SEC Insider Transactions from Kaye Edward M. MD.

Last updated: 2026-03-17 23:02 UTC | Total transactions: 102

Dr. Edward M. Kaye sold Cytokinetics Inc. ($CYTK) shares on the open market six times in the past year for a total of $3.4 million, with his most recent sale on December 1, 2025; these rank 2,472nd among insiders by value. He also sold Stoke Therapeutics Inc. ($STOK) shares 20 times for $4.4 million, most recently on December 8, 2025, ranking 2,114th. Among 11,678 insiders with sales, the average is $8.6 million over 6.4 transactions. Dr. Kaye made no open market purchases.

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Transaction Date Company Ticker Insider Name Title Transaction Type Security Shares Price Shares Owned Following Total Shares Outstanding % of Owned % of Outstanding
March 15, 2026 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Common Stock 35500 $0.00 84,624.0000 60,397,681 72.27% 0.06%
March 15, 2026 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Restricted Stock Units 35500 $0.00 35,500.0000 60,397,681 50.00% 0.06%
March 15, 2026 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Restricted Stock Units 26250 $0.00 52,500.0000 60,397,681 33.33% 0.04%
March 15, 2026 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Common Stock 26250 $0.00 110,874.0000 60,397,681 31.02% 0.04%
Feb. 27, 2026 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Not found D Stock Option (Right to Buy) 15000 $0.00 0.0000 150,675,742 100.00% 0.01%
Feb. 27, 2026 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Not found D Stock Option (Right to Buy) 22000 $0.00 0.0000 150,675,742 100.00% 0.01%
Feb. 27, 2026 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Not found D Stock Option (Right to Buy) 22000 $0.00 0.0000 150,675,742 100.00% 0.01%
Feb. 27, 2026 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Not found D Stock Option (Right to Buy) 10034 $0.00 0.0000 150,675,742 100.00% 0.01%
Feb. 27, 2026 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Not found D Stock Option (Right to Buy) 13489 $0.00 0.0000 150,675,742 100.00% 0.01%
Feb. 27, 2026 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Not found D Stock Option (Right to Buy) 9534 $0.00 0.0000 150,675,742 100.00% 0.01%
Feb. 27, 2026 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Not found D Stock Option (Right to Buy) 11323 $0.00 0.0000 150,675,742 100.00% 0.01%
Feb. 27, 2026 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Not found D Common Stock 6692 $0.00 0.0000 150,675,742 100.00% 0.00%
Jan. 15, 2026 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 197 $63.44 10,174.0000 122,264,929 1.97% 0.00%
Dec. 8, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 1331 $33.10 49,124.0000 60,397,681 2.64% 0.00%
Dec. 8, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 3825 $31.44 58,729.0000 60,397,681 6.11% 0.01%
Dec. 8, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 8274 $32.52 50,455.0000 60,397,681 14.09% 0.01%
Dec. 5, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 6367 $31.33 64,735.0000 60,397,681 8.95% 0.01%
Dec. 3, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Common Stock 26250 $0.00 77,555.0000 60,397,681 51.16% 0.04%
Dec. 4, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 5222 $30.76 72,333.0000 60,397,681 6.73% 0.01%
Dec. 3, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Performance Stock Units 26250 $0.00 0.0000 60,397,681 100.00% 0.04%
Dec. 5, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 500 $31.85 62,554.0000 60,397,681 0.79% 0.00%
Dec. 4, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 1231 $31.32 71,102.0000 60,397,681 1.70% 0.00%
Dec. 5, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 1681 $31.15 63,054.0000 60,397,681 2.60% 0.00%
Dec. 2, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 405 $30.14 52,375.0000 60,397,681 0.77% 0.00%
Dec. 2, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 661 $29.56 52,780.0000 60,397,681 1.24% 0.00%
Dec. 1, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Common Stock 4317 $0.00 53,441.0000 56,341,074 8.79% 0.01%
Dec. 1, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Restricted Stock Units 4317 $0.00 0.0000 60,397,681 100.00% 0.01%
Dec. 3, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 651 $30.85 51,305.0000 60,397,681 1.25% 0.00%
Dec. 3, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 419 $30.34 51,956.0000 60,397,681 0.80% 0.00%
Dec. 1, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director M Non-Qualified Stock Option (Right to Buy) 8064 $0.00 0.0000 122,264,929 100.00% 0.01%
