1, 2025 | Horn Howard | Chief Financial Officer | A | Stock Option (Right to Buy) | 28160 | $0.00 | 28,160.0000 | 90,538,118 | 9999.99% | 0.03% |
| March 1, 2025 | Huang Dennis Karl | See Remarks | A | Stock Option (Right to Buy) | 26074 | $0.00 | 26,074.0000 | 90,538,118 | 9999.99% | 0.03% |
| March 1, 2025 | Kassberg Thomas Richard | CBO & EVP | A | Common Stock | 18443 | $0.00 | 271,266.0000 | 90,538,118 | 7.29% | 0.02% |
| March 3, 2025 | Kassberg Thomas Richard | CBO & EVP | S | Common Stock | 6028 | $42.10 | 265,238.0000 | 90,538,118 | 2.22% | 0.01% |
| March 3, 2025 | Kassberg Thomas Richard | CBO & EVP | F | Common Stock | 508 | $42.92 | 264,730.0000 | 90,538,118 | 0.19% | 0.00% |
| March 1, 2025 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Common Stock | 18443 | $0.00 | 88,133.0000 | 90,538,118 | 26.46% | 0.02% |
| March 3, 2025 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 12846 | $42.10 | 75,287.0000 | 90,538,118 | 14.58% | 0.01% |
| March 1, 2025 | Crombez Eric | EVP and Chief Medical Officer | A | Common Stock | 16813 | $0.00 | 65,244.0000 | 90,538,118 | 34.72% | 0.02% |
| March 1, 2025 | Crombez Eric | EVP and Chief Medical Officer | A | Common Stock | 14971 | $0.00 | 80,215.0000 | 90,538,118 | 22.95% | 0.02% |
| March 3, 2025 | Crombez Eric | EVP and Chief Medical Officer | S | Common Stock | 8945 | $42.10 | 71,922.0000 | 90,538,118 | 11.06% | 0.01% |
| March 1, 2025 | Pinion John Richard | See Remarks | A | Common Stock | 14494 | $0.00 | 103,762.0000 | 90,538,118 | 16.24% | 0.02% |
| Feb. 27, 2025 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 2230 | $42.93 | 55,751.0000 | 90,538,118 | 3.85% | 0.00% |
| Feb. 27, 2025 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 760 | $42.75 | 54,991.0000 | 90,538,118 | 1.36% | 0.00% |
| March 1, 2025 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Common Stock | 14494 | $0.00 | 69,690.0000 | 90,538,118 | 26.26% | 0.02% |
| March 1, 2025 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Stock Option (Right to Buy) | 26074 | $0.00 | 26,074.0000 | 90,538,118 | 9999.99% | 0.03% |
| Dec. 30, 2024 | KAKKIS EMIL D | President & CEO | S | Common Stock | 11727 | $42.23 | 2,748,590.0000 | 95,493,996 | 0.42% | 0.01% |
| Dec. 9, 2024 | KAKKIS EMIL D | President & CEO | G | Common Stock | 20000 | $0.00 | 2,768,590.0000 | 95,493,996 | 0.72% | 0.02% |
| Dec. 10, 2024 | KAKKIS EMIL D | President & CEO | S | Common Stock | 8273 | $50.00 | 2,760,317.0000 | 95,493,996 | 0.30% | 0.01% |
| Dec. 10, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | G | Common Stock | 648 | $0.00 | 41,840.0000 | 95,493,996 | 1.53% | 0.00% |
| Oct. 10, 2024 | Horn Howard | Chief Financial Officer | S | Common Stock | 7465 | $52.76 | 92,301.0000 | 95,493,996 | 7.48% | 0.01% |
| Sept. 16, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Common Stock | 700 | $0.00 | 42,251.0000 | 73,543,862 | 1.68% | 0.00% |
