In the last 12 months, insiders at AGIOS PHARMACEUTICALS, INC. ($AGIO) filed 561 transactions with the SEC: 0 open-market purchases totaling $0 and 136 sales totaling $22,307,441. Net insider sentiment: net selling.
AGIOS PHARMACEUTICALS, INC. operates in the Pharmaceutical preparations industry (Life sciences sector).
Most Active Insiders
- Schenkein David P (Director) — 44 transactions totaling $13,752,392
- Goff Brian (Chief Executive Officer) — 59 transactions totaling $4,751,204
- Gheuens Sarah (Chief Medical Officer) — 77 transactions totaling $2,178,392
- Burns James William (Chief Legal Officer) — 66 transactions totaling $2,046,594
- Ballal Rahul D. (Director) — 25 transactions totaling $1,636,947
View all SEC Filings for AGIOS PHARMACEUTICALS, INC. (AGIO).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| March 5, 2026 | Viswanadhan Krishnan | Chief Corp Dev & Strategy | M | Common stock | 8100 | $0.00 | 8,100.0000 | 74,665,003 | 9999.99% | 0.01% |
| March 5, 2026 | Viswanadhan Krishnan | Chief Corp Dev & Strategy | M | Restricted stock units | 8100 | $0.00 | 16,200.0000 | 74,665,003 | 33.33% | 0.01% |
| March 5, 2026 | Viswanadhan Krishnan | Chief Corp Dev & Strategy | S | Common stock | 2959 | $27.80 | 5,141.0000 | 74,665,003 | 36.53% | 0.00% |
| March 3, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 5272 | $28.88 | 868.0000 | 74,665,003 | 85.86% | 0.01% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | S | Common stock | 8267 | $28.96 | 157,466.0000 | 74,665,003 | 4.99% | 0.01% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | M | Common stock | 13000 | $0.00 | 170,466.0000 | 74,665,003 | 8.26% | 0.02% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | S | Common stock | 5918 | $28.96 | 164,548.0000 | 74,665,003 | 3.47% | 0.01% |
| March 1, 2026 | Goff Brian | Chief Executive Officer | A | Restricted stock units | 48000 | $0.00 | 48,000.0000 | 74,665,003 | 9999.99% | 0.06% |
| March 1, 2026 | Goff Brian | Chief Executive Officer | A | Stock options (right to buy) | 174000 | $0.00 | 174,000.0000 | 74,665,003 | 9999.99% | 0.23% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 8500 | $0.00 | 0.0000 | 74,665,003 | 100.00% | 0.01% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 18000 | $0.00 | 18,000.0000 | 74,665,003 | 50.00% | 0.02% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 13000 | $0.00 | 26,000.0000 | 74,665,003 | 33.33% | 0.02% |
| March 2, 2026 | Burns James William | Chief Legal Officer | M | Common stock | 4000 | $0.00 | 35,718.0000 | 74,665,003 | 12.61% | 0.01% |
| March 2, 2026 | Burns James William | Chief Legal Officer | S | Common stock | 1187 | $28.96 | 34,531.0000 | 74,665,003 | 3.32% | 0.00% |
| March 2, 2026 | Burns James William | Chief Legal Officer | M | Common stock | 5666 | $0.00 | 40,197.0000 | 74,665,003 | 16.41% | 0.01% |
| March 2, 2026 | Burns James William | Chief Legal Officer | S | Common stock | 1681 | $28.96 | 38,516.0000 | 74,665,003 | 4.18% | 0.00% |
| March 2, 2026 | Burns James William | Chief Legal Officer | M | Common stock | 4000 | $0.00 | 42,516.0000 | 74,665,003 | 10.39% | 0.01% |
| March 2, 2026 | Burns James William | Chief Legal Officer | S | Common stock | 1187 | $28.96 | 41,329.0000 | 74,665,003 | 2.79% | 0.00% |
| March 2, 2026 | Burns James William | Chief Legal Officer | M | Common stock | 3920 | $0.00 | 45,249.0000 | 74,665,003 | 9.48% | 0.01% |
| March 2, 2026 | Burns James William | Chief Legal Officer | S | Common stock | 1163 | $28.96 | 44,086.0000 | 74,665,003 | 2.57% | 0.00% |
| March 1, 2026 | Burns James William | Chief Legal Officer | A | Restricted stock units | 14000 | $0.00 | 14,000.0000 | 74,665,003 | 9999.99% | 0.02% |
| March 1, 2026 | Burns James William | Chief Legal Officer | A | Stock options (right to buy) | 52000 | $0.00 | 52,000.0000 | 74,665,003 | 9999.99% | 0.07% |
| March 2, 2026 | Burns James William | Chief Legal Officer | M | Restricted stock units | 4000 | $0.00 | 0.0000 | 74,665,003 | 100.00% | 0.01% |
| March 2, 2026 | Burns James William | Chief Legal Officer | M | Restricted stock units | 5666 | $0.00 | 5,667.0000 | 74,665,003 | 50.00% | 0.01% |
| March 2, 2026 | Burns James William | Chief Legal Officer | M | Restricted stock units | 4000 | $0.00 | 8,000.0000 | 74,665,003 | 33.33% | 0.01% |