Dec. 1, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director M Common Stock 20000 $14.25 38,041.0000 122,264,929 110.86% 0.02%
Dec. 1, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director M Common Stock 8064 $12.40 18,041.0000 122,264,929 80.83% 0.01%
Dec. 1, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director S Common Stock 28064 $66.72 9,977.0000 122,264,929 73.77% 0.02%
Dec. 1, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director M Non-Qualified Stock Option (Right to Buy) 20000 $0.00 0.0000 122,264,929 100.00% 0.02%
Nov. 11, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director M Non-Qualified Stock Option (Right to Buy) 5175 $0.00 0.0000 122,264,929 100.00% 0.00%
Nov. 11, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director M Common Stock 5175 $9.66 15,152.0000 122,264,929 51.87% 0.00%
Nov. 11, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director S Common Stock 5175 $65.08 9,977.0000 122,264,929 34.15% 0.00%
Oct. 15, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 199 $62.80 9,977.0000 118,410,689 2.04% 0.00%
Oct. 8, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Common Stock 25000 $0.60 74,124.0000 60,397,681 50.89% 0.04%
Oct. 8, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Stock Option (Right to Buy) 25000 $0.00 542,801.0000 60,397,681 4.40% 0.04%
Oct. 8, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 25000 $30.00 49,124.0000 60,397,681 33.73% 0.04%
Oct. 3, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 42461 $25.09 49,124.0000 60,397,681 46.36% 0.07%
Oct. 6, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director S Common Stock 6757 $60.00 9,778.0000 118,410,689 40.86% 0.01%
Sept. 30, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director S Common Stock 6695 $55.08 16,535.0000 118,410,689 28.82% 0.01%
Sept. 4, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found D Restricted Stock Units 144000 $0.00 0.0000 54,008,883 100.00% 0.27%
Sept. 4, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found D Employee Stock Option (Right to Buy) 178500 $0.00 37,500.0000 54,008,883 82.64% 0.33%
Sept. 2, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 14860 $20.14 137,581.0000 54,008,883 9.75% 0.03%
Aug. 29, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 1029 $20.00 152,441.0000 54,008,883 0.67% 0.00%
Sept. 3, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 45996 $20.13 91,585.0000 54,008,883 33.43% 0.09%
Sept. 2, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director S Common Stock 6756 $50.00 23,230.0000 118,410,689 22.53% 0.01%
Aug. 18, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 12126 $18.24 153,470.0000 54,008,883 7.32% 0.02%
Aug. 14, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Performance Stock Units 26250 $0.00 26,250.0000 54,008,883 50.00% 0.05%
Aug. 14, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found M Common Stock 26250 $0.00 165,596.0000 54,008,883 18.84% 0.05%
Aug. 14, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found A Performance Stock Units 52500 $0.00 52,500.0000 54,008,883 9999.99% 0.10%
July 15, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 328 $38.01 29,986.0000 118,410,689 1.11% 0.00%
June 10, 2025 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Director A Stock Option (Right to Buy) 10034 $0.00 10,034.0000 120,212,301 9999.99% 0.01%
June 10, 2025 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Director A Common Stock 6692 $0.00 6,692.0000 120,212,301 9999.99% 0.01%
June 5, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director S Common Stock 3636 $32.10 29,658.0000 118,410,689 10.92% 0.00%
May 14, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 7333 $0.00 33,294.0000 118,410,689 28.25% 0.01%
May 14, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Non-Qualified Stock Option (Right to Buy) 10880 $0.00 10,880.0000 118,410,689 9999.99% 0.01%
April 15, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 324 $38.56 25,961.0000 118,410,689 1.26% 0.00%
March 20, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found A Employee Stock Option (Right to Buy) 216000 $0.00 216,000.0000 54,008,883 9999.99% 0.40%
March 19, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 8907 $8.27 139,346.0000 54,008,883 6.01% 0.02%
March 18, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found S Common Stock 10382 $8.67 148,253.0000 54,008,883 6.54% 0.02%
March 20, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD Not found A Restricted Stock Units 144000 $0.00 144,000.0000 54,008,883 9999.99% 0.27%
