In the last 12 months, insiders at ALNYLAM PHARMACEUTICALS, INC. ($ALNY) filed 962 transactions with the SEC: 2 open-market purchases totaling $10,363 and 739 sales totaling $182,679,070. Net insider sentiment: net selling.
ALNYLAM PHARMACEUTICALS, INC. operates in the Pharmaceutical preparations industry (Life sciences sector).
Most Active Insiders
- Greenstreet Yvonne (Chief Executive Officer) — 189 transactions totaling $72,580,799
- Garg Pushkal (CMO & EVP Dev & Med Affairs) — 94 transactions totaling $25,696,633
- Ausiello Dennis A (Director) — 37 transactions totaling $25,589,053
- Fitzgerald Kevin Joseph (CSO & EVP, Head of Research) — 172 transactions totaling $22,510,102
- PYOTT DAVID E I (Director) — 15 transactions totaling $12,668,319
View all SEC Filings for ALNYLAM PHARMACEUTICALS, INC. (ALNY).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| March 5, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 124 | $321.81 | 21,640.0000 | 134,684,000 | 0.57% | 0.00% |
| March 5, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 233 | $323.25 | 21,407.0000 | 134,684,000 | 1.08% | 0.00% |
| March 5, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 148 | $324.60 | 21,259.0000 | 134,684,000 | 0.69% | 0.00% |
| March 5, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 153 | $326.24 | 21,106.0000 | 134,684,000 | 0.72% | 0.00% |
| March 4, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 75 | $324.88 | 21,821.0000 | 134,684,000 | 0.34% | 0.00% |
| March 4, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 210 | $323.84 | 21,896.0000 | 134,684,000 | 0.95% | 0.00% |
| March 4, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 96 | $323.01 | 22,106.0000 | 134,684,000 | 0.43% | 0.00% |
| March 4, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 79 | $321.82 | 22,202.0000 | 134,684,000 | 0.35% | 0.00% |
| March 4, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 59 | $320.81 | 22,281.0000 | 134,684,000 | 0.26% | 0.00% |
| March 4, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 28 | $320.01 | 22,340.0000 | 134,684,000 | 0.13% | 0.00% |
| March 4, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 29 | $319.03 | 22,368.0000 | 134,684,000 | 0.13% | 0.00% |
| March 4, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 57 | $325.67 | 21,764.0000 | 134,684,000 | 0.26% | 0.00% |
| March 4, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 208 | $325.67 | 34,297.0000 | 134,684,000 | 0.60% | 0.00% |
| March 4, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 272 | $324.88 | 34,505.0000 | 134,684,000 | 0.78% | 0.00% |
| March 4, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 767 | $323.84 | 34,777.0000 | 134,684,000 | 2.16% | 0.00% |
| March 4, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 106 | $319.03 | 23,981.0000 | 134,684,000 | 0.44% | 0.00% |
| March 4, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 102 | $320.01 | 23,879.0000 | 134,684,000 | 0.43% | 0.00% |
| March 4, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 215 | $320.81 | 23,664.0000 | 134,684,000 | 0.90% | 0.00% |
| March 4, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 289 | $321.82 | 23,375.0000 | 134,684,000 | 1.22% | 0.00% |
| March 4, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 350 | $323.01 | 23,025.0000 | 134,684,000 | 1.50% | 0.00% |
| March 4, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 767 | $323.84 | 22,258.0000 | 134,684,000 | 3.33% | 0.00% |
| March 4, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 272 | $324.88 | 21,986.0000 | 134,684,000 | 1.22% | 0.00% |
| March 4, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 208 | $325.67 | 21,778.0000 | 134,684,000 | 0.95% | 0.00% |
| March 5, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 654 | $322.33 | 21,124.0000 | 134,684,000 | 3.00% | 0.00% |
| March 5, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 740 | $323.55 | 20,384.0000 | 134,684,000 | 3.50% | 0.00% |
| March 5, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 510 | $324.59 | 19,874.0000 | 134,684,000 | 2.50% | 0.00% |
| March 5, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 500 | $326.08 | 19,374.0000 | 134,684,000 | 2.52% | 0.00% |
| March 4, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 135 | $319.03 | 98,900.0000 | 134,684,000 | 0.14% | 0.00% |
| March 4, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 129 | $320.01 | 98,771.0000 | 134,684,000 | 0.13% | 0.00% |
| March 4, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 274 | $320.81 | 98,497.0000 | 134,684,000 | 0.28% | 0.00% |
| March 4, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 368 | $321.82 | 98,129.0000 | 134,684,000 | 0.37% | 0.00% |
| March 4, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 444 | $323.01 | 97,685.0000 | 134,684,000 | 0.45% | 0.00% |
| March 4, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 973 | $323.84 | 96,712.0000 | 134,684,000 | 1.00% | 0.00% |
| March 4, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 345 | $324.88 | 96,367.0000 | 134,684,000 | 0.36% | 0.00% |
| March 4, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 265 | $325.67 | 96,102.0000 | 134,684,000 | 0.27% | 0.00% |
| March 4, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 114 | $319.03 | 64,216.0000 | 134,684,000 | 0.18% | 0.00% |
| March 4, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 109 | $320.01 | 64,107.0000 | 134,684,000 | 0.17% | 0.00% |
| March 4, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 230 | $320.81 | 63,877.0000 | 134,684,000 | 0.36% | 0.00% |
| March 4, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 309 | $321.82 | 63,568.0000 | 134,684,000 | 0.48% | 0.00% |
| March 4, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 374 | $323.01 | 63,194.0000 | 134,684,000 | 0.59% | 0.00% |
| March 4, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 818 | $323.84 | 62,376.0000 | 134,684,000 | 1.29% | 0.00% |
| March 4, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 291 | $324.88 | 62,085.0000 | 134,684,000 | 0.47% | 0.00% |
| March 4, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 223 | $325.67 | 61,862.0000 | 134,684,000 | 0.36% | 0.00% |
| March 4, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 106 | $319.03 | 36,500.0000 | 134,684,000 | 0.29% | 0.00% |
| March 4, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 102 | $320.01 | 36,398.0000 | 134,684,000 | 0.28% | 0.00% |
| March 4, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 215 | $320.81 | 36,183.0000 | 134,684,000 | 0.59% | 0.00% |
| March 4, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 289 | $321.82 | 35,894.0000 | 134,684,000 | 0.80% | 0.00% |
| March 4, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 350 | $323.01 | 35,544.0000 | 134,684,000 | 0.98% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 258 | $325.63 | 37,809.0000 | 134,684,000 | 0.68% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 392 | $326.81 | 37,417.0000 | 134,684,000 | 1.04% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 329 | $327.67 | 37,088.0000 | 134,684,000 | 0.88% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 100 | $328.71 | 36,988.0000 | 134,684,000 | 0.27% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 170 | $329.71 | 36,818.0000 | 134,684,000 | 0.46% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 81 | $330.85 | 36,737.0000 | 134,684,000 | 0.22% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 94 | $331.93 | 36,643.0000 | 134,684,000 | 0.26% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 37 | $332.64 | 36,606.0000 | 134,684,000 | 0.10% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Stock Option (right to buy) | 10480 | $0.00 | 10,480.0000 | 134,684,000 | 9999.99% | 0.01% |
| March 2, 2026 | SUPRAN BRYAN | EVP, CLO and Secretary | A | Common Stock | 1539 | $0.00 | 14,565.0000 | 134,684,000 | 11.81% | 0.00% |
| March 2, 2026 | SUPRAN BRYAN | EVP, CLO and Secretary | A | Stock Option (right to buy) | 3381 | $0.00 | 3,381.0000 | 134,684,000 | 9999.99% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 13844 | $0.00 | 105,834.0000 | 134,684,000 | 15.05% | 0.01% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 200 | $323.62 | 105,634.0000 | 134,684,000 | 0.19% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 382 | $324.65 | 105,252.0000 | 134,684,000 | 0.36% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1098 | $325.63 | 104,154.0000 | 134,684,000 | 1.04% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1669 | $326.81 | 102,485.0000 | 134,684,000 | 1.60% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1399 | $327.67 | 101,086.0000 | 134,684,000 | 1.37% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 424 | $328.71 | 100,662.0000 | 134,684,000 | 0.42% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 722 | $329.71 | 99,940.0000 | 134,684,000 | 0.72% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 346 | $330.85 | 99,594.0000 | 134,684,000 | 0.35% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 160 | $332.64 | 99,035.0000 | 134,684,000 | 0.16% | 0.00% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | A | Stock Option (right to buy) | 30425 | $0.00 | 30,425.0000 | 134,684,000 | 9999.99% | 0.02% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | A | Stock Price Performance Stock Unit | 110746 | $0.00 | 110,746.0000 | 134,684,000 | 9999.99% | 0.08% |
| March 2, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 399 | $331.93 | 99,195.0000 | 134,684,000 | 0.40% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 4769 | $0.00 | 66,536.0000 | 134,684,000 | 7.72% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 65 | $323.62 | 66,471.0000 | 134,684,000 | 0.10% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 124 | $324.65 | 66,347.0000 | 134,684,000 | 0.19% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 356 | $325.63 | 65,991.0000 | 134,684,000 | 0.54% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 541 | $326.81 | 65,450.0000 | 134,684,000 | 0.82% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 454 | $327.67 | 64,996.0000 | 134,684,000 | 0.69% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 138 | $328.71 | 64,858.0000 | 134,684,000 | 0.21% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 234 | $329.71 | 64,624.0000 | 134,684,000 | 0.36% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 112 | $330.85 | 64,512.0000 | 134,684,000 | 0.17% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 129 | $331.93 | 64,383.0000 | 134,684,000 | 0.20% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 53 | $332.64 | 64,330.0000 | 134,684,000 | 0.08% | 0.00% |
| March 2, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Stock Option (right to buy) | 10480 | $0.00 | 10,480.0000 | 134,684,000 | 9999.99% | 0.01% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | A | Common Stock | 4769 | $0.00 | 27,579.0000 | 134,684,000 | 20.91% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 50 | $323.62 | 27,529.0000 | 134,684,000 | 0.18% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 97 | $324.65 | 27,432.0000 | 134,684,000 | 0.35% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 277 | $325.63 | 27,155.0000 | 134,684,000 | 1.01% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 421 | $326.81 | 26,734.0000 | 134,684,000 | 1.55% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 353 | $327.67 | 26,381.0000 | 134,684,000 | 1.32% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 107 | $328.71 | 26,274.0000 | 134,684,000 | 0.41% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 182 | $329.71 | 26,092.0000 | 134,684,000 | 0.69% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 87 | $330.85 | 26,005.0000 | 134,684,000 | 0.33% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 101 | $331.93 | 25,904.0000 | 134,684,000 | 0.39% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 42 | $332.64 | 25,862.0000 | 134,684,000 | 0.16% | 0.00% |
| March 3, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 355 | $316.74 | 25,507.0000 | 134,684,000 | 1.37% | 0.00% |
| March 3, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 317 | $319.06 | 25,190.0000 | 134,684,000 | 1.24% | 0.00% |
| March 3, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 640 | $320.48 | 24,550.0000 | 134,684,000 | 2.54% | 0.00% |
| March 3, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 463 | $321.50 | 24,087.0000 | 134,684,000 | 1.89% | 0.00% |
| March 2, 2026 | Garg Pushkal | EVP Chief R&D | A | Stock Option (right to buy) | 10480 | $0.00 | 10,480.0000 | 134,684,000 | 9999.99% | 0.01% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 3688 | $0.00 | 25,647.0000 | 134,684,000 | 16.79% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 47 | $323.62 | 25,600.0000 | 134,684,000 | 0.18% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 90 | $324.65 | 25,510.0000 | 134,684,000 | 0.35% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 258 | $325.63 | 25,252.0000 | 134,684,000 | 1.01% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 392 | $326.81 | 24,860.0000 | 134,684,000 | 1.55% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 329 | $327.67 | 24,531.0000 | 134,684,000 | 1.32% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 100 | $328.71 | 24,431.0000 | 134,684,000 | 0.41% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 170 | $329.71 | 24,261.0000 | 134,684,000 | 0.70% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 81 | $330.85 | 24,180.0000 | 134,684,000 | 0.33% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 94 | $331.93 | 24,086.0000 | 134,684,000 | 0.39% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 37 | $332.64 | 24,049.0000 | 134,684,000 | 0.15% | 0.00% |
| March 3, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 289 | $316.55 | 23,760.0000 | 134,684,000 | 1.20% | 0.00% |
| March 3, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 282 | $318.62 | 23,478.0000 | 134,684,000 | 1.19% | 0.00% |
| March 3, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 722 | $320.51 | 22,756.0000 | 134,684,000 | 3.08% | 0.00% |
