In the last 12 months, insiders at CRISPR Therapeutics AG ($CRSP) filed 310 transactions with the SEC: 6 open-market purchases totaling $53,004,170 and 80 sales totaling $42,183,682. Net insider sentiment: net buying.
CRISPR Therapeutics AG operates in the Biological products, (no disgnostic substances) industry (Life sciences sector).
Most Active Insiders
- George Simeon (Not found) — 8 transactions totaling $126,499,915
- Kulkarni Samarth (Chief Executive Officer) — 123 transactions totaling $39,682,333
- Prasad Raju (Chief Financial Officer) — 45 transactions totaling $8,519,497
- KASINGER JAMES R. (General Counsel and Secretary) — 64 transactions totaling $2,267,005
- Treco Douglas A (Not found) — 3 transactions totaling $1,140,600
View all SEC Filings for CRISPR Therapeutics AG (CRSP).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| March 20, 2026 | Patel Naimish | Chief Medical Officer | A | Stock Option (Right to Buy) | 38499 | $0.00 | 38,499.0000 | 95,985,312 | 9999.99% | 0.04% |
| March 20, 2026 | Prasad Raju | Chief Financial Officer | M | Restricted Stock Units | 6250 | $0.00 | 12,500.0000 | 95,985,312 | 33.33% | 0.01% |
| March 20, 2026 | Prasad Raju | Chief Financial Officer | A | Restricted Stock Units | 27500 | $0.00 | 27,500.0000 | 95,985,312 | 9999.99% | 0.03% |
| March 20, 2026 | Prasad Raju | Chief Financial Officer | A | Stock Option (Right to Buy) | 38499 | $0.00 | 38,499.0000 | 95,985,312 | 9999.99% | 0.04% |
| March 23, 2026 | Prasad Raju | Chief Financial Officer | S | Common Shares | 3708 | $46.78 | 15,565.0000 | 95,985,312 | 19.24% | 0.00% |
| March 20, 2026 | Prasad Raju | Chief Financial Officer | M | Common Shares | 6250 | $0.00 | 19,273.0000 | 95,985,312 | 47.99% | 0.01% |
| March 20, 2026 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 19687 | $0.00 | 39,375.0000 | 95,985,312 | 33.33% | 0.02% |
| March 20, 2026 | Kulkarni Samarth | Chief Executive Officer | A | Restricted Stock Units | 81875 | $0.00 | 81,875.0000 | 95,985,312 | 9999.99% | 0.09% |
| March 20, 2026 | Kulkarni Samarth | Chief Executive Officer | A | Stock Option (Right to Buy) | 114249 | $0.00 | 114,249.0000 | 95,985,312 | 9999.99% | 0.12% |
| March 23, 2026 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 10020 | $46.78 | 255,501.0000 | 95,985,312 | 3.77% | 0.01% |
| March 20, 2026 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 19687 | $0.00 | 265,521.0000 | 95,985,312 | 8.01% | 0.02% |
| March 20, 2026 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 6250 | $0.00 | 12,000.0000 | 95,985,312 | 34.25% | 0.01% |
| March 20, 2026 | KASINGER JAMES R. | General Counsel and Secretary | A | Restricted Stock Units | 25000 | $0.00 | 25,000.0000 | 95,985,312 | 9999.99% | 0.03% |
| March 20, 2026 | KASINGER JAMES R. | General Counsel and Secretary | A | Stock Option (Right to Buy) | 38499 | $0.00 | 38,499.0000 | 95,985,312 | 9999.99% | 0.04% |
| March 23, 2026 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 3182 | $46.78 | 94,308.0000 | 95,985,312 | 3.26% | 0.00% |
| March 20, 2026 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 6250 | $0.00 | 97,490.0000 | 95,985,312 | 6.85% | 0.01% |
| March 20, 2026 | Patel Naimish | Chief Medical Officer | A | Restricted Stock Units | 30000 | $0.00 | 30,000.0000 | 95,985,312 | 9999.99% | 0.03% |
| March 14, 2026 | Patel Naimish | Chief Medical Officer | M | Restricted Stock Units | 8125 | $0.00 | 24,375.0000 | 95,985,312 | 25.00% | 0.01% |
| March 14, 2026 | Patel Naimish | Chief Medical Officer | M | Common Shares | 8125 | $0.00 | 16,293.0000 | 95,985,312 | 99.47% | 0.01% |
| March 16, 2026 | Patel Naimish | Chief Medical Officer | S | Common Shares | 3150 | $48.26 | 13,143.0000 | 95,985,312 | 19.33% | 0.00% |
| March 14, 2026 | Prasad Raju | Chief Financial Officer | M | Common Shares | 10000 | $0.00 | 16,767.0000 | 95,985,312 | 147.78% | 0.01% |
| March 14, 2026 | Prasad Raju | Chief Financial Officer | M | Common Shares | 6875 | $0.00 | 23,642.0000 | 95,985,312 | 41.00% | 0.01% |
| March 16, 2026 | Prasad Raju | Chief Financial Officer | S | Common Shares | 5848 | $48.26 | 17,794.0000 | 95,985,312 | 24.74% | 0.01% |
| March 16, 2026 | Prasad Raju | Chief Financial Officer | S | Common Shares | 4021 | $48.26 | 13,773.0000 | 95,985,312 | 22.60% | 0.00% |
| March 16, 2026 | Prasad Raju | Chief Financial Officer | G | Common Shares | 750 | $0.00 | 13,023.0000 | 95,985,312 | 5.45% | 0.00% |
| March 14, 2026 | Prasad Raju | Chief Financial Officer | M | Restricted Stock Units | 10000 | $0.00 | 10,000.0000 | 95,985,312 | 50.00% | 0.01% |
| March 14, 2026 | Prasad Raju | Chief Financial Officer | M | Restricted Stock Units | 6875 | $0.00 | 20,625.0000 | 95,985,312 | 25.00% | 0.01% |
| March 14, 2026 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 6875 | $0.00 | 94,690.0000 | 95,985,312 | 7.83% | 0.01% |
| March 16, 2026 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 3450 | $48.26 | 91,240.0000 | 95,985,312 | 3.64% | 0.00% |
| March 14, 2026 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 6875 | $0.00 | 20,625.0000 | 95,985,312 | 25.00% | 0.01% |