March 15, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Restricted Stock Units 35500 $0.00 71,000.0000 54,008,883 33.33% 0.07%
March 15, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Common Stock 26250 $0.00 158,635.0000 54,008,883 19.83% 0.05%
March 15, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Common Stock 35500 $0.00 132,385.0000 54,008,883 36.64% 0.07%
March 15, 2025 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Restricted Stock Units 26250 $0.00 78,750.0000 54,008,883 25.00% 0.05%
Jan. 2, 2025 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 255 $48.93 25,637.0000 0 1.00% 0.00%
Dec. 30, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Common Stock 35000 $0.60 96,885.0000 56,341,074 56.56% 0.06%
Dec. 30, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Employee Stock Option (Right to Buy) 35000 $0.00 567,801.0000 56,341,074 5.81% 0.06%
Dec. 9, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO S Common Stock 6786 $12.99 61,885.0000 56,341,074 9.88% 0.01%
Dec. 6, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO S Common Stock 6170 $12.78 68,671.0000 56,341,074 8.24% 0.01%
Dec. 3, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Common Stock 26250 $0.00 74,841.0000 56,341,074 54.02% 0.05%
Dec. 3, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO A Performance Stock Units 52500 $0.00 52,500.0000 56,341,074 9999.99% 0.09%
Dec. 3, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Performance Stock Units 26250 $0.00 26,250.0000 56,341,074 50.00% 0.05%
Dec. 3, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Performance Stock Units 26500 $0.00 26,500.0000 56,341,074 50.00% 0.05%
Dec. 3, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Common Stock 26500 $0.00 75,091.0000 56,341,074 54.54% 0.05%
Dec. 3, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO A Performance Stock Units 53000 $0.00 53,000.0000 56,341,074 9999.99% 0.09%
Dec. 1, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Common Stock 21591 $0.00 48,591.0000 56,341,074 79.97% 0.04%
Dec. 1, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Restricted Stock Unit (RSU) 21591 $0.00 4,317.0000 56,341,074 83.34% 0.04%
Oct. 1, 2024 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 237 $52.60 25,382.0000 0 0.94% 0.00%
July 1, 2024 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 228 $0.00 25,145.0000 0 0.92% 0.00%
June 13, 2024 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Director A Stock Option (Right to Buy) 13489 $0.00 13,489.0000 0 9999.99% 0.00%
March 27, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO A Employee Stock Option (Right to Buy) 159000 $0.00 159,000.0000 43,994,862 9999.99% 0.36%
March 27, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO A Restricted Stock Units 105000 $0.00 105,000.0000 43,994,862 9999.99% 0.24%
May 20, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO S Common Stock 2664 $16.05 27,000.0000 43,994,862 8.98% 0.01%
May 20, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO S Common Stock 39686 $15.39 29,664.0000 43,994,862 57.23% 0.09%
May 15, 2024 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Non-Qualified Stock Option (Right to Buy) 3636 $0.00 3,636.0000 0 9999.99% 0.00%
May 15, 2024 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 5600 $0.00 24,917.0000 0 28.99% 0.00%
March 15, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Common Stock 35500 $0.00 80,500.0000 43,994,862 78.89% 0.08%
March 15, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO M Restricted Stock Units 35500 $0.00 106,500.0000 43,994,862 25.00% 0.08%
March 19, 2024 Stoke Therapeutics, Inc. $STOK Kaye Edward M. MD CEO S Common Stock 11150 $6.10 69,350.0000 43,994,862 13.85% 0.03%
Jan. 2, 2024 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 148 $84.12 19,317.0000 0 0.77% 0.00%
Oct. 2, 2023 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 448 $27.88 19,169.0000 0 2.39% 0.00%
July 3, 2023 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 374 $33.36 18,721.0000 0 2.04% 0.00%
June 15, 2023 Avidity Biosciences, Inc. $RNAM Kaye Edward M. MD Director A Stock Option (Right to Buy) 22000 $0.00 22,000.0000 0 9999.99% 0.00%
May 10, 2023 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 5000 $0.00 18,347.0000 0 37.46% 0.00%
May 10, 2023 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Non-Qualified Stock Option (Right to Buy) 10000 $0.00 10,000.0000 0 9999.99% 0.00%
April 3, 2023 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 298 $37.71 13,347.0000 0 2.28% 0.00%
Jan. 3, 2023 CYTOKINETICS INC $CYTK Kaye Edward M. MD Director A Common Stock 253 $44.35 13,049.0000 0 1.98% 0.00%