| March 3, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 359 | $321.58 | 22,397.0000 | 134,684,000 | 1.58% | 0.00% |
| March 2, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Stock Option (right to buy) | 8105 | $0.00 | 8,105.0000 | 134,684,000 | 9999.99% | 0.01% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 4769 | $0.00 | 38,204.0000 | 134,684,000 | 14.26% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 47 | $323.62 | 38,157.0000 | 134,684,000 | 0.12% | 0.00% |
| March 2, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 90 | $324.65 | 38,067.0000 | 134,684,000 | 0.24% | 0.00% |
| Feb. 27, 2026 | Garg Pushkal | EVP Chief R&D | M | Restricted Stock Units | 1908 | $0.00 | 0.0000 | 134,684,000 | 100.00% | 0.00% |
| Feb. 27, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 140 | $334.39 | 22,810.0000 | 134,684,000 | 0.61% | 0.00% |
| Feb. 27, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 942 | $332.48 | 22,950.0000 | 134,684,000 | 3.94% | 0.00% |
| Feb. 27, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 1159 | $331.49 | 23,892.0000 | 134,684,000 | 4.63% | 0.00% |
| Feb. 27, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 2259 | $330.73 | 25,051.0000 | 134,684,000 | 8.27% | 0.00% |
| Feb. 27, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 127 | $328.92 | 27,310.0000 | 134,684,000 | 0.46% | 0.00% |
| Feb. 27, 2026 | Garg Pushkal | EVP Chief R&D | M | Common Stock | 1908 | $0.00 | 27,437.0000 | 134,684,000 | 7.47% | 0.00% |
| Feb. 27, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | M | Restricted Stock Units | 1666 | $0.00 | 0.0000 | 134,684,000 | 100.00% | 0.00% |
| Feb. 27, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | M | Common Stock | 1666 | $0.00 | 33,435.0000 | 134,684,000 | 5.24% | 0.00% |
| Feb. 27, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | M | Restricted Stock Units | 1908 | $0.00 | 0.0000 | 134,684,000 | 100.00% | 0.00% |
| Feb. 27, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | M | Common Stock | 1908 | $0.00 | 61,767.0000 | 134,684,000 | 3.19% | 0.00% |
| Feb. 27, 2026 | Greenstreet Yvonne | Chief Executive Officer | M | Restricted Stock Units | 5921 | $0.00 | 0.0000 | 134,684,000 | 100.00% | 0.00% |
| Feb. 27, 2026 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 5921 | $0.00 | 91,990.0000 | 134,684,000 | 6.88% | 0.00% |
| Feb. 23, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 158 | $0.00 | 21,959.0000 | 134,684,000 | 0.72% | 0.00% |
| Feb. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 14209 | $0.00 | 93,027.0000 | 134,684,000 | 18.03% | 0.01% |
| Feb. 13, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 2242 | $310.08 | 59,859.0000 | 134,684,000 | 3.61% | 0.00% |
| Feb. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 4579 | $0.00 | 62,101.0000 | 134,684,000 | 7.96% | 0.00% |
| Feb. 17, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 2041 | $331.96 | 21,801.0000 | 134,684,000 | 8.56% | 0.00% |
| Feb. 13, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 1959 | $310.08 | 23,842.0000 | 134,684,000 | 7.59% | 0.00% |
| Feb. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 4000 | $0.00 | 25,801.0000 | 134,684,000 | 18.35% | 0.00% |
| Feb. 13, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 1959 | $310.08 | 31,769.0000 | 134,684,000 | 5.81% | 0.00% |
| Feb. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 4000 | $0.00 | 33,728.0000 | 134,684,000 | 13.46% | 0.00% |
| Feb. 13, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 6958 | $310.08 | 86,069.0000 | 134,684,000 | 7.48% | 0.01% |
| Feb. 13, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 2242 | $310.08 | 25,529.0000 | 134,684,000 | 8.07% | 0.00% |
| Feb. 12, 2026 | Garg Pushkal | EVP Chief R&D | A | Common Stock | 4579 | $0.00 | 27,771.0000 | 134,684,000 | 19.74% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 537 | $359.14 | 85,694.0000 | 134,684,000 | 0.62% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 39 | $353.95 | 31,199.0000 | 134,684,000 | 0.12% | 0.00% |
| Jan. 11, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 3800 | $0.00 | 31,238.0000 | 134,684,000 | 13.85% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 27 | $377.82 | 57,522.0000 | 134,684,000 | 0.05% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 34 | $375.65 | 57,549.0000 | 134,684,000 | 0.06% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 25 | $374.44 | 57,583.0000 | 134,684,000 | 0.04% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 6 | $372.46 | 57,608.0000 | 134,684,000 | 0.01% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 36 | $370.87 | 57,614.0000 | 134,684,000 | 0.06% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 73 | $369.48 | 57,650.0000 | 134,684,000 | 0.13% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 170 | $368.62 | 57,723.0000 | 134,684,000 | 0.29% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 76 | $367.40 | 57,893.0000 | 134,684,000 | 0.13% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 92 | $366.41 | 57,969.0000 | 134,684,000 | 0.16% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 405 | $365.56 | 58,061.0000 | 134,684,000 | 0.69% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 365 | $364.83 | 58,466.0000 | 134,684,000 | 0.62% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 87 | $363.55 | 58,831.0000 | 134,684,000 | 0.15% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 135 | $362.38 | 58,918.0000 | 134,684,000 | 0.23% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 181 | $361.45 | 59,053.0000 | 134,684,000 | 0.31% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 284 | $360.22 | 59,234.0000 | 134,684,000 | 0.48% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 156 | $359.14 | 59,518.0000 | 134,684,000 | 0.26% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 226 | $358.18 | 59,674.0000 | 134,684,000 | 0.38% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 176 | $357.17 | 59,900.0000 | 134,684,000 | 0.29% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 76 | $356.09 | 60,076.0000 | 134,684,000 | 0.13% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 78 | $355.16 | 60,152.0000 | 134,684,000 | 0.13% | 0.00% |
| Jan. 12, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 72 | $353.95 | 60,230.0000 | 134,684,000 | 0.12% | 0.00% |
| Jan. 11, 2026 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 6193 | $0.00 | 60,302.0000 | 134,684,000 | 11.45% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 94 | $377.82 | 78,818.0000 | 134,684,000 | 0.12% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 118 | $375.65 | 78,912.0000 | 134,684,000 | 0.15% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 88 | $374.44 | 79,030.0000 | 134,684,000 | 0.11% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 21 | $372.46 | 79,118.0000 | 134,684,000 | 0.03% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 118 | $370.87 | 79,139.0000 | 134,684,000 | 0.15% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 253 | $369.48 | 79,257.0000 | 134,684,000 | 0.32% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 584 | $368.62 | 79,510.0000 | 134,684,000 | 0.73% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 261 | $367.40 | 80,094.0000 | 134,684,000 | 0.32% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 316 | $366.41 | 80,355.0000 | 134,684,000 | 0.39% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1395 | $365.56 | 80,671.0000 | 134,684,000 | 1.70% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1259 | $364.83 | 82,066.0000 | 134,684,000 | 1.51% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 301 | $363.55 | 83,325.0000 | 134,684,000 | 0.36% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 464 | $362.38 | 83,626.0000 | 134,684,000 | 0.55% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 624 | $361.45 | 84,090.0000 | 134,684,000 | 0.74% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 980 | $360.22 | 84,714.0000 | 134,684,000 | 1.14% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 42 | $355.16 | 31,157.0000 | 134,684,000 | 0.13% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 778 | $358.18 | 86,231.0000 | 134,684,000 | 0.89% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 607 | $357.17 | 87,009.0000 | 134,684,000 | 0.69% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 263 | $356.09 | 87,616.0000 | 134,684,000 | 0.30% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 269 | $355.16 | 87,879.0000 | 134,684,000 | 0.31% | 0.00% |
| Jan. 12, 2026 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 247 | $353.95 | 88,148.0000 | 134,684,000 | 0.28% | 0.00% |
| Jan. 11, 2026 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 19003 | $0.00 | 88,395.0000 | 134,684,000 | 27.39% | 0.01% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 15 | $377.82 | 23,192.0000 | 134,684,000 | 0.06% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 19 | $375.65 | 23,207.0000 | 134,684,000 | 0.08% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 14 | $374.44 | 23,226.0000 | 134,684,000 | 0.06% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 3 | $372.46 | 23,240.0000 | 134,684,000 | 0.01% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 18 | $370.87 | 23,243.0000 | 134,684,000 | 0.08% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 40 | $369.48 | 23,261.0000 | 134,684,000 | 0.17% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 92 | $368.62 | 23,301.0000 | 134,684,000 | 0.39% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 41 | $367.40 | 23,393.0000 | 134,684,000 | 0.17% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 50 | $366.41 | 23,434.0000 | 134,684,000 | 0.21% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 220 | $365.56 | 23,484.0000 | 134,684,000 | 0.93% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 199 | $364.83 | 23,704.0000 | 134,684,000 | 0.83% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 47 | $363.55 | 23,903.0000 | 134,684,000 | 0.20% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 73 | $362.38 | 23,950.0000 | 134,684,000 | 0.30% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 98 | $361.45 | 24,023.0000 | 134,684,000 | 0.41% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 155 | $360.22 | 24,121.0000 | 134,684,000 | 0.64% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 85 | $359.14 | 24,276.0000 | 134,684,000 | 0.35% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 123 | $358.18 | 24,361.0000 | 134,684,000 | 0.50% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 96 | $357.17 | 24,484.0000 | 134,684,000 | 0.39% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 41 | $356.09 | 24,580.0000 | 134,684,000 | 0.17% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 42 | $355.16 | 24,621.0000 | 134,684,000 | 0.17% | 0.00% |
| Jan. 12, 2026 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 39 | $353.95 | 24,663.0000 | 134,684,000 | 0.16% | 0.00% |
| Jan. 11, 2026 | Garg Pushkal | EVP Chief R&D | A | Common Stock | 3800 | $0.00 | 24,702.0000 | 134,684,000 | 18.18% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 39 | $353.95 | 25,562.0000 | 134,684,000 | 0.15% | 0.00% |
| Jan. 11, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 3800 | $0.00 | 25,601.0000 | 134,684,000 | 17.43% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 15 | $377.82 | 29,728.0000 | 134,684,000 | 0.05% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 19 | $375.65 | 29,743.0000 | 134,684,000 | 0.06% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 14 | $374.44 | 29,762.0000 | 134,684,000 | 0.05% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 2 | $372.46 | 29,776.0000 | 134,684,000 | 0.01% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 19 | $370.87 | 29,778.0000 | 134,684,000 | 0.06% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 40 | $369.48 | 29,797.0000 | 134,684,000 | 0.13% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 50 | $366.41 | 29,970.0000 | 134,684,000 | 0.17% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 92 | $368.62 | 29,837.0000 | 134,684,000 | 0.31% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 41 | $367.40 | 29,929.0000 | 134,684,000 | 0.14% | 0.00% |
| Jan. 13, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 122 | $374.33 | 21,801.0000 | 134,684,000 | 0.56% | 0.00% |
| Jan. 13, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 280 | $372.93 | 21,923.0000 | 134,684,000 | 1.26% | 0.00% |
| Jan. 13, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 485 | $371.24 | 22,203.0000 | 134,684,000 | 2.14% | 0.00% |
| Jan. 13, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 644 | $370.00 | 22,688.0000 | 134,684,000 | 2.76% | 0.00% |
| Jan. 13, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 562 | $368.76 | 23,332.0000 | 134,684,000 | 2.35% | 0.00% |
| Jan. 13, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 197 | $367.52 | 23,894.0000 | 134,684,000 | 0.82% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 15 | $377.82 | 24,091.0000 | 134,684,000 | 0.06% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 19 | $375.65 | 24,106.0000 | 134,684,000 | 0.08% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 14 | $374.44 | 24,125.0000 | 134,684,000 | 0.06% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 2 | $372.46 | 24,139.0000 | 134,684,000 | 0.01% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 19 | $370.87 | 24,141.0000 | 134,684,000 | 0.08% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 40 | $369.48 | 24,160.0000 | 134,684,000 | 0.17% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 92 | $368.62 | 24,200.0000 | 134,684,000 | 0.38% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 41 | $367.40 | 24,292.0000 | 134,684,000 | 0.17% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 50 | $366.41 | 24,333.0000 | 134,684,000 | 0.21% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 220 | $365.56 | 24,383.0000 | 134,684,000 | 0.89% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 199 | $364.83 | 24,603.0000 | 134,684,000 | 0.80% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 47 | $363.55 | 24,802.0000 | 134,684,000 | 0.19% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 73 | $362.38 | 24,849.0000 | 134,684,000 | 0.29% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 98 | $361.45 | 24,922.0000 | 134,684,000 | 0.39% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 155 | $360.22 | 25,020.0000 | 134,684,000 | 0.62% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 85 | $359.14 | 25,175.0000 | 134,684,000 | 0.34% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 123 | $358.18 | 25,260.0000 | 134,684,000 | 0.48% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 96 | $357.17 | 25,383.0000 | 134,684,000 | 0.38% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 41 | $356.09 | 25,479.0000 | 134,684,000 | 0.16% | 0.00% |
