In the last 12 months, insiders at EXELIXIS, INC. ($EXEL) filed 412 transactions with the SEC: 5 open-market purchases totaling $16,455,962 and 95 sales totaling $103,851,164. Net insider sentiment: net selling.
EXELIXIS, INC. operates in the Biological products, (no disgnostic substances) industry (Life sciences sector).
Most Active Insiders
- MORRISSEY MICHAEL (President and CEO) — 65 transactions totaling $110,126,964
- Haley Patrick J. (EVP, Commercial) — 56 transactions totaling $38,539,511
- Senner Christopher J. (EVP and CFO) — 41 transactions totaling $31,696,391
- Aftab Dana (CSO/EVP Disc & Trans Research) — 40 transactions totaling $19,595,038
- JOHNSON DAVID EDWARD (Director) — 10 transactions totaling $19,058,001
View all SEC Filings for EXELIXIS, INC. (EXEL).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| Feb. 26, 2026 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 160437 | $0.00 | 3,622,236.0000 | 281,863,000 | 4.63% | 0.06% |
| Feb. 26, 2026 | Aftab Dana | EVP, Research and Development | A | Common Stock | 52018 | $0.00 | 673,959.0000 | 281,863,000 | 8.36% | 0.02% |
| Feb. 26, 2026 | Senner Christopher J. | EVP and CFO | A | Common Stock | 52018 | $0.00 | 1,030,833.0000 | 281,863,000 | 5.31% | 0.02% |
| Feb. 26, 2026 | Hefti Brenda | SVP and General Counsel | A | Common Stock | 23119 | $0.00 | 125,158.0000 | 281,863,000 | 22.66% | 0.01% |
| Feb. 26, 2026 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 40459 | $0.00 | 422,367.0000 | 281,863,000 | 10.59% | 0.01% |
| Feb. 24, 2026 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 100278 | $0.00 | 3,622,236.0000 | 281,863,000 | 2.69% | 0.04% |
| Feb. 24, 2026 | Aftab Dana | EVP, Research and Development | S | Common Stock | 47918 | $44.50 | 621,941.0000 | 281,863,000 | 7.15% | 0.02% |
| Feb. 19, 2026 | Aftab Dana | EVP, Research and Development | S | Common Stock | 29873 | $44.35 | 669,859.0000 | 281,863,000 | 4.27% | 0.01% |
| Feb. 18, 2026 | WYSZOMIERSKI JACK L | Director | M | Common Stock | 20634 | $19.77 | 379,516.0000 | 281,863,000 | 5.75% | 0.01% |
| Feb. 18, 2026 | WYSZOMIERSKI JACK L | Director | S | Common Stock | 99574 | $44.01 | 279,942.0000 | 281,863,000 | 26.24% | 0.04% |
| Feb. 18, 2026 | WYSZOMIERSKI JACK L | Director | M | Option (right to buy) | 20634 | $0.00 | 0.0000 | 281,863,000 | 100.00% | 0.01% |
| Feb. 17, 2026 | Smith Julie | Director | S | Common Stock | 42422 | $43.33 | 20,590.0000 | 281,863,000 | 67.32% | 0.02% |
| Feb. 18, 2026 | Smith Julie | Director | M | Common Stock | 44087 | $19.39 | 64,677.0000 | 281,863,000 | 214.12% | 0.02% |
| Feb. 18, 2026 | Smith Julie | Director | S | Common Stock | 44087 | $44.50 | 20,590.0000 | 281,863,000 | 68.16% | 0.02% |
| Feb. 18, 2026 | Smith Julie | Director | S | Common Stock | 20030 | $44.30 | 20,590.0000 | 281,863,000 | 49.31% | 0.01% |
| Feb. 18, 2026 | Smith Julie | Director | M | Common Stock | 20030 | $21.69 | 40,620.0000 | 281,863,000 | 97.28% | 0.01% |
| Feb. 17, 2026 | Smith Julie | Director | M | Option (right to buy) | 42422 | $0.00 | 0.0000 | 281,863,000 | 100.00% | 0.02% |
| Feb. 18, 2026 | Smith Julie | Director | M | Option (right to buy) | 44087 | $0.00 | 0.0000 | 281,863,000 | 100.00% | 0.02% |
| Feb. 18, 2026 | Smith Julie | Director | M | Option (right to buy) | 20030 | $0.00 | 0.0000 | 281,863,000 | 100.00% | 0.01% |
| Feb. 17, 2026 | Smith Julie | Director | M | Common Stock | 42422 | $18.19 | 63,012.0000 | 281,863,000 | 206.03% | 0.02% |
| Feb. 13, 2026 | Oliver Bob | Director | S | Common Stock | 21162 | $43.90 | 21,120.0000 | 281,863,000 | 50.05% | 0.01% |
| Feb. 15, 2026 | Hefti Brenda | SVP and General Counsel | F | Common Stock | 5430 | $43.92 | 120,708.0000 | 281,863,000 | 4.30% | 0.00% |
| Feb. 18, 2026 | Hefti Brenda | SVP and General Counsel | S | Common Stock | 18669 | $44.01 | 102,039.0000 | 281,863,000 | 15.47% | 0.01% |
| Feb. 13, 2026 | Oliver Bob | Director | M | Option (right to buy) | 9088 | $0.00 | 12,118.0000 | 281,863,000 | 42.86% | 0.00% |
| Feb. 13, 2026 | Senner Christopher J. | EVP and CFO | S | Common Stock | 34278 | $43.00 | 1,045,302.0000 | 281,863,000 | 3.18% | 0.01% |
| Feb. 15, 2026 | Senner Christopher J. | EVP and CFO | F | Common Stock | 35870 | $43.92 | 1,009,432.0000 | 281,863,000 | 3.43% | 0.01% |
| Feb. 17, 2026 | Senner Christopher J. | EVP and CFO | S | Common Stock | 30617 | $43.67 | 978,815.0000 | 281,863,000 | 3.03% | 0.01% |
| Feb. 15, 2026 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 31483 | $43.92 | 449,722.0000 | 281,863,000 | 6.54% | 0.01% |
| Feb. 17, 2026 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 3036 | $43.84 | 446,686.0000 | 281,863,000 | 0.68% | 0.00% |
| Feb. 17, 2026 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 64778 | $43.50 | 381,908.0000 | 281,863,000 | 14.50% | 0.02% |
| Feb. 13, 2026 | MORRISSEY MICHAEL | President and CEO | M | Common Stock | 494700 | $21.31 | 4,427,903.0000 | 281,863,000 | 12.58% | 0.18% |
| Feb. 13, 2026 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 369606 | $43.92 | 4,058,297.0000 | 281,863,000 | 8.35% | 0.13% |
| Feb. 15, 2026 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 120390 | $43.92 | 3,937,907.0000 | 281,863,000 | 2.97% | 0.04% |
| Feb. 17, 2026 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 250736 | $0.00 | 3,687,171.0000 | 281,863,000 | 6.37% | 0.09% |
| Feb. 17, 2026 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 250736 | $0.00 | 3,436,983.0000 | 281,863,000 | 7.87% | 0.09% |
| Feb. 18, 2026 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 125094 | $0.00 | 3,562,077.0000 | 281,863,000 | 3.39% | 0.04% |
| Feb. 18, 2026 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 125094 | $0.00 | 3,562,077.0000 | 281,863,000 | 3.64% | 0.04% |
| Feb. 13, 2026 | MORRISSEY MICHAEL | President and CEO | M | Option (right to buy) | 494700 | $0.00 | 0.0000 | 281,863,000 | 100.00% | 0.18% |
| Feb. 13, 2026 | Eckhardt Sue Gail | Director | S | Common Stock | 3856 | $43.79 | 17,524.0000 | 281,863,000 | 18.04% | 0.00% |
| Feb. 15, 2026 | Aftab Dana | EVP, Research and Development | F | Common Stock | 26485 | $43.92 | 712,452.0000 | 281,863,000 | 3.58% | 0.01% |
| Feb. 15, 2026 | Aftab Dana | EVP, Research and Development | F | Common Stock | 12720 | $43.92 | 699,732.0000 | 281,863,000 | 1.79% | 0.00% |
| Feb. 13, 2026 | Oliver Bob | Director | M | Common Stock | 9088 | $19.28 | 51,370.0000 | 281,863,000 | 21.49% | 0.00% |
| Feb. 13, 2026 | Oliver Bob | Director | S | Common Stock | 9088 | $43.61 | 42,282.0000 | 281,863,000 | 17.69% | 0.00% |
| Jan. 15, 2026 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 139524 | $45.23 | 3,557,373.0000 | 281,863,000 | 3.77% | 0.05% |
| Jan. 15, 2026 | Senner Christopher J. | EVP and CFO | F | Common Stock | 40459 | $45.23 | 1,079,580.0000 | 281,863,000 | 3.61% | 0.01% |
| Jan. 15, 2026 | Senner Christopher J. | EVP and CFO | A | Common Stock | 149474 | $0.00 | 1,120,039.0000 | 281,863,000 | 15.40% | 0.05% |
