In the last 12 months, insiders at Spero Therapeutics, Inc. ($SPRO) filed 91 transactions with the SEC: 0 open-market purchases totaling $0 and 42 sales totaling $1,294,956. Net insider sentiment: net selling.
Spero Therapeutics, Inc. operates in the Pharmaceutical preparations industry (Life sciences sector).
Most Active Insiders
- Rajavelu Esther (See Remarks) — 9 transactions totaling $343,496
- Keutzer Timothy (Chief Operating Officer) — 16 transactions totaling $244,052
- Mahadevia Ankit (Not found) — 9 transactions totaling $173,708
- Shukla Sath (CEO and President) — 8 transactions totaling $158,113
- Shukla Sath (CEO & President) — 5 transactions totaling $124,882
View all SEC Filings for Spero Therapeutics, Inc. (SPRO).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| Feb. 6, 2026 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 18652 | $2.36 | 742,506.0000 | 56,339,295 | 2.45% | 0.03% |
| Feb. 6, 2026 | Rajavelu Esther | See Remarks | S | Common Stock | 50816 | $2.36 | 1,012,091.0000 | 56,339,295 | 4.78% | 0.09% |
| Feb. 6, 2026 | Rajavelu Esther | See Remarks | S | Common Stock | 37101 | $2.36 | 1,062,907.0000 | 56,339,295 | 3.37% | 0.07% |
| Feb. 4, 2026 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 3471 | $2.24 | 761,158.0000 | 56,339,295 | 0.45% | 0.01% |
| Feb. 2, 2026 | Keutzer Timothy | Chief Operating Officer | A | Stock Option (Right to Buy) | 137000 | $0.00 | 137,000.0000 | 56,339,295 | 9999.99% | 0.24% |
| Feb. 3, 2026 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 24224 | $2.14 | 764,629.0000 | 56,339,295 | 3.07% | 0.04% |
| Feb. 2, 2026 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 18891 | $2.20 | 788,853.0000 | 56,339,295 | 2.34% | 0.03% |
| Feb. 2, 2026 | Keutzer Timothy | Chief Operating Officer | A | Common Stock | 68000 | $0.00 | 807,744.0000 | 56,339,295 | 9.19% | 0.12% |
| Feb. 2, 2026 | Rajavelu Esther | See Remarks | S | Common Stock | 18442 | $2.20 | 1,100,008.0000 | 56,339,295 | 1.65% | 0.03% |
| Feb. 2, 2026 | Rajavelu Esther | See Remarks | A | Common Stock | 249000 | $0.00 | 1,118,450.0000 | 56,339,295 | 28.64% | 0.44% |
| Feb. 2, 2026 | Rajavelu Esther | See Remarks | A | Stock Option (Right to Buy) | 498000 | $0.00 | 498,000.0000 | 56,339,295 | 9999.99% | 0.88% |
| Nov. 7, 2025 | Rajavelu Esther | See Remarks | S | Common Stock | 40270 | $2.37 | 869,450.0000 | 56,339,295 | 4.43% | 0.07% |
| Aug. 28, 2025 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 1695 | $1.97 | 739,744.0000 | 55,900,641 | 0.23% | 0.00% |
| Aug. 28, 2025 | Mahadevia Ankit | Not found | S | Common Stock | 6572 | $1.97 | 703,294.0000 | 55,900,641 | 0.93% | 0.01% |
| June 12, 2025 | Jackson Scott Thomas | Not found | A | Common Stock | 20000 | $0.00 | 75,000.0000 | 55,900,641 | 36.36% | 0.04% |
| June 12, 2025 | Deshpande Milind | Not found | A | Common Stock | 20000 | $0.00 | 91,454.0000 | 55,900,641 | 27.99% | 0.04% |
| June 12, 2025 | VINK PATRICK V.J.J. | Not found | A | Common Stock | 20000 | $0.00 | 75,000.0000 | 55,900,641 | 36.36% | 0.04% |