| Jan. 12, 2026 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 42 | $355.16 | 25,520.0000 | 134,684,000 | 0.16% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 220 | $365.56 | 30,020.0000 | 134,684,000 | 0.73% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 199 | $364.83 | 30,240.0000 | 134,684,000 | 0.65% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 47 | $363.55 | 30,439.0000 | 134,684,000 | 0.15% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 73 | $362.38 | 30,486.0000 | 134,684,000 | 0.24% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 98 | $361.45 | 30,559.0000 | 134,684,000 | 0.32% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 155 | $360.22 | 30,657.0000 | 134,684,000 | 0.50% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 85 | $359.14 | 30,812.0000 | 134,684,000 | 0.28% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 123 | $358.18 | 30,897.0000 | 134,684,000 | 0.40% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 96 | $357.17 | 31,020.0000 | 134,684,000 | 0.31% | 0.00% |
| Jan. 12, 2026 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 41 | $356.09 | 31,116.0000 | 134,684,000 | 0.13% | 0.00% |
| Jan. 5, 2026 | Arbuckle Stuart A | Director | A | Stock Option (right to buy) | 3279 | $0.00 | 3,279.0000 | 134,684,000 | 9999.99% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 839 | $119.13 | 66,655.0000 | 137,348,000 | 1.27% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 659 | $0.00 | 28,141.0000 | 137,348,000 | 2.29% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 839 | $0.00 | 0.0000 | 137,348,000 | 100.00% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 847 | $0.00 | 0.0000 | 137,348,000 | 100.00% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 2352 | $0.00 | 0.0000 | 137,348,000 | 100.00% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | F | Common Stock | 1121 | $445.12 | 69,392.0000 | 137,348,000 | 1.59% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 659 | $151.59 | 70,513.0000 | 137,348,000 | 0.94% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 2352 | $85.00 | 69,007.0000 | 137,348,000 | 3.53% | 0.00% |
| Nov. 26, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 847 | $118.05 | 69,854.0000 | 137,348,000 | 1.23% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | M | Stock Option (right to buy) | 8161 | $0.00 | 839.0000 | 137,348,000 | 90.68% | 0.01% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 295 | $463.08 | 21,801.0000 | 137,348,000 | 1.34% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 323 | $461.96 | 22,096.0000 | 137,348,000 | 1.44% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 707 | $460.84 | 22,419.0000 | 137,348,000 | 3.06% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 622 | $459.89 | 23,126.0000 | 137,348,000 | 2.62% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 794 | $458.41 | 23,748.0000 | 137,348,000 | 3.24% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 262 | $457.39 | 24,542.0000 | 137,348,000 | 1.06% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 364 | $456.25 | 24,804.0000 | 137,348,000 | 1.45% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 368 | $455.24 | 25,168.0000 | 137,348,000 | 1.44% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 129 | $451.51 | 25,536.0000 | 137,348,000 | 0.50% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 96 | $450.09 | 25,665.0000 | 137,348,000 | 0.37% | 0.00% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 8168 | $449.00 | 25,761.0000 | 137,348,000 | 24.07% | 0.01% |
| Nov. 17, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | M | Common Stock | 8161 | $119.13 | 33,929.0000 | 137,348,000 | 31.67% | 0.01% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 2132 | $449.15 | 78,623.0000 | 137,348,000 | 2.64% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 711 | $448.07 | 80,755.0000 | 137,348,000 | 0.87% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Performance Stock Option 2017 (right to buy) | 10000 | $0.00 | 0.0000 | 137,348,000 | 100.00% | 0.01% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Performance Stock Option 2017 (right to buy) | 15000 | $0.00 | 10,000.0000 | 137,348,000 | 60.00% | 0.01% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Performance Stock Option 2016 (right to buy) | 650 | $0.00 | 0.0000 | 137,348,000 | 100.00% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 261 | $456.03 | 65,816.0000 | 137,348,000 | 0.39% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 195 | $454.69 | 66,077.0000 | 137,348,000 | 0.29% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 881 | $453.99 | 66,272.0000 | 137,348,000 | 1.31% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1599 | $452.85 | 67,153.0000 | 137,348,000 | 2.33% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1702 | $451.94 | 68,752.0000 | 137,348,000 | 2.42% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 2218 | $450.69 | 70,454.0000 | 137,348,000 | 3.05% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1477 | $450.02 | 72,672.0000 | 137,348,000 | 1.99% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1013 | $448.76 | 74,149.0000 | 137,348,000 | 1.35% | 0.00% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 654 | $447.73 | 75,162.0000 | 137,348,000 | 0.86% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 650 | $42.22 | 66,466.0000 | 137,348,000 | 0.99% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 15000 | $119.13 | 81,466.0000 | 137,348,000 | 22.57% | 0.01% |
| Nov. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 10000 | $119.13 | 75,816.0000 | 137,348,000 | 15.19% | 0.01% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 430 | $458.42 | 65,816.0000 | 137,348,000 | 0.65% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 604 | $457.71 | 66,246.0000 | 137,348,000 | 0.90% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 2420 | $456.64 | 66,850.0000 | 137,348,000 | 3.49% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 3406 | $455.56 | 69,270.0000 | 137,348,000 | 4.69% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1960 | $454.84 | 72,676.0000 | 137,348,000 | 2.63% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1069 | $453.52 | 74,636.0000 | 137,348,000 | 1.41% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1210 | $452.43 | 75,705.0000 | 137,348,000 | 1.57% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1255 | $451.16 | 76,915.0000 | 137,348,000 | 1.61% | 0.00% |
| Nov. 12, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 453 | $450.17 | 78,170.0000 | 137,348,000 | 0.58% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 332 | $451.86 | 25,388.0000 | 137,348,000 | 1.29% | 0.00% |
| Oct. 3, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 215 | $454.37 | 20,902.0000 | 137,348,000 | 1.02% | 0.00% |
| Oct. 3, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 417 | $453.51 | 21,117.0000 | 137,348,000 | 1.94% | 0.00% |
| Oct. 3, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 898 | $451.76 | 21,534.0000 | 137,348,000 | 4.00% | 0.00% |
| Oct. 3, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 810 | $450.63 | 22,432.0000 | 137,348,000 | 3.49% | 0.00% |
| Oct. 3, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 682 | $449.99 | 23,242.0000 | 137,348,000 | 2.85% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 3 | $457.64 | 23,924.0000 | 137,348,000 | 0.01% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 147 | $457.43 | 23,927.0000 | 137,348,000 | 0.61% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 73 | $455.82 | 24,074.0000 | 137,348,000 | 0.30% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 244 | $454.84 | 24,147.0000 | 137,348,000 | 1.00% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 329 | $453.77 | 24,391.0000 | 137,348,000 | 1.33% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 668 | $452.69 | 24,720.0000 | 137,348,000 | 2.63% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 541 | $450.81 | 25,720.0000 | 137,348,000 | 2.06% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 249 | $449.79 | 26,261.0000 | 137,348,000 | 0.94% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 180 | $448.77 | 26,510.0000 | 137,348,000 | 0.67% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 56 | $447.92 | 26,690.0000 | 137,348,000 | 0.21% | 0.00% |
| Oct. 2, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 115 | $446.53 | 26,746.0000 | 137,348,000 | 0.43% | 0.00% |
| Oct. 1, 2025 | Garg Pushkal | EVP Chief R&D | A | Common Stock | 2851 | $0.00 | 26,861.0000 | 137,348,000 | 11.87% | 0.00% |
| Oct. 1, 2025 | Garg Pushkal | EVP Chief R&D | A | Common Stock | 3108 | $0.00 | 24,010.0000 | 137,348,000 | 14.87% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 3 | $457.64 | 25,768.0000 | 137,348,000 | 0.01% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 122 | $457.43 | 25,771.0000 | 137,348,000 | 0.47% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 60 | $455.82 | 25,893.0000 | 137,348,000 | 0.23% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 203 | $454.84 | 25,953.0000 | 137,348,000 | 0.78% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 273 | $453.77 | 26,156.0000 | 137,348,000 | 1.03% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 555 | $452.69 | 26,429.0000 | 137,348,000 | 2.06% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 276 | $451.86 | 26,984.0000 | 137,348,000 | 1.01% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 449 | $450.81 | 27,260.0000 | 137,348,000 | 1.62% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 207 | $449.79 | 27,709.0000 | 137,348,000 | 0.74% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 150 | $448.77 | 27,916.0000 | 137,348,000 | 0.53% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 47 | $447.92 | 28,066.0000 | 137,348,000 | 0.17% | 0.00% |
| Oct. 2, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 96 | $446.53 | 28,113.0000 | 137,348,000 | 0.34% | 0.00% |
| Oct. 1, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 2851 | $0.00 | 28,209.0000 | 137,348,000 | 11.24% | 0.00% |
| Oct. 1, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 2102 | $0.00 | 25,358.0000 | 137,348,000 | 9.04% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 1 | $457.64 | 27,438.0000 | 137,348,000 | 0.00% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 70 | $457.43 | 27,439.0000 | 137,348,000 | 0.25% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 35 | $455.82 | 27,509.0000 | 137,348,000 | 0.13% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 117 | $454.84 | 27,544.0000 | 137,348,000 | 0.42% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 157 | $453.77 | 27,661.0000 | 137,348,000 | 0.56% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 319 | $452.69 | 27,818.0000 | 137,348,000 | 1.13% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 159 | $451.86 | 28,137.0000 | 137,348,000 | 0.56% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 260 | $450.81 | 28,296.0000 | 137,348,000 | 0.91% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 119 | $449.79 | 28,556.0000 | 137,348,000 | 0.41% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 86 | $448.77 | 28,675.0000 | 137,348,000 | 0.30% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 27 | $447.92 | 28,761.0000 | 137,348,000 | 0.09% | 0.00% |
| Oct. 2, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 55 | $446.53 | 28,788.0000 | 137,348,000 | 0.19% | 0.00% |
| Oct. 1, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 2851 | $0.00 | 28,843.0000 | 137,348,000 | 10.97% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 9 | $457.64 | 65,816.0000 | 137,348,000 | 0.01% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 446 | $457.43 | 65,825.0000 | 137,348,000 | 0.67% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 221 | $455.82 | 66,271.0000 | 137,348,000 | 0.33% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 741 | $454.84 | 66,492.0000 | 137,348,000 | 1.10% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 999 | $453.77 | 67,233.0000 | 137,348,000 | 1.46% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 2029 | $452.69 | 68,232.0000 | 137,348,000 | 2.89% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1010 | $451.86 | 70,261.0000 | 137,348,000 | 1.42% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1642 | $450.81 | 71,271.0000 | 137,348,000 | 2.25% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 758 | $449.79 | 72,913.0000 | 137,348,000 | 1.03% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 548 | $448.77 | 73,671.0000 | 137,348,000 | 0.74% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 171 | $447.92 | 74,219.0000 | 137,348,000 | 0.23% | 0.00% |
| Oct. 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 350 | $446.53 | 74,390.0000 | 137,348,000 | 0.47% | 0.00% |
| Oct. 1, 2025 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 14252 | $0.00 | 74,740.0000 | 137,348,000 | 23.56% | 0.01% |