| Jan. 15, 2026 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 32332 | $45.23 | 481,205.0000 | 281,863,000 | 6.30% | 0.01% |
| Jan. 15, 2026 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 139508 | $0.00 | 513,537.0000 | 281,863,000 | 37.30% | 0.05% |
| Jan. 15, 2026 | Aftab Dana | EVP, Research and Development | F | Common Stock | 27254 | $45.23 | 738,937.0000 | 281,863,000 | 3.56% | 0.01% |
| Jan. 15, 2026 | Aftab Dana | EVP, Research and Development | A | Common Stock | 119578 | $0.00 | 766,191.0000 | 281,863,000 | 18.49% | 0.04% |
| Jan. 15, 2026 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 548073 | $0.00 | 3,696,897.0000 | 281,863,000 | 17.41% | 0.19% |
| Dec. 3, 2025 | Hefti Brenda | SVP and General Counsel | A | Common Stock | 30170 | $0.00 | 126,138.0000 | 283,701,000 | 31.44% | 0.01% |
| Nov. 25, 2025 | JOHNSON DAVID EDWARD | Director | P | Common Stock | 27532 | $43.12 | 1,571,438.0000 | 283,701,000 | 1.78% | 0.01% |
| Nov. 21, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 28043 | $42.58 | 374,029.0000 | 283,701,000 | 6.97% | 0.01% |
| Nov. 20, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 10000 | $42.11 | 402,072.0000 | 283,701,000 | 2.43% | 0.00% |
| Nov. 21, 2025 | Aftab Dana | EVP, Research and Development | G | Common Stock | 24000 | $0.00 | 646,613.0000 | 283,701,000 | 3.58% | 0.01% |
| Nov. 20, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 23539 | $41.93 | 374,029.0000 | 283,701,000 | 5.92% | 0.01% |
| Nov. 20, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 10648 | $41.77 | 374,029.0000 | 283,701,000 | 2.77% | 0.00% |
| Nov. 17, 2025 | Oliver Bob | Director | G | Common Stock | 1044 | $0.00 | 42,282.0000 | 283,701,000 | 2.41% | 0.00% |
| Nov. 12, 2025 | PAPADOPOULOS STELIOS | Director | S | Common Stock | 100000 | $43.55 | 1,189,228.0000 | 283,701,000 | 7.76% | 0.04% |
| Nov. 11, 2025 | Beckerle Mary C | Director | S | Common Stock | 18838 | $41.90 | 21,380.0000 | 283,701,000 | 46.84% | 0.01% |
| Nov. 11, 2025 | Beckerle Mary C | Director | M | Option (right to buy) | 5784 | $0.00 | 16,710.0000 | 283,701,000 | 25.71% | 0.00% |
| Nov. 12, 2025 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 101548 | $0.00 | 3,228,824.0000 | 283,701,000 | 3.25% | 0.04% |
| Nov. 12, 2025 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 101548 | $0.00 | 3,148,824.0000 | 283,701,000 | 3.12% | 0.04% |
| Nov. 11, 2025 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 160000 | $0.00 | 3,127,276.0000 | 283,701,000 | 4.87% | 0.06% |
| Nov. 11, 2025 | Aftab Dana | EVP, Research and Development | S | Common Stock | 48383 | $42.50 | 670,613.0000 | 283,701,000 | 6.73% | 0.02% |
| Nov. 12, 2025 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 80000 | $0.00 | 3,148,824.0000 | 283,701,000 | 2.48% | 0.03% |
| Nov. 11, 2025 | Beckerle Mary C | Director | M | Common Stock | 5784 | $23.24 | 46,002.0000 | 283,701,000 | 14.38% | 0.00% |
| Nov. 11, 2025 | Beckerle Mary C | Director | S | Common Stock | 5784 | $42.03 | 40,218.0000 | 283,701,000 | 12.57% | 0.00% |
| Oct. 8, 2025 | Aftab Dana | EVP, Research & Development | A | Common Stock | 50673 | $0.00 | 718,996.0000 | 283,701,000 | 7.58% | 0.02% |
| June 2, 2025 | Eckhardt Sue Gail | Director | S | Common Stock | 4 | $43.67 | 21,380.0000 | 296,132,000 | 0.02% | 0.00% |
| June 3, 2025 | WYSZOMIERSKI JACK L | Director | S | Common Stock | 7535 | $43.09 | 358,882.0000 | 296,132,000 | 2.06% | 0.00% |
| June 2, 2025 | Eckhardt Sue Gail | Director | S | Common Stock | 18834 | $42.74 | 21,384.0000 | 296,132,000 | 46.83% | 0.01% |
| May 29, 2025 | JOHNSON DAVID EDWARD | Director | A | Option (right to buy) | 21464 | $0.00 | 21,464.0000 | 296,132,000 | 9999.99% | 0.01% |
| May 29, 2025 | Smith Julie | Director | A | Common Stock | 9812 | $0.00 | 20,590.0000 | 296,132,000 | 91.04% | 0.00% |
| May 29, 2025 | Beckerle Mary C | Director | A | Common Stock | 9812 | $0.00 | 40,218.0000 | 296,132,000 | 32.27% | 0.00% |
| May 29, 2025 | Eckhardt Sue Gail | Director | A | Common Stock | 9812 | $0.00 | 40,218.0000 | 296,132,000 | 32.27% | 0.00% |
| May 29, 2025 | PAPADOPOULOS STELIOS | Director | A | Common Stock | 9812 | $0.00 | 1,289,228.0000 | 296,132,000 | 0.77% | 0.00% |
| May 29, 2025 | Freire Maria C | Director | A | Common Stock | 9812 | $0.00 | 100,819.0000 | 296,132,000 | 10.78% | 0.00% |
| May 29, 2025 | WYSZOMIERSKI JACK L | Director | A | Common Stock | 9812 | $0.00 | 366,417.0000 | 296,132,000 | 2.75% | 0.00% |
| May 29, 2025 | POSTE GEORGE | Director | A | Common Stock | 9812 | $0.00 | 178,832.0000 | 296,132,000 | 5.81% | 0.00% |
| May 29, 2025 | Heyman Tomas J. | Director | A | Common Stock | 9812 | $0.00 | 42,282.0000 | 296,132,000 | 30.22% | 0.00% |
| May 29, 2025 | Oliver Bob | Director | A | Common Stock | 9812 | $0.00 | 43,326.0000 | 296,132,000 | 29.28% | 0.00% |
| May 20, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 34387 | $44.06 | 446,259.0000 | 296,132,000 | 7.15% | 0.01% |
| May 21, 2025 | Heyman Tomas J. | Director | S | Common Stock | 4544 | $44.29 | 32,470.0000 | 296,132,000 | 12.28% | 0.00% |
| May 16, 2025 | Senner Christopher J. | EVP and CFO | S | Common Stock | 100000 | $46.00 | 970,565.0000 | 296,132,000 | 9.34% | 0.03% |
| May 16, 2025 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | S | Common Stock | 72776 | $45.47 | 465,393.0000 | 296,132,000 | 13.52% | 0.02% |
| May 16, 2025 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | M | Option (right to buy) | 40000 | $0.00 | 120,000.0000 | 296,132,000 | 25.00% | 0.01% |
| May 16, 2025 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | M | Common Stock | 40000 | $21.75 | 538,169.0000 | 296,132,000 | 8.03% | 0.01% |
| May 15, 2025 | Haley Patrick J. | EVP, Commercial | M | Option (right to buy) | 116383 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.04% |
| May 16, 2025 | Senner Christopher J. | EVP and CFO | M | Option (right to buy) | 100000 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.03% |
| May 15, 2025 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | F | Common Stock | 8303 | $44.65 | 498,169.0000 | 296,132,000 | 1.64% | 0.00% |
| May 15, 2025 | PAPADOPOULOS STELIOS | Director | M | Common Stock | 20634 | $19.77 | 1,300,050.0000 | 296,132,000 | 1.61% | 0.01% |
| May 15, 2025 | PAPADOPOULOS STELIOS | Director | S | Common Stock | 20634 | $44.35 | 1,279,416.0000 | 296,132,000 | 1.59% | 0.01% |
| May 15, 2025 | PAPADOPOULOS STELIOS | Director | M | Common Stock | 15874 | $20.50 | 1,295,290.0000 | 296,132,000 | 1.24% | 0.01% |
| May 15, 2025 | PAPADOPOULOS STELIOS | Director | S | Common Stock | 15874 | $44.35 | 1,279,416.0000 | 296,132,000 | 1.23% | 0.01% |
| May 15, 2025 | PAPADOPOULOS STELIOS | Director | M | Option (right to buy) | 20634 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| May 15, 2025 | PAPADOPOULOS STELIOS | Director | M | Option (right to buy) | 15874 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| May 14, 2025 | MORRISSEY MICHAEL | President and CEO | M | Common Stock | 308365 | $18.80 | 3,801,958.0000 | 296,132,000 | 8.83% | 0.10% |