| March 2, 2026 | Burns James William | Chief Legal Officer | M | Restricted stock units | 3920 | $0.00 | 7,839.0000 | 74,665,003 | 33.34% | 0.01% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 4000 | $0.00 | 68,795.0000 | 74,665,003 | 6.17% | 0.01% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1187 | $28.96 | 67,608.0000 | 74,665,003 | 1.73% | 0.00% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 5666 | $0.00 | 73,274.0000 | 74,665,003 | 8.38% | 0.01% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1681 | $28.96 | 71,593.0000 | 74,665,003 | 2.29% | 0.00% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 4000 | $0.00 | 75,593.0000 | 74,665,003 | 5.59% | 0.01% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1187 | $28.96 | 74,406.0000 | 74,665,003 | 1.57% | 0.00% |
| March 1, 2026 | Gheuens Sarah | Chief Medical Officer | A | Restricted stock units | 14000 | $0.00 | 14,000.0000 | 74,665,003 | 9999.99% | 0.02% |
| March 1, 2026 | Gheuens Sarah | Chief Medical Officer | A | Restricted stock units | 22000 | $0.00 | 22,000.0000 | 74,665,003 | 9999.99% | 0.03% |
| March 1, 2026 | Gheuens Sarah | Chief Medical Officer | A | Stock options (right to buy) | 52000 | $0.00 | 52,000.0000 | 74,665,003 | 9999.99% | 0.07% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 4000 | $0.00 | 0.0000 | 74,665,003 | 100.00% | 0.01% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 5666 | $0.00 | 5,667.0000 | 74,665,003 | 50.00% | 0.01% |
| March 2, 2026 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 4000 | $0.00 | 8,000.0000 | 74,665,003 | 33.33% | 0.01% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | M | Common stock | 2000 | $0.00 | 39,394.0000 | 74,665,003 | 5.35% | 0.00% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | S | Common stock | 594 | $28.96 | 38,800.0000 | 74,665,003 | 1.51% | 0.00% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | M | Common stock | 5666 | $0.00 | 44,466.0000 | 74,665,003 | 14.60% | 0.01% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | S | Common stock | 1681 | $28.96 | 42,785.0000 | 74,665,003 | 3.78% | 0.00% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | M | Common stock | 4000 | $0.00 | 46,785.0000 | 74,665,003 | 9.35% | 0.01% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | S | Common stock | 1187 | $28.96 | 45,598.0000 | 74,665,003 | 2.54% | 0.00% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | M | Common stock | 5303 | $0.00 | 50,901.0000 | 74,665,003 | 11.63% | 0.01% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | S | Common stock | 1573 | $28.96 | 49,328.0000 | 74,665,003 | 3.09% | 0.00% |
| March 1, 2026 | Jones Cecilia | Chief Financial Officer | A | Restricted stock units | 14000 | $0.00 | 14,000.0000 | 74,665,003 | 9999.99% | 0.02% |
| March 1, 2026 | Jones Cecilia | Chief Financial Officer | A | Stock options (right to buy) | 52000 | $0.00 | 52,000.0000 | 74,665,003 | 9999.99% | 0.07% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 2000 | $0.00 | 0.0000 | 74,665,003 | 100.00% | 0.00% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 5666 | $0.00 | 5,667.0000 | 74,665,003 | 50.00% | 0.01% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 4000 | $0.00 | 8,000.0000 | 74,665,003 | 33.33% | 0.01% |
| March 2, 2026 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 5303 | $0.00 | 10,607.0000 | 74,665,003 | 33.33% | 0.01% |
| March 2, 2026 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 5666 | $0.00 | 40,459.0000 | 74,665,003 | 16.28% | 0.01% |
| March 2, 2026 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 1681 | $28.96 | 38,778.0000 | 74,665,003 | 4.15% | 0.00% |
| March 2, 2026 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 4000 | $0.00 | 42,778.0000 | 74,665,003 | 10.32% | 0.01% |
| March 2, 2026 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 1187 | $28.96 | 41,591.0000 | 74,665,003 | 2.77% | 0.00% |
| March 1, 2026 | Milanova Tsveta | Chief Commercial Officer | A | Restricted stock units | 14000 | $0.00 | 14,000.0000 | 74,665,003 | 9999.99% | 0.02% |
| March 1, 2026 | Milanova Tsveta | Chief Commercial Officer | A | Stock options (right to buy) | 52000 | $0.00 | 52,000.0000 | 74,665,003 | 9999.99% | 0.07% |
| March 2, 2026 | Milanova Tsveta | Chief Commercial Officer | M | Restricted stock units | 5666 | $0.00 | 5,667.0000 | 74,665,003 | 50.00% | 0.01% |