| Sept. 3, 2024 | KAKKIS EMIL D | President & CEO | S | Common Stock | 20000 | $55.85 | 2,788,582.0000 | 73,543,862 | 0.71% | 0.03% |
| Sept. 3, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 91 | $56.19 | 41,551.0000 | 73,543,862 | 0.22% | 0.00% |
| Aug. 6, 2024 | KAKKIS EMIL D | President & CEO | S | Common Stock | 20000 | $50.17 | 2,808,582.0000 | 73,543,862 | 0.71% | 0.03% |
| July 2, 2024 | Sanders Corazon (Corsee) D. | Not found | S | Common Stock | 584 | $40.98 | 12,009.0000 | 73,543,862 | 4.64% | 0.00% |
| June 18, 2024 | WELCH DANIEL G | Not found | A | Stock Option (Right to Buy) | 9900 | $0.00 | 9,900.0000 | 73,543,862 | 9999.99% | 0.01% |
| June 18, 2024 | SULIMAN SHEHNAAZ | Not found | A | Stock Option (Right to Buy) | 9900 | $0.00 | 9,900.0000 | 73,543,862 | 9999.99% | 0.01% |
| June 18, 2024 | SULIMAN SHEHNAAZ | Not found | A | Common Stock | 5345 | $0.00 | 20,200.0000 | 73,543,862 | 35.98% | 0.01% |
| June 18, 2024 | Sanders Corazon (Corsee) D. | Not found | A | Stock Option (Right to Buy) | 9900 | $0.00 | 9,900.0000 | 73,543,862 | 9999.99% | 0.01% |
| June 18, 2024 | Sanders Corazon (Corsee) D. | Not found | A | Common Stock | 5345 | $0.00 | 12,593.0000 | 73,543,862 | 73.74% | 0.01% |
| June 18, 2024 | Ray Amrit | Not found | A | Stock Option (Right to Buy) | 9900 | $0.00 | 9,900.0000 | 73,543,862 | 9999.99% | 0.01% |
| June 18, 2024 | Ray Amrit | Not found | A | Common Stock | 5345 | $0.00 | 17,625.0000 | 73,543,862 | 43.53% | 0.01% |
| June 18, 2024 | NARACHI MICHAEL | Not found | A | Stock Option (Right to Buy) | 9900 | $0.00 | 9,900.0000 | 73,543,862 | 9999.99% | 0.01% |
| June 18, 2024 | WELCH DANIEL G | Not found | A | Common Stock | 5345 | $0.00 | 26,950.0000 | 73,543,862 | 24.74% | 0.01% |
| June 18, 2024 | Fust Matthew K | Not found | A | Stock Option (Right to Buy) | 9900 | $0.00 | 9,900.0000 | 73,543,862 | 9999.99% | 0.01% |
| June 18, 2024 | Fust Matthew K | Not found | A | Common Stock | 5345 | $0.00 | 20,205.0000 | 73,543,862 | 35.97% | 0.01% |
| June 18, 2024 | Dunsire Deborah | Not found | A | Stock Option (Right to Buy) | 9900 | $0.00 | 9,900.0000 | 73,543,862 | 9999.99% | 0.01% |
| June 18, 2024 | Dunsire Deborah | Not found | A | Common Stock | 5345 | $0.00 | 25,075.0000 | 73,543,862 | 27.09% | 0.01% |
| June 18, 2024 | NARACHI MICHAEL | Not found | A | Common Stock | 5345 | $0.00 | 26,950.0000 | 73,543,862 | 24.74% | 0.01% |
| June 12, 2024 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 9806 | $45.00 | 57,981.0000 | 73,543,862 | 14.47% | 0.01% |
| June 10, 2024 | Sanders Corazon (Corsee) D. | Not found | S | Common Stock | 1737 | $41.10 | 7,248.0000 | 73,543,862 | 19.33% | 0.00% |
| May 2, 2024 | Crombez Eric | EVP and Chief Medical Officer | S | Common Stock | 354 | $43.66 | 48,431.0000 | 73,543,862 | 0.73% | 0.00% |
| April 18, 2024 | Crombez Eric | EVP and Chief Medical Officer | S | Common Stock | 142 | $44.10 | 48,785.0000 | 73,543,862 | 0.29% | 0.00% |