| Oct. 1, 2025 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 3860 | $0.00 | 60,488.0000 | 137,348,000 | 6.82% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 4 | $457.64 | 54,109.0000 | 137,348,000 | 0.01% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 191 | $457.43 | 54,113.0000 | 137,348,000 | 0.35% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 95 | $455.82 | 54,304.0000 | 137,348,000 | 0.17% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 317 | $454.84 | 54,399.0000 | 137,348,000 | 0.58% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 428 | $453.77 | 54,716.0000 | 137,348,000 | 0.78% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 869 | $452.69 | 55,144.0000 | 137,348,000 | 1.55% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 432 | $451.86 | 56,013.0000 | 137,348,000 | 0.77% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 704 | $450.81 | 56,445.0000 | 137,348,000 | 1.23% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 324 | $449.79 | 57,149.0000 | 137,348,000 | 0.56% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 234 | $448.77 | 57,473.0000 | 137,348,000 | 0.41% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 73 | $447.92 | 57,707.0000 | 137,348,000 | 0.13% | 0.00% |
| Oct. 2, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 150 | $446.53 | 57,780.0000 | 137,348,000 | 0.26% | 0.00% |
| Oct. 1, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 4644 | $0.00 | 57,930.0000 | 137,348,000 | 8.72% | 0.00% |
| Oct. 1, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 3108 | $0.00 | 53,286.0000 | 137,348,000 | 6.19% | 0.00% |
| Oct. 1, 2025 | SUPRAN BRYAN | EVP, CLO and Secretary | A | Common Stock | 13026 | $0.00 | 13,026.0000 | 137,348,000 | 9999.99% | 0.01% |
| Sept. 9, 2025 | Reitan Colleen F | Director | M | Stock Option (right to buy) | 18000 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.01% |
| Sept. 9, 2025 | Reitan Colleen F | Director | M | Common Stock | 18000 | $100.65 | 18,775.0000 | 127,651,000 | 2322.58% | 0.01% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 1645 | $457.44 | 17,130.0000 | 127,651,000 | 8.76% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 1888 | $458.86 | 15,242.0000 | 127,651,000 | 11.02% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 1403 | $459.73 | 13,839.0000 | 127,651,000 | 9.20% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 473 | $460.71 | 13,366.0000 | 127,651,000 | 3.42% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 2290 | $461.92 | 11,076.0000 | 127,651,000 | 17.13% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 1652 | $463.00 | 9,424.0000 | 127,651,000 | 14.92% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 799 | $464.36 | 8,625.0000 | 127,651,000 | 8.48% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 222 | $471.25 | 8,403.0000 | 127,651,000 | 2.57% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 823 | $472.82 | 7,580.0000 | 127,651,000 | 9.79% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 838 | $474.22 | 6,742.0000 | 127,651,000 | 11.06% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 951 | $474.85 | 5,791.0000 | 127,651,000 | 14.11% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 972 | $476.31 | 4,819.0000 | 127,651,000 | 16.78% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 1183 | $477.47 | 3,636.0000 | 127,651,000 | 24.55% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 1450 | $478.67 | 2,186.0000 | 127,651,000 | 39.88% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 1386 | $479.55 | 800.0000 | 127,651,000 | 63.40% | 0.00% |
| Sept. 9, 2025 | Reitan Colleen F | Director | S | Common Stock | 25 | $480.98 | 775.0000 | 127,651,000 | 3.13% | 0.00% |
| Aug. 29, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 144 | $452.49 | 25,992.0000 | 127,651,000 | 0.55% | 0.00% |
| Aug. 29, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 195 | $445.53 | 29,271.0000 | 127,651,000 | 0.66% | 0.00% |
| Aug. 29, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 899 | $446.98 | 28,372.0000 | 127,651,000 | 3.07% | 0.00% |
| Aug. 29, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 1289 | $448.05 | 27,083.0000 | 127,651,000 | 4.54% | 0.00% |
| Aug. 29, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 681 | $449.54 | 26,402.0000 | 127,651,000 | 2.51% | 0.00% |
| Aug. 29, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 266 | $451.52 | 26,136.0000 | 127,651,000 | 1.01% | 0.00% |
| Aug. 18, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 536 | $452.96 | 51,475.0000 | 127,651,000 | 1.03% | 0.00% |
| Aug. 18, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 168 | $451.99 | 52,011.0000 | 127,651,000 | 0.32% | 0.00% |
| Aug. 18, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 63 | $450.92 | 52,179.0000 | 127,651,000 | 0.12% | 0.00% |
| Aug. 18, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 147 | $449.92 | 52,242.0000 | 127,651,000 | 0.28% | 0.00% |
| Aug. 18, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 63 | $447.98 | 52,389.0000 | 127,651,000 | 0.12% | 0.00% |
| Aug. 15, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 4644 | $0.00 | 52,452.0000 | 127,651,000 | 9.71% | 0.00% |
| Aug. 18, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 12 | $455.82 | 29,466.0000 | 127,651,000 | 0.04% | 0.00% |
| Aug. 18, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1646 | $452.96 | 60,608.0000 | 127,651,000 | 2.64% | 0.00% |
| Aug. 18, 2025 | BONNEY MICHAEL W | Director | M | Stock Option (right to buy) | 11250 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.01% |
| Aug. 18, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 11250 | $450.00 | 20,804.0000 | 127,651,000 | 35.10% | 0.01% |
| Aug. 18, 2025 | BONNEY MICHAEL W | Director | M | Common Stock | 11250 | $70.20 | 32,054.0000 | 127,651,000 | 54.08% | 0.01% |
| Aug. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 12 | $455.82 | 23,256.0000 | 127,651,000 | 0.05% | 0.00% |
| Aug. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 241 | $454.84 | 23,268.0000 | 127,651,000 | 1.03% | 0.00% |
| Aug. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 543 | $454.04 | 23,509.0000 | 127,651,000 | 2.26% | 0.00% |
| Aug. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 329 | $452.96 | 24,052.0000 | 127,651,000 | 1.35% | 0.00% |
| Aug. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 103 | $451.99 | 24,381.0000 | 127,651,000 | 0.42% | 0.00% |
| Aug. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 39 | $450.92 | 24,484.0000 | 127,651,000 | 0.16% | 0.00% |
| Aug. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 90 | $449.92 | 24,523.0000 | 127,651,000 | 0.37% | 0.00% |
| Aug. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 39 | $447.98 | 24,613.0000 | 127,651,000 | 0.16% | 0.00% |
| Aug. 15, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 2851 | $0.00 | 24,652.0000 | 127,651,000 | 13.08% | 0.00% |
| Aug. 18, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 60 | $455.82 | 56,628.0000 | 127,651,000 | 0.11% | 0.00% |
| Aug. 18, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1204 | $454.84 | 56,688.0000 | 127,651,000 | 2.08% | 0.00% |
| Aug. 18, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 2716 | $454.04 | 57,892.0000 | 127,651,000 | 4.48% | 0.00% |
| Aug. 18, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 514 | $451.99 | 62,254.0000 | 127,651,000 | 0.82% | 0.00% |
| Aug. 18, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 195 | $450.92 | 62,768.0000 | 127,651,000 | 0.31% | 0.00% |
| Aug. 18, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 450 | $449.92 | 62,963.0000 | 127,651,000 | 0.71% | 0.00% |
| Aug. 18, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 194 | $447.98 | 63,413.0000 | 127,651,000 | 0.30% | 0.00% |
| Aug. 15, 2025 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 14252 | $0.00 | 63,607.0000 | 127,651,000 | 28.88% | 0.01% |
| Aug. 18, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 19 | $455.82 | 50,178.0000 | 127,651,000 | 0.04% | 0.00% |
| Aug. 18, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 392 | $454.84 | 50,197.0000 | 127,651,000 | 0.77% | 0.00% |
| Aug. 18, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 886 | $454.04 | 50,589.0000 | 127,651,000 | 1.72% | 0.00% |
| Aug. 18, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 241 | $454.84 | 29,478.0000 | 127,651,000 | 0.81% | 0.00% |
| Aug. 18, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 543 | $454.04 | 29,719.0000 | 127,651,000 | 1.79% | 0.00% |
| Aug. 18, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 329 | $452.96 | 30,262.0000 | 127,651,000 | 1.08% | 0.00% |
| Aug. 18, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 103 | $451.99 | 30,591.0000 | 127,651,000 | 0.34% | 0.00% |
| Aug. 18, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 39 | $450.92 | 30,694.0000 | 127,651,000 | 0.13% | 0.00% |
| Aug. 18, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 90 | $449.92 | 30,733.0000 | 127,651,000 | 0.29% | 0.00% |
| Aug. 18, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 39 | $447.98 | 30,823.0000 | 127,651,000 | 0.13% | 0.00% |
| Aug. 15, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 2851 | $0.00 | 30,862.0000 | 127,651,000 | 10.18% | 0.00% |
| Aug. 15, 2025 | Garg Pushkal | EVP Chief R&D | A | Common Stock | 2851 | $0.00 | 23,753.0000 | 127,651,000 | 13.64% | 0.00% |
| Aug. 19, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 45 | $461.74 | 20,902.0000 | 127,651,000 | 0.21% | 0.00% |
| Aug. 19, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 305 | $461.01 | 20,947.0000 | 127,651,000 | 1.44% | 0.00% |
| Aug. 19, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 260 | $459.59 | 21,252.0000 | 127,651,000 | 1.21% | 0.00% |
| Aug. 19, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 231 | $458.27 | 21,512.0000 | 127,651,000 | 1.06% | 0.00% |
| Aug. 19, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 338 | $457.26 | 21,743.0000 | 127,651,000 | 1.53% | 0.00% |
| Aug. 19, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 276 | $455.41 | 22,081.0000 | 127,651,000 | 1.23% | 0.00% |
| Aug. 18, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 12 | $455.82 | 22,357.0000 | 127,651,000 | 0.05% | 0.00% |
| Aug. 18, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 241 | $454.84 | 22,369.0000 | 127,651,000 | 1.07% | 0.00% |
| Aug. 18, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 543 | $454.04 | 22,610.0000 | 127,651,000 | 2.35% | 0.00% |
| Aug. 18, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 329 | $452.96 | 23,153.0000 | 127,651,000 | 1.40% | 0.00% |
| Aug. 18, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 103 | $451.99 | 23,482.0000 | 127,651,000 | 0.44% | 0.00% |
| Aug. 18, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 39 | $450.92 | 23,585.0000 | 127,651,000 | 0.17% | 0.00% |
| Aug. 18, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 90 | $449.92 | 23,624.0000 | 127,651,000 | 0.38% | 0.00% |
| Aug. 18, 2025 | Garg Pushkal | EVP Chief R&D | S | Common Stock | 39 | $447.98 | 23,714.0000 | 127,651,000 | 0.16% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 1938 | $432.94 | 31,936.0000 | 127,651,000 | 5.72% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 7675 | $435.40 | 22,163.0000 | 127,651,000 | 25.72% | 0.01% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Common Stock | 5153 | $128.31 | 18,564.0000 | 127,651,000 | 38.42% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 5358 | $436.00 | 16,805.0000 | 127,651,000 | 24.18% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 1922 | $437.56 | 14,883.0000 | 127,651,000 | 11.44% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Common Stock | 9000 | $72.01 | 13,411.0000 | 127,651,000 | 204.04% | 0.01% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 2098 | $434.50 | 29,838.0000 | 127,651,000 | 6.57% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Stock Option (right to buy) | 3454 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Stock Option (right to buy) | 4032 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Stock Option (right to buy) | 5228 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Stock Option (right to buy) | 4581 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 2086 | $438.34 | 12,797.0000 | 127,651,000 | 14.02% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 5302 | $439.27 | 7,495.0000 | 127,651,000 | 41.43% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 1238 | $440.54 | 6,257.0000 | 127,651,000 | 16.52% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 1205 | $441.88 | 5,052.0000 | 127,651,000 | 19.26% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 641 | $442.66 | 4,411.0000 | 127,651,000 | 12.69% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Stock Option (right to buy) | 9000 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.01% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Stock Option (right to buy) | 5153 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Common Stock | 4581 | $148.77 | 23,145.0000 | 127,651,000 | 24.68% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Common Stock | 5228 | $151.22 | 28,373.0000 | 127,651,000 | 22.59% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Common Stock | 4032 | $171.95 | 32,405.0000 | 127,651,000 | 14.21% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | M | Common Stock | 3454 | $189.87 | 35,859.0000 | 127,651,000 | 10.66% | 0.00% |
| Aug. 14, 2025 | Ausiello Dennis A | Director | S | Common Stock | 1985 | $430.81 | 33,874.0000 | 127,651,000 | 5.54% | 0.00% |
| July 1, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 7763 | $0.00 | 21,801.0000 | 127,651,000 | 55.30% | 0.01% |
| May 30, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 25469 | $304.00 | 55,526.0000 | 127,651,000 | 31.45% | 0.02% |
| June 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 12080 | $0.00 | 839.0000 | 127,651,000 | 93.51% | 0.01% |
| May 30, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 12081 | $0.00 | 12,919.0000 | 127,651,000 | 48.32% | 0.01% |
| June 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 7217 | $0.00 | 847.0000 | 127,651,000 | 89.50% | 0.01% |