| May 14, 2025 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 220494 | $44.65 | 3,581,464.0000 | 296,132,000 | 5.80% | 0.07% |
| May 15, 2025 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 104769 | $44.65 | 3,476,695.0000 | 296,132,000 | 2.93% | 0.04% |
| May 16, 2025 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 87871 | $0.00 | 3,388,824.0000 | 296,132,000 | 2.53% | 0.03% |
| May 16, 2025 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 87871 | $0.00 | 3,388,824.0000 | 296,132,000 | 2.66% | 0.03% |
| May 14, 2025 | MORRISSEY MICHAEL | President and CEO | M | Option (right to buy) | 308365 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.10% |
| May 15, 2025 | Hessekiel Jeffrey | EVP & General Counsel | F | Common Stock | 34035 | $44.65 | 719,395.0000 | 296,132,000 | 4.52% | 0.01% |
| May 15, 2025 | Hessekiel Jeffrey | EVP & General Counsel | S | Common Stock | 25000 | $46.18 | 694,395.0000 | 296,132,000 | 3.48% | 0.01% |
| May 14, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 10000 | $42.68 | 525,351.0000 | 296,132,000 | 1.87% | 0.00% |
| May 15, 2025 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 34705 | $44.65 | 490,646.0000 | 296,132,000 | 6.61% | 0.01% |
| May 15, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 10000 | $46.95 | 480,646.0000 | 296,132,000 | 2.04% | 0.00% |
| May 15, 2025 | Haley Patrick J. | EVP, Commercial | M | Common Stock | 116383 | $18.80 | 597,029.0000 | 296,132,000 | 24.21% | 0.04% |
| May 15, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 116383 | $48.05 | 480,646.0000 | 296,132,000 | 19.49% | 0.04% |
| May 16, 2025 | Senner Christopher J. | EVP and CFO | M | Common Stock | 100000 | $18.80 | 1,070,565.0000 | 296,132,000 | 10.30% | 0.03% |
| May 15, 2025 | Senner Christopher J. | EVP and CFO | F | Common Stock | 41422 | $44.65 | 970,565.0000 | 296,132,000 | 4.09% | 0.01% |
| May 15, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 30693 | $44.65 | 668,323.0000 | 296,132,000 | 4.39% | 0.01% |
| May 16, 2025 | POSTE GEORGE | Director | M | Option (right to buy) | 20634 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| May 16, 2025 | POSTE GEORGE | Director | S | Common Stock | 20634 | $45.99 | 169,020.0000 | 296,132,000 | 10.88% | 0.01% |
| May 16, 2025 | POSTE GEORGE | Director | M | Common Stock | 20634 | $19.77 | 189,654.0000 | 296,132,000 | 12.21% | 0.01% |
| May 1, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 1508 | $39.00 | 699,016.0000 | 296,132,000 | 0.22% | 0.00% |
| March 31, 2025 | Hessekiel Jeffrey | EVP & General Counsel | A | Common Stock | 154070 | $0.00 | 752,677.0000 | 296,132,000 | 25.74% | 0.05% |
| March 31, 2025 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | A | Common Stock | 159383 | $0.00 | 506,472.0000 | 296,132,000 | 45.92% | 0.05% |
| March 31, 2025 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 589719 | $0.00 | 3,405,722.0000 | 296,132,000 | 20.94% | 0.20% |
| March 31, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | A | Common Stock | 132819 | $0.00 | 699,771.0000 | 296,132,000 | 23.43% | 0.04% |
| March 31, 2025 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 159383 | $0.00 | 534,598.0000 | 296,132,000 | 42.48% | 0.05% |
| March 31, 2025 | Senner Christopher J. | EVP and CFO | A | Common Stock | 170009 | $0.00 | 1,011,987.0000 | 296,132,000 | 20.19% | 0.06% |
| March 3, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 10000 | $38.80 | 375,215.0000 | 296,132,000 | 2.60% | 0.00% |
| Feb. 27, 2025 | Smith Julie | Director | M | Common Stock | 31167 | $20.50 | 41,945.0000 | 296,132,000 | 289.17% | 0.01% |
| Feb. 26, 2025 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 47718 | $0.00 | 385,215.0000 | 296,132,000 | 14.14% | 0.02% |
| Feb. 26, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | A | Common Stock | 49209 | $0.00 | 566,952.0000 | 296,132,000 | 9.50% | 0.02% |
| Feb. 26, 2025 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 184909 | $0.00 | 2,816,003.0000 | 296,132,000 | 7.03% | 0.06% |
| Feb. 28, 2025 | Smith Julie | Director | M | Option (right to buy) | 19294 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| Feb. 27, 2025 | Smith Julie | Director | M | Option (right to buy) | 23347 | $0.00 | 19,294.0000 | 296,132,000 | 54.75% | 0.01% |
| Feb. 27, 2025 | Smith Julie | Director | M | Option (right to buy) | 31167 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| Feb. 28, 2025 | Smith Julie | Director | S | Common Stock | 19294 | $37.62 | 10,778.0000 | 296,132,000 | 64.16% | 0.01% |
| Feb. 28, 2025 | Smith Julie | Director | M | Common Stock | 19294 | $19.77 | 30,072.0000 | 296,132,000 | 179.01% | 0.01% |
| Feb. 27, 2025 | Smith Julie | Director | S | Common Stock | 54514 | $38.13 | 10,778.0000 | 296,132,000 | 83.49% | 0.02% |
| Feb. 27, 2025 | Smith Julie | Director | M | Common Stock | 23347 | $19.77 | 65,292.0000 | 296,132,000 | 55.66% | 0.01% |
| Feb. 26, 2025 | Senner Christopher J. | EVP and CFO | A | Common Stock | 59648 | $0.00 | 841,978.0000 | 296,132,000 | 7.62% | 0.02% |
| Feb. 28, 2025 | WYSZOMIERSKI JACK L | Director | M | Option (right to buy) | 15874 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| Feb. 28, 2025 | WYSZOMIERSKI JACK L | Director | S | Common Stock | 8768 | $37.80 | 356,605.0000 | 296,132,000 | 2.40% | 0.00% |
| Feb. 28, 2025 | WYSZOMIERSKI JACK L | Director | M | Common Stock | 15874 | $20.50 | 365,373.0000 | 296,132,000 | 4.54% | 0.01% |
| Feb. 26, 2025 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | A | Common Stock | 52192 | $0.00 | 347,089.0000 | 296,132,000 | 17.70% | 0.02% |
| Feb. 26, 2025 | Hessekiel Jeffrey | EVP & General Counsel | A | Common Stock | 52192 | $0.00 | 598,607.0000 | 296,132,000 | 9.55% | 0.02% |
| Feb. 24, 2025 | Senner Christopher J. | EVP and CFO | S | Common Stock | 29314 | $36.14 | 782,330.0000 | 296,132,000 | 3.61% | 0.01% |
| Feb. 24, 2025 | Senner Christopher J. | EVP and CFO | M | Common Stock | 29314 | $18.80 | 811,644.0000 | 296,132,000 | 3.75% | 0.01% |
| Feb. 24, 2025 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 177985 | $0.00 | 2,631,094.0000 | 296,132,000 | 7.26% | 0.06% |
| Feb. 24, 2025 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 177985 | $0.00 | 2,631,094.0000 | 296,132,000 | 6.34% | 0.06% |
| Feb. 24, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 26987 | $36.75 | 517,743.0000 | 296,132,000 | 4.95% | 0.01% |
| Feb. 25, 2025 | Oliver Bob | Director | M | Option (right to buy) | 15147 | $0.00 | 21,206.0000 | 296,132,000 | 41.67% | 0.01% |
| Feb. 25, 2025 | Oliver Bob | Director | S | Common Stock | 18647 | $37.25 | 33,514.0000 | 296,132,000 | 35.75% | 0.01% |
| Feb. 25, 2025 | Oliver Bob | Director | M | Common Stock | 15147 | $19.28 | 52,161.0000 | 296,132,000 | 40.92% | 0.01% |
| Feb. 24, 2025 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 52636 | $36.98 | 337,497.0000 | 296,132,000 | 13.49% | 0.02% |
| Feb. 24, 2025 | Senner Christopher J. | EVP and CFO | M | Option (right to buy) | 29314 | $0.00 | 100,000.0000 | 296,132,000 | 22.67% | 0.01% |