| April 16, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | F | Common Stock | 14 | $42.31 | 41,366.0000 | 73,543,862 | 0.03% | 0.00% |
| March 11, 2024 | Kassberg Thomas Richard | CBO & EVP | S | Common Stock | 11509 | $49.93 | 252,823.0000 | 73,543,862 | 4.35% | 0.02% |
| March 7, 2024 | Fust Matthew K | Not found | S | Common Stock | 7500 | $50.88 | 14,860.0000 | 73,543,862 | 33.54% | 0.01% |
| March 7, 2024 | Fust Matthew K | Not found | S | Common Stock | 2550 | $50.89 | 24,505.0000 | 73,543,862 | 9.43% | 0.00% |
| March 7, 2024 | Fust Matthew K | Not found | S | Common Stock | 2145 | $50.85 | 22,360.0000 | 73,543,862 | 8.75% | 0.00% |
| March 1, 2024 | Horn Howard | Chief Financial Officer | A | Stock Option (Right to Buy) | 34200 | $0.00 | 34,200.0000 | 73,543,862 | 9999.99% | 0.05% |
| March 1, 2024 | Horn Howard | Chief Financial Officer | A | Common Stock | 19400 | $0.00 | 99,766.0000 | 73,543,862 | 24.14% | 0.03% |
| March 1, 2024 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Common Stock | 17800 | $0.00 | 69,782.0000 | 73,543,862 | 34.24% | 0.02% |
| March 1, 2024 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Common Stock | 957 | $0.00 | 70,739.0000 | 73,543,862 | 1.37% | 0.00% |
| March 1, 2024 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 3756 | $53.76 | 67,340.0000 | 73,543,862 | 5.28% | 0.01% |
| March 1, 2024 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Stock Option (Right to Buy) | 31400 | $0.00 | 31,400.0000 | 73,543,862 | 9999.99% | 0.04% |
| March 1, 2024 | Kassberg Thomas Richard | CBO & EVP | A | Common Stock | 17800 | $0.00 | 264,660.0000 | 73,543,862 | 7.21% | 0.02% |
| March 1, 2024 | Kassberg Thomas Richard | CBO & EVP | A | Common Stock | 957 | $0.00 | 265,617.0000 | 73,543,862 | 0.36% | 0.00% |
| March 1, 2024 | Kassberg Thomas Richard | CBO & EVP | F | Common Stock | 274 | $53.69 | 265,343.0000 | 73,543,862 | 0.10% | 0.00% |
| March 1, 2024 | Kassberg Thomas Richard | CBO & EVP | S | Common Stock | 1011 | $53.76 | 264,332.0000 | 73,543,862 | 0.38% | 0.00% |
| March 1, 2024 | Kassberg Thomas Richard | CBO & EVP | A | Stock Option (Right to Buy) | 31400 | $0.00 | 31,400.0000 | 73,543,862 | 9999.99% | 0.04% |
| March 1, 2024 | Huang Dennis Karl | See Remarks | A | Common Stock | 17800 | $0.00 | 82,515.0000 | 73,543,862 | 27.51% | 0.02% |
| March 1, 2024 | Huang Dennis Karl | See Remarks | A | Common Stock | 957 | $0.00 | 83,472.0000 | 73,543,862 | 1.16% | 0.00% |
| March 1, 2024 | Huang Dennis Karl | See Remarks | F | Common Stock | 470 | $53.69 | 83,002.0000 | 73,543,862 | 0.56% | 0.00% |
| March 1, 2024 | Huang Dennis Karl | See Remarks | A | Stock Option (Right to Buy) | 31400 | $0.00 | 31,400.0000 | 73,543,862 | 9999.99% | 0.04% |
| March 1, 2024 | Pinion John Richard | See Remarks | A | Common Stock | 17800 | $0.00 | 92,544.0000 | 73,543,862 | 23.81% | 0.02% |