| March 14, 2026 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 20625 | $0.00 | 256,183.0000 | 95,985,312 | 8.76% | 0.02% |
| March 16, 2026 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 10349 | $48.26 | 245,834.0000 | 95,985,312 | 4.04% | 0.01% |
| March 14, 2026 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 20625 | $0.00 | 61,875.0000 | 95,985,312 | 25.00% | 0.02% |
| March 10, 2026 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 5500 | $0.00 | 90,615.0000 | 95,985,312 | 6.46% | 0.01% |
| March 10, 2026 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 19250 | $0.00 | 19,250.0000 | 95,985,312 | 50.00% | 0.02% |
| March 11, 2026 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 9798 | $52.80 | 235,558.0000 | 95,985,312 | 3.99% | 0.01% |
| March 10, 2026 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 19250 | $0.00 | 245,356.0000 | 95,985,312 | 8.51% | 0.02% |
| March 10, 2026 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 5500 | $0.00 | 5,500.0000 | 95,985,312 | 50.00% | 0.01% |
| March 11, 2026 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 2800 | $52.80 | 87,815.0000 | 95,985,312 | 3.09% | 0.00% |
| Feb. 18, 2026 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 13250 | $0.00 | 233,073.0000 | 95,985,312 | 6.03% | 0.01% |
| Feb. 18, 2026 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 3825 | $0.00 | 0.0000 | 95,985,312 | 100.00% | 0.00% |
| Feb. 19, 2026 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 2112 | $52.58 | 85,115.0000 | 95,985,312 | 2.42% | 0.00% |
| Feb. 18, 2026 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 3825 | $0.00 | 87,227.0000 | 95,985,312 | 4.59% | 0.00% |
| Feb. 18, 2026 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 13250 | $0.00 | 0.0000 | 95,985,312 | 100.00% | 0.01% |
| Feb. 19, 2026 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 6967 | $52.58 | 226,106.0000 | 95,985,312 | 2.99% | 0.01% |
| April 3, 2025 | Patel Naimish | Chief Medical Officer | P | Common Shares | 1508 | $32.96 | 1,508.0000 | 85,774,474 | 9999.99% | 0.00% |
| Jan. 22, 2026 | Prasad Raju | Chief Financial Officer | S | Common Shares | 34972 | $60.19 | 6,767.0000 | 95,300,233 | 83.79% | 0.04% |
| Jan. 22, 2026 | Prasad Raju | Chief Financial Officer | M | Stock Option (Right to Buy) | 34972 | $0.00 | 41,667.0000 | 95,300,233 | 45.63% | 0.04% |
| Jan. 22, 2026 | Prasad Raju | Chief Financial Officer | M | Common Shares | 34972 | $45.15 | 41,739.0000 | 95,300,233 | 516.80% | 0.04% |
| Jan. 20, 2026 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 8567 | $52.10 | 279,823.0000 | 95,300,233 | 2.97% | 0.01% |
| Jan. 22, 2026 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 60000 | $60.23 | 219,823.0000 | 95,300,233 | 21.44% | 0.06% |
| Jan. 20, 2026 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 21433 | $51.61 | 288,390.0000 | 95,300,233 | 6.92% | 0.02% |
| Jan. 6, 2026 | Prasad Raju | Chief Financial Officer | S | Common Shares | 18933 | $60.18 | 17,534.0000 | 95,300,233 | 51.92% | 0.02% |
| Jan. 6, 2026 | Prasad Raju | Chief Financial Officer | M | Common Shares | 23361 | $45.15 | 30,128.0000 | 95,300,233 | 345.22% | 0.02% |
| Jan. 6, 2026 | Prasad Raju | Chief Financial Officer | M | Common Shares | 6339 | $44.31 | 36,467.0000 | 95,300,233 | 21.04% | 0.01% |
| Jan. 6, 2026 | Prasad Raju | Chief Financial Officer | S | Common Shares | 5004 | $60.00 | 12,530.0000 | 95,300,233 | 28.54% | 0.01% |
| Jan. 6, 2026 | Prasad Raju | Chief Financial Officer | S | Common Shares | 5763 | $60.21 | 6,767.0000 | 95,300,233 | 45.99% | 0.01% |
| Jan. 6, 2026 | Prasad Raju | Chief Financial Officer | M | Stock Option (Right to Buy) | 23361 | $0.00 | 76,639.0000 | 95,300,233 | 23.36% | 0.02% |
| Jan. 6, 2026 | Prasad Raju | Chief Financial Officer | M | Stock Option (Right to Buy) | 6339 | $0.00 | 7,493.0000 | 95,300,233 | 45.83% | 0.01% |
| Dec. 22, 2025 | Prasad Raju | Chief Financial Officer | S | Common Shares | 3528 | $55.10 | 13,239.0000 | 95,300,233 | 21.04% | 0.00% |
| Dec. 22, 2025 | Prasad Raju | Chief Financial Officer | S | Common Shares | 5472 | $56.33 | 7,767.0000 | 95,300,233 | 41.33% | 0.01% |
| Dec. 22, 2025 | Prasad Raju | Chief Financial Officer | S | Common Shares | 1000 | $56.89 | 6,767.0000 | 95,300,233 | 12.87% | 0.00% |
| Dec. 18, 2025 | Kulkarni Samarth | Chief Executive Officer | G | Common Shares | 30000 | $0.00 | 309,823.0000 | 95,300,233 | 8.83% | 0.03% |
| Oct. 16, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 100000 | $0.00 | 300,000.0000 | 85,774,474 | 25.00% | 0.12% |
| Oct. 16, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 100000 | $0.00 | 390,758.0000 | 85,774,474 | 34.39% | 0.12% |
| Oct. 17, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 50895 | $67.91 | 339,863.0000 | 85,774,474 | 13.02% | 0.06% |
| Oct. 13, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 2114 | $0.00 | 2,113.0000 | 85,774,474 | 50.01% | 0.00% |
| Oct. 13, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 8334 | $0.00 | 295,000.0000 | 85,774,474 | 2.91% | 0.01% |