| June 12, 2025 | Pottage John C Jr | Not found | A | Common Stock | 20000 | $0.00 | 75,000.0000 | 55,900,641 | 36.36% | 0.04% |
| June 12, 2025 | Smith Cynthia | Not found | A | Common Stock | 20000 | $0.00 | 75,000.0000 | 55,900,641 | 36.36% | 0.04% |
| June 12, 2025 | THOMAS FRANK E | Not found | A | Common Stock | 20000 | $0.00 | 75,000.0000 | 55,900,641 | 36.36% | 0.04% |
| June 12, 2025 | Tregoning Kathleen | Not found | A | Common Stock | 20000 | $0.00 | 75,000.0000 | 55,900,641 | 36.36% | 0.04% |
| June 12, 2025 | Mahadevia Ankit | Not found | A | Common Stock | 20000 | $0.00 | 709,866.0000 | 55,900,641 | 2.90% | 0.04% |
| May 2, 2025 | Rajavelu Esther | See Remarks | A | Common Stock | 185000 | $0.00 | 909,720.0000 | 55,900,641 | 25.53% | 0.33% |
| Feb. 5, 2025 | Mahadevia Ankit | Not found | S | Common Stock | 55260 | $0.78 | 689,866.0000 | 0 | 7.42% | 0.00% |
| Feb. 5, 2025 | Mahadevia Ankit | Not found | S | Common Stock | 13959 | $0.78 | 745,126.0000 | 0 | 1.84% | 0.00% |
| Feb. 5, 2025 | Shukla Sath | CEO & President | S | Common Stock | 106408 | $0.78 | 1,736,883.0000 | 0 | 5.77% | 0.00% |
| Feb. 5, 2025 | Shukla Sath | CEO & President | S | Common Stock | 42786 | $0.78 | 1,843,291.0000 | 0 | 2.27% | 0.00% |
| Feb. 5, 2025 | Shukla Sath | CEO & President | S | Common Stock | 6139 | $0.78 | 1,886,077.0000 | 0 | 0.32% | 0.00% |
| Feb. 3, 2025 | Shukla Sath | CEO & President | A | Common Stock | 751407 | $0.00 | 1,892,216.0000 | 0 | 65.87% | 0.00% |
| Feb. 5, 2025 | Rajavelu Esther | CFO & CBO | S | Common Stock | 20689 | $0.78 | 724,720.0000 | 0 | 2.78% | 0.00% |
| Feb. 5, 2025 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 24920 | $0.78 | 741,439.0000 | 0 | 3.25% | 0.00% |
| Feb. 3, 2025 | Rajavelu Esther | CFO & CBO | A | Common Stock | 266139 | $0.00 | 645,409.0000 | 0 | 70.17% | 0.00% |
| Feb. 5, 2025 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 3974 | $0.78 | 794,002.0000 | 0 | 0.50% | 0.00% |
| Feb. 3, 2025 | Keutzer Timothy | Chief Operating Officer | A | Common Stock | 266139 | $0.00 | 797,976.0000 | 0 | 50.04% | 0.00% |
| Feb. 3, 2025 | Rajavelu Esther | CFO & CBO | A | Common Stock | 100000 | $0.00 | 745,409.0000 | 0 | 15.49% | 0.00% |
| Feb. 5, 2025 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 27643 | $0.78 | 766,359.0000 | 0 | 3.48% | 0.00% |
| Nov. 7, 2024 | Rajavelu Esther | CFO & CBO | S | Common Stock | 23351 | $1.31 | 396,515.0000 | 0 | 5.56% | 0.00% |
| Nov. 8, 2024 | Rajavelu Esther | CFO & CBO | S | Common Stock | 17245 | $1.30 | 379,270.0000 | 0 | 4.35% | 0.00% |
| Aug. 27, 2024 | Shukla Sath | CEO & President | S | Common Stock | 2757 | $1.35 | 1,140,809.0000 | 0 | 0.24% | 0.00% |
| Aug. 27, 2024 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 2213 | $1.35 | 531,837.0000 | 0 | 0.41% | 0.00% |
| Aug. 27, 2024 | Mahadevia Ankit | Not found | S | Common Stock | 5912 | $1.35 | 759,085.0000 | 0 | 0.77% | 0.00% |
| Aug. 5, 2024 | Shukla Sath | CEO and President | S | Common Stock | 17641 | $1.31 | 1,143,566.0000 | 0 | 1.52% | 0.00% |