| Feb. 14, 2025 | POSTE GEORGE | Director | M | Option (right to buy) | 15874 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| Feb. 15, 2025 | Senner Christopher J. | EVP and CFO | F | Common Stock | 21591 | $35.00 | 782,330.0000 | 296,132,000 | 2.69% | 0.01% |
| Feb. 14, 2025 | Beckerle Mary C | Director | M | Common Stock | 8354 | $23.24 | 42,616.0000 | 296,132,000 | 24.38% | 0.00% |
| Feb. 14, 2025 | Beckerle Mary C | Director | S | Common Stock | 8354 | $34.87 | 34,262.0000 | 296,132,000 | 19.60% | 0.00% |
| Feb. 14, 2025 | Beckerle Mary C | Director | S | Common Stock | 3856 | $34.90 | 30,406.0000 | 296,132,000 | 11.25% | 0.00% |
| Feb. 14, 2025 | Beckerle Mary C | Director | M | Option (right to buy) | 8354 | $0.00 | 22,494.0000 | 296,132,000 | 27.08% | 0.00% |
| Feb. 14, 2025 | POSTE GEORGE | Director | M | Common Stock | 15874 | $20.50 | 184,894.0000 | 296,132,000 | 9.39% | 0.01% |
| Feb. 14, 2025 | POSTE GEORGE | Director | S | Common Stock | 15874 | $34.74 | 169,020.0000 | 296,132,000 | 8.59% | 0.01% |
| Feb. 15, 2025 | Hessekiel Jeffrey | EVP & General Counsel | F | Common Stock | 18134 | $35.00 | 546,415.0000 | 296,132,000 | 3.21% | 0.01% |
| Feb. 15, 2025 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 18906 | $35.00 | 390,133.0000 | 296,132,000 | 4.62% | 0.01% |
| Feb. 15, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 16053 | $35.00 | 557,425.0000 | 296,132,000 | 2.80% | 0.01% |
| Feb. 15, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 12695 | $35.00 | 544,730.0000 | 296,132,000 | 2.28% | 0.00% |
| Feb. 14, 2025 | Freire Maria C | Director | M | Common Stock | 15874 | $20.50 | 106,881.0000 | 296,132,000 | 17.44% | 0.01% |
| Feb. 14, 2025 | Freire Maria C | Director | M | Common Stock | 28240 | $22.10 | 135,121.0000 | 296,132,000 | 26.42% | 0.01% |
| Feb. 14, 2025 | Freire Maria C | Director | S | Common Stock | 44114 | $34.94 | 91,007.0000 | 296,132,000 | 32.65% | 0.01% |
| Feb. 14, 2025 | Freire Maria C | Director | M | Option (right to buy) | 15874 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| Feb. 14, 2025 | Freire Maria C | Director | M | Option (right to buy) | 28240 | $0.00 | 0.0000 | 296,132,000 | 100.00% | 0.01% |
| Feb. 15, 2025 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 63570 | $35.00 | 2,631,094.0000 | 296,132,000 | 2.36% | 0.02% |
| Feb. 14, 2025 | Eckhardt Sue Gail | Director | M | Common Stock | 7712 | $23.24 | 41,974.0000 | 296,132,000 | 22.51% | 0.00% |
| Feb. 14, 2025 | Eckhardt Sue Gail | Director | S | Common Stock | 7712 | $35.01 | 34,262.0000 | 296,132,000 | 18.37% | 0.00% |
| Feb. 14, 2025 | Eckhardt Sue Gail | Director | S | Common Stock | 3856 | $35.04 | 30,406.0000 | 296,132,000 | 11.25% | 0.00% |
| Feb. 14, 2025 | Eckhardt Sue Gail | Director | M | Option (right to buy) | 7712 | $0.00 | 23,136.0000 | 296,132,000 | 25.00% | 0.00% |
| Jan. 16, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | A | Common Stock | 104106 | $0.00 | 596,048.0000 | 296,132,000 | 21.16% | 0.04% |
| Jan. 16, 2025 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 123750 | $0.00 | 436,602.0000 | 296,132,000 | 39.56% | 0.04% |
| Jan. 16, 2025 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 120244 | $37.27 | 2,694,664.0000 | 296,132,000 | 4.27% | 0.04% |
| Jan. 16, 2025 | Senner Christopher J. | EVP and CFO | A | Common Stock | 132973 | $0.00 | 839,870.0000 | 296,132,000 | 18.81% | 0.04% |
| Jan. 16, 2025 | Senner Christopher J. | EVP and CFO | F | Common Stock | 35949 | $37.27 | 803,921.0000 | 296,132,000 | 4.28% | 0.01% |
| Jan. 16, 2025 | Hessekiel Jeffrey | EVP & General Counsel | A | Common Stock | 118780 | $0.00 | 590,838.0000 | 296,132,000 | 25.16% | 0.04% |
| Jan. 16, 2025 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 22570 | $37.27 | 573,478.0000 | 296,132,000 | 3.79% | 0.01% |
| Jan. 16, 2025 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 473226 | $0.00 | 2,814,908.0000 | 296,132,000 | 20.21% | 0.16% |
| Jan. 16, 2025 | Hessekiel Jeffrey | EVP & General Counsel | F | Common Stock | 26289 | $37.27 | 564,549.0000 | 296,132,000 | 4.45% | 0.01% |
| Jan. 16, 2025 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 27563 | $37.27 | 409,039.0000 | 296,132,000 | 6.31% | 0.01% |
| Dec. 20, 2024 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 179788 | $0.00 | 2,341,682.0000 | 296,994,000 | 8.32% | 0.06% |
| Dec. 20, 2024 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 179788 | $0.00 | 2,341,682.0000 | 296,994,000 | 7.13% | 0.06% |
| Nov. 27, 2024 | Hessekiel Jeffrey | EVP & General Counsel | M | Option (right to buy) | 129314 | $0.00 | 0.0000 | 296,994,000 | 100.00% | 0.04% |
| Nov. 29, 2024 | Hessekiel Jeffrey | EVP & General Counsel | S | Common Stock | 60000 | $36.67 | 487,058.0000 | 296,994,000 | 10.97% | 0.02% |
| Nov. 27, 2024 | Hessekiel Jeffrey | EVP & General Counsel | F | Common Stock | 98908 | $35.93 | 547,058.0000 | 296,994,000 | 15.31% | 0.03% |
| Nov. 27, 2024 | Hessekiel Jeffrey | EVP & General Counsel | M | Common Stock | 129314 | $18.80 | 645,966.0000 | 296,994,000 | 25.03% | 0.04% |
| Nov. 29, 2024 | Hessekiel Jeffrey | EVP & General Counsel | G | Common Stock | 15000 | $0.00 | 472,058.0000 | 296,994,000 | 3.08% | 0.01% |
| Nov. 22, 2024 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 10000 | $35.27 | 312,852.0000 | 296,994,000 | 3.10% | 0.00% |
| Nov. 18, 2024 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 22207 | $34.31 | 342,233.0000 | 296,994,000 | 6.09% | 0.01% |
| Nov. 15, 2024 | Hessekiel Jeffrey | EVP & General Counsel | F | Common Stock | 14672 | $35.05 | 516,652.0000 | 296,994,000 | 2.76% | 0.00% |
| Nov. 15, 2024 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 14672 | $35.05 | 364,440.0000 | 296,994,000 | 3.87% | 0.00% |
| Nov. 15, 2024 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | F | Common Stock | 27224 | $35.05 | 294,897.0000 | 296,994,000 | 8.45% | 0.01% |
| Nov. 15, 2024 | Senner Christopher J. | EVP and CFO | F | Common Stock | 17506 | $35.05 | 706,897.0000 | 296,994,000 | 2.42% | 0.01% |
| Nov. 15, 2024 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 47642 | $35.05 | 2,341,682.0000 | 296,994,000 | 1.99% | 0.02% |
| Nov. 15, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 12838 | $35.05 | 491,942.0000 | 296,994,000 | 2.54% | 0.00% |
| Nov. 18, 2024 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 19381 | $34.41 | 322,852.0000 | 296,994,000 | 5.66% | 0.01% |
| Nov. 5, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | M | Common Stock | 96986 | $18.80 | 601,766.0000 | 296,994,000 | 19.21% | 0.03% |
| Nov. 5, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 96986 | $35.00 | 504,780.0000 | 296,994,000 | 16.12% | 0.03% |
| Nov. 5, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | M | Option (right to buy) | 96986 | $0.00 | 0.0000 | 296,994,000 | 100.00% | 0.03% |
| Nov. 1, 2024 | POSTE GEORGE | Director | S | Common Stock | 30000 | $34.00 | 169,020.0000 | 296,994,000 | 15.07% | 0.01% |