| Oct. 14, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 4242 | $66.60 | 290,758.0000 | 85,774,474 | 1.44% | 0.00% |
| Oct. 13, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 8334 | $0.00 | 8,333.0000 | 85,774,474 | 50.00% | 0.01% |
| Oct. 13, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 2114 | $0.00 | 84,478.0000 | 85,774,474 | 2.57% | 0.00% |
| Oct. 14, 2025 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 1076 | $66.60 | 83,402.0000 | 85,774,474 | 1.27% | 0.00% |
| Oct. 3, 2025 | Patel Naimish | Chief Medical Officer | A | Stock Option (Right to Buy) | 16500 | $0.00 | 16,500.0000 | 85,774,474 | 9999.99% | 0.02% |
| Oct. 3, 2025 | Prasad Raju | Chief Financial Officer | A | Stock Option (Right to Buy) | 16500 | $0.00 | 16,500.0000 | 85,774,474 | 9999.99% | 0.02% |
| Oct. 3, 2025 | KASINGER JAMES R. | General Counsel and Secretary | A | Stock Option (Right to Buy) | 16500 | $0.00 | 16,500.0000 | 85,774,474 | 9999.99% | 0.02% |
| Oct. 3, 2025 | Kulkarni Samarth | Chief Executive Officer | A | Stock Option (Right to Buy) | 49500 | $0.00 | 49,500.0000 | 85,774,474 | 9999.99% | 0.06% |
| Sept. 17, 2025 | Kulkarni Samarth | Chief Executive Officer | G | Common Shares | 6000 | $0.00 | 286,626.0000 | 85,774,474 | 2.05% | 0.01% |
| Aug. 16, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 25000 | $0.00 | 0.0000 | 85,774,474 | 100.00% | 0.03% |
| Aug. 16, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 25000 | $0.00 | 305,707.0000 | 85,774,474 | 8.91% | 0.03% |
| Aug. 18, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 13081 | $58.15 | 292,626.0000 | 85,774,474 | 4.28% | 0.02% |
| Aug. 6, 2025 | Treco Douglas A | Not found | P | Common Shares | 20000 | $57.03 | 22,000.0000 | 85,774,474 | 1000.00% | 0.02% |
| July 16, 2025 | George Simeon | Not found | P | Common Shares | 960983 | $52.03 | 2,038,763.0000 | 85,774,474 | 89.16% | 1.12% |
| July 16, 2025 | George Simeon | Not found | P | Common Shares | 6510 | $52.03 | 2,038,763.0000 | 85,774,474 | 0.32% | 0.01% |
| July 16, 2025 | George Simeon | Not found | P | Common Shares | 22319 | $52.03 | 2,038,763.0000 | 85,774,474 | 1.11% | 0.03% |
| June 5, 2025 | Fleming Harold Edward | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | Greene John | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | Mahatme Sandesh | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | Fardis Maria | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | High Katherine A | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | George Simeon | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | Behbahani Ali | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | Morrison Briggs | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | Treco Douglas A | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| June 5, 2025 | Rommel Christian | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| May 30, 2025 | Prasad Raju | Chief Financial Officer | A | Restricted Stock Units | 20000 | $0.00 | 20,000.0000 | 85,774,474 | 9999.99% | 0.02% |
| May 30, 2025 | Patel Naimish | Chief Medical Officer | A | Restricted Stock Units | 25000 | $0.00 | 25,000.0000 | 85,774,474 | 9999.99% | 0.03% |
| May 28, 2025 | Patel Naimish | Chief Medical Officer | M | Restricted Stock Units | 10000 | $0.00 | 30,000.0000 | 85,774,474 | 25.00% | 0.01% |
| May 28, 2025 | Patel Naimish | Chief Medical Officer | M | Common Shares | 10000 | $0.00 | 10,000.0000 | 85,774,474 | 9999.99% | 0.01% |
| May 29, 2025 | Patel Naimish | Chief Medical Officer | S | Common Shares | 3932 | $35.94 | 6,068.0000 | 85,774,474 | 39.32% | 0.00% |
| March 20, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 19688 | $0.00 | 59,062.0000 | 85,774,474 | 25.00% | 0.02% |
| March 20, 2025 | Bruno Julianne | Chief Operating Officer | M | Common Shares | 3750 | $0.00 | 19,346.0000 | 85,774,474 | 24.04% | 0.00% |
| March 21, 2025 | Bruno Julianne | Chief Operating Officer | S | Common Shares | 1714 | $41.23 | 17,632.0000 | 85,774,474 | 8.86% | 0.00% |
| March 20, 2025 | Bruno Julianne | Chief Operating Officer | M | Restricted Stock Units | 3750 | $0.00 | 11,250.0000 | 85,774,474 | 25.00% | 0.00% |
| March 20, 2025 | Prasad Raju | Chief Financial Officer | M | Common Shares | 6250 | $0.00 | 18,964.0000 | 85,774,474 | 49.16% | 0.01% |
| March 21, 2025 | Prasad Raju | Chief Financial Officer | S | Common Shares | 2197 | $41.23 | 16,767.0000 | 85,774,474 | 11.59% | 0.00% |
| March 20, 2025 | Prasad Raju | Chief Financial Officer | M | Restricted Stock Units | 6250 | $0.00 | 18,750.0000 | 85,774,474 | 25.00% | 0.01% |
| March 21, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 10031 | $41.23 | 280,707.0000 | 85,774,474 | 3.45% | 0.01% |
| March 20, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 6250 | $0.00 | 84,914.0000 | 85,774,474 | 7.95% | 0.01% |
| March 20, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 19688 | $0.00 | 290,738.0000 | 85,774,474 | 7.26% | 0.02% |
| March 21, 2025 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 3185 | $41.23 | 81,729.0000 | 85,774,474 | 3.75% | 0.00% |