| March 1, 2024 | Pinion John Richard | See Remarks | A | Common Stock | 957 | $0.00 | 93,501.0000 | 73,543,862 | 1.03% | 0.00% |
| March 1, 2024 | Pinion John Richard | See Remarks | F | Common Stock | 60 | $53.69 | 93,441.0000 | 73,543,862 | 0.06% | 0.00% |
| March 1, 2024 | Pinion John Richard | See Remarks | S | Common Stock | 4173 | $53.76 | 89,268.0000 | 73,543,862 | 4.47% | 0.01% |
| March 1, 2024 | Pinion John Richard | See Remarks | A | Stock Option (Right to Buy) | 31400 | $0.00 | 31,400.0000 | 73,543,862 | 9999.99% | 0.04% |
| March 1, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Common Stock | 13950 | $0.00 | 41,842.0000 | 73,543,862 | 50.01% | 0.02% |
| March 1, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | F | Common Stock | 121 | $53.69 | 41,721.0000 | 73,543,862 | 0.29% | 0.00% |
| March 1, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 341 | $53.76 | 41,380.0000 | 73,543,862 | 0.82% | 0.00% |
| March 1, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Stock Option (Right to Buy) | 8200 | $0.00 | 8,200.0000 | 73,543,862 | 9999.99% | 0.01% |
| March 1, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Stock Option (Right to Buy) | 2351 | $0.00 | 2,351.0000 | 73,543,862 | 9999.99% | 0.00% |
| March 1, 2024 | Crombez Eric | EVP and Chief Medical Officer | A | Common Stock | 19400 | $0.00 | 49,912.0000 | 73,543,862 | 63.58% | 0.03% |
| March 1, 2024 | Crombez Eric | EVP and Chief Medical Officer | S | Common Stock | 1238 | $53.76 | 48,927.0000 | 73,543,862 | 2.47% | 0.00% |
| March 1, 2024 | Crombez Eric | EVP and Chief Medical Officer | A | Stock Option (Right to Buy) | 34200 | $0.00 | 34,200.0000 | 73,543,862 | 9999.99% | 0.05% |
| March 1, 2024 | Crombez Eric | EVP and Chief Medical Officer | A | Stock Option (Right to Buy) | 2351 | $0.00 | 2,351.0000 | 73,543,862 | 9999.99% | 0.00% |
| March 1, 2024 | Harris Erik | EVP & Chief Commercial Officer | A | Common Stock | 19400 | $0.00 | 70,681.0000 | 73,543,862 | 37.83% | 0.03% |
| March 1, 2024 | Harris Erik | EVP & Chief Commercial Officer | A | Common Stock | 957 | $0.00 | 71,638.0000 | 73,543,862 | 1.35% | 0.00% |
| March 1, 2024 | Harris Erik | EVP & Chief Commercial Officer | S | Common Stock | 4768 | $53.76 | 67,163.0000 | 73,543,862 | 6.63% | 0.01% |
| March 1, 2024 | Harris Erik | EVP & Chief Commercial Officer | A | Stock Option (Right to Buy) | 34200 | $0.00 | 34,200.0000 | 73,543,862 | 9999.99% | 0.05% |
| March 1, 2024 | KAKKIS EMIL D | President & CEO | A | Common Stock | 38428 | $0.00 | 2,842,183.0000 | 73,543,862 | 1.37% | 0.05% |
| March 1, 2024 | KAKKIS EMIL D | President & CEO | F | Common Stock | 17417 | $53.69 | 2,824,766.0000 | 73,543,862 | 0.61% | 0.02% |
| March 1, 2024 | KAKKIS EMIL D | President & CEO | A | Common Stock | 3132 | $0.00 | 2,827,898.0000 | 73,543,862 | 0.11% | 0.00% |