| Nov. 1, 2024 | Hessekiel Jeffrey | EVP & General Counsel | S | Common Stock | 50000 | $34.13 | 531,324.0000 | 296,994,000 | 8.60% | 0.02% |
| Oct. 30, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 1162 | $31.40 | 504,780.0000 | 296,994,000 | 0.23% | 0.00% |
| Oct. 31, 2024 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 46000 | $0.00 | 2,389,324.0000 | 296,994,000 | 1.89% | 0.02% |
| Oct. 28, 2024 | Hessekiel Jeffrey | EVP & General Counsel | S | Common Stock | 25000 | $28.39 | 581,324.0000 | 296,994,000 | 4.12% | 0.01% |
| Oct. 1, 2024 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 463702 | $26.30 | 2,451,622.0000 | 296,994,000 | 15.91% | 0.16% |
| Oct. 2, 2024 | Haley Patrick J. | EVP, Commercial | M | Common Stock | 100000 | $24.41 | 475,223.0000 | 296,994,000 | 26.65% | 0.03% |
| Oct. 2, 2024 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 96111 | $26.50 | 379,112.0000 | 296,994,000 | 20.22% | 0.03% |
| Oct. 2, 2024 | Haley Patrick J. | EVP, Commercial | M | Option (right to buy) | 100000 | $0.00 | 0.0000 | 296,994,000 | 100.00% | 0.03% |
| Oct. 1, 2024 | MORRISSEY MICHAEL | President and CEO | M | Common Stock | 480000 | $24.41 | 2,915,324.0000 | 296,994,000 | 19.71% | 0.16% |
| Oct. 3, 2024 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 16298 | $0.00 | 2,435,324.0000 | 296,994,000 | 0.66% | 0.01% |
| Oct. 3, 2024 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 16298 | $0.00 | 2,435,324.0000 | 296,994,000 | 0.67% | 0.01% |
| Oct. 1, 2024 | MORRISSEY MICHAEL | President and CEO | M | Option (right to buy) | 480000 | $0.00 | 0.0000 | 296,994,000 | 100.00% | 0.16% |
| Sept. 23, 2024 | Hessekiel Jeffrey | EVP & General Counsel | S | Common Stock | 25000 | $26.38 | 606,324.0000 | 321,464,000 | 3.96% | 0.01% |
| Aug. 26, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Option (right to buy) | 20000 | $0.00 | 0.0000 | 321,464,000 | 100.00% | 0.01% |
| Aug. 26, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | S | Common Stock | 20000 | $25.79 | 631,324.0000 | 321,464,000 | 3.07% | 0.01% |
| Aug. 26, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Common Stock | 20000 | $24.41 | 651,324.0000 | 321,464,000 | 3.17% | 0.01% |
| Aug. 14, 2024 | Freire Maria C | Director | S | Common Stock | 8250 | $26.56 | 91,007.0000 | 321,464,000 | 8.31% | 0.00% |
| Aug. 13, 2024 | Smith Julie | Director | J | Common Stock | 4682 | $0.00 | 10,778.0000 | 321,464,000 | 30.28% | 0.00% |
| Aug. 12, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 20883 | $27.06 | 505,942.0000 | 321,464,000 | 3.96% | 0.01% |
| Aug. 8, 2024 | POSTE GEORGE | Director | S | Common Stock | 33725 | $26.89 | 199,020.0000 | 321,464,000 | 14.49% | 0.01% |
| Aug. 7, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Option (right to buy) | 80000 | $0.00 | 20,000.0000 | 321,464,000 | 80.00% | 0.02% |
| Aug. 7, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | M | Common Stock | 95000 | $24.41 | 621,825.0000 | 321,464,000 | 18.03% | 0.03% |
| Aug. 7, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 95000 | $25.00 | 526,825.0000 | 321,464,000 | 15.28% | 0.03% |
| Aug. 7, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | M | Option (right to buy) | 95000 | $0.00 | 0.0000 | 321,464,000 | 100.00% | 0.03% |
| Aug. 7, 2024 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 14000 | $25.50 | 375,223.0000 | 321,464,000 | 3.60% | 0.00% |
| Aug. 7, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Common Stock | 80000 | $24.41 | 711,324.0000 | 321,464,000 | 12.67% | 0.02% |
| Aug. 7, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | S | Common Stock | 80000 | $25.97 | 631,324.0000 | 321,464,000 | 11.25% | 0.02% |
| Aug. 9, 2024 | Senner Christopher J. | EVP and CFO | M | Common Stock | 125000 | $24.41 | 849,403.0000 | 321,464,000 | 17.26% | 0.04% |
| Aug. 9, 2024 | Senner Christopher J. | EVP and CFO | S | Common Stock | 125000 | $27.19 | 724,403.0000 | 321,464,000 | 14.72% | 0.04% |
| Aug. 9, 2024 | Senner Christopher J. | EVP and CFO | M | Option (right to buy) | 125000 | $0.00 | 0.0000 | 321,464,000 | 100.00% | 0.04% |
| June 4, 2024 | WYSZOMIERSKI JACK L | Director | S | Common Stock | 8287 | $22.00 | 349,499.0000 | 321,464,000 | 2.32% | 0.00% |
| May 31, 2024 | POSTE GEORGE | Director | A | Common Stock | 18838 | $0.00 | 232,745.0000 | 321,464,000 | 8.81% | 0.01% |
| May 31, 2024 | Heyman Tomas J. | Director | A | Common Stock | 18838 | $0.00 | 37,014.0000 | 321,464,000 | 103.64% | 0.01% |
| May 31, 2024 | Freire Maria C | Director | A | Common Stock | 18838 | $0.00 | 99,257.0000 | 321,464,000 | 23.42% | 0.01% |
| May 31, 2024 | PAPADOPOULOS STELIOS | Director | A | Common Stock | 18838 | $0.00 | 1,279,416.0000 | 321,464,000 | 1.49% | 0.01% |
| May 31, 2024 | JOHNSON DAVID EDWARD | Director | A | Option (right to buy) | 42767 | $0.00 | 42,767.0000 | 321,464,000 | 9999.99% | 0.01% |
| May 31, 2024 | Smith Julie | Director | A | Option (right to buy) | 20030 | $0.00 | 20,030.0000 | 321,464,000 | 9999.99% | 0.01% |
| May 31, 2024 | Smith Julie | Director | A | Common Stock | 10015 | $0.00 | 15,460.0000 | 321,464,000 | 183.93% | 0.00% |
| May 31, 2024 | Beckerle Mary C | Director | A | Common Stock | 18838 | $0.00 | 34,262.0000 | 321,464,000 | 122.13% | 0.01% |
| May 31, 2024 | Eckhardt Sue Gail | Director | A | Common Stock | 18838 | $0.00 | 34,262.0000 | 321,464,000 | 122.13% | 0.01% |
| May 31, 2024 | WYSZOMIERSKI JACK L | Director | A | Common Stock | 18838 | $0.00 | 357,786.0000 | 321,464,000 | 5.56% | 0.01% |
| May 31, 2024 | Oliver Bob | Director | A | Common Stock | 18838 | $0.00 | 37,014.0000 | 321,464,000 | 103.64% | 0.01% |
| May 30, 2024 | JOHNSON DAVID EDWARD | Director | P | Common Stock | 225000 | $20.76 | 1,543,906.0000 | 321,464,000 | 17.06% | 0.07% |
| May 28, 2024 | JOHNSON DAVID EDWARD | Director | P | Common Stock | 200000 | $20.32 | 1,318,906.0000 | 321,464,000 | 17.87% | 0.06% |
| May 21, 2024 | Smith Julie | Director | S | Common Stock | 27280 | $21.12 | 5,445.0000 | 321,464,000 | 83.36% | 0.01% |
| May 21, 2024 | POSTE GEORGE | Director | M | Option (right to buy) | 11686 | $0.00 | 0.0000 | 321,464,000 | 100.00% | 0.00% |
| May 20, 2024 | PAPADOPOULOS STELIOS | Director | M | Option (right to buy) | 11686 | $0.00 | 0.0000 | 321,464,000 | 100.00% | 0.00% |
| May 20, 2024 | PAPADOPOULOS STELIOS | Director | S | Common Stock | 11437 | $21.00 | 1,260,578.0000 | 321,464,000 | 0.90% | 0.00% |
| May 20, 2024 | PAPADOPOULOS STELIOS | Director | M | Common Stock | 11686 | $19.57 | 1,272,015.0000 | 321,464,000 | 0.93% | 0.00% |
| May 21, 2024 | POSTE GEORGE | Director | M | Common Stock | 11686 | $19.57 | 225,593.0000 | 321,464,000 | 5.46% | 0.00% |
| May 21, 2024 | POSTE GEORGE | Director | S | Common Stock | 11686 | $20.96 | 213,907.0000 | 321,464,000 | 5.18% | 0.00% |
| May 15, 2024 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 39681 | $20.99 | 2,419,026.0000 | 321,464,000 | 1.61% | 0.01% |
| May 15, 2024 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 34262 | $20.99 | 2,458,707.0000 | 321,464,000 | 1.37% | 0.01% |