| March 20, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 6250 | $0.00 | 18,750.0000 | 85,774,474 | 25.00% | 0.01% |
| March 14, 2025 | Bruno Julianne | Chief Operating Officer | A | Restricted Stock Units | 27500 | $0.00 | 27,500.0000 | 85,774,474 | 9999.99% | 0.03% |
| March 14, 2025 | KASINGER JAMES R. | General Counsel and Secretary | A | Stock Option (Right to Buy) | 36666 | $0.00 | 36,666.0000 | 85,774,474 | 9999.99% | 0.04% |
| March 14, 2025 | Bruno Julianne | Chief Operating Officer | A | Stock Option (Right to Buy) | 36666 | $0.00 | 36,666.0000 | 85,774,474 | 9999.99% | 0.04% |
| March 14, 2025 | Kulkarni Samarth | Chief Executive Officer | A | Restricted Stock Units | 82500 | $0.00 | 82,500.0000 | 85,774,474 | 9999.99% | 0.10% |
| March 14, 2025 | Patel Naimish | Chief Medical Officer | A | Stock Option (Right to Buy) | 46667 | $0.00 | 46,667.0000 | 85,774,474 | 9999.99% | 0.05% |
| March 14, 2025 | Patel Naimish | Chief Medical Officer | A | Restricted Stock Units | 32500 | $0.00 | 32,500.0000 | 85,774,474 | 9999.99% | 0.04% |
| March 14, 2025 | Prasad Raju | Chief Financial Officer | M | Common Shares | 10000 | $0.00 | 16,476.0000 | 85,774,474 | 154.42% | 0.01% |
| March 17, 2025 | Prasad Raju | Chief Financial Officer | S | Common Shares | 3762 | $41.80 | 12,714.0000 | 85,774,474 | 22.83% | 0.00% |
| March 14, 2025 | Prasad Raju | Chief Financial Officer | M | Restricted Stock Units | 10000 | $0.00 | 20,000.0000 | 85,774,474 | 33.33% | 0.01% |
| March 14, 2025 | Prasad Raju | Chief Financial Officer | A | Stock Option (Right to Buy) | 36666 | $0.00 | 36,666.0000 | 85,774,474 | 9999.99% | 0.04% |
| March 14, 2025 | Prasad Raju | Chief Financial Officer | A | Restricted Stock Units | 27500 | $0.00 | 27,500.0000 | 85,774,474 | 9999.99% | 0.03% |
| March 14, 2025 | Kulkarni Samarth | Chief Executive Officer | A | Stock Option (Right to Buy) | 110000 | $0.00 | 110,000.0000 | 85,774,474 | 9999.99% | 0.13% |
| March 14, 2025 | KASINGER JAMES R. | General Counsel and Secretary | A | Restricted Stock Units | 27500 | $0.00 | 27,500.0000 | 85,774,474 | 9999.99% | 0.03% |
| March 10, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 5500 | $0.00 | 80,380.0000 | 85,774,474 | 7.35% | 0.01% |
| March 11, 2025 | Bruno Julianne | Chief Operating Officer | M | Restricted Stock Units | 435 | $0.00 | 0.0000 | 85,774,474 | 100.00% | 0.00% |
| March 10, 2025 | Bruno Julianne | Chief Operating Officer | M | Restricted Stock Units | 2399 | $0.00 | 4,796.0000 | 85,774,474 | 33.34% | 0.00% |
| March 12, 2025 | Bruno Julianne | Chief Operating Officer | S | Common Shares | 190 | $43.32 | 15,596.0000 | 85,774,474 | 1.20% | 0.00% |
| March 11, 2025 | Bruno Julianne | Chief Operating Officer | M | Common Shares | 435 | $0.00 | 15,786.0000 | 85,774,474 | 2.83% | 0.00% |
| March 11, 2025 | Bruno Julianne | Chief Operating Officer | S | Common Shares | 1198 | $42.42 | 15,351.0000 | 85,774,474 | 7.24% | 0.00% |
| March 10, 2025 | Bruno Julianne | Chief Operating Officer | M | Common Shares | 2399 | $0.00 | 16,549.0000 | 85,774,474 | 16.95% | 0.00% |
| March 11, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 2250 | $0.00 | 0.0000 | 85,774,474 | 100.00% | 0.00% |
| March 10, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 5500 | $0.00 | 11,000.0000 | 85,774,474 | 33.33% | 0.01% |
| March 12, 2025 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 1116 | $43.32 | 78,664.0000 | 85,774,474 | 1.40% | 0.00% |
| March 11, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 2250 | $0.00 | 79,780.0000 | 85,774,474 | 2.90% | 0.00% |
| March 11, 2025 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 2850 | $42.42 | 77,530.0000 | 85,774,474 | 3.55% | 0.00% |
| March 11, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 9000 | $0.00 | 0.0000 | 85,774,474 | 100.00% | 0.01% |
| March 10, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 19250 | $0.00 | 38,500.0000 | 85,774,474 | 33.33% | 0.02% |
| March 12, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 4462 | $43.32 | 271,050.0000 | 85,774,474 | 1.62% | 0.01% |
| March 11, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 9000 | $0.00 | 275,512.0000 | 85,774,474 | 3.38% | 0.01% |
| March 11, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 9973 | $42.42 | 266,512.0000 | 85,774,474 | 3.61% | 0.01% |
| March 10, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 19250 | $0.00 | 276,485.0000 | 85,774,474 | 7.48% | 0.02% |
| Feb. 26, 2025 | Greene John | Not found | P | Common Shares | 7000 | $44.85 | 7,000.0000 | 85,774,474 | 9999.99% | 0.01% |
| Feb. 19, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 18360 | $55.21 | 257,235.0000 | 85,774,474 | 6.66% | 0.02% |
| Feb. 19, 2025 | Bruno Julianne | Chief Operating Officer | S | Common Shares | 333 | $52.80 | 14,150.0000 | 85,774,474 | 2.30% | 0.00% |
| Feb. 18, 2025 | Bruno Julianne | Chief Operating Officer | M | Common Shares | 650 | $0.00 | 14,483.0000 | 85,774,474 | 4.70% | 0.00% |
| Feb. 18, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 3825 | $0.00 | 3,825.0000 | 85,774,474 | 50.00% | 0.00% |