| Aug. 2, 2024 | Shukla Sath | CEO and President | S | Common Stock | 14800 | $1.32 | 1,161,207.0000 | 0 | 1.26% | 0.00% |
| May 29, 2024 | Mahadevia Ankit | Not found | A | Common Stock | 20000 | $0.00 | 764,997.0000 | 0 | 2.68% | 0.00% |
| May 29, 2024 | Pottage John C Jr | Not found | A | Common Stock | 20000 | $0.00 | 55,000.0000 | 0 | 57.14% | 0.00% |
| May 29, 2024 | Deshpande Milind | Not found | A | Common Stock | 20000 | $0.00 | 71,454.0000 | 0 | 38.87% | 0.00% |
| May 29, 2024 | Jackson Scott Thomas | Not found | A | Common Stock | 20000 | $0.00 | 55,000.0000 | 0 | 57.14% | 0.00% |
| May 29, 2024 | THOMAS FRANK E | Not found | A | Common Stock | 20000 | $0.00 | 55,000.0000 | 0 | 57.14% | 0.00% |
| May 29, 2024 | Smith Cynthia | Not found | A | Common Stock | 20000 | $0.00 | 55,000.0000 | 0 | 57.14% | 0.00% |
| May 29, 2024 | Tregoning Kathleen | Not found | A | Common Stock | 20000 | $0.00 | 55,000.0000 | 0 | 57.14% | 0.00% |
| May 29, 2024 | VINK PATRICK V.J.J. | Not found | A | Common Stock | 20000 | $0.00 | 55,000.0000 | 0 | 57.14% | 0.00% |
| Feb. 1, 2024 | Shukla Sath | CEO and President | A | Common Stock | 679501 | $0.00 | 1,252,001.0000 | 0 | 118.69% | 0.00% |
| Feb. 1, 2024 | Keutzer Timothy | Chief Operating Officer | A | Common Stock | 239731 | $0.00 | 565,021.0000 | 0 | 73.70% | 0.00% |
| Feb. 2, 2024 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 30971 | $1.36 | 534,050.0000 | 0 | 5.48% | 0.00% |
| Feb. 2, 2024 | Mahadevia Ankit | Not found | S | Common Stock | 63795 | $1.37 | 744,997.0000 | 0 | 7.89% | 0.00% |
| Feb. 1, 2024 | JOSEPH TAMARA L | Chief Legal Officer | A | Common Stock | 239731 | $0.00 | 562,521.0000 | 0 | 74.27% | 0.00% |
| Feb. 2, 2024 | JOSEPH TAMARA L | Chief Legal Officer | S | Common Stock | 30906 | $1.37 | 531,615.0000 | 0 | 5.49% | 0.00% |
| Feb. 1, 2024 | HAMED KAMAL | Chief Medical Officer | A | Common Stock | 239731 | $0.00 | 816,192.0000 | 0 | 41.59% | 0.00% |
| Feb. 2, 2024 | HAMED KAMAL | Chief Medical Officer | S | Common Stock | 28075 | $1.37 | 788,117.0000 | 0 | 3.44% | 0.00% |
| Feb. 1, 2024 | Rajavelu Esther | See Remarks | A | Common Stock | 119866 | $0.00 | 419,866.0000 | 0 | 39.96% | 0.00% |
| Feb. 2, 2024 | Shukla Sath | CEO and President | S | Common Stock | 30901 | $1.37 | 1,221,100.0000 | 0 | 2.47% | 0.00% |
| Feb. 5, 2024 | Shukla Sath | CEO and President | S | Common Stock | 45093 | $1.45 | 1,176,007.0000 | 0 | 3.69% | 0.00% |
| Jan. 2, 2024 | Tregoning Kathleen | Not found | A | Stock Option (Right to Buy) | 35604 | $1.12 | 35,604.0000 | 0 | 9999.99% | 0.00% |
| Nov. 13, 2023 | Rajavelu Esther | See Remarks | A | Common Stock | 300000 | $0.00 | 300,000.0000 | 0 | 9999.99% | 0.00% |
| Oct. 5, 2023 | Jackson Scott Thomas | Not found | A | Common Stock | 20000 | $0.00 | 35,000.0000 | 0 | 133.33% | 0.00% |
| Oct. 5, 2023 | Mahadevia Ankit | Not found | A | Common Stock | 20000 | $0.00 | 808,792.0000 | 0 | 2.54% | 0.00% |
| Oct. 5, 2023 | Deshpande Milind | Not found | A | Common Stock | 20000 | $0.00 | 51,454.0000 | 0 | 63.58% | 0.00% |