| May 15, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 8658 | $20.99 | 526,825.0000 | 321,464,000 | 1.62% | 0.00% |
| May 15, 2024 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 4435 | $20.99 | 415,832.0000 | 321,464,000 | 1.06% | 0.00% |
| May 15, 2024 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 7548 | $20.99 | 408,284.0000 | 321,464,000 | 1.82% | 0.00% |
| May 15, 2024 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 8960 | $20.99 | 399,324.0000 | 321,464,000 | 2.19% | 0.00% |
| May 15, 2024 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 10101 | $20.99 | 389,223.0000 | 321,464,000 | 2.53% | 0.00% |
| May 15, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 7240 | $20.99 | 650,025.0000 | 321,464,000 | 1.10% | 0.00% |
| May 15, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 8600 | $20.99 | 641,425.0000 | 321,464,000 | 1.32% | 0.00% |
| May 15, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 10101 | $20.99 | 631,324.0000 | 321,464,000 | 1.57% | 0.00% |
| May 15, 2024 | Senner Christopher J. | EVP and CFO | F | Common Stock | 8621 | $20.99 | 746,092.0000 | 321,464,000 | 1.14% | 0.00% |
| May 15, 2024 | Senner Christopher J. | EVP and CFO | F | Common Stock | 10211 | $20.99 | 735,881.0000 | 321,464,000 | 1.37% | 0.00% |
| May 15, 2024 | Senner Christopher J. | EVP and CFO | F | Common Stock | 11478 | $20.99 | 724,403.0000 | 321,464,000 | 1.56% | 0.00% |
| May 15, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 7538 | $20.99 | 535,483.0000 | 321,464,000 | 1.39% | 0.00% |
| May 15, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 6409 | $20.99 | 543,021.0000 | 321,464,000 | 1.17% | 0.00% |
| May 13, 2024 | WYSZOMIERSKI JACK L | Director | M | Common Stock | 11686 | $19.57 | 349,871.0000 | 321,464,000 | 3.46% | 0.00% |
| May 13, 2024 | WYSZOMIERSKI JACK L | Director | M | Option (right to buy) | 11686 | $0.00 | 0.0000 | 321,464,000 | 100.00% | 0.00% |
| May 13, 2024 | WYSZOMIERSKI JACK L | Director | S | Common Stock | 10923 | $21.37 | 338,948.0000 | 321,464,000 | 3.12% | 0.00% |
| March 21, 2024 | Garber Alan M | Director | S | Common Stock | 19205 | $24.01 | 35,703.0000 | 321,464,000 | 34.98% | 0.01% |
| March 21, 2024 | Garber Alan M | Director | M | Common Stock | 23491 | $19.57 | 54,908.0000 | 321,464,000 | 74.77% | 0.01% |
| March 21, 2024 | Garber Alan M | Director | M | Option (right to buy) | 23491 | $0.00 | 0.0000 | 321,464,000 | 100.00% | 0.01% |
| Feb. 23, 2024 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 241670 | $0.00 | 2,492,969.0000 | 321,464,000 | 10.73% | 0.08% |
| Feb. 23, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | A | Common Stock | 63350 | $0.00 | 548,216.0000 | 321,464,000 | 13.07% | 0.02% |
| Feb. 23, 2024 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | A | Common Stock | 82121 | $0.00 | 322,121.0000 | 321,464,000 | 34.22% | 0.03% |
| Feb. 23, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | A | Common Stock | 63350 | $0.00 | 656,051.0000 | 321,464,000 | 10.69% | 0.02% |
| Feb. 23, 2024 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 47020 | $21.45 | 419,053.0000 | 321,464,000 | 10.09% | 0.01% |
| Feb. 23, 2024 | Senner Christopher J. | EVP and CFO | A | Common Stock | 82121 | $0.00 | 754,713.0000 | 321,464,000 | 12.21% | 0.03% |
| Feb. 23, 2024 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 63350 | $0.00 | 466,073.0000 | 321,464,000 | 15.73% | 0.02% |
| Feb. 21, 2024 | JOHNSON DAVID EDWARD | Director | P | Common Stock | 190000 | $20.70 | 1,118,906.0000 | 321,464,000 | 20.45% | 0.06% |
| Feb. 15, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 10630 | $20.39 | 484,866.0000 | 321,464,000 | 2.15% | 0.00% |
| Jan. 11, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 11606 | $22.86 | 495,496.0000 | 321,464,000 | 2.29% | 0.00% |
| Jan. 11, 2024 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 250374 | $0.00 | 2,315,016.0000 | 321,464,000 | 12.13% | 0.08% |
| Jan. 11, 2024 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 63717 | $22.86 | 2,251,299.0000 | 321,464,000 | 2.75% | 0.02% |
| Jan. 11, 2024 | Senner Christopher J. | EVP and CFO | A | Common Stock | 80186 | $0.00 | 694,454.0000 | 321,464,000 | 13.05% | 0.02% |
| Jan. 11, 2024 | Senner Christopher J. | EVP and CFO | F | Common Stock | 21862 | $22.86 | 672,592.0000 | 321,464,000 | 3.15% | 0.01% |
| Jan. 11, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | A | Common Stock | 71418 | $0.00 | 605,762.0000 | 321,464,000 | 13.37% | 0.02% |
| Jan. 11, 2024 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 13061 | $22.86 | 592,701.0000 | 321,464,000 | 2.16% | 0.00% |
| Jan. 11, 2024 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 74462 | $0.00 | 416,336.0000 | 321,464,000 | 21.78% | 0.02% |
| Jan. 11, 2024 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 13613 | $22.86 | 402,723.0000 | 321,464,000 | 3.27% | 0.00% |
| Jan. 11, 2024 | Aftab Dana | CSO/EVP Disc & Trans Research | A | Common Stock | 63224 | $0.00 | 507,102.0000 | 321,464,000 | 14.24% | 0.02% |
| Jan. 5, 2024 | Beckerle Mary C | Director | A | Common Stock | 15424 | $0.00 | 15,424.0000 | 321,464,000 | 9999.99% | 0.00% |
| Jan. 5, 2024 | Eckhardt Sue Gail | Director | A | Common Stock | 15424 | $0.00 | 15,424.0000 | 321,464,000 | 9999.99% | 0.00% |
| Jan. 5, 2024 | Eckhardt Sue Gail | Director | A | Option (right to buy) | 30848 | $0.00 | 30,848.0000 | 321,464,000 | 9999.99% | 0.01% |
| Jan. 5, 2024 | Beckerle Mary C | Director | A | Option (right to buy) | 30848 | $0.00 | 30,848.0000 | 321,464,000 | 9999.99% | 0.01% |
| Dec. 13, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | S | Common Stock | 25000 | $23.01 | 534,344.0000 | 324,556,000 | 4.47% | 0.01% |
| Dec. 14, 2023 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 50000 | $23.35 | 341,874.0000 | 324,556,000 | 12.76% | 0.02% |
| Dec. 14, 2023 | Haley Patrick J. | EVP, Commercial | M | Option (right to buy) | 50000 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.02% |
| Dec. 14, 2023 | Haley Patrick J. | EVP, Commercial | M | Common Stock | 50000 | $16.29 | 391,874.0000 | 324,556,000 | 14.63% | 0.02% |
| Dec. 12, 2023 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 14149 | $22.50 | 341,874.0000 | 324,556,000 | 3.97% | 0.00% |
| Dec. 4, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | S | Common Stock | 25000 | $22.06 | 559,344.0000 | 324,556,000 | 4.28% | 0.01% |
| Nov. 30, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | S | Common Stock | 25000 | $22.01 | 584,344.0000 | 324,556,000 | 4.10% | 0.01% |
| Nov. 27, 2023 | JOHNSON DAVID EDWARD | Director | P | Common Stock | 120409 | $21.61 | 928,906.0000 | 324,556,000 | 14.89% | 0.04% |
| Nov. 27, 2023 | JOHNSON DAVID EDWARD | Director | S | Common Stock | 120409 | $21.61 | 808,497.0000 | 324,556,000 | 12.96% | 0.04% |
| Nov. 16, 2023 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 19020 | $0.00 | 2,064,642.0000 | 324,556,000 | 0.91% | 0.01% |