| Feb. 16, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 20000 | $0.00 | 0.0000 | 85,774,474 | 100.00% | 0.02% |
| Feb. 19, 2025 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 1947 | $52.80 | 74,880.0000 | 85,774,474 | 2.53% | 0.00% |
| Feb. 18, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 3825 | $0.00 | 76,827.0000 | 85,774,474 | 5.24% | 0.00% |
| Feb. 18, 2025 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 9595 | $53.85 | 73,002.0000 | 85,774,474 | 11.62% | 0.01% |
| Feb. 16, 2025 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 20000 | $0.00 | 82,597.0000 | 85,774,474 | 31.95% | 0.02% |
| Feb. 18, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 13250 | $0.00 | 13,250.0000 | 85,774,474 | 50.00% | 0.02% |
| Feb. 19, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 6928 | $52.80 | 275,595.0000 | 85,774,474 | 2.45% | 0.01% |
| Feb. 18, 2025 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 11640 | $55.05 | 282,523.0000 | 85,774,474 | 3.96% | 0.01% |
| Feb. 18, 2025 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 13250 | $0.00 | 294,163.0000 | 85,774,474 | 4.72% | 0.02% |
| Feb. 18, 2025 | Bruno Julianne | Chief Operating Officer | M | Restricted Stock Units | 650 | $0.00 | 650.0000 | 85,774,474 | 50.00% | 0.00% |
| Dec. 24, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 13751 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 24, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 13751 | $16.21 | 280,913.0000 | 0 | 5.15% | 0.00% |
| Dec. 2, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 15000 | $55.10 | 267,162.0000 | 0 | 5.32% | 0.00% |
| Nov. 11, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 23121 | $55.43 | 289,041.0000 | 0 | 7.41% | 0.00% |
| Nov. 11, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 6879 | $56.27 | 282,162.0000 | 0 | 2.38% | 0.00% |
| Oct. 16, 2024 | Patel Naimish | Chief Medical Officer | A | Stock Option (Right to Buy) | 18333 | $0.00 | 18,333.0000 | 0 | 9999.99% | 0.00% |
| Oct. 16, 2024 | Bruno Julianne | Chief Operating Officer | A | Stock Option (Right to Buy) | 18333 | $0.00 | 18,333.0000 | 0 | 9999.99% | 0.00% |
| Oct. 16, 2024 | KASINGER JAMES R. | General Counsel and Secretary | A | Restricted Stock Units | 30000 | $0.00 | 30,000.0000 | 0 | 9999.99% | 0.00% |
| Oct. 16, 2024 | KASINGER JAMES R. | General Counsel and Secretary | A | Stock Option (Right to Buy) | 18333 | $0.00 | 18,333.0000 | 0 | 9999.99% | 0.00% |
| Oct. 16, 2024 | Prasad Raju | Chief Financial Officer | A | Restricted Stock Units | 15000 | $0.00 | 15,000.0000 | 0 | 9999.99% | 0.00% |
| Oct. 16, 2024 | Prasad Raju | Chief Financial Officer | A | Stock Option (Right to Buy) | 18333 | $0.00 | 18,333.0000 | 0 | 9999.99% | 0.00% |
| Oct. 16, 2024 | Kulkarni Samarth | Chief Executive Officer | A | Restricted Stock Units | 400000 | $0.00 | 400,000.0000 | 0 | 9999.99% | 0.00% |
| Oct. 16, 2024 | Kulkarni Samarth | Chief Executive Officer | A | Stock Option (Right to Buy) | 55000 | $0.00 | 55,000.0000 | 0 | 9999.99% | 0.00% |
| Oct. 13, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 8333 | $0.00 | 316,455.0000 | 0 | 2.70% | 0.00% |
| Oct. 14, 2024 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 1089 | $46.28 | 62,597.0000 | 0 | 1.71% | 0.00% |
| Oct. 13, 2024 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 2113 | $0.00 | 63,686.0000 | 0 | 3.43% | 0.00% |
| Oct. 13, 2024 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 2113 | $0.00 | 4,227.0000 | 0 | 33.33% | 0.00% |
| Oct. 13, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 8333 | $0.00 | 16,667.0000 | 0 | 33.33% | 0.00% |
| Oct. 14, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 4293 | $46.28 | 312,162.0000 | 0 | 1.36% | 0.00% |
| Aug. 8, 2024 | Kulkarni Samarth | Chief Executive Officer | G | Common Shares | 100000 | $0.00 | 308,122.0000 | 0 | 24.50% | 0.00% |
| June 21, 2024 | Bruno Julianne | Chief Operating Officer | S | Common Shares | 3366 | $56.09 | 13,833.0000 | 0 | 19.57% | 0.00% |
| June 20, 2024 | Bruno Julianne | Chief Operating Officer | M | Common Shares | 7000 | $0.00 | 17,199.0000 | 0 | 68.63% | 0.00% |
| June 20, 2024 | Bruno Julianne | Chief Operating Officer | M | Restricted Stock Units | 7000 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| May 30, 2024 | Fleming Harold Edward | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2024 | Behbahani Ali | Not found | A | Stock Option (Right to buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2024 | High Katherine A | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2024 | Treco Douglas A | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2024 | George Simeon | Not found | A | Stock Option (Right to buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2024 | Mahatme Sandesh | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2024 | Fardis Maria | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2024 | Greene John | Not found | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2024 | Rommel Christian | Not found | A | Stock Option (Right to Buy) | 26000 | $0.00 | 26,000.0000 | 0 | 9999.99% | 0.00% |