| March 1, 2024 | KAKKIS EMIL D | President & CEO | A | Stock Option (Right to Buy) | 70094 | $0.00 | 70,094.0000 | 73,543,862 | 9999.99% | 0.10% |
| Feb. 7, 2024 | KAKKIS EMIL D | President & CEO | S | Common Stock | 30000 | $45.00 | 2,803,755.0000 | 73,543,862 | 1.06% | 0.04% |
| Dec. 29, 2023 | KAKKIS EMIL D | President & CEO | S | Common Stock | 30000 | $47.87 | 2,833,755.0000 | 69,914,225 | 1.05% | 0.04% |
| Jan. 2, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | M | Stock Option (Right to Buy) | 3000 | $0.00 | 0.0000 | 73,543,862 | 100.00% | 0.00% |
| Jan. 2, 2024 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | M | Common Stock | 3000 | $21.00 | 27,892.0000 | 73,543,862 | 12.05% | 0.00% |
| Dec. 20, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Common Stock | 1000 | $0.00 | 24,614.0000 | 69,914,225 | 4.23% | 0.00% |
| Oct. 23, 2023 | Kassberg Thomas Richard | CBO & EVP | M | Stock Option (Right to Buy) | 39878 | $0.00 | 0.0000 | 69,914,225 | 100.00% | 0.06% |
| Oct. 23, 2023 | Kassberg Thomas Richard | CBO & EVP | S | Common Stock | 39878 | $32.78 | 246,860.0000 | 69,914,225 | 13.91% | 0.06% |
| Oct. 23, 2023 | Kassberg Thomas Richard | CBO & EVP | M | Common Stock | 39878 | $6.86 | 286,738.0000 | 69,914,225 | 16.15% | 0.06% |
| Oct. 19, 2023 | KAKKIS EMIL D | President & CEO | S | Common Stock | 47853 | $33.52 | 2,863,728.0000 | 69,914,225 | 1.64% | 0.07% |
| Oct. 19, 2023 | KAKKIS EMIL D | President & CEO | M | Stock Option (Right to Buy) | 47853 | $0.00 | 0.0000 | 69,914,225 | 100.00% | 0.07% |
| Oct. 19, 2023 | KAKKIS EMIL D | President & CEO | M | Common Stock | 47853 | $6.86 | 2,911,014.0000 | 69,914,225 | 1.67% | 0.07% |
| Oct. 9, 2023 | Horn Howard | Chief Financial Officer | A | Common Stock | 80366 | $0.00 | 80,336.0000 | 69,914,225 | 0.00% | 0.11% |
| Oct. 9, 2023 | Horn Howard | Chief Financial Officer | A | Stock Option (Right to Buy) | 140469 | $0.00 | 140,469.0000 | 69,914,225 | 9999.99% | 0.20% |
| Sept. 27, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Stock Option (Right to Buy) | 2351 | $0.00 | 2,351.0000 | 69,914,225 | 9999.99% | 0.00% |
| Sept. 27, 2023 | Crombez Eric | EVP and Chief Medical Officer | A | Stock Option (Right to Buy) | 2351 | $0.00 | 2,351.0000 | 69,914,225 | 9999.99% | 0.00% |
| Sept. 7, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | M | Common Stock | 2000 | $21.00 | 25,777.0000 | 69,914,225 | 8.41% | 0.00% |
| Sept. 7, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | M | Stock Option (Right to Buy) | 2000 | $0.00 | 3,000.0000 | 69,914,225 | 40.00% | 0.00% |
| Sept. 7, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 163 | $38.34 | 23,614.0000 | 69,914,225 | 0.69% | 0.00% |
| Sept. 7, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 2000 | $41.00 | 23,777.0000 | 69,914,225 | 7.76% | 0.00% |
| Sept. 5, 2023 | Harris Erik | EVP & Chief Commercial Officer | S | Common Stock | 6000 | $37.96 | 51,281.0000 | 69,914,225 | 10.47% | 0.01% |