| March 2, 2026 | Milanova Tsveta | Chief Commercial Officer | M | Restricted stock units | 4000 | $0.00 | 8,000.0000 | 74,665,003 | 33.33% | 0.01% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 2350 | $0.00 | 3,293.0000 | 74,665,003 | 249.20% | 0.00% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 698 | $28.96 | 2,595.0000 | 74,665,003 | 21.20% | 0.00% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 2450 | $0.00 | 4,970.0000 | 74,665,003 | 97.22% | 0.00% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 727 | $28.96 | 4,243.0000 | 74,665,003 | 14.63% | 0.00% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 2695 | $0.00 | 6,938.0000 | 74,665,003 | 63.52% | 0.00% |
| March 1, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | A | Restricted stock units | 8452 | $0.00 | 8,452.0000 | 74,665,003 | 9999.99% | 0.01% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 2350 | $0.00 | 0.0000 | 74,665,003 | 100.00% | 0.00% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 2450 | $0.00 | 2,450.0000 | 74,665,003 | 50.00% | 0.00% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 2695 | $0.00 | 5,390.0000 | 74,665,003 | 33.33% | 0.00% |
| March 1, 2026 | Viswanadhan Krishnan | Chief Corp Dev & Strategy | A | Restricted stock units | 14000 | $0.00 | 14,000.0000 | 74,665,003 | 9999.99% | 0.02% |
| March 1, 2026 | Viswanadhan Krishnan | Chief Corp Dev & Strategy | A | Stock options (right to buy) | 52000 | $0.00 | 52,000.0000 | 74,665,003 | 9999.99% | 0.07% |
| March 2, 2026 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 798 | $28.96 | 6,140.0000 | 74,665,003 | 11.50% | 0.00% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | M | Common stock | 8500 | $0.00 | 151,603.0000 | 74,665,003 | 5.94% | 0.01% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | S | Common stock | 3870 | $28.96 | 147,733.0000 | 74,665,003 | 2.55% | 0.01% |
| March 2, 2026 | Goff Brian | Chief Executive Officer | M | Common stock | 18000 | $0.00 | 165,733.0000 | 74,665,003 | 12.18% | 0.02% |
| Jan. 5, 2026 | Milanova Tsveta | Chief Commercial Officer | M | Restricted stock units | 8475 | $0.00 | 0.0000 | 74,665,003 | 100.00% | 0.01% |
| Jan. 5, 2026 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 2872 | $27.02 | 34,793.0000 | 74,665,003 | 7.63% | 0.00% |
| Jan. 5, 2026 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 8475 | $0.00 | 37,665.0000 | 74,665,003 | 29.03% | 0.01% |
| Dec. 30, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 2932 | $27.09 | 64,795.0000 | 74,496,287,000 | 4.33% | 0.00% |
| Dec. 30, 2025 | Gheuens Sarah | Chief Medical Officer | M | Performance share units | 6000 | $0.00 | 0.0000 | 74,496,287,000 | 100.00% | 0.00% |
| Dec. 30, 2025 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 6000 | $0.00 | 32,122.0000 | 74,496,287,000 | 22.97% | 0.00% |
| Dec. 30, 2025 | Jones Cecilia | Chief Financial Officer | M | Common stock | 6000 | $0.00 | 40,326.0000 | 74,496,287,000 | 17.48% | 0.00% |
| Dec. 30, 2025 | Jones Cecilia | Chief Financial Officer | M | Performance share units | 6000 | $0.00 | 0.0000 | 74,496,287,000 | 100.00% | 0.00% |
| Dec. 30, 2025 | Jones Cecilia | Chief Financial Officer | S | Common stock | 2932 | $27.09 | 37,394.0000 | 74,496,287,000 | 7.27% | 0.00% |
| Dec. 30, 2025 | Milanova Tsveta | Chief Commercial Officer | M | Performance share units | 6000 | $0.00 | 0.0000 | 74,496,287,000 | 100.00% | 0.00% |
| Dec. 30, 2025 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 2932 | $27.09 | 29,190.0000 | 74,496,287,000 | 9.13% | 0.00% |
| Dec. 30, 2025 | Burns James William | Chief Legal Officer | M | Common stock | 6000 | $0.00 | 34,650.0000 | 74,496,287,000 | 20.94% | 0.00% |
| Dec. 30, 2025 | Burns James William | Chief Legal Officer | S | Common stock | 2932 | $27.09 | 31,718.0000 | 74,496,287,000 | 8.46% | 0.00% |
| Dec. 30, 2025 | Burns James William | Chief Legal Officer | M | Performance share units | 6000 | $0.00 | 0.0000 | 74,496,287,000 | 100.00% | 0.00% |
| Dec. 30, 2025 | Goff Brian | Chief Executive Officer | M | Common stock | 25528 | $0.00 | 149,056.0000 | 74,496,287,000 | 20.67% | 0.00% |
| Dec. 30, 2025 | Goff Brian | Chief Executive Officer | S | Common stock | 12473 | $27.09 | 136,583.0000 | 74,496,287,000 | 8.37% | 0.00% |
| Dec. 30, 2025 | Goff Brian | Chief Executive Officer | M | Common stock | 12750 | $0.00 | 149,333.0000 | 74,496,287,000 | 9.33% | 0.00% |