| May 28, 2024 | Patel Naimish | Chief Medical Officer | A | Restricted Stock Units | 40000 | $0.00 | 40,000.0000 | 0 | 9999.99% | 0.00% |
| May 28, 2024 | Patel Naimish | Chief Medical Officer | A | Stock Option (Right to Buy) | 85000 | $0.00 | 85,000.0000 | 0 | 9999.99% | 0.00% |
| May 23, 2024 | Bruno Julianne | Chief Operating Officer | A | Restricted Stock Units | 20000 | $0.00 | 20,000.0000 | 0 | 9999.99% | 0.00% |
| April 15, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 1204 | $60.40 | 408,122.0000 | 0 | 0.29% | 0.00% |
| April 15, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 19582 | $19.12 | 427,704.0000 | 0 | 4.80% | 0.00% |
| April 15, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 19582 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| April 15, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 18378 | $59.88 | 409,326.0000 | 0 | 4.30% | 0.00% |
| March 20, 2024 | Kulkarni Samarth | Chief Executive Officer | A | Stock Option (Right to Buy) | 105000 | $0.00 | 105,000.0000 | 0 | 9999.99% | 0.00% |
| March 20, 2024 | Prasad Raju | Chief Financial Officer | A | Restricted Stock Units | 25000 | $0.00 | 25,000.0000 | 0 | 9999.99% | 0.00% |
| March 20, 2024 | Prasad Raju | Chief Financial Officer | A | Stock Option (Right to Buy) | 36168 | $0.00 | 36,168.0000 | 0 | 9999.99% | 0.00% |
| March 20, 2024 | KASINGER JAMES R. | General Counsel and Secretary | A | Restricted Stock Units | 25000 | $0.00 | 25,000.0000 | 0 | 9999.99% | 0.00% |
| March 20, 2024 | KASINGER JAMES R. | General Counsel and Secretary | A | Stock Option (Right to Buy) | 33333 | $0.00 | 33,333.0000 | 0 | 9999.99% | 0.00% |
| March 20, 2024 | Kulkarni Samarth | Chief Executive Officer | A | Restricted Stock Units | 78750 | $0.00 | 78,750.0000 | 0 | 9999.99% | 0.00% |
| March 15, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 10613 | $71.97 | 417,509.0000 | 0 | 2.48% | 0.00% |
| March 15, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 20000 | $19.12 | 428,122.0000 | 0 | 4.90% | 0.00% |
| March 14, 2024 | Prasad Raju | Chief Financial Officer | M | Restricted Stock Units | 10000 | $0.00 | 30,000.0000 | 0 | 25.00% | 0.00% |
| March 15, 2024 | Prasad Raju | Chief Financial Officer | S | Common Shares | 3524 | $72.69 | 6,476.0000 | 0 | 35.24% | 0.00% |
| March 14, 2024 | Prasad Raju | Chief Financial Officer | M | Common Shares | 10000 | $0.00 | 10,000.0000 | 0 | 9999.99% | 0.00% |
| March 15, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 9387 | $73.06 | 408,122.0000 | 0 | 2.25% | 0.00% |
| March 15, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 20000 | $0.00 | 19,582.0000 | 0 | 50.53% | 0.00% |
| March 12, 2024 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 1146 | $74.44 | 61,174.0000 | 0 | 1.84% | 0.00% |
| March 10, 2024 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 5500 | $0.00 | 62,871.0000 | 0 | 9.59% | 0.00% |
| March 11, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 9000 | $0.00 | 9,000.0000 | 0 | 50.00% | 0.00% |
| March 10, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 19250 | $0.00 | 57,750.0000 | 0 | 25.00% | 0.00% |
| March 12, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 4583 | $74.44 | 408,122.0000 | 0 | 1.11% | 0.00% |
| March 11, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 9000 | $0.00 | 412,705.0000 | 0 | 2.23% | 0.00% |
| March 11, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 9802 | $78.26 | 403,705.0000 | 0 | 2.37% | 0.00% |
| March 10, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 19250 | $0.00 | 413,507.0000 | 0 | 4.88% | 0.00% |
| March 11, 2024 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 2250 | $0.00 | 2,250.0000 | 0 | 50.00% | 0.00% |
| March 10, 2024 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 5500 | $0.00 | 16,500.0000 | 0 | 25.00% | 0.00% |
| March 11, 2024 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 2250 | $0.00 | 62,320.0000 | 0 | 3.75% | 0.00% |
| March 11, 2024 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 2801 | $78.26 | 60,070.0000 | 0 | 4.46% | 0.00% |
| Feb. 27, 2024 | George Simeon | Not found | A | Common Shares | 63177 | $71.50 | 1,048,951.0000 | 0 | 6.41% | 0.00% |
| Feb. 27, 2024 | George Simeon | Not found | A | Common Shares | 216578 | $71.50 | 1,048,951.0000 | 0 | 26.02% | 0.00% |
| Feb. 27, 2024 | George Simeon | Not found | A | Common Shares | 769196 | $71.50 | 1,048,951.0000 | 0 | 274.95% | 0.00% |
| Feb. 18, 2024 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 3825 | $0.00 | 59,284.0000 | 0 | 6.90% | 0.00% |
| Feb. 20, 2024 | KASINGER JAMES R. | General Counsel and Secretary | S | Common Shares | 1913 | $79.67 | 57,371.0000 | 0 | 3.23% | 0.00% |
| Feb. 18, 2024 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 3825 | $0.00 | 7,650.0000 | 0 | 33.33% | 0.00% |
| Feb. 18, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 13250 | $0.00 | 400,627.0000 | 0 | 3.42% | 0.00% |