| Oct. 5, 2023 | VINK PATRICK V.J.J. | Not found | A | Common Stock | 20000 | $0.00 | 35,000.0000 | 0 | 133.33% | 0.00% |
| Oct. 5, 2023 | Tregoning Kathleen | Not found | A | Common Stock | 20000 | $0.00 | 35,000.0000 | 0 | 133.33% | 0.00% |
| Oct. 5, 2023 | Pottage John C Jr | Not found | A | Common Stock | 20000 | $0.00 | 35,000.0000 | 0 | 133.33% | 0.00% |
| Oct. 5, 2023 | Smith Cynthia | Not found | A | Common Stock | 20000 | $0.00 | 35,000.0000 | 0 | 133.33% | 0.00% |
| Oct. 5, 2023 | THOMAS FRANK E | Not found | A | Common Stock | 20000 | $0.00 | 35,000.0000 | 0 | 133.33% | 0.00% |
| Sept. 13, 2023 | HAMED KAMAL | Chief Medical Officer | S | Common Stock | 39496 | $1.27 | 576,461.0000 | 0 | 6.41% | 0.00% |
| Aug. 28, 2023 | Keutzer Timothy | Chief Development Officer | S | Common Stock | 1854 | $1.26 | 325,290.0000 | 0 | 0.57% | 0.00% |
| Aug. 28, 2023 | JOSEPH TAMARA L | Chief Legal Officer | S | Common Stock | 1854 | $1.26 | 322,790.0000 | 0 | 0.57% | 0.00% |
| Aug. 28, 2023 | Mahadevia Ankit | Not found | S | Common Stock | 9040 | $1.26 | 788,792.0000 | 0 | 1.13% | 0.00% |
| Aug. 28, 2023 | Shukla Sath | CEO and President | S | Common Stock | 1854 | $1.26 | 576,663.0000 | 0 | 0.32% | 0.00% |
| Aug. 29, 2023 | Shukla Sath | CEO and President | S | Common Stock | 4163 | $1.30 | 572,500.0000 | 0 | 0.72% | 0.00% |
| Aug. 1, 2023 | Shukla Sath | CEO and President | A | Common Stock | 266000 | $0.00 | 578,517.0000 | 0 | 85.12% | 0.00% |
| June 12, 2023 | HAMED KAMAL | Chief Medical Officer | A | Common Stock | 140000 | $0.00 | 615,957.0000 | 0 | 29.41% | 0.00% |
| Feb. 3, 2023 | Mahadevia Ankit | CEO and President | S | Common Stock | 12286 | $1.81 | 797,832.0000 | 0 | 1.52% | 0.00% |
| Feb. 2, 2023 | Shukla Sath | Chief Financial Officer | S | Common Stock | 9504 | $1.83 | 312,517.0000 | 0 | 2.95% | 0.00% |
| Feb. 1, 2023 | Shukla Sath | Chief Financial Officer | A | Common Stock | 265957 | $0.00 | 322,021.0000 | 0 | 474.38% | 0.00% |
| Feb. 1, 2023 | JOSEPH TAMARA L | Chief Legal Officer | A | Common Stock | 265957 | $0.00 | 328,038.0000 | 0 | 428.40% | 0.00% |
| Feb. 2, 2023 | Keutzer Timothy | Chief Operating Officer | S | Common Stock | 3394 | $1.86 | 327,144.0000 | 0 | 1.03% | 0.00% |
| Feb. 1, 2023 | Keutzer Timothy | Chief Operating Officer | A | Common Stock | 265957 | $0.00 | 330,538.0000 | 0 | 411.82% | 0.00% |
| Feb. 2, 2023 | JOSEPH TAMARA L | Chief Legal Officer | S | Common Stock | 3394 | $1.86 | 324,644.0000 | 0 | 1.03% | 0.00% |
| Feb. 1, 2023 | Mahadevia Ankit | CEO and President | A | Common Stock | 531914 | $0.00 | 810,118.0000 | 0 | 191.20% | 0.00% |
| Feb. 1, 2023 | HAMED KAMAL | Chief Medical Officer | A | Common Stock | 265957 | $0.00 | 475,957.0000 | 0 | 126.65% | 0.00% |
| Jan. 3, 2023 | Tregoning Kathleen | Director | A | Stock Option (Right to Buy) | 30943 | $1.29 | 30,943.0000 | 0 | 9999.99% | 0.00% |
| Jan. 3, 2023 | VINK PATRICK V.J.J. | Director | A | Stock Option (Right to Buy) | 15471 | $1.29 | 15,471.0000 | 0 | 9999.99% | 0.00% |