| Sept. 1, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 87 | $38.23 | 23,777.0000 | 69,914,225 | 0.36% | 0.00% |
| Sept. 1, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 883 | $37.04 | 23,864.0000 | 69,914,225 | 3.57% | 0.00% |
| June 30, 2023 | Sanders Corazon (Corsee) D. | Director | S | Common Stock | 585 | $46.76 | 8,985.0000 | 69,914,225 | 6.11% | 0.00% |
| June 19, 2023 | Harris Erik | EVP & Chief Commercial Officer | S | Common Stock | 305 | $48.20 | 57,281.0000 | 69,914,225 | 0.53% | 0.00% |
| June 7, 2023 | Ray Amrit | Director | A | Stock Option (Right to Buy) | 7110 | $0.00 | 7,110.0000 | 69,914,225 | 9999.99% | 0.01% |
| June 7, 2023 | Fust Matthew K | Director | A | Common Stock | 3860 | $0.00 | 30,355.0000 | 69,914,225 | 14.57% | 0.01% |
| June 7, 2023 | Fust Matthew K | Director | D | Common Stock | 3300 | $51.82 | 27,055.0000 | 69,914,225 | 10.87% | 0.00% |
| June 7, 2023 | Fust Matthew K | Director | A | Stock Option (Right to Buy) | 7110 | $0.00 | 7,110.0000 | 69,914,225 | 9999.99% | 0.01% |
| June 7, 2023 | Sanders Corazon (Corsee) D. | Director | A | Common Stock | 3860 | $0.00 | 11,055.0000 | 69,914,225 | 53.65% | 0.01% |
| June 8, 2023 | Sanders Corazon (Corsee) D. | Director | S | Common Stock | 1485 | $51.65 | 9,570.0000 | 69,914,225 | 13.43% | 0.00% |
| June 7, 2023 | Sanders Corazon (Corsee) D. | Director | A | Stock Option (Right to Buy) | 7110 | $0.00 | 7,110.0000 | 69,914,225 | 9999.99% | 0.01% |
| June 7, 2023 | SULIMAN SHEHNAAZ | Director | A | Common Stock | 3860 | $0.00 | 14,855.0000 | 69,914,225 | 35.11% | 0.01% |
| June 7, 2023 | SULIMAN SHEHNAAZ | Director | A | Stock Option (Right to Buy) | 7110 | $0.00 | 7,110.0000 | 69,914,225 | 9999.99% | 0.01% |
| June 7, 2023 | NARACHI MICHAEL | Director | A | Common Stock | 3860 | $0.00 | 21,605.0000 | 69,914,225 | 21.75% | 0.01% |
| June 7, 2023 | NARACHI MICHAEL | Director | A | Common Stock | 7110 | $0.00 | 7,110.0000 | 69,914,225 | 9999.99% | 0.01% |
| June 7, 2023 | Dunsire Deborah | Director | A | Common Stock | 3860 | $0.00 | 19,730.0000 | 69,914,225 | 24.32% | 0.01% |
| June 7, 2023 | Dunsire Deborah | Director | A | Stock Option (Right to Buy) | 7110 | $0.00 | 7,110.0000 | 69,914,225 | 9999.99% | 0.01% |
| June 7, 2023 | WELCH DANIEL G | Director | A | Common Stock | 3860 | $0.00 | 21,605.0000 | 69,914,225 | 21.75% | 0.01% |
| June 7, 2023 | WELCH DANIEL G | Director | A | Stock Option (Right to Buy) | 7110 | $0.00 | 7,110.0000 | 69,914,225 | 9999.99% | 0.01% |
| June 7, 2023 | Ray Amrit | Director | A | Common Stock | 3860 | $0.00 | 12,280.0000 | 69,914,225 | 45.84% | 0.01% |
| May 18, 2023 | Pinion John Richard | See Remarks | S | Common Stock | 2012 | $50.00 | 74,744.0000 | 69,914,225 | 2.62% | 0.00% |
| May 9, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | M | Stock Option (Right to Buy) | 3000 | $0.00 | 5,000.0000 | 69,914,225 | 37.50% | 0.00% |