| Feb. 20, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 6370 | $79.67 | 394,257.0000 | 0 | 1.59% | 0.00% |
| Feb. 18, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 13250 | $0.00 | 26,500.0000 | 0 | 33.33% | 0.00% |
| Feb. 15, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 20000 | $19.12 | 407,377.0000 | 0 | 5.16% | 0.00% |
| Feb. 15, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 12949 | $79.94 | 394,428.0000 | 0 | 3.18% | 0.00% |
| Feb. 15, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 5951 | $81.04 | 388,477.0000 | 0 | 1.51% | 0.00% |
| Feb. 15, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 1100 | $81.66 | 387,377.0000 | 0 | 0.28% | 0.00% |
| Feb. 15, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 20000 | $0.00 | 39,582.0000 | 0 | 33.57% | 0.00% |
| Jan. 29, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 50000 | $19.12 | 437,377.0000 | 0 | 12.91% | 0.00% |
| Jan. 29, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 49300 | $60.50 | 388,077.0000 | 0 | 11.27% | 0.00% |
| Jan. 29, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 700 | $61.10 | 387,377.0000 | 0 | 0.18% | 0.00% |
| Jan. 29, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 50000 | $0.00 | 100,000.0000 | 0 | 33.33% | 0.00% |
| Jan. 16, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 20000 | $0.00 | 59,582.0000 | 0 | 25.13% | 0.00% |
| Jan. 16, 2024 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 20000 | $62.50 | 387,377.0000 | 0 | 4.91% | 0.00% |
| Jan. 16, 2024 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 20000 | $19.12 | 407,377.0000 | 0 | 5.16% | 0.00% |
| Oct. 13, 2023 | Kulkarni Samarth | Chief Executive Officer | A | Stock Option (Right to Buy) | 52500 | $0.00 | 52,500.0000 | 0 | 9999.99% | 0.00% |
| Oct. 13, 2023 | Morrow Phuong Khanh | Chief Medical Officer | A | Stock Option (Right to Buy) | 16667 | $0.00 | 16,667.0000 | 0 | 9999.99% | 0.00% |
| Oct. 13, 2023 | Prasad Raju | Chief Financial Officer | A | Stock Option (Right to Buy) | 13832 | $0.00 | 13,832.0000 | 0 | 9999.99% | 0.00% |
| Oct. 13, 2023 | KASINGER JAMES R. | General Counsel and Secretary | A | Restricted Stock Units | 6340 | $0.00 | 6,340.0000 | 0 | 9999.99% | 0.00% |
| Oct. 13, 2023 | KASINGER JAMES R. | General Counsel and Secretary | A | Stock Option (Right to Buy) | 16667 | $0.00 | 16,667.0000 | 0 | 9999.99% | 0.00% |
| Oct. 13, 2023 | Kulkarni Samarth | Chief Executive Officer | A | Restricted Stock Unit | 25000 | $0.00 | 25,000.0000 | 0 | 9999.99% | 0.00% |
| June 8, 2023 | Greene John | Director | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| June 8, 2023 | Fleming Harold Edward | Director | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| June 8, 2023 | Fardis Maria | Director | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| June 8, 2023 | George Simeon | Director | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| June 8, 2023 | Behbahani Ali | Director | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| June 8, 2023 | Treco Douglas A | Director | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| June 8, 2023 | High Katherine A | Director | A | Stock Option (Right to Buy) | 13000 | $0.00 | 13,000.0000 | 0 | 9999.99% | 0.00% |
| May 30, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 9300 | $65.63 | 389,777.0000 | 0 | 2.33% | 0.00% |
| May 30, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 5999 | $64.46 | 399,077.0000 | 0 | 1.48% | 0.00% |
| May 30, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 7301 | $63.61 | 405,076.0000 | 0 | 1.77% | 0.00% |
| May 30, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 25000 | $0.00 | 79,582.0000 | 0 | 23.90% | 0.00% |
| May 30, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 25000 | $19.12 | 412,377.0000 | 0 | 6.45% | 0.00% |
| May 30, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 2400 | $66.83 | 387,377.0000 | 0 | 0.62% | 0.00% |
| May 23, 2023 | Morrow Phuong Khanh | Chief Medical Officer | M | Restricted Stock Units | 6938 | $0.00 | 20,812.0000 | 0 | 50.01% | 0.00% |
| May 24, 2023 | Morrow Phuong Khanh | Chief Medical Officer | F | Common Shares | 2527 | $65.91 | 4,411.0000 | 0 | 36.42% | 0.00% |
| May 23, 2023 | Morrow Phuong Khanh | Chief Medical Officer | M | Common Shares | 6938 | $0.00 | 6,938.0000 | 0 | 9999.99% | 0.00% |
| April 25, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 25000 | $0.00 | 104,582.0000 | 0 | 19.29% | 0.00% |
| April 25, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 20607 | $50.50 | 391,770.0000 | 0 | 5.00% | 0.00% |
| April 25, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 25000 | $19.12 | 412,377.0000 | 0 | 6.45% | 0.00% |
| April 25, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 4393 | $51.45 | 387,377.0000 | 0 | 1.12% | 0.00% |
| March 29, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 5281 | $44.78 | 387,377.0000 | 0 | 1.34% | 0.00% |
| March 29, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 19719 | $44.37 | 392,658.0000 | 0 | 4.78% | 0.00% |
| March 29, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 25000 | $19.12 | 412,377.0000 | 0 | 6.45% | 0.00% |