| Dec. 30, 2025 | Goff Brian | Chief Executive Officer | S | Common stock | 6230 | $27.09 | 143,103.0000 | 74,496,287,000 | 4.17% | 0.00% |
| Dec. 30, 2025 | Goff Brian | Chief Executive Officer | M | Performance share units | 25528 | $0.00 | 25,528.0000 | 74,496,287,000 | 50.00% | 0.00% |
| Dec. 30, 2025 | Goff Brian | Chief Executive Officer | M | Performance share units | 12750 | $0.00 | 0.0000 | 74,496,287,000 | 100.00% | 0.00% |
| Dec. 30, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 6000 | $0.00 | 67,727.0000 | 74,496,287,000 | 9.72% | 0.00% |
| Nov. 12, 2025 | Scadden David | Director | S | Common stock | 200 | $43.84 | 17,603.0000 | 74,496,287,000 | 1.12% | 0.00% |
| Nov. 12, 2025 | Scadden David | Director | M | Stock options (right to buy) | 200 | $0.00 | 26,907.0000 | 74,496,287,000 | 0.74% | 0.00% |
| Nov. 12, 2025 | Scadden David | Director | M | Common stock | 200 | $18.09 | 17,803.0000 | 74,496,287,000 | 1.14% | 0.00% |
| Nov. 11, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 2454 | $43.78 | 61,727.0000 | 74,496,287,000 | 3.82% | 0.00% |
| Nov. 11, 2025 | Gheuens Sarah | Chief Medical Officer | M | Stock options (right to buy) | 2454 | $0.00 | 26,130.0000 | 74,496,287,000 | 8.59% | 0.00% |
| Nov. 11, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 2454 | $25.01 | 64,181.0000 | 74,496,287,000 | 3.98% | 0.00% |
| Oct. 30, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 200 | $43.81 | 61,727.0000 | 74,496,287,000 | 0.32% | 0.00% |
| Oct. 30, 2025 | Gheuens Sarah | Chief Medical Officer | M | Stock options (right to buy) | 200 | $0.00 | 28,584.0000 | 74,496,287,000 | 0.69% | 0.00% |
| Oct. 30, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 200 | $25.01 | 61,927.0000 | 74,496,287,000 | 0.32% | 0.00% |
| Oct. 27, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 3302 | $25.01 | 65,029.0000 | 74,496,287,000 | 5.35% | 0.00% |
| Oct. 27, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 3302 | $43.92 | 61,727.0000 | 74,496,287,000 | 5.08% | 0.00% |
| Oct. 27, 2025 | Gheuens Sarah | Chief Medical Officer | M | Stock options (right to buy) | 3302 | $0.00 | 28,784.0000 | 74,496,287,000 | 10.29% | 0.00% |
| Oct. 8, 2025 | Scadden David | Director | S | Common stock | 200 | $41.00 | 17,603.0000 | 74,496,287,000 | 1.12% | 0.00% |
| Oct. 8, 2025 | Scadden David | Director | M | Stock options (right to buy) | 200 | $0.00 | 27,107.0000 | 74,496,287,000 | 0.73% | 0.00% |
| Oct. 8, 2025 | Scadden David | Director | M | Common stock | 200 | $18.09 | 17,803.0000 | 74,496,287,000 | 1.14% | 0.00% |
| Sept. 30, 2025 | Scadden David | Director | M | Stock options (right to buy) | 200 | $0.00 | 27,307.0000 | 74,254,956,000 | 0.73% | 0.00% |
| Sept. 30, 2025 | Scadden David | Director | S | Common stock | 200 | $40.00 | 17,603.0000 | 74,254,956,000 | 1.12% | 0.00% |
| Sept. 30, 2025 | Scadden David | Director | M | Common stock | 200 | $18.09 | 17,803.0000 | 74,254,956,000 | 1.14% | 0.00% |
| Sept. 26, 2025 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 7472 | $0.00 | 0.0000 | 74,254,956,000 | 100.00% | 0.00% |
| Sept. 26, 2025 | Jones Cecilia | Chief Financial Officer | M | Common stock | 7472 | $0.00 | 37,521.0000 | 74,254,956,000 | 24.87% | 0.00% |
| Sept. 26, 2025 | Jones Cecilia | Chief Financial Officer | S | Common stock | 3651 | $36.77 | 33,870.0000 | 74,254,956,000 | 9.73% | 0.00% |
| Sept. 5, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 8546 | $36.87 | 868.0000 | 74,254,956,000 | 90.78% | 0.00% |
| Aug. 27, 2025 | Scadden David | Director | S | Common stock | 200 | $40.00 | 17,603.0000 | 74,254,956,000 | 1.12% | 0.00% |
| Aug. 27, 2025 | Scadden David | Director | M | Common stock | 200 | $18.09 | 17,803.0000 | 74,254,956,000 | 1.14% | 0.00% |
| Aug. 27, 2025 | Scadden David | Director | M | Stock options (right to buy) | 200 | $0.00 | 27,507.0000 | 74,254,956,000 | 0.72% | 0.00% |
| Aug. 11, 2025 | Ballal Rahul D. | Director | M | Common stock | 2302 | $0.00 | 12,414.0000 | 74,254,956,000 | 22.77% | 0.00% |
| Aug. 11, 2025 | Smith Cynthia | Director | M | Restricted stock units | 2302 | $0.00 | 0.0000 | 74,254,956,000 | 100.00% | 0.00% |
| Aug. 11, 2025 | Smith Cynthia | Director | M | Common stock | 2302 | $0.00 | 12,414.0000 | 74,254,956,000 | 22.77% | 0.00% |