| May 30, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 19559 | $0.00 | 8,064.0000 | 127,651,000 | 70.81% | 0.02% |
| June 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 19297 | $306.00 | 49,355.0000 | 127,651,000 | 28.11% | 0.02% |
| June 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 7217 | $118.05 | 68,652.0000 | 127,651,000 | 11.75% | 0.01% |
| June 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 12080 | $119.13 | 61,435.0000 | 127,651,000 | 24.48% | 0.01% |
| May 30, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 6171 | $306.00 | 49,355.0000 | 127,651,000 | 11.11% | 0.00% |
| May 30, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 19559 | $118.05 | 80,995.0000 | 127,651,000 | 31.84% | 0.02% |
| May 30, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 12081 | $119.13 | 61,436.0000 | 127,651,000 | 24.48% | 0.01% |
| May 15, 2025 | BONNEY MICHAEL W | Director | M | Common Stock | 11250 | $131.21 | 32,054.0000 | 127,651,000 | 54.08% | 0.01% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 549 | $267.14 | 31,505.0000 | 127,651,000 | 1.71% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 729 | $268.56 | 30,776.0000 | 127,651,000 | 2.31% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 245 | $269.79 | 30,531.0000 | 127,651,000 | 0.80% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 431 | $271.68 | 30,100.0000 | 127,651,000 | 1.41% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 660 | $273.16 | 29,440.0000 | 127,651,000 | 2.19% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 882 | $273.75 | 28,558.0000 | 127,651,000 | 3.00% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 301 | $275.63 | 28,257.0000 | 127,651,000 | 1.05% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 1263 | $277.16 | 26,994.0000 | 127,651,000 | 4.47% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 1239 | $278.01 | 25,755.0000 | 127,651,000 | 4.59% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 432 | $280.03 | 25,323.0000 | 127,651,000 | 1.68% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 372 | $281.10 | 24,951.0000 | 127,651,000 | 1.47% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 802 | $282.03 | 24,149.0000 | 127,651,000 | 3.21% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 1728 | $282.81 | 22,421.0000 | 127,651,000 | 7.16% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | S | Common Stock | 1617 | $283.83 | 20,804.0000 | 127,651,000 | 7.21% | 0.00% |
| May 15, 2025 | BONNEY MICHAEL W | Director | M | Stock Option (right to buy) | 11250 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.01% |
| May 16, 2025 | Greenstreet Yvonne | Chief Executive Officer | G | Common Stock | 8376 | $0.00 | 49,355.0000 | 127,651,000 | 14.51% | 0.01% |
| April 16, 2025 | Reitan Colleen F | Director | S | Common Stock | 36 | $232.86 | 0.0000 | 127,651,000 | 100.00% | 0.00% |
| May 8, 2025 | Ausiello Dennis A | Director | A | Common Stock | 775 | $0.00 | 4,411.0000 | 127,651,000 | 21.31% | 0.00% |
| May 8, 2025 | Ausiello Dennis A | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | BONNEY MICHAEL W | Director | A | Common Stock | 775 | $0.00 | 20,804.0000 | 127,651,000 | 3.87% | 0.00% |
| May 8, 2025 | BONNEY MICHAEL W | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | BRANDICOURT OLIVIER | Director | A | Common Stock | 775 | $0.00 | 775.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | BRANDICOURT OLIVIER | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | HAMBURG MARGARET A | Director | A | Common Stock | 775 | $0.00 | 911.0000 | 127,651,000 | 569.85% | 0.00% |
| May 8, 2025 | HAMBURG MARGARET A | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | KELLOGG PETER N | Director | A | Common Stock | 775 | $0.00 | 775.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | KELLOGG PETER N | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | PYOTT DAVID E I | Director | A | Common Stock | 775 | $0.00 | 28,811.0000 | 127,651,000 | 2.76% | 0.00% |
| May 8, 2025 | PYOTT DAVID E I | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| Aug. 29, 2024 | Reitan Colleen F | Director | P | Common Stock | 32 | $286.00 | 32.0000 | 124,906,000 | 9999.99% | 0.00% |
| Oct. 17, 2024 | Reitan Colleen F | Director | P | Common Stock | 4 | $302.67 | 36.0000 | 128,590,000 | 12.50% | 0.00% |
| May 8, 2025 | Reitan Colleen F | Director | A | Common Stock | 775 | $0.00 | 775.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | Reitan Colleen F | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | SCHULMAN AMY W | Director | A | Common Stock | 775 | $0.00 | 11,961.0000 | 127,651,000 | 6.93% | 0.00% |
| May 8, 2025 | SCHULMAN AMY W | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | Sigal Charles Elliott | Director | A | Common Stock | 775 | $0.00 | 2,775.0000 | 127,651,000 | 38.75% | 0.00% |
| May 8, 2025 | Sigal Charles Elliott | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | Bertozzi Carolyn R | Director | A | Common Stock | 775 | $0.00 | 775.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 8, 2025 | Bertozzi Carolyn R | Director | A | Stock Option (right to buy) | 1558 | $0.00 | 1,558.0000 | 127,651,000 | 9999.99% | 0.00% |
| May 2, 2025 | Greenstreet Yvonne | Chief Executive Officer | G | Common Stock | 41311 | $0.00 | 57,731.0000 | 127,651,000 | 41.71% | 0.03% |
| March 24, 2025 | PYOTT DAVID E I | Director | S | Common Stock | 7440 | $299.00 | 28,036.0000 | 127,651,000 | 20.97% | 0.01% |
| March 24, 2025 | PYOTT DAVID E I | Director | M | Stock Option (right to buy) | 7440 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.01% |
| March 21, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 4321 | $285.00 | 20,902.0000 | 127,651,000 | 17.13% | 0.00% |
| March 24, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Stock Option (right to buy) | 5445 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.00% |
| March 24, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 5445 | $300.00 | 20,902.0000 | 127,651,000 | 20.67% | 0.00% |
| March 24, 2025 | PYOTT DAVID E I | Director | M | Common Stock | 7440 | $88.95 | 35,476.0000 | 127,651,000 | 26.54% | 0.01% |
| March 24, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Common Stock | 5445 | $42.22 | 26,347.0000 | 127,651,000 | 26.05% | 0.00% |
| March 13, 2025 | SCHULMAN AMY W | Director | M | Common Stock | 2750 | $131.21 | 11,186.0000 | 127,651,000 | 32.60% | 0.00% |
| March 13, 2025 | SCHULMAN AMY W | Director | M | Stock Option (right to buy) | 2750 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 1 | $248.36 | 16,053.0000 | 127,651,000 | 0.01% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 465 | $242.69 | 15,588.0000 | 127,651,000 | 2.90% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 487 | $243.94 | 15,101.0000 | 127,651,000 | 3.12% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 219 | $245.30 | 14,882.0000 | 127,651,000 | 1.45% | 0.00% |
| March 4, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 121 | $239.24 | 14,761.0000 | 127,651,000 | 0.81% | 0.00% |
| March 4, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 328 | $240.95 | 14,433.0000 | 127,651,000 | 2.22% | 0.00% |
| March 4, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 324 | $241.68 | 14,109.0000 | 127,651,000 | 2.24% | 0.00% |
| March 4, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 71 | $242.93 | 14,038.0000 | 127,651,000 | 0.50% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Stock Option (right to buy) | 7819 | $0.00 | 7,819.0000 | 127,651,000 | 9999.99% | 0.01% |
| March 3, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 14137 | $0.00 | 28,482.0000 | 127,651,000 | 98.55% | 0.01% |
| March 3, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 131 | $242.37 | 28,351.0000 | 127,651,000 | 0.46% | 0.00% |
| March 3, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 142 | $243.36 | 28,209.0000 | 127,651,000 | 0.50% | 0.00% |
| March 3, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 96 | $244.41 | 28,113.0000 | 127,651,000 | 0.34% | 0.00% |
| March 3, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 70 | $245.26 | 28,043.0000 | 127,651,000 | 0.25% | 0.00% |
| March 3, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 29 | $246.18 | 28,014.0000 | 127,651,000 | 0.10% | 0.00% |
| March 3, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 3 | $247.35 | 28,011.0000 | 127,651,000 | 0.01% | 0.00% |
| March 3, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Stock Option (right to buy) | 7819 | $0.00 | 7,819.0000 | 127,651,000 | 9999.99% | 0.01% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Common Stock | 14137 | $0.00 | 27,780.0000 | 127,651,000 | 103.62% | 0.01% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 213 | $242.37 | 27,567.0000 | 127,651,000 | 0.77% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 235 | $243.36 | 27,332.0000 | 127,651,000 | 0.85% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 158 | $244.41 | 27,174.0000 | 127,651,000 | 0.58% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 116 | $245.26 | 27,058.0000 | 127,651,000 | 0.43% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 48 | $246.18 | 27,010.0000 | 127,651,000 | 0.18% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 5 | $247.35 | 27,005.0000 | 127,651,000 | 0.02% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 1 | $248.36 | 27,004.0000 | 127,651,000 | 0.00% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 583 | $243.13 | 26,421.0000 | 127,651,000 | 2.16% | 0.00% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | A | Stock Option (right to buy) | 36293 | $0.00 | 36,293.0000 | 127,651,000 | 9999.99% | 0.03% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 273 | $244.43 | 26,148.0000 | 127,651,000 | 1.03% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 117 | $245.53 | 26,031.0000 | 127,651,000 | 0.45% | 0.00% |
| March 4, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 147 | $239.25 | 25,884.0000 | 127,651,000 | 0.56% | 0.00% |
| March 4, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 343 | $240.92 | 25,541.0000 | 127,651,000 | 1.33% | 0.00% |
| March 4, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 198 | $241.60 | 25,343.0000 | 127,651,000 | 0.78% | 0.00% |
| March 4, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 120 | $242.70 | 25,223.0000 | 127,651,000 | 0.47% | 0.00% |
| March 3, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Stock Option (right to buy) | 7819 | $0.00 | 7,819.0000 | 127,651,000 | 9999.99% | 0.01% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 15117 | $0.00 | 49,072.0000 | 127,651,000 | 44.52% | 0.01% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 350 | $242.37 | 48,722.0000 | 127,651,000 | 0.71% | 0.00% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 382 | $243.36 | 48,340.0000 | 127,651,000 | 0.78% | 0.00% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 258 | $244.41 | 48,082.0000 | 127,651,000 | 0.53% | 0.00% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 189 | $245.26 | 47,893.0000 | 127,651,000 | 0.39% | 0.00% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 77 | $246.18 | 47,816.0000 | 127,651,000 | 0.16% | 0.00% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 7 | $247.35 | 47,809.0000 | 127,651,000 | 0.01% | 0.00% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 1 | $248.36 | 47,808.0000 | 127,651,000 | 0.00% | 0.00% |
| March 3, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Stock Option (right to buy) | 9800 | $0.00 | 9,800.0000 | 127,651,000 | 9999.99% | 0.01% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 17965 | $0.00 | 102,919.0000 | 127,651,000 | 21.15% | 0.01% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1068 | $242.37 | 101,851.0000 | 127,651,000 | 1.04% | 0.00% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1173 | $243.36 | 100,678.0000 | 127,651,000 | 1.15% | 0.00% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 791 | $244.41 | 99,887.0000 | 127,651,000 | 0.79% | 0.00% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 580 | $245.26 | 99,307.0000 | 127,651,000 | 0.58% | 0.00% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 238 | $246.18 | 99,069.0000 | 127,651,000 | 0.24% | 0.00% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 4 | $248.36 | 99,042.0000 | 127,651,000 | 0.00% | 0.00% |
| March 3, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 23 | $247.35 | 99,046.0000 | 127,651,000 | 0.02% | 0.00% |
| March 3, 2025 | Hesslein Robert W. | EVP, CLO and Secretary | A | Common Stock | 757 | $0.00 | 8,002.0000 | 127,651,000 | 10.45% | 0.00% |
| March 3, 2025 | Hesslein Robert W. | EVP, CLO and Secretary | A | Stock Option (right to buy) | 1529 | $0.00 | 1,529.0000 | 127,651,000 | 9999.99% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 3871 | $0.00 | 16,793.0000 | 127,651,000 | 29.96% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 204 | $242.37 | 16,589.0000 | 127,651,000 | 1.21% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 224 | $243.36 | 16,365.0000 | 127,651,000 | 1.35% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 151 | $244.41 | 16,214.0000 | 127,651,000 | 0.92% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 111 | $245.26 | 16,103.0000 | 127,651,000 | 0.68% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 45 | $246.18 | 16,058.0000 | 127,651,000 | 0.28% | 0.00% |
| March 3, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 4 | $247.35 | 16,054.0000 | 127,651,000 | 0.02% | 0.00% |
| Feb. 28, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 123 | $238.33 | 87,573.0000 | 127,651,000 | 0.14% | 0.00% |
| Feb. 27, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 5921 | $0.00 | 87,854.0000 | 127,651,000 | 7.23% | 0.00% |
| Feb. 28, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 158 | $236.51 | 87,696.0000 | 127,651,000 | 0.18% | 0.00% |
| Feb. 28, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 127 | $239.18 | 87,446.0000 | 127,651,000 | 0.15% | 0.00% |
| Feb. 28, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 284 | $240.32 | 87,162.0000 | 127,651,000 | 0.32% | 0.00% |