| Nov. 7, 2023 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 116893 | $0.00 | 2,083,662.0000 | 324,556,000 | 5.31% | 0.04% |
| Nov. 7, 2023 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 116893 | $0.00 | 2,083,662.0000 | 324,556,000 | 5.94% | 0.04% |
| Sept. 6, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | A | Common Stock | 57900 | $0.00 | 623,698.0000 | 324,556,000 | 10.23% | 0.02% |
| Sept. 6, 2023 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 14354 | $22.27 | 356,023.0000 | 324,556,000 | 3.88% | 0.00% |
| Sept. 6, 2023 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 57900 | $0.00 | 370,377.0000 | 324,556,000 | 18.53% | 0.02% |
| Sept. 6, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 12560 | $22.27 | 443,878.0000 | 324,556,000 | 2.75% | 0.00% |
| Sept. 6, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | A | Common Stock | 50660 | $0.00 | 456,438.0000 | 324,556,000 | 12.48% | 0.02% |
| Sept. 6, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 14354 | $22.27 | 609,344.0000 | 324,556,000 | 2.30% | 0.00% |
| Sept. 6, 2023 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 46608 | $22.27 | 2,083,662.0000 | 324,556,000 | 2.19% | 0.01% |
| Sept. 6, 2023 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 188005 | $0.00 | 2,130,270.0000 | 324,556,000 | 9.68% | 0.06% |
| Sept. 6, 2023 | Senner Christopher J. | EVP and CFO | F | Common Stock | 17147 | $22.27 | 614,268.0000 | 324,556,000 | 2.72% | 0.01% |
| Sept. 6, 2023 | Senner Christopher J. | EVP and CFO | A | Common Stock | 65135 | $0.00 | 631,415.0000 | 324,556,000 | 11.50% | 0.02% |
| Aug. 31, 2023 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 56221 | $0.00 | 1,942,265.0000 | 324,556,000 | 2.81% | 0.02% |
| Sept. 1, 2023 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 57500 | $0.00 | 1,942,265.0000 | 324,556,000 | 2.88% | 0.02% |
| Aug. 31, 2023 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 56221 | $0.00 | 1,999,765.0000 | 324,556,000 | 2.89% | 0.02% |
| Aug. 30, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 4600 | $22.47 | 405,778.0000 | 324,556,000 | 1.12% | 0.00% |
| Aug. 28, 2023 | MORRISSEY MICHAEL | President and CEO | M | Common Stock | 360000 | $15.31 | 2,303,544.0000 | 324,556,000 | 18.52% | 0.11% |
| Aug. 28, 2023 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 303779 | $22.18 | 1,999,765.0000 | 324,556,000 | 13.19% | 0.09% |
| Aug. 28, 2023 | MORRISSEY MICHAEL | President and CEO | M | Option (right to buy) | 360000 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.11% |
| Aug. 24, 2023 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | A | Common Stock | 240000 | $0.00 | 240,000.0000 | 324,556,000 | 9999.99% | 0.07% |
| Aug. 24, 2023 | Peterson Amy C. | EVP Prod Dev & Med Aff & CMO | A | Option (right to buy) | 160000 | $0.00 | 160,000.0000 | 324,556,000 | 9999.99% | 0.05% |
| Aug. 15, 2023 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 7177 | $21.51 | 312,477.0000 | 324,556,000 | 2.25% | 0.00% |
| Aug. 15, 2023 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 23304 | $21.51 | 1,943,544.0000 | 324,556,000 | 1.18% | 0.01% |
| Aug. 15, 2023 | Senner Christopher J. | EVP and CFO | F | Common Stock | 8074 | $21.51 | 566,280.0000 | 324,556,000 | 1.41% | 0.00% |
| Aug. 15, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 7177 | $21.51 | 565,798.0000 | 324,556,000 | 1.25% | 0.00% |
| Aug. 15, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 6280 | $21.51 | 410,378.0000 | 324,556,000 | 1.51% | 0.00% |
| Aug. 3, 2023 | Senner Christopher J. | EVP and CFO | M | Option (right to buy) | 60000 | $0.00 | 60,000.0000 | 324,556,000 | 50.00% | 0.02% |
| Aug. 4, 2023 | Senner Christopher J. | EVP and CFO | M | Option (right to buy) | 60000 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.02% |
| Aug. 3, 2023 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 30553 | $20.67 | 319,654.0000 | 324,556,000 | 8.72% | 0.01% |
| Aug. 3, 2023 | Senner Christopher J. | EVP and CFO | M | Common Stock | 60000 | $14.74 | 634,354.0000 | 324,556,000 | 10.45% | 0.02% |
| Aug. 3, 2023 | Senner Christopher J. | EVP and CFO | S | Common Stock | 60000 | $20.51 | 574,354.0000 | 324,556,000 | 9.46% | 0.02% |
| Aug. 4, 2023 | Senner Christopher J. | EVP and CFO | M | Common Stock | 60000 | $14.74 | 634,354.0000 | 324,556,000 | 10.45% | 0.02% |
| Aug. 4, 2023 | Senner Christopher J. | EVP and CFO | S | Common Stock | 60000 | $20.68 | 574,354.0000 | 324,556,000 | 9.46% | 0.02% |
| Aug. 1, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | S | Common Stock | 55710 | $19.63 | 572,975.0000 | 324,556,000 | 8.86% | 0.02% |
| Aug. 1, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Common Stock | 55710 | $14.74 | 628,685.0000 | 324,556,000 | 9.72% | 0.02% |
| Aug. 1, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Option (right to buy) | 55710 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.02% |
| June 1, 2023 | PAPADOPOULOS STELIOS | Director | A | Common Stock | 20718 | $0.00 | 1,260,329.0000 | 324,556,000 | 1.67% | 0.01% |
| June 1, 2023 | Smith Julie | Director | A | Option (right to buy) | 44087 | $0.00 | 44,087.0000 | 324,556,000 | 9999.99% | 0.01% |
| May 31, 2023 | JOHNSON DAVID EDWARD | Director | A | Common Stock | 18176 | $0.00 | 928,906.0000 | 324,556,000 | 2.00% | 0.01% |
| May 31, 2023 | JOHNSON DAVID EDWARD | Director | A | Option (right to buy) | 36353 | $0.00 | 36,353.0000 | 324,556,000 | 9999.99% | 0.01% |
| June 1, 2023 | POSTE GEORGE | Director | A | Common Stock | 20718 | $0.00 | 213,907.0000 | 324,556,000 | 10.72% | 0.01% |
| May 31, 2023 | Heyman Tomas J. | Director | A | Option (right to buy) | 36353 | $0.00 | 36,353.0000 | 324,556,000 | 9999.99% | 0.01% |
| June 1, 2023 | Freire Maria C | Director | A | Common Stock | 20718 | $0.00 | 80,419.0000 | 324,556,000 | 34.70% | 0.01% |
| June 1, 2023 | Garber Alan M | Director | A | Option (right to buy) | 44087 | $0.00 | 44,087.0000 | 324,556,000 | 9999.99% | 0.01% |
| May 31, 2023 | Oliver Bob | Director | A | Common Stock | 18176 | $0.00 | 18,176.0000 | 324,556,000 | 9999.99% | 0.01% |
| May 31, 2023 | Oliver Bob | Director | A | Option (right to buy) | 36353 | $0.00 | 36,353.0000 | 324,556,000 | 9999.99% | 0.01% |
| May 31, 2023 | Heyman Tomas J. | Director | A | Common Stock | 18176 | $0.00 | 18,176.0000 | 324,556,000 | 9999.99% | 0.01% |
| June 1, 2023 | Wright Jacqueline | Director | A | Common Stock | 20718 | $0.00 | 51,756.0000 | 324,556,000 | 66.75% | 0.01% |
| June 1, 2023 | WYSZOMIERSKI JACK L | Director | A | Common Stock | 20718 | $0.00 | 338,185.0000 | 324,556,000 | 6.53% | 0.01% |
| May 15, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 7027 | $19.18 | 572,975.0000 | 324,556,000 | 1.21% | 0.00% |
| May 15, 2023 | Senner Christopher J. | EVP and CFO | F | Common Stock | 10002 | $19.18 | 574,354.0000 | 324,556,000 | 1.71% | 0.00% |
| May 15, 2023 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 33518 | $19.18 | 1,966,848.0000 | 324,556,000 | 1.68% | 0.01% |