| Aug. 11, 2025 | Ballal Rahul D. | Director | M | Restricted stock units | 2302 | $0.00 | 0.0000 | 74,254,956,000 | 100.00% | 0.00% |
| Aug. 8, 2025 | Goff Brian | Chief Executive Officer | M | Common stock | 22691 | $0.00 | 134,613.0000 | 74,254,956,000 | 20.27% | 0.00% |
| Aug. 8, 2025 | Goff Brian | Chief Executive Officer | S | Common stock | 11085 | $36.67 | 123,528.0000 | 74,254,956,000 | 8.23% | 0.00% |
| Aug. 8, 2025 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 22691 | $0.00 | 0.0000 | 74,254,956,000 | 100.00% | 0.00% |
| July 10, 2025 | Scadden David | Director | M | Common stock | 1400 | $18.09 | 19,003.0000 | 74,254,956,000 | 7.95% | 0.00% |
| July 10, 2025 | Scadden David | Director | S | Common stock | 1400 | $40.00 | 17,603.0000 | 74,254,956,000 | 7.37% | 0.00% |
| July 10, 2025 | Scadden David | Director | M | Stock options (right to buy) | 1400 | $0.00 | 27,707.0000 | 74,254,956,000 | 4.81% | 0.00% |
| July 9, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 11914 | $25.01 | 73,185.0000 | 74,254,956,000 | 19.44% | 0.00% |
| July 9, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 11067 | $37.93 | 62,118.0000 | 74,254,956,000 | 15.12% | 0.00% |
| July 9, 2025 | Gheuens Sarah | Chief Medical Officer | M | Stock options (right to buy) | 11914 | $0.00 | 32,086.0000 | 74,254,956,000 | 27.08% | 0.00% |
| July 9, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 847 | $38.76 | 61,271.0000 | 74,254,956,000 | 1.36% | 0.00% |
| July 8, 2025 | Backstrom Jay T. | Director | A | Stock options (right to buy) | 23393 | $0.00 | 23,393.0000 | 74,254,956,000 | 9999.99% | 0.00% |
| July 8, 2025 | Backstrom Jay T. | Director | A | Restricted stock units | 4341 | $0.00 | 4,341.0000 | 74,254,956,000 | 9999.99% | 0.00% |
| July 1, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 8374 | $0.00 | 65,362.0000 | 74,254,956,000 | 14.69% | 0.00% |
| July 1, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 4091 | $34.17 | 61,271.0000 | 74,254,956,000 | 6.26% | 0.00% |
| July 1, 2025 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 8374 | $0.00 | 8,375.0000 | 74,254,956,000 | 50.00% | 0.00% |
| June 24, 2025 | Burns James William | Chief Legal Officer | M | Common stock | 6000 | $0.00 | 31,449.0000 | 74,103,192,000 | 23.58% | 0.00% |
| June 24, 2025 | Burns James William | Chief Legal Officer | S | Common stock | 2799 | $33.54 | 28,650.0000 | 74,103,192,000 | 8.90% | 0.00% |
| June 24, 2025 | Burns James William | Chief Legal Officer | M | Performance share units | 6000 | $0.00 | 6,000.0000 | 74,103,192,000 | 50.00% | 0.00% |
| June 24, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 6000 | $0.00 | 59,897.0000 | 74,103,192,000 | 11.13% | 0.00% |
| June 24, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 2909 | $33.54 | 56,988.0000 | 74,103,192,000 | 4.86% | 0.00% |
| June 24, 2025 | Gheuens Sarah | Chief Medical Officer | M | Performance share units | 6000 | $0.00 | 6,000.0000 | 74,103,192,000 | 50.00% | 0.00% |
| June 24, 2025 | Jones Cecilia | Chief Financial Officer | M | Common stock | 6000 | $0.00 | 31,829.0000 | 74,103,192,000 | 23.23% | 0.00% |
| June 24, 2025 | Jones Cecilia | Chief Financial Officer | S | Common stock | 1780 | $33.54 | 30,049.0000 | 74,103,192,000 | 5.59% | 0.00% |
| June 24, 2025 | Jones Cecilia | Chief Financial Officer | M | Performance share units | 6000 | $0.00 | 6,000.0000 | 74,103,192,000 | 50.00% | 0.00% |
| June 24, 2025 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 6000 | $0.00 | 28,892.0000 | 74,103,192,000 | 26.21% | 0.00% |
| June 24, 2025 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 2770 | $33.54 | 26,122.0000 | 74,103,192,000 | 9.59% | 0.00% |
| June 24, 2025 | Milanova Tsveta | Chief Commercial Officer | M | Performance share units | 6000 | $0.00 | 6,000.0000 | 74,103,192,000 | 50.00% | 0.00% |
| June 24, 2025 | Goff Brian | Chief Executive Officer | M | Common stock | 25527 | $0.00 | 117,872.0000 | 74,103,192,000 | 27.64% | 0.00% |
| June 24, 2025 | Goff Brian | Chief Executive Officer | S | Common stock | 12471 | $33.54 | 105,401.0000 | 74,103,192,000 | 10.58% | 0.00% |
| June 24, 2025 | Goff Brian | Chief Executive Officer | M | Common stock | 12750 | $0.00 | 118,151.0000 | 74,103,192,000 | 12.10% | 0.00% |
| June 24, 2025 | Goff Brian | Chief Executive Officer | S | Common stock | 6229 | $33.54 | 111,922.0000 | 74,103,192,000 | 5.27% | 0.00% |