| Feb. 28, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 461 | $241.51 | 86,701.0000 | 127,651,000 | 0.53% | 0.00% |
| Feb. 28, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1093 | $242.44 | 85,608.0000 | 127,651,000 | 1.26% | 0.00% |
| Feb. 28, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 440 | $243.23 | 85,168.0000 | 127,651,000 | 0.51% | 0.00% |
| Feb. 28, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 214 | $244.11 | 84,954.0000 | 127,651,000 | 0.25% | 0.00% |
| Feb. 27, 2025 | Greenstreet Yvonne | Chief Executive Officer | M | Restricted Stock Units | 5921 | $0.00 | 5,921.0000 | 127,651,000 | 50.00% | 0.00% |
| Feb. 27, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | M | Common Stock | 1908 | $0.00 | 34,751.0000 | 127,651,000 | 5.81% | 0.00% |
| Feb. 28, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 42 | $236.51 | 34,709.0000 | 127,651,000 | 0.12% | 0.00% |
| Feb. 28, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 34 | $238.33 | 34,675.0000 | 127,651,000 | 0.10% | 0.00% |
| Feb. 28, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 35 | $239.18 | 34,640.0000 | 127,651,000 | 0.10% | 0.00% |
| Feb. 28, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 78 | $240.32 | 34,562.0000 | 127,651,000 | 0.23% | 0.00% |
| Feb. 28, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 127 | $241.51 | 34,435.0000 | 127,651,000 | 0.37% | 0.00% |
| Feb. 28, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 300 | $242.44 | 34,135.0000 | 127,651,000 | 0.87% | 0.00% |
| Feb. 28, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 121 | $243.23 | 34,014.0000 | 127,651,000 | 0.35% | 0.00% |
| Feb. 28, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 59 | $244.11 | 33,955.0000 | 127,651,000 | 0.17% | 0.00% |
| Feb. 27, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | M | Restricted Stock Units | 1908 | $0.00 | 1,908.0000 | 127,651,000 | 50.00% | 0.00% |
| Feb. 27, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | M | Common Stock | 1667 | $0.00 | 14,858.0000 | 127,651,000 | 12.64% | 0.00% |
| Feb. 28, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 28 | $236.51 | 14,830.0000 | 127,651,000 | 0.19% | 0.00% |
| Feb. 28, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 22 | $238.33 | 14,808.0000 | 127,651,000 | 0.15% | 0.00% |
| Feb. 28, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 23 | $239.18 | 14,785.0000 | 127,651,000 | 0.16% | 0.00% |
| Feb. 28, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 50 | $240.32 | 14,735.0000 | 127,651,000 | 0.34% | 0.00% |
| Feb. 28, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 82 | $241.51 | 14,653.0000 | 127,651,000 | 0.56% | 0.00% |
| Feb. 28, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 192 | $242.44 | 14,461.0000 | 127,651,000 | 1.31% | 0.00% |
| Feb. 28, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 78 | $243.23 | 14,383.0000 | 127,651,000 | 0.54% | 0.00% |
| Feb. 28, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 38 | $244.11 | 14,345.0000 | 127,651,000 | 0.26% | 0.00% |
| Feb. 27, 2025 | Tanguler Tolga | EVP, Chief Commercial Officer | M | Restricted Stock Units | 1667 | $0.00 | 1,666.0000 | 127,651,000 | 50.02% | 0.00% |
| Feb. 27, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Common Stock | 1908 | $0.00 | 14,578.0000 | 127,651,000 | 15.06% | 0.00% |
| Feb. 28, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 51 | $236.51 | 14,527.0000 | 127,651,000 | 0.35% | 0.00% |
| Feb. 28, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 40 | $238.33 | 14,487.0000 | 127,651,000 | 0.28% | 0.00% |
| Feb. 28, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 41 | $239.18 | 14,446.0000 | 127,651,000 | 0.28% | 0.00% |
| Feb. 28, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 91 | $240.32 | 14,355.0000 | 127,651,000 | 0.63% | 0.00% |
| Feb. 28, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 149 | $241.51 | 14,206.0000 | 127,651,000 | 1.04% | 0.00% |
| Feb. 28, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 352 | $242.44 | 13,854.0000 | 127,651,000 | 2.48% | 0.00% |
| Feb. 28, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 142 | $243.23 | 13,712.0000 | 127,651,000 | 1.02% | 0.00% |
| Feb. 28, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 69 | $244.11 | 13,643.0000 | 127,651,000 | 0.50% | 0.00% |
| Feb. 27, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Restricted Stock Units | 1908 | $0.00 | 1,908.0000 | 127,651,000 | 50.00% | 0.00% |
| Feb. 28, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 27 | $236.51 | 13,391.0000 | 127,651,000 | 0.20% | 0.00% |
| Feb. 28, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 21 | $238.33 | 13,370.0000 | 127,651,000 | 0.16% | 0.00% |
| Feb. 28, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 22 | $239.18 | 13,348.0000 | 127,651,000 | 0.16% | 0.00% |
| Feb. 28, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 48 | $240.32 | 13,300.0000 | 127,651,000 | 0.36% | 0.00% |
| Feb. 28, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 79 | $241.51 | 13,221.0000 | 127,651,000 | 0.59% | 0.00% |
| Feb. 28, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 187 | $242.44 | 13,034.0000 | 127,651,000 | 1.41% | 0.00% |
| Feb. 28, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 75 | $243.23 | 12,959.0000 | 127,651,000 | 0.58% | 0.00% |
| Feb. 28, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 37 | $244.11 | 12,922.0000 | 127,651,000 | 0.29% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 239 | $253.37 | 33,354.0000 | 127,651,000 | 0.71% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 110 | $255.56 | 14,676.0000 | 127,651,000 | 0.74% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 126 | $256.29 | 14,550.0000 | 127,651,000 | 0.86% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 60 | $257.51 | 14,490.0000 | 127,651,000 | 0.41% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 77 | $258.07 | 14,413.0000 | 127,651,000 | 0.53% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 27 | $259.72 | 14,386.0000 | 127,651,000 | 0.19% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 49 | $260.57 | 14,337.0000 | 127,651,000 | 0.34% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 60 | $261.45 | 14,277.0000 | 127,651,000 | 0.42% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 27 | $263.33 | 14,250.0000 | 127,651,000 | 0.19% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 32 | $264.87 | 14,218.0000 | 127,651,000 | 0.22% | 0.00% |
| Feb. 18, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 862 | $250.11 | 13,356.0000 | 127,651,000 | 6.06% | 0.00% |
| Feb. 18, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 306 | $250.73 | 13,050.0000 | 127,651,000 | 2.29% | 0.00% |
| Feb. 18, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 110 | $251.60 | 12,940.0000 | 127,651,000 | 0.84% | 0.00% |
| Feb. 18, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 83 | $256.05 | 12,857.0000 | 127,651,000 | 0.64% | 0.00% |
| Feb. 18, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 107 | $257.99 | 12,750.0000 | 127,651,000 | 0.83% | 0.00% |
| Feb. 18, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 80 | $259.10 | 12,670.0000 | 127,651,000 | 0.63% | 0.00% |
| Feb. 13, 2025 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 3859 | $0.00 | 83,146.0000 | 127,651,000 | 4.87% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 271 | $252.50 | 82,875.0000 | 127,651,000 | 0.33% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 300 | $253.37 | 82,575.0000 | 127,651,000 | 0.36% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 201 | $254.35 | 82,374.0000 | 127,651,000 | 0.24% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 85 | $255.56 | 82,289.0000 | 127,651,000 | 0.10% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 98 | $256.29 | 82,191.0000 | 127,651,000 | 0.12% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 47 | $257.51 | 82,144.0000 | 127,651,000 | 0.06% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 59 | $258.07 | 82,085.0000 | 127,651,000 | 0.07% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 21 | $259.72 | 82,064.0000 | 127,651,000 | 0.03% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 38 | $260.57 | 82,026.0000 | 127,651,000 | 0.05% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 47 | $261.45 | 81,979.0000 | 127,651,000 | 0.06% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 21 | $263.33 | 81,958.0000 | 127,651,000 | 0.03% | 0.00% |
| Feb. 14, 2025 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 25 | $264.87 | 81,933.0000 | 127,651,000 | 0.03% | 0.00% |
| Feb. 13, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 3109 | $0.00 | 33,810.0000 | 127,651,000 | 10.13% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 217 | $252.50 | 33,593.0000 | 127,651,000 | 0.64% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 160 | $254.35 | 33,194.0000 | 127,651,000 | 0.48% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 68 | $255.56 | 33,126.0000 | 127,651,000 | 0.20% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 78 | $256.29 | 33,048.0000 | 127,651,000 | 0.24% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 37 | $257.51 | 33,011.0000 | 127,651,000 | 0.11% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 47 | $258.07 | 32,964.0000 | 127,651,000 | 0.14% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 17 | $259.72 | 32,947.0000 | 127,651,000 | 0.05% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 30 | $260.57 | 32,917.0000 | 127,651,000 | 0.09% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 37 | $261.45 | 32,880.0000 | 127,651,000 | 0.11% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 17 | $263.33 | 32,863.0000 | 127,651,000 | 0.05% | 0.00% |
| Feb. 14, 2025 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 20 | $264.87 | 32,843.0000 | 127,651,000 | 0.06% | 0.00% |
| Feb. 13, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 2103 | $0.00 | 15,521.0000 | 127,651,000 | 15.67% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 145 | $252.50 | 15,376.0000 | 127,651,000 | 0.93% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 164 | $253.37 | 15,212.0000 | 127,651,000 | 1.07% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 110 | $254.35 | 15,102.0000 | 127,651,000 | 0.72% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 47 | $255.56 | 15,055.0000 | 127,651,000 | 0.31% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 53 | $256.29 | 15,002.0000 | 127,651,000 | 0.35% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 26 | $257.51 | 14,976.0000 | 127,651,000 | 0.17% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 33 | $258.07 | 14,943.0000 | 127,651,000 | 0.22% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 12 | $259.72 | 14,931.0000 | 127,651,000 | 0.08% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 21 | $260.57 | 14,910.0000 | 127,651,000 | 0.14% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 26 | $261.45 | 14,884.0000 | 127,651,000 | 0.17% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 12 | $263.33 | 14,872.0000 | 127,651,000 | 0.08% | 0.00% |
| Feb. 14, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 14 | $264.87 | 14,858.0000 | 127,651,000 | 0.09% | 0.00% |
| Feb. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 1086 | $250.21 | 13,772.0000 | 127,651,000 | 7.31% | 0.00% |
| Feb. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 115 | $251.60 | 13,657.0000 | 127,651,000 | 0.84% | 0.00% |
| Feb. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 80 | $256.05 | 13,577.0000 | 127,651,000 | 0.59% | 0.00% |
| Feb. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 76 | $257.79 | 13,501.0000 | 127,651,000 | 0.56% | 0.00% |
| Feb. 18, 2025 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 83 | $259.10 | 13,418.0000 | 127,651,000 | 0.61% | 0.00% |
| Feb. 13, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Common Stock | 3109 | $0.00 | 15,779.0000 | 127,651,000 | 24.54% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 349 | $252.50 | 15,430.0000 | 127,651,000 | 2.21% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 386 | $253.37 | 15,044.0000 | 127,651,000 | 2.50% | 0.00% |
| Feb. 14, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 258 | $254.35 | 14,786.0000 | 127,651,000 | 1.71% | 0.00% |
| Jan. 27, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Performance Stock Option 2015 (right to buy) | 25000 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.02% |
| Jan. 27, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Common Stock | 25000 | $88.95 | 65,262.0000 | 127,651,000 | 62.09% | 0.02% |
| Jan. 27, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 52592 | $285.00 | 12,670.0000 | 127,651,000 | 80.59% | 0.04% |
| Jan. 27, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Stock Option (right to buy) | 23876 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.02% |
| Jan. 27, 2025 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Common Stock | 23876 | $88.95 | 40,262.0000 | 127,651,000 | 145.71% | 0.02% |
| Jan. 23, 2025 | SHARP PHILLIP A | Director | M | Stock Option (right to buy) | 11250 | $0.00 | 0.0000 | 127,651,000 | 100.00% | 0.01% |
| Jan. 23, 2025 | SHARP PHILLIP A | Director | S | Common Stock | 11250 | $275.00 | 266,899.0000 | 127,651,000 | 4.04% | 0.01% |
| Jan. 23, 2025 | SHARP PHILLIP A | Director | M | Common Stock | 11250 | $131.21 | 278,149.0000 | 127,651,000 | 4.22% | 0.01% |
| Dec. 12, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 121 | $247.48 | 18,017.0000 | 128,590,000 | 0.67% | 0.00% |
| Dec. 12, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 140 | $254.37 | 16,387.0000 | 128,590,000 | 0.85% | 0.00% |
| Dec. 12, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 100 | $252.94 | 16,527.0000 | 128,590,000 | 0.60% | 0.00% |
| Dec. 12, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 1 | $255.80 | 16,386.0000 | 128,590,000 | 0.01% | 0.00% |
| Dec. 12, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 186 | $248.99 | 17,831.0000 | 128,590,000 | 1.03% | 0.00% |