| May 9, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | M | Common Stock | 3000 | $21.00 | 30,747.0000 | 69,914,225 | 10.81% | 0.00% |
| May 4, 2023 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 4378 | $45.00 | 51,982.0000 | 69,914,225 | 7.77% | 0.01% |
| May 1, 2023 | Crombez Eric | EVP and Chief Medical Officer | A | Stock Option (Right to Buy) | 8362 | $0.00 | 8,362.0000 | 69,914,225 | 9999.99% | 0.01% |
| May 1, 2023 | Crombez Eric | EVP and Chief Medical Officer | A | Common Stock | 4658 | $0.00 | 30,512.0000 | 69,914,225 | 18.02% | 0.01% |
| April 16, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | F | Common Stock | 14 | $38.20 | 27,701.0000 | 69,914,225 | 0.05% | 0.00% |
| April 16, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | D | Common Stock | 181 | $38.20 | 27,520.0000 | 69,914,225 | 0.65% | 0.00% |
| March 1, 2023 | KAKKIS EMIL D | President & CEO | A | Common Stock | 8716 | $0.00 | 2,833,391.0000 | 69,914,225 | 0.31% | 0.01% |
| March 1, 2023 | KAKKIS EMIL D | President & CEO | A | Common Stock | 46200 | $0.00 | 2,879,591.0000 | 69,914,225 | 1.63% | 0.07% |
| March 1, 2023 | KAKKIS EMIL D | President & CEO | F | Common Stock | 16140 | $45.65 | 2,863,161.0000 | 69,914,225 | 0.56% | 0.02% |
| March 1, 2023 | KAKKIS EMIL D | President & CEO | A | Stock Option (Right to Buy) | 83500 | $0.00 | 83,500.0000 | 69,914,225 | 9999.99% | 0.12% |
| March 1, 2023 | Harris Erik | EVP & Chief Commercial Officer | A | Common Stock | 2663 | $0.00 | 38,823.0000 | 69,914,225 | 7.36% | 0.00% |
| March 1, 2023 | Harris Erik | EVP & Chief Commercial Officer | A | Common Stock | 22000 | $0.00 | 60,823.0000 | 69,914,225 | 56.67% | 0.03% |
| March 1, 2023 | Harris Erik | EVP & Chief Commercial Officer | S | Common Stock | 3664 | $45.25 | 57,344.0000 | 69,914,225 | 6.01% | 0.01% |
| March 1, 2023 | Harris Erik | EVP & Chief Commercial Officer | A | Stock Option (Right to Buy) | 39400 | $0.00 | 39,400.0000 | 69,914,225 | 9999.99% | 0.06% |
| March 1, 2023 | Huang Dennis Karl | See Remarks | A | Common Stock | 2663 | $0.00 | 53,703.0000 | 69,914,225 | 5.22% | 0.00% |
| March 1, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Stock Option (Right to Buy) | 10120 | $0.00 | 10,120.0000 | 69,914,225 | 9999.99% | 0.01% |
| March 1, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | D | Common Stock | 1333 | $45.65 | 21,715.0000 | 69,914,225 | 5.78% | 0.00% |
| March 1, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 100 | $45.65 | 23,048.0000 | 69,914,225 | 0.43% | 0.00% |
| March 1, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | A | Common Stock | 7590 | $0.00 | 23,148.0000 | 69,914,225 | 48.79% | 0.01% |
| March 1, 2023 | Kassberg Thomas Richard | CBO & EVP | A | Stock Option (Right to Buy) | 39400 | $0.00 | 39,400.0000 | 69,914,225 | 9999.99% | 0.06% |