| June 24, 2025 | Goff Brian | Chief Executive Officer | M | Performance share units | 25527 | $0.00 | 51,056.0000 | 74,103,192,000 | 33.33% | 0.00% |
| June 24, 2025 | Goff Brian | Chief Executive Officer | M | Performance share units | 12750 | $0.00 | 12,750.0000 | 74,103,192,000 | 50.00% | 0.00% |
| June 20, 2025 | Ballal Rahul D. | Director | M | Common stock | 2120 | $0.00 | 10,112.0000 | 74,103,192,000 | 26.53% | 0.00% |
| June 18, 2025 | Ballal Rahul D. | Director | A | Restricted stock units | 2816 | $0.00 | 2,816.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 18, 2025 | Ballal Rahul D. | Director | A | Stock options (right to buy) | 15768 | $0.00 | 15,768.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 20, 2025 | Ballal Rahul D. | Director | M | Restricted stock units | 2120 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| June 20, 2025 | CAPELLO JEFFREY D | Director | M | Common stock | 2120 | $0.00 | 6,073.0000 | 74,103,192,000 | 53.63% | 0.00% |
| June 18, 2025 | CAPELLO JEFFREY D | Director | A | Restricted stock units | 2861 | $0.00 | 2,861.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 18, 2025 | CAPELLO JEFFREY D | Director | A | Stock options (right to buy) | 15768 | $0.00 | 15,768.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 20, 2025 | CAPELLO JEFFREY D | Director | M | Restricted stock units | 2120 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| June 20, 2025 | Foster-Cheek Kaye I | Director | M | Common stock | 2120 | $0.00 | 9,668.0000 | 74,103,192,000 | 28.09% | 0.00% |
| June 18, 2025 | Foster-Cheek Kaye I | Director | A | Restricted stock units | 2816 | $0.00 | 2,816.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 18, 2025 | Foster-Cheek Kaye I | Director | A | Stock options (right to buy) | 15768 | $0.00 | 15,768.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 20, 2025 | Foster-Cheek Kaye I | Director | M | Restricted stock units | 2120 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| June 20, 2025 | FOUSE JACQUALYN A | Director | M | Common stock | 2120 | $0.00 | 151,340.0000 | 74,103,192,000 | 1.42% | 0.00% |
| June 18, 2025 | FOUSE JACQUALYN A | Director | A | Restricted stock units | 2816 | $0.00 | 2,816.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 18, 2025 | FOUSE JACQUALYN A | Director | A | Stock options (right to buy) | 15768 | $0.00 | 15,768.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 20, 2025 | FOUSE JACQUALYN A | Director | M | Restricted stock units | 2120 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| June 20, 2025 | Ho Maykin | Director | M | Common stock | 2120 | $0.00 | 17,032.0000 | 74,103,192,000 | 14.22% | 0.00% |
| June 18, 2025 | Ho Maykin | Director | A | Restricted stock units | 2816 | $0.00 | 2,816.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 18, 2025 | Ho Maykin | Director | A | Stock options (right to buy) | 15768 | $0.00 | 15,768.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 20, 2025 | Ho Maykin | Director | M | Restricted stock units | 2120 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| June 20, 2025 | Owen Adams Catherine | Director | M | Common stock | 2120 | $0.00 | 6,073.0000 | 74,103,192,000 | 53.63% | 0.00% |
| June 18, 2025 | Owen Adams Catherine | Director | A | Restricted stock units | 2816 | $0.00 | 2,816.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 18, 2025 | Owen Adams Catherine | Director | A | Stock options (right to buy) | 15768 | $0.00 | 15,768.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 20, 2025 | Owen Adams Catherine | Director | M | Restricted stock units | 2120 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| June 20, 2025 | Scadden David | Director | M | Common stock | 2120 | $0.00 | 17,603.0000 | 74,103,192,000 | 13.69% | 0.00% |
| June 18, 2025 | Scadden David | Director | A | Restricted stock units | 2816 | $0.00 | 2,816.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 18, 2025 | Scadden David | Director | A | Stock options (right to buy) | 15768 | $0.00 | 15,768.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 20, 2025 | Scadden David | Director | M | Restricted stock units | 2120 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| June 20, 2025 | Smith Cynthia | Director | M | Common stock | 2120 | $0.00 | 10,112.0000 | 74,103,192,000 | 26.53% | 0.00% |