| Dec. 12, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 426 | $250.08 | 17,405.0000 | 128,590,000 | 2.39% | 0.00% |
| Dec. 12, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 778 | $251.68 | 16,627.0000 | 128,590,000 | 4.47% | 0.00% |
| Nov. 26, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 945 | $251.42 | 30,798.0000 | 128,590,000 | 2.98% | 0.00% |
| Nov. 27, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 110 | $254.48 | 13,418.0000 | 128,590,000 | 0.81% | 0.00% |
| Nov. 27, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 360 | $253.44 | 13,528.0000 | 128,590,000 | 2.59% | 0.00% |
| Nov. 27, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 851 | $251.98 | 13,888.0000 | 128,590,000 | 5.77% | 0.00% |
| Nov. 27, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 210 | $250.45 | 14,739.0000 | 128,590,000 | 1.40% | 0.00% |
| Nov. 26, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 84 | $252.27 | 14,949.0000 | 128,590,000 | 0.56% | 0.00% |
| Nov. 26, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 826 | $251.42 | 15,033.0000 | 128,590,000 | 5.21% | 0.00% |
| Nov. 26, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 318 | $250.68 | 15,859.0000 | 128,590,000 | 1.97% | 0.00% |
| Nov. 26, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 215 | $249.60 | 16,177.0000 | 128,590,000 | 1.31% | 0.00% |
| Nov. 26, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 26 | $247.77 | 16,392.0000 | 128,590,000 | 0.16% | 0.00% |
| Nov. 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 3000 | $0.00 | 16,418.0000 | 128,590,000 | 22.36% | 0.00% |
| Nov. 26, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 84 | $252.27 | 13,191.0000 | 128,590,000 | 0.63% | 0.00% |
| Nov. 26, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 826 | $251.42 | 13,275.0000 | 128,590,000 | 5.86% | 0.00% |
| Nov. 26, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 318 | $250.68 | 14,101.0000 | 128,590,000 | 2.21% | 0.00% |
| Nov. 26, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 215 | $249.60 | 14,419.0000 | 128,590,000 | 1.47% | 0.00% |
| Nov. 26, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 26 | $247.77 | 14,634.0000 | 128,590,000 | 0.18% | 0.00% |
| Nov. 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 3000 | $0.00 | 14,660.0000 | 128,590,000 | 25.73% | 0.00% |
| Nov. 26, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 97 | $252.27 | 30,701.0000 | 128,590,000 | 0.31% | 0.00% |
| Nov. 26, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 364 | $250.68 | 31,743.0000 | 128,590,000 | 1.13% | 0.00% |
| Nov. 26, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 246 | $249.60 | 32,107.0000 | 128,590,000 | 0.76% | 0.00% |
| Nov. 26, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 30 | $247.77 | 32,353.0000 | 128,590,000 | 0.09% | 0.00% |
| Nov. 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 3434 | $0.00 | 32,383.0000 | 128,590,000 | 11.86% | 0.00% |
| Nov. 26, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 97 | $252.27 | 18,138.0000 | 128,590,000 | 0.53% | 0.00% |
| Nov. 26, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 945 | $251.42 | 18,235.0000 | 128,590,000 | 4.93% | 0.00% |
| Nov. 26, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 364 | $250.68 | 19,180.0000 | 128,590,000 | 1.86% | 0.00% |
| Nov. 26, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 246 | $249.60 | 19,544.0000 | 128,590,000 | 1.24% | 0.00% |
| Nov. 26, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 30 | $247.77 | 19,790.0000 | 128,590,000 | 0.15% | 0.00% |
| Nov. 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Common Stock | 3434 | $0.00 | 19,820.0000 | 128,590,000 | 20.96% | 0.00% |
| Nov. 26, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 300 | $252.27 | 79,287.0000 | 128,590,000 | 0.38% | 0.00% |
| Nov. 26, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 2933 | $251.42 | 79,587.0000 | 128,590,000 | 3.55% | 0.00% |
| Nov. 26, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1131 | $250.68 | 82,520.0000 | 128,590,000 | 1.35% | 0.00% |
| Nov. 26, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 762 | $249.60 | 83,651.0000 | 128,590,000 | 0.90% | 0.00% |
| Nov. 26, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 93 | $247.77 | 84,413.0000 | 128,590,000 | 0.11% | 0.00% |
| Nov. 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 10658 | $0.00 | 84,506.0000 | 128,590,000 | 14.43% | 0.01% |
| Oct. 8, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Common Stock | 96 | $0.00 | 16,386.0000 | 128,590,000 | 0.59% | 0.00% |
| Oct. 1, 2024 | Hesslein Robert W. | EVP, CLO and Secretary | A | Common Stock | 7245 | $0.00 | 7,245.0000 | 128,590,000 | 9999.99% | 0.01% |
| Aug. 20, 2024 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 15000 | $0.00 | 2,352.0000 | 124,906,000 | 86.45% | 0.01% |
| Aug. 20, 2024 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 15000 | $85.00 | 88,848.0000 | 124,906,000 | 20.31% | 0.01% |
| Aug. 20, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 15000 | $280.00 | 73,848.0000 | 124,906,000 | 16.88% | 0.01% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 5736 | $271.32 | 18,624.0000 | 124,906,000 | 23.55% | 0.00% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 3913 | $272.43 | 14,711.0000 | 124,906,000 | 21.01% | 0.00% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 1158 | $273.73 | 13,553.0000 | 124,906,000 | 7.87% | 0.00% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 135 | $274.65 | 13,418.0000 | 124,906,000 | 1.00% | 0.00% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | M | Stock Option (right to buy) | 6667 | $0.00 | 0.0000 | 124,906,000 | 100.00% | 0.01% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | M | Stock Option (right to buy) | 14058 | $0.00 | 2,192.0000 | 124,906,000 | 86.51% | 0.01% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | M | Common Stock | 6667 | $97.72 | 21,385.0000 | 124,906,000 | 45.30% | 0.01% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | M | Common Stock | 14058 | $85.00 | 35,443.0000 | 124,906,000 | 65.74% | 0.01% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 1421 | $268.66 | 34,022.0000 | 124,906,000 | 4.01% | 0.00% |
| Aug. 12, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 9662 | $270.17 | 24,360.0000 | 124,906,000 | 28.40% | 0.01% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | M | Stock Option (right to buy) | 9000 | $0.00 | 0.0000 | 124,906,000 | 100.00% | 0.01% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | M | Common Stock | 11250 | $131.21 | 14,886.0000 | 124,906,000 | 309.41% | 0.01% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | M | Common Stock | 9000 | $105.26 | 23,886.0000 | 124,906,000 | 60.46% | 0.01% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | S | Common Stock | 1627 | $259.56 | 22,259.0000 | 124,906,000 | 6.81% | 0.00% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | S | Common Stock | 3742 | $260.40 | 18,517.0000 | 124,906,000 | 16.81% | 0.00% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | S | Common Stock | 6212 | $261.63 | 12,305.0000 | 124,906,000 | 33.55% | 0.00% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | S | Common Stock | 4367 | $262.79 | 7,938.0000 | 124,906,000 | 35.49% | 0.00% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | S | Common Stock | 3408 | $263.72 | 4,530.0000 | 124,906,000 | 42.93% | 0.00% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | S | Common Stock | 632 | $264.95 | 3,898.0000 | 124,906,000 | 13.95% | 0.00% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | S | Common Stock | 262 | $266.45 | 3,636.0000 | 124,906,000 | 6.72% | 0.00% |
| Aug. 6, 2024 | Ausiello Dennis A | Director | M | Stock Option (right to buy) | 11250 | $0.00 | 0.0000 | 124,906,000 | 100.00% | 0.01% |
| Aug. 1, 2024 | Greenstreet Yvonne | Chief Executive Officer | M | Stock Option (right to buy) | 15148 | $0.00 | 17,352.0000 | 124,906,000 | 46.61% | 0.01% |
| Aug. 1, 2024 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 15148 | $85.00 | 88,996.0000 | 124,906,000 | 20.51% | 0.01% |
| Aug. 1, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 15148 | $270.00 | 73,848.0000 | 124,906,000 | 17.02% | 0.01% |
| July 11, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 7093 | $261.00 | 73,848.0000 | 124,906,000 | 8.76% | 0.01% |
| June 25, 2024 | SCHULMAN AMY W | Director | S | Common Stock | 8500 | $240.00 | 8,436.0000 | 124,906,000 | 50.19% | 0.01% |
| June 25, 2024 | SCHULMAN AMY W | Director | M | Common Stock | 8500 | $131.21 | 16,936.0000 | 124,906,000 | 100.76% | 0.01% |
| June 25, 2024 | SCHULMAN AMY W | Director | M | Stock Option (right to buy) | 8500 | $0.00 | 2,750.0000 | 124,906,000 | 75.56% | 0.01% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 169 | $228.30 | 18,060.0000 | 124,906,000 | 0.93% | 0.00% |
| June 24, 2024 | PYOTT DAVID E I | Director | M | Common Stock | 17560 | $88.95 | 45,596.0000 | 124,906,000 | 62.63% | 0.01% |
| June 24, 2024 | PYOTT DAVID E I | Director | M | Common Stock | 7420 | $70.20 | 53,016.0000 | 124,906,000 | 16.27% | 0.01% |
| June 24, 2024 | PYOTT DAVID E I | Director | M | Common Stock | 7470 | $71.99 | 60,486.0000 | 124,906,000 | 14.09% | 0.01% |
| June 24, 2024 | PYOTT DAVID E I | Director | S | Common Stock | 17560 | $220.00 | 42,926.0000 | 124,906,000 | 29.03% | 0.01% |
| June 24, 2024 | PYOTT DAVID E I | Director | S | Common Stock | 7420 | $221.00 | 35,506.0000 | 124,906,000 | 17.29% | 0.01% |
| June 24, 2024 | PYOTT DAVID E I | Director | S | Common Stock | 7470 | $222.00 | 28,036.0000 | 124,906,000 | 21.04% | 0.01% |
| June 24, 2024 | PYOTT DAVID E I | Director | M | Stock Option (right to buy) | 7420 | $0.00 | 3,830.0000 | 124,906,000 | 65.96% | 0.01% |
| June 24, 2024 | PYOTT DAVID E I | Director | M | Stock Option (right to buy) | 7470 | $0.00 | 3,780.0000 | 124,906,000 | 66.40% | 0.01% |
| June 24, 2024 | PYOTT DAVID E I | Director | M | Stock Option (right to buy) | 17560 | $0.00 | 7,440.0000 | 124,906,000 | 70.24% | 0.01% |
| June 24, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Common Stock | 4295 | $0.00 | 18,393.0000 | 124,906,000 | 30.47% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 78 | $221.71 | 18,315.0000 | 124,906,000 | 0.42% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 17 | $224.17 | 18,298.0000 | 124,906,000 | 0.09% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 24 | $225.55 | 18,274.0000 | 124,906,000 | 0.13% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 45 | $226.82 | 18,229.0000 | 124,906,000 | 0.25% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 348 | $229.06 | 17,712.0000 | 124,906,000 | 1.93% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 398 | $229.93 | 17,314.0000 | 124,906,000 | 2.25% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 129 | $231.59 | 17,185.0000 | 124,906,000 | 0.75% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 283 | $232.54 | 16,902.0000 | 124,906,000 | 1.65% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 151 | $233.53 | 16,751.0000 | 124,906,000 | 0.89% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 242 | $234.66 | 16,509.0000 | 124,906,000 | 1.44% | 0.00% |
| June 25, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 219 | $235.19 | 16,290.0000 | 124,906,000 | 1.33% | 0.00% |
| June 24, 2024 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 16953 | $0.00 | 89,242.0000 | 124,906,000 | 23.45% | 0.01% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 308 | $221.71 | 88,934.0000 | 124,906,000 | 0.35% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 66 | $224.17 | 88,868.0000 | 124,906,000 | 0.07% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 93 | $225.55 | 88,775.0000 | 124,906,000 | 0.10% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 177 | $226.82 | 88,598.0000 | 124,906,000 | 0.20% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 666 | $228.30 | 87,932.0000 | 124,906,000 | 0.75% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1374 | $229.06 | 86,558.0000 | 124,906,000 | 1.56% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1572 | $229.93 | 84,986.0000 | 124,906,000 | 1.82% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 511 | $231.59 | 84,475.0000 | 124,906,000 | 0.60% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1119 | $232.54 | 83,356.0000 | 124,906,000 | 1.32% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 595 | $233.53 | 82,761.0000 | 124,906,000 | 0.71% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 957 | $234.66 | 81,804.0000 | 124,906,000 | 1.16% | 0.00% |
| June 25, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 863 | $235.19 | 80,941.0000 | 124,906,000 | 1.05% | 0.00% |
| June 24, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 3278 | $0.00 | 30,554.0000 | 124,906,000 | 12.02% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 59 | $221.71 | 30,495.0000 | 124,906,000 | 0.19% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 13 | $224.17 | 30,482.0000 | 124,906,000 | 0.04% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 18 | $225.55 | 30,464.0000 | 124,906,000 | 0.06% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 34 | $226.82 | 30,430.0000 | 124,906,000 | 0.11% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 129 | $228.30 | 30,301.0000 | 124,906,000 | 0.42% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 266 | $229.06 | 30,035.0000 | 124,906,000 | 0.88% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 304 | $229.93 | 29,731.0000 | 124,906,000 | 1.01% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 99 | $231.59 | 29,632.0000 | 124,906,000 | 0.33% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 216 | $232.54 | 29,416.0000 | 124,906,000 | 0.73% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 115 | $233.53 | 29,301.0000 | 124,906,000 | 0.39% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 185 | $234.66 | 29,116.0000 | 124,906,000 | 0.63% | 0.00% |