| May 15, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 4373 | $19.18 | 422,773.0000 | 324,556,000 | 1.02% | 0.00% |
| May 15, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 6115 | $19.18 | 416,658.0000 | 324,556,000 | 1.45% | 0.00% |
| May 15, 2023 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 3026 | $19.18 | 365,246.0000 | 324,556,000 | 0.82% | 0.00% |
| May 15, 2023 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 6274 | $19.18 | 358,972.0000 | 324,556,000 | 1.72% | 0.00% |
| May 15, 2023 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 8765 | $19.18 | 350,207.0000 | 324,556,000 | 2.44% | 0.00% |
| May 15, 2023 | Senner Christopher J. | EVP and CFO | F | Common Stock | 8444 | $19.18 | 584,356.0000 | 324,556,000 | 1.42% | 0.00% |
| May 15, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 4940 | $19.18 | 580,002.0000 | 324,556,000 | 0.84% | 0.00% |
| April 3, 2023 | Haley Patrick J. | EVP, Commercial | A | Common Stock | 79719 | $0.00 | 366,764.0000 | 324,556,000 | 27.77% | 0.02% |
| April 3, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | A | Common Stock | 79719 | $0.00 | 608,434.0000 | 324,556,000 | 15.08% | 0.02% |
| April 5, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Common Stock | 13930 | $14.74 | 622,364.0000 | 324,556,000 | 2.29% | 0.00% |
| April 5, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | S | Common Stock | 38930 | $20.01 | 583,434.0000 | 324,556,000 | 6.26% | 0.01% |
| April 5, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Option (right to buy) | 13930 | $0.00 | 55,710.0000 | 324,556,000 | 20.00% | 0.00% |
| April 3, 2023 | MORRISSEY MICHAEL | President and CEO | A | Common Stock | 313185 | $0.00 | 2,000,366.0000 | 324,556,000 | 18.56% | 0.10% |
| April 3, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | A | Common Stock | 68331 | $0.00 | 425,638.0000 | 324,556,000 | 19.12% | 0.02% |
| April 3, 2023 | Senner Christopher J. | EVP and CFO | A | Common Stock | 85414 | $0.00 | 592,800.0000 | 324,556,000 | 16.83% | 0.03% |
| April 3, 2023 | Goodman Vicki L | EVP, Prod Dev & Med Aff &CMO | A | Common Stock | 82566 | $0.00 | 307,654.0000 | 324,556,000 | 36.68% | 0.03% |
| March 10, 2023 | WYSZOMIERSKI JACK L | Director | S | Common Stock | 15300 | $16.61 | 317,467.0000 | 324,556,000 | 4.60% | 0.00% |
| March 10, 2023 | WYSZOMIERSKI JACK L | Director | M | Common Stock | 40000 | $6.30 | 332,767.0000 | 324,556,000 | 13.66% | 0.01% |
| March 10, 2023 | WYSZOMIERSKI JACK L | Director | M | Option (right to buy) | 40000 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.01% |
| March 1, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | S | Common Stock | 77860 | $17.13 | 528,715.0000 | 324,556,000 | 12.84% | 0.02% |
| March 1, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Common Stock | 27860 | $14.74 | 606,575.0000 | 324,556,000 | 4.81% | 0.01% |
| March 1, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | M | Option (right to buy) | 27860 | $0.00 | 69,640.0000 | 324,556,000 | 28.57% | 0.01% |
| Feb. 27, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | M | Common Stock | 10 | $14.74 | 357,317.0000 | 324,556,000 | 0.00% | 0.00% |
| Feb. 28, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | M | Option (right to buy) | 82490 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.03% |
| Feb. 27, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | M | Option (right to buy) | 10 | $0.00 | 82,490.0000 | 324,556,000 | 0.01% | 0.00% |
| Feb. 28, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 82490 | $17.50 | 357,307.0000 | 324,556,000 | 18.76% | 0.03% |
| Feb. 28, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | M | Common Stock | 82490 | $14.74 | 439,797.0000 | 324,556,000 | 23.09% | 0.03% |
| Feb. 27, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | S | Common Stock | 10 | $17.50 | 357,307.0000 | 324,556,000 | 0.00% | 0.00% |
| Feb. 21, 2023 | Garber Alan M | Director | M | Common Stock | 40000 | $6.30 | 71,417.0000 | 324,556,000 | 127.32% | 0.01% |
| Feb. 21, 2023 | Garber Alan M | Director | M | Option (right to buy) | 40000 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.01% |
| Feb. 21, 2023 | Garber Alan M | Director | S | Common Stock | 40000 | $17.49 | 31,417.0000 | 324,556,000 | 56.01% | 0.01% |
| Feb. 15, 2023 | Goodman Vicki L | EVP, Prod Dev & Med Aff &CMO | F | Common Stock | 17299 | $18.08 | 225,088.0000 | 324,556,000 | 7.14% | 0.01% |
| Feb. 15, 2023 | Senner Christopher J. | EVP and CFO | F | Common Stock | 5278 | $18.08 | 507,386.0000 | 324,556,000 | 1.03% | 0.00% |
| Feb. 15, 2023 | Haley Patrick J. | EVP, Commercial | F | Common Stock | 1556 | $18.08 | 287,045.0000 | 324,556,000 | 0.54% | 0.00% |
| Feb. 15, 2023 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 11522 | $18.08 | 1,687,181.0000 | 324,556,000 | 0.68% | 0.00% |
| Feb. 15, 2023 | Hessekiel Jeffrey | EVP, General Counsel & Sec | F | Common Stock | 1929 | $18.08 | 578,715.0000 | 324,556,000 | 0.33% | 0.00% |
| Feb. 15, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | F | Common Stock | 1529 | $18.08 | 357,307.0000 | 324,556,000 | 0.43% | 0.00% |
| Feb. 9, 2023 | FELDBAUM CARL B | Director | S | Common Stock | 40000 | $17.78 | 18,701.0000 | 324,556,000 | 68.14% | 0.01% |
| Feb. 9, 2023 | FELDBAUM CARL B | Director | M | Common Stock | 40000 | $6.30 | 58,701.0000 | 324,556,000 | 213.89% | 0.01% |
| Feb. 9, 2023 | FELDBAUM CARL B | Director | M | Option (right to buy) | 40000 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.01% |
| Feb. 6, 2023 | Haley Patrick J. | EVP, Commercial | S | Common Stock | 25000 | $17.37 | 288,601.0000 | 324,556,000 | 7.97% | 0.01% |
| Feb. 6, 2023 | Haley Patrick J. | EVP, Commercial | M | Common Stock | 25000 | $4.20 | 313,601.0000 | 324,556,000 | 8.66% | 0.01% |
| Feb. 6, 2023 | Haley Patrick J. | EVP, Commercial | M | Option (right to buy) | 25000 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.01% |
| Jan. 30, 2023 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 37994 | $0.00 | 1,698,703.0000 | 324,556,000 | 2.19% | 0.01% |
| Jan. 30, 2023 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 37994 | $0.00 | 1,698,703.0000 | 324,556,000 | 2.29% | 0.01% |
| Dec. 7, 2022 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 106010 | $0.00 | 1,698,703.0000 | 0 | 6.66% | 0.00% |
| Jan. 24, 2023 | MORRISSEY MICHAEL | President and CEO | F | Common Stock | 62006 | $17.36 | 1,698,703.0000 | 324,556,000 | 3.52% | 0.02% |
| Jan. 24, 2023 | MORRISSEY MICHAEL | President and CEO | M | Option (right to buy) | 100000 | $0.00 | 0.0000 | 324,556,000 | 100.00% | 0.03% |
| Jan. 24, 2023 | MORRISSEY MICHAEL | President and CEO | M | Common Stock | 100000 | $4.20 | 1,760,709.0000 | 324,556,000 | 6.02% | 0.03% |
| Dec. 7, 2022 | MORRISSEY MICHAEL | President and CEO | G | Common Stock | 106010 | $0.00 | 1,660,709.0000 | 0 | 6.00% | 0.00% |
| Jan. 5, 2023 | Aftab Dana | CSO/EVP Disc & Trans Research | A | Common Stock | 100000 | $0.00 | 358,836.0000 | 324,556,000 | 38.63% | 0.03% |