| June 18, 2025 | Smith Cynthia | Director | A | Restricted stock units | 2816 | $0.00 | 2,816.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 18, 2025 | Smith Cynthia | Director | A | Stock options (right to buy) | 15768 | $0.00 | 15,768.0000 | 74,103,192,000 | 9999.99% | 0.00% |
| June 20, 2025 | Smith Cynthia | Director | M | Restricted stock units | 2120 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| June 13, 2025 | CAPELLO JEFFREY D | Director | M | Restricted stock units | 1977 | $0.00 | 1,976.0000 | 74,103,192,000 | 50.01% | 0.00% |
| June 13, 2025 | CAPELLO JEFFREY D | Director | M | Common stock | 1977 | $0.00 | 3,953.0000 | 74,103,192,000 | 100.05% | 0.00% |
| June 13, 2025 | Owen Adams Catherine | Director | M | Common stock | 1977 | $0.00 | 3,953.0000 | 74,103,192,000 | 100.05% | 0.00% |
| June 13, 2025 | Owen Adams Catherine | Director | M | Restricted stock units | 1977 | $0.00 | 1,976.0000 | 74,103,192,000 | 50.01% | 0.00% |
| April 8, 2025 | FOUSE JACQUALYN A | Director | M | Common stock | 15933 | $0.00 | 156,717.0000 | 74,103,192,000 | 11.32% | 0.00% |
| April 8, 2025 | FOUSE JACQUALYN A | Director | M | Restricted stock units | 15933 | $0.00 | 0.0000 | 74,103,192,000 | 100.00% | 0.00% |
| April 10, 2025 | FOUSE JACQUALYN A | Director | S | Common stock | 7497 | $25.90 | 149,220.0000 | 74,103,192,000 | 4.78% | 0.00% |
| March 5, 2025 | Viswanadhan Krishnan | Chief Corp Dev & Strategy | A | Stock options (right to buy) | 55374 | $0.00 | 55,374.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 5, 2025 | Viswanadhan Krishnan | Chief Corp Dev & Strategy | A | Restricted stock units | 24300 | $0.00 | 24,300.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 3, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 231 | $35.54 | 6,038.0000 | 73,372,696,000 | 3.68% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | M | Common stock | 3833 | $0.00 | 19,787.0000 | 73,372,696,000 | 24.03% | 0.00% |
| March 3, 2025 | Burns James William | Chief Legal Officer | S | Common stock | 1137 | $35.54 | 18,650.0000 | 73,372,696,000 | 5.75% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | M | Common stock | 4000 | $0.00 | 22,650.0000 | 73,372,696,000 | 21.45% | 0.00% |
| March 3, 2025 | Burns James William | Chief Legal Officer | S | Common stock | 1187 | $35.54 | 21,463.0000 | 73,372,696,000 | 5.24% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | M | Common stock | 5667 | $0.00 | 27,130.0000 | 73,372,696,000 | 26.40% | 0.00% |
| March 3, 2025 | Burns James William | Chief Legal Officer | S | Common stock | 1681 | $35.54 | 25,449.0000 | 73,372,696,000 | 6.20% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | A | Restricted stock units | 12000 | $0.00 | 12,000.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | A | Restricted stock units | 11759 | $0.00 | 11,759.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | A | Stock options (right to buy) | 43500 | $0.00 | 43,500.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | M | Restricted stock units | 3833 | $0.00 | 0.0000 | 73,372,696,000 | 100.00% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | M | Restricted stock units | 4000 | $0.00 | 4,000.0000 | 73,372,696,000 | 50.00% | 0.00% |
| March 1, 2025 | Burns James William | Chief Legal Officer | M | Restricted stock units | 5667 | $0.00 | 11,333.0000 | 73,372,696,000 | 33.34% | 0.00% |
| March 1, 2025 | Jones Cecilia | Chief Financial Officer | M | Common stock | 2000 | $0.00 | 22,437.0000 | 73,372,696,000 | 9.79% | 0.00% |
| March 3, 2025 | Jones Cecilia | Chief Financial Officer | S | Common stock | 594 | $35.54 | 21,843.0000 | 73,372,696,000 | 2.65% | 0.00% |
| March 1, 2025 | Jones Cecilia | Chief Financial Officer | M | Common stock | 5667 | $0.00 | 27,510.0000 | 73,372,696,000 | 25.94% | 0.00% |
| March 3, 2025 | Jones Cecilia | Chief Financial Officer | S | Common stock | 1681 | $35.54 | 25,829.0000 | 73,372,696,000 | 6.11% | 0.00% |
| March 1, 2025 | Jones Cecilia | Chief Financial Officer | A | Restricted stock units | 12000 | $0.00 | 12,000.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Jones Cecilia | Chief Financial Officer | A | Restricted stock units | 15910 | $0.00 | 15,910.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Jones Cecilia | Chief Financial Officer | A | Stock options (right to buy) | 43500 | $0.00 | 43,500.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 2000 | $0.00 | 2,000.0000 | 73,372,696,000 | 50.00% | 0.00% |
