Mano Michael, EVP, CLO and Secretary at Karyopharm Therapeutics Inc. ($KPTI), made two open market sales of common shares in the last 365 days, totaling $34,683. His most recent sale occurred on March 2, 2026. These sales rank 10,700th among 11,678 individual insiders, far below the average of 8.6 million per insider across about 6.4 transactions. Mano Michael recorded no open market purchases in this period.
| Transaction Date | Company | Ticker | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| March 2, 2026 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | EVP, CLO&Secretary | S | Common Stock | 3526 | $9.41 | 93,964.0000 | 18,343,968 | 3.62% | 0.02% |
| Jan. 31, 2026 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | EVP, CLO&Secretary | A | Common Stock | 32415 | $0.00 | 97,490.0000 | 17,050,876,000 | 49.81% | 0.00% |
| Oct. 15, 2025 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Common Stock | 43650 | $0.00 | 65,075.0000 | 126,240,054 | 203.73% | 0.03% |
| Sept. 12, 2025 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Common Stock | 612 | $0.00 | 21,659.0000 | 126,240,054 | 2.91% | 0.00% |
| Sept. 15, 2025 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | S | Common Stock | 234 | $6.43 | 21,425.0000 | 126,240,054 | 1.08% | 0.00% |
| March 4, 2025 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | S | Common Stock | 2793 | $6.29 | 21,047.0000 | 126,240,054 | 11.72% | 0.00% |
| Feb. 28, 2025 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Common Stock | 3333 | $0.00 | 21,590.0000 | 126,240,054 | 18.26% | 0.00% |
| Feb. 28, 2025 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Stock Option (right to buy) | 4500 | $0.00 | 4,500.0000 | 126,240,054 | 9999.99% | 0.00% |
| Feb. 28, 2025 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Stock Option (right to buy) | 6666 | $0.00 | 6,666.0000 | 126,240,054 | 9999.99% | 0.01% |
| Feb. 28, 2025 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Common Stock | 2250 | $0.00 | 23,840.0000 | 126,240,054 | 10.42% | 0.00% |
| Sept. 4, 2024 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | S | Common Stock | 3971 | $0.72 | 273,881.0000 | 0 | 1.43% | 0.00% |
| March 1, 2024 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | S | Common | 3576 | $1.20 | 277,852.0000 | 0 | 1.27% | 0.00% |
| Feb. 29, 2024 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | S | Common | 16973 | $1.17 | 281,428.0000 | 0 | 5.69% | 0.00% |
| Feb. 28, 2024 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Common Stock | 147000 | $0.00 | 298,401.0000 | 0 | 97.09% | 0.00% |
| Jan. 24, 2024 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Common Stock | 9167 | $0.00 | 151,401.0000 | 0 | 6.45% | 0.00% |
| Sept. 1, 2023 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | S | Common Stock | 3888 | $1.33 | 142,234.0000 | 0 | 2.66% | 0.00% |
| Feb. 28, 2023 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | A | Common Stock | 70000 | $0.00 | 153,000.0000 | 0 | 84.34% | 0.00% |
| March 1, 2023 | Karyopharm Therapeutics Inc. | $KPTI | Mano Michael | SVP, General Counsel&Secretary | S | Common Stock | 6878 | $3.03 | 146,122.0000 | 0 | 4.50% | 0.00% |