| March 1, 2023 | Kassberg Thomas Richard | CBO & EVP | D | Common Stock | 3394 | $45.65 | 246,860.0000 | 69,914,225 | 1.36% | 0.00% |
| March 1, 2023 | Kassberg Thomas Richard | CBO & EVP | S | Common Stock | 1968 | $45.27 | 250,254.0000 | 69,914,225 | 0.78% | 0.00% |
| March 1, 2023 | Kassberg Thomas Richard | CBO & EVP | A | Common Stock | 22000 | $0.00 | 252,222.0000 | 69,914,225 | 9.56% | 0.03% |
| March 1, 2023 | Kassberg Thomas Richard | CBO & EVP | A | Common Stock | 2663 | $0.00 | 230,222.0000 | 69,914,225 | 1.17% | 0.00% |
| March 1, 2023 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Stock Option (Right to Buy) | 39400 | $0.00 | 39,400.0000 | 69,914,225 | 9999.99% | 0.06% |
| March 1, 2023 | Parschauer Karah Herdman | EVP and Chief Legal Officer | S | Common Stock | 3161 | $45.25 | 56,139.0000 | 69,914,225 | 5.33% | 0.00% |
| March 1, 2023 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Common Stock | 22000 | $0.00 | 59,101.0000 | 69,914,225 | 59.30% | 0.03% |
| March 1, 2023 | Parschauer Karah Herdman | EVP and Chief Legal Officer | A | Common Stock | 2663 | $0.00 | 37,101.0000 | 69,914,225 | 7.73% | 0.00% |
| March 1, 2023 | Bedrosian Camille L | EVP and Chief Medical Officer | S | Common Stock | 3881 | $45.25 | 46,720.0000 | 69,914,225 | 7.67% | 0.01% |
| March 1, 2023 | Bedrosian Camille L | EVP and Chief Medical Officer | A | Common Stock | 2663 | $0.00 | 50,601.0000 | 69,914,225 | 5.56% | 0.00% |
| March 1, 2023 | Huang Dennis Karl | See Remarks | A | Common Stock | 22000 | $0.00 | 75,703.0000 | 69,914,225 | 40.97% | 0.03% |
| March 1, 2023 | Huang Dennis Karl | See Remarks | D | Common Stock | 10599 | $45.65 | 64,715.0000 | 69,914,225 | 14.07% | 0.02% |
| March 1, 2023 | Huang Dennis Karl | See Remarks | A | Stock Option (Right to Buy) | 39400 | $0.00 | 39,400.0000 | 69,914,225 | 9999.99% | 0.06% |
| March 1, 2023 | Pinion John Richard | See Remarks | A | Common Stock | 2663 | $0.00 | 61,929.0000 | 69,914,225 | 4.49% | 0.00% |
| March 1, 2023 | Pinion John Richard | See Remarks | A | Common Stock | 22000 | $0.00 | 83,929.0000 | 69,914,225 | 35.52% | 0.03% |
| March 1, 2023 | Pinion John Richard | See Remarks | S | Common Stock | 3755 | $45.26 | 80,174.0000 | 69,914,225 | 4.47% | 0.01% |
| March 1, 2023 | Pinion John Richard | See Remarks | D | Common Stock | 4014 | $45.65 | 76,160.0000 | 69,914,225 | 5.01% | 0.01% |
| March 1, 2023 | Pinion John Richard | See Remarks | A | 3/1/2023 | 39400 | $0.00 | 39,400.0000 | 69,914,225 | 9999.99% | 0.06% |
| March 1, 2023 | Huang Dennis Karl | See Remarks | S | Common Stock | 389 | $45.65 | 75,314.0000 | 69,914,225 | 0.51% | 0.00% |
| Feb. 28, 2023 | Huizenga Theodore Alan | SVP, Chief Accounting Officer | S | Common Stock | 639 | $43.40 | 15,558.0000 | 69,914,225 | 3.95% | 0.00% |
| Dec. 30, 2022 | KAKKIS EMIL D | President & CEO | S | Common Stock | 19582 | $45.57 | 2,824,385.0000 | 0 | 0.69% | 0.00% |