| March 29, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 25000 | $0.00 | 129,582.0000 | 0 | 16.17% | 0.00% |
| March 10, 2023 | KASINGER JAMES R. | General Counsel and Secretary | A | Restricted Stock Units | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| March 14, 2023 | Prasad Raju | Chief Financial Officer | A | Stock Option (Right to Buy) | 100000 | $0.00 | 100,000.0000 | 0 | 9999.99% | 0.00% |
| March 10, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 11833 | $0.00 | 387,821.0000 | 0 | 3.15% | 0.00% |
| March 13, 2023 | Kulkarni Samarth | Chief Executive Officer | F | Common Shares | 5358 | $43.22 | 382,463.0000 | 0 | 1.38% | 0.00% |
| March 11, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 9000 | $0.00 | 391,463.0000 | 0 | 2.35% | 0.00% |
| March 13, 2023 | Kulkarni Samarth | Chief Executive Officer | F | Common Shares | 4086 | $43.22 | 387,377.0000 | 0 | 1.04% | 0.00% |
| March 10, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 11833 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| March 10, 2023 | Kulkarni Samarth | Chief Executive Officer | A | Stock Option (Right to Buy) | 188000 | $0.00 | 188,000.0000 | 0 | 9999.99% | 0.00% |
| March 10, 2023 | Kulkarni Samarth | Chief Executive Officer | A | Restricted Stock Units | 77000 | $0.00 | 77,000.0000 | 0 | 9999.99% | 0.00% |
| March 11, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 9000 | $0.00 | 18,000.0000 | 0 | 33.33% | 0.00% |
| March 10, 2023 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 2833 | $0.00 | 54,899.0000 | 0 | 5.44% | 0.00% |
| March 13, 2023 | KASINGER JAMES R. | General Counsel and Secretary | F | Common Shares | 1283 | $43.22 | 53,616.0000 | 0 | 2.34% | 0.00% |
| March 11, 2023 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 2250 | $0.00 | 55,866.0000 | 0 | 4.20% | 0.00% |
| March 13, 2023 | KASINGER JAMES R. | General Counsel and Secretary | F | Common Shares | 1022 | $43.22 | 54,844.0000 | 0 | 1.83% | 0.00% |
| March 10, 2023 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 2833 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| March 10, 2023 | KASINGER JAMES R. | General Counsel and Secretary | A | Stock Option (Right to Buy) | 40000 | $0.00 | 40,000.0000 | 0 | 9999.99% | 0.00% |
| March 14, 2023 | Prasad Raju | Chief Financial Officer | A | Restricted Stock Units | 40000 | $0.00 | 40,000.0000 | 0 | 9999.99% | 0.00% |
| March 11, 2023 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 2250 | $0.00 | 4,500.0000 | 0 | 33.33% | 0.00% |
| March 10, 2023 | Morrow Phuong Khanh | Chief Medical Officer | A | Stock Option (Right to Buy) | 44620 | $0.00 | 44,620.0000 | 0 | 9999.99% | 0.00% |
| March 10, 2023 | Morrow Phuong Khanh | Chief Medical Officer | A | Restricted Stock Units | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 1100 | $49.20 | 375,988.0000 | 0 | 0.29% | 0.00% |
| Feb. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 13720 | $48.57 | 377,088.0000 | 0 | 3.51% | 0.00% |
| Feb. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 25000 | $19.12 | 400,988.0000 | 0 | 6.65% | 0.00% |
| Feb. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 10180 | $47.71 | 390,808.0000 | 0 | 2.54% | 0.00% |
| Feb. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 25000 | $0.00 | 154,582.0000 | 0 | 13.92% | 0.00% |
| Feb. 21, 2023 | Kulkarni Samarth | Chief Executive Officer | F | Common Shares | 6373 | $48.26 | 375,988.0000 | 0 | 1.67% | 0.00% |
| Feb. 18, 2023 | Smith Brendan | Chief Financial Officer | M | Restricted Stock Units | 3825 | $0.00 | 11,475.0000 | 0 | 25.00% | 0.00% |
| Feb. 21, 2023 | Smith Brendan | Chief Financial Officer | F | Common Shares | 1392 | $48.26 | 5,072.0000 | 0 | 21.53% | 0.00% |
| Feb. 18, 2023 | Smith Brendan | Chief Financial Officer | M | Common Shares | 3825 | $0.00 | 6,464.0000 | 0 | 144.94% | 0.00% |
| Feb. 18, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 13250 | $0.00 | 382,361.0000 | 0 | 3.59% | 0.00% |
| Feb. 18, 2023 | KASINGER JAMES R. | General Counsel and Secretary | M | Restricted Stock Units | 3825 | $0.00 | 11,475.0000 | 0 | 25.00% | 0.00% |
| Feb. 21, 2023 | KASINGER JAMES R. | General Counsel and Secretary | F | Common Shares | 1950 | $48.26 | 52,066.0000 | 0 | 3.61% | 0.00% |
| Feb. 18, 2023 | KASINGER JAMES R. | General Counsel and Secretary | M | Common Shares | 3825 | $0.00 | 54,016.0000 | 0 | 7.62% | 0.00% |
| Feb. 18, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Restricted Stock Units | 13250 | $0.00 | 39,750.0000 | 0 | 25.00% | 0.00% |
| Jan. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Stock Option (Right to Buy) | 25000 | $0.00 | 179,582.0000 | 0 | 12.22% | 0.00% |
| Jan. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | M | Common Shares | 25000 | $19.12 | 394,111.0000 | 0 | 6.77% | 0.00% |
| Jan. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 1800 | $50.60 | 392,311.0000 | 0 | 0.46% | 0.00% |
| Jan. 27, 2023 | Kulkarni Samarth | Chief Executive Officer | S | Common Shares | 23200 | $51.54 | 369,111.0000 | 0 | 5.91% | 0.00% |