| June 25, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 167 | $235.19 | 28,949.0000 | 124,906,000 | 0.57% | 0.00% |
| June 24, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 3278 | $0.00 | 13,265.0000 | 124,906,000 | 32.82% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 59 | $221.71 | 13,206.0000 | 124,906,000 | 0.44% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 13 | $224.17 | 13,193.0000 | 124,906,000 | 0.10% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 18 | $225.55 | 13,175.0000 | 124,906,000 | 0.14% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 34 | $226.82 | 13,141.0000 | 124,906,000 | 0.26% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 129 | $228.30 | 13,012.0000 | 124,906,000 | 0.98% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 266 | $229.06 | 12,746.0000 | 124,906,000 | 2.04% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 304 | $229.93 | 12,442.0000 | 124,906,000 | 2.39% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 99 | $231.59 | 12,343.0000 | 124,906,000 | 0.80% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 216 | $232.54 | 12,127.0000 | 124,906,000 | 1.75% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 115 | $233.53 | 12,012.0000 | 124,906,000 | 0.95% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 185 | $234.66 | 11,827.0000 | 124,906,000 | 1.54% | 0.00% |
| June 25, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 167 | $235.19 | 11,660.0000 | 124,906,000 | 1.41% | 0.00% |
| June 24, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | A | Common Stock | 2498 | $0.00 | 15,916.0000 | 124,906,000 | 18.62% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 45 | $221.71 | 15,871.0000 | 124,906,000 | 0.28% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 9 | $224.17 | 15,862.0000 | 124,906,000 | 0.06% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 13 | $225.55 | 15,849.0000 | 124,906,000 | 0.08% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 26 | $226.82 | 15,823.0000 | 124,906,000 | 0.16% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 96 | $228.30 | 15,727.0000 | 124,906,000 | 0.61% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 198 | $229.06 | 15,529.0000 | 124,906,000 | 1.26% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 227 | $229.93 | 15,302.0000 | 124,906,000 | 1.46% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 74 | $231.59 | 15,228.0000 | 124,906,000 | 0.48% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 161 | $232.54 | 15,067.0000 | 124,906,000 | 1.06% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 86 | $233.53 | 14,981.0000 | 124,906,000 | 0.57% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 138 | $234.66 | 14,843.0000 | 124,906,000 | 0.92% | 0.00% |
| June 25, 2024 | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | S | Common Stock | 125 | $235.19 | 14,718.0000 | 124,906,000 | 0.84% | 0.00% |
| May 29, 2024 | SCHULMAN AMY W | Director | M | Common Stock | 30000 | $66.83 | 30,136.0000 | 124,906,000 | 9999.99% | 0.02% |
| May 29, 2024 | SCHULMAN AMY W | Director | S | Common Stock | 10121 | $148.21 | 20,015.0000 | 124,906,000 | 33.58% | 0.01% |
| May 29, 2024 | SCHULMAN AMY W | Director | S | Common Stock | 11516 | $148.93 | 8,499.0000 | 124,906,000 | 57.54% | 0.01% |
| May 29, 2024 | SCHULMAN AMY W | Director | S | Common Stock | 63 | $149.76 | 8,436.0000 | 124,906,000 | 0.74% | 0.00% |
| May 29, 2024 | SCHULMAN AMY W | Director | M | Stock Option (right to buy) | 30000 | $0.00 | 0.0000 | 124,906,000 | 100.00% | 0.02% |
| May 16, 2024 | BRANDICOURT OLIVIER | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | HAMBURG MARGARET A | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | Reitan Colleen F | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | BONNEY MICHAEL W | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | SCHULMAN AMY W | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | SHARP PHILLIP A | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | Ausiello Dennis A | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | PYOTT DAVID E I | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | KELLOGG PETER N | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | Bertozzi Carolyn R | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| May 16, 2024 | Sigal Charles Elliott | Director | A | Stock Option (right to buy) | 5228 | $0.00 | 5,228.0000 | 124,906,000 | 9999.99% | 0.00% |
| March 1, 2024 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 23754 | $0.00 | 72,289.0000 | 124,906,000 | 48.94% | 0.02% |
| March 1, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 4751 | $0.00 | 9,987.0000 | 124,906,000 | 90.74% | 0.00% |
| March 1, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Stock Option (right to buy) | 9279 | $0.00 | 9,279.0000 | 124,906,000 | 9999.99% | 0.01% |
| March 1, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Common Stock | 4751 | $0.00 | 14,098.0000 | 124,906,000 | 50.83% | 0.00% |
| March 1, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Stock Option (right to buy) | 9279 | $0.00 | 9,279.0000 | 124,906,000 | 9999.99% | 0.01% |
| March 1, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 7741 | $0.00 | 27,276.0000 | 124,906,000 | 39.63% | 0.01% |
| March 1, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Stock Option (right to buy) | 15118 | $0.00 | 15,118.0000 | 124,906,000 | 9999.99% | 0.01% |
| March 1, 2024 | Greenstreet Yvonne | Chief Executive Officer | A | Stock Option (right to buy) | 46394 | $0.00 | 46,394.0000 | 124,906,000 | 9999.99% | 0.04% |
| Feb. 29, 2024 | SHARP PHILLIP A | Director | S | Common Stock | 101 | $154.07 | 267,415.0000 | 124,906,000 | 0.04% | 0.00% |
| Feb. 29, 2024 | SHARP PHILLIP A | Director | M | Common Stock | 30000 | $59.25 | 296,899.0000 | 124,906,000 | 11.24% | 0.02% |
| Feb. 29, 2024 | SHARP PHILLIP A | Director | S | Common Stock | 13005 | $150.60 | 283,894.0000 | 124,906,000 | 4.38% | 0.01% |
| Feb. 29, 2024 | SHARP PHILLIP A | Director | S | Common Stock | 13557 | $151.43 | 270,337.0000 | 124,906,000 | 4.78% | 0.01% |
| Feb. 29, 2024 | SHARP PHILLIP A | Director | S | Common Stock | 915 | $152.40 | 269,422.0000 | 124,906,000 | 0.34% | 0.00% |
| Feb. 29, 2024 | SHARP PHILLIP A | Director | M | Stock Option (right to buy) | 30000 | $0.00 | 0.0000 | 124,906,000 | 100.00% | 0.02% |
| Feb. 29, 2024 | SHARP PHILLIP A | Director | S | Common Stock | 1906 | $153.62 | 267,516.0000 | 124,906,000 | 0.71% | 0.00% |
| Feb. 29, 2024 | SHARP PHILLIP A | Director | S | Common Stock | 516 | $156.54 | 266,899.0000 | 124,906,000 | 0.19% | 0.00% |
| Feb. 27, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Common Stock | 1908 | $0.00 | 9,921.0000 | 124,906,000 | 23.81% | 0.00% |
| Feb. 27, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | M | Restricted Stock Units | 1908 | $0.00 | 3,816.0000 | 124,906,000 | 33.33% | 0.00% |
| Feb. 27, 2024 | Greenstreet Yvonne | Chief Executive Officer | M | Common Stock | 5921 | $0.00 | 51,467.0000 | 124,906,000 | 13.00% | 0.00% |
| Feb. 28, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 1259 | $154.54 | 50,208.0000 | 124,906,000 | 2.45% | 0.00% |
| Feb. 28, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 993 | $155.45 | 49,215.0000 | 124,906,000 | 1.98% | 0.00% |
| Feb. 28, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 588 | $156.38 | 48,627.0000 | 124,906,000 | 1.19% | 0.00% |
| Feb. 28, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 84 | $157.30 | 48,543.0000 | 124,906,000 | 0.17% | 0.00% |
| Feb. 28, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 8 | $158.09 | 48,535.0000 | 124,906,000 | 0.02% | 0.00% |
| Feb. 27, 2024 | Greenstreet Yvonne | Chief Executive Officer | M | Restricted Stock Units | 5921 | $0.00 | 11,842.0000 | 124,906,000 | 33.33% | 0.00% |
| Feb. 28, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 247 | $154.54 | 9,674.0000 | 124,906,000 | 2.49% | 0.00% |
| Feb. 28, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 194 | $155.45 | 9,480.0000 | 124,906,000 | 2.01% | 0.00% |
| Feb. 28, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 115 | $156.38 | 9,365.0000 | 124,906,000 | 1.21% | 0.00% |
| Feb. 28, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 17 | $157.30 | 9,348.0000 | 124,906,000 | 0.18% | 0.00% |
| Feb. 28, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 1 | $158.09 | 9,347.0000 | 124,906,000 | 0.01% | 0.00% |
| Feb. 27, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | M | Restricted Stock Units | 1908 | $0.00 | 3,816.0000 | 124,906,000 | 33.33% | 0.00% |
| Feb. 27, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | M | Common Stock | 878 | $0.00 | 4,462.0000 | 124,906,000 | 24.50% | 0.00% |
| Feb. 28, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | S | Common Stock | 142 | $154.54 | 4,320.0000 | 124,906,000 | 3.18% | 0.00% |
| Feb. 28, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | S | Common Stock | 111 | $155.45 | 4,209.0000 | 124,906,000 | 2.57% | 0.00% |
| Feb. 28, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | S | Common Stock | 66 | $156.38 | 4,143.0000 | 124,906,000 | 1.57% | 0.00% |
| Feb. 28, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | S | Common Stock | 9 | $157.30 | 4,134.0000 | 124,906,000 | 0.22% | 0.00% |
| Feb. 28, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | S | Common Stock | 1 | $158.09 | 4,133.0000 | 124,906,000 | 0.02% | 0.00% |
| Feb. 27, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | M | Restricted Stock Units | 878 | $0.00 | 1,754.0000 | 124,906,000 | 33.36% | 0.00% |
| Feb. 27, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | M | Common Stock | 1667 | $0.00 | 5,737.0000 | 124,906,000 | 40.96% | 0.00% |
| Feb. 28, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 216 | $154.54 | 5,521.0000 | 124,906,000 | 3.77% | 0.00% |
| Feb. 28, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 170 | $155.45 | 5,351.0000 | 124,906,000 | 3.08% | 0.00% |
| Feb. 28, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 100 | $156.38 | 5,251.0000 | 124,906,000 | 1.87% | 0.00% |
| Feb. 28, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 14 | $157.30 | 5,237.0000 | 124,906,000 | 0.27% | 0.00% |
| Feb. 28, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 1 | $158.09 | 5,236.0000 | 124,906,000 | 0.02% | 0.00% |
| Feb. 27, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | M | Restricted Stock Units | 1667 | $0.00 | 3,333.0000 | 124,906,000 | 33.34% | 0.00% |
| Feb. 27, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | M | Common Stock | 1908 | $0.00 | 20,109.0000 | 124,906,000 | 10.48% | 0.00% |
| Feb. 28, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 247 | $154.54 | 19,862.0000 | 124,906,000 | 1.23% | 0.00% |
| Feb. 28, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 194 | $155.45 | 19,668.0000 | 124,906,000 | 0.98% | 0.00% |
| Feb. 28, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 115 | $156.38 | 19,553.0000 | 124,906,000 | 0.58% | 0.00% |
| Feb. 28, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 17 | $157.30 | 19,536.0000 | 124,906,000 | 0.09% | 0.00% |
| Feb. 28, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 1 | $158.09 | 19,535.0000 | 124,906,000 | 0.01% | 0.00% |
| Feb. 15, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | A | Common Stock | 3278 | $0.00 | 19,208.0000 | 124,906,000 | 20.58% | 0.00% |
| Feb. 16, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 518 | $148.24 | 18,321.0000 | 124,906,000 | 2.75% | 0.00% |
| Feb. 15, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | A | Common Stock | 4295 | $0.00 | 9,321.0000 | 124,906,000 | 85.46% | 0.00% |
| Feb. 16, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 480 | $147.50 | 8,841.0000 | 124,906,000 | 5.15% | 0.00% |
| Feb. 16, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 672 | $148.24 | 8,169.0000 | 124,906,000 | 7.60% | 0.00% |
| Feb. 16, 2024 | Garg Pushkal | CMO & EVP Dev & Med Affairs | S | Common Stock | 156 | $149.03 | 8,013.0000 | 124,906,000 | 1.91% | 0.00% |
| Feb. 16, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 369 | $147.50 | 18,839.0000 | 124,906,000 | 1.92% | 0.00% |
| Feb. 16, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 840 | $149.03 | 45,546.0000 | 124,906,000 | 1.81% | 0.00% |
| Feb. 16, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 3614 | $148.24 | 46,386.0000 | 124,906,000 | 7.23% | 0.00% |
| Feb. 16, 2024 | Greenstreet Yvonne | Chief Executive Officer | S | Common Stock | 2576 | $147.50 | 50,000.0000 | 124,906,000 | 4.90% | 0.00% |
| Feb. 15, 2024 | Greenstreet Yvonne | Chief Executive Officer | A | Common Stock | 16953 | $0.00 | 52,576.0000 | 124,906,000 | 47.59% | 0.01% |
| Feb. 16, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 121 | $149.03 | 4,070.0000 | 124,906,000 | 2.89% | 0.00% |
| Feb. 16, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 519 | $148.24 | 4,191.0000 | 124,906,000 | 11.02% | 0.00% |
| Feb. 16, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | S | Common Stock | 369 | $147.50 | 4,710.0000 | 124,906,000 | 7.27% | 0.00% |
| Feb. 15, 2024 | Tanguler Tolga | EVP, Chief Commercial Officer | A | Common Stock | 3278 | $0.00 | 5,079.0000 | 124,906,000 | 182.01% | 0.00% |
| Feb. 16, 2024 | Poulton Jeffrey V. | EVP, Chief Financial Officer | S | Common Stock | 120 | $149.03 | 18,201.0000 | 124,906,000 | 0.65% | 0.00% |
| Feb. 2, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | S | Common Stock | 269 | $172.38 | 3,584.0000 | 124,906,000 | 6.98% | 0.00% |
| Feb. 1, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | M | Restricted Stock Units | 5175 | $0.00 | 5,175.0000 | 124,906,000 | 50.00% | 0.00% |
| Feb. 2, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | S | Common Stock | 820 | $171.14 | 3,853.0000 | 124,906,000 | 17.55% | 0.00% |
| Feb. 2, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | S | Common Stock | 502 | $170.01 | 4,673.0000 | 124,906,000 | 9.70% | 0.00% |
| Feb. 1, 2024 | Franchini Indrani Lall | EVP, CLO & Secretary | M | Common Stock | 5175 | $0.00 | 5,175.0000 | 124,906,000 | 9999.99% | 0.00% |