| March 1, 2025 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 5667 | $0.00 | 11,333.0000 | 73,372,696,000 | 33.34% | 0.00% |
| March 1, 2025 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 5667 | $0.00 | 24,573.0000 | 73,372,696,000 | 29.97% | 0.00% |
| March 3, 2025 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 1681 | $35.54 | 22,892.0000 | 73,372,696,000 | 6.84% | 0.00% |
| March 1, 2025 | Milanova Tsveta | Chief Commercial Officer | A | Restricted stock units | 12000 | $0.00 | 12,000.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Milanova Tsveta | Chief Commercial Officer | A | Stock options (right to buy) | 43500 | $0.00 | 43,500.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Milanova Tsveta | Chief Commercial Officer | M | Restricted stock units | 5667 | $0.00 | 11,333.0000 | 73,372,696,000 | 33.34% | 0.00% |
| March 1, 2025 | Goff Brian | Chief Executive Officer | M | Common stock | 8500 | $0.00 | 87,292.0000 | 73,372,696,000 | 10.79% | 0.00% |
| March 3, 2025 | Goff Brian | Chief Executive Officer | S | Common stock | 4153 | $35.54 | 83,139.0000 | 73,372,696,000 | 4.76% | 0.00% |
| March 1, 2025 | Goff Brian | Chief Executive Officer | M | Common stock | 18000 | $0.00 | 101,139.0000 | 73,372,696,000 | 21.65% | 0.00% |
| March 3, 2025 | Goff Brian | Chief Executive Officer | S | Common stock | 8794 | $35.54 | 92,345.0000 | 73,372,696,000 | 8.69% | 0.00% |
| March 1, 2025 | Goff Brian | Chief Executive Officer | A | Restricted stock units | 39000 | $0.00 | 39,000.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Goff Brian | Chief Executive Officer | A | Stock options (right to buy) | 142500 | $0.00 | 142,500.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 8500 | $0.00 | 8,500.0000 | 73,372,696,000 | 50.00% | 0.00% |
| March 1, 2025 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 18000 | $0.00 | 36,000.0000 | 73,372,696,000 | 33.33% | 0.00% |
| March 1, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 3833 | $0.00 | 48,235.0000 | 73,372,696,000 | 8.63% | 0.00% |
| March 3, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1137 | $35.54 | 47,098.0000 | 73,372,696,000 | 2.36% | 0.00% |
| March 1, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 4000 | $0.00 | 51,098.0000 | 73,372,696,000 | 8.49% | 0.00% |
| March 3, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1187 | $35.54 | 49,911.0000 | 73,372,696,000 | 2.32% | 0.00% |
| March 1, 2025 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 5667 | $0.00 | 55,578.0000 | 73,372,696,000 | 11.35% | 0.00% |
| March 3, 2025 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1681 | $35.54 | 53,897.0000 | 73,372,696,000 | 3.02% | 0.00% |
| March 1, 2025 | Gheuens Sarah | Chief Medical Officer | A | Restricted stock units | 12000 | $0.00 | 12,000.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Gheuens Sarah | Chief Medical Officer | A | Stock options (right to buy) | 43500 | $0.00 | 43,500.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 3833 | $0.00 | 0.0000 | 73,372,696,000 | 100.00% | 0.00% |
| March 1, 2025 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 4000 | $0.00 | 4,000.0000 | 73,372,696,000 | 50.00% | 0.00% |
| March 1, 2025 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 5667 | $0.00 | 11,333.0000 | 73,372,696,000 | 33.34% | 0.00% |
| March 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 777 | $0.00 | 6,269.0000 | 73,372,696,000 | 14.15% | 0.00% |
| March 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 2350 | $0.00 | 8,388.0000 | 73,372,696,000 | 38.92% | 0.00% |
| March 3, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 697 | $35.54 | 7,691.0000 | 73,372,696,000 | 8.31% | 0.00% |
| March 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 2450 | $0.00 | 10,141.0000 | 73,372,696,000 | 31.86% | 0.00% |
| March 3, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 727 | $35.54 | 9,414.0000 | 73,372,696,000 | 7.17% | 0.00% |
| March 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | A | Restricted stock units | 8085 | $0.00 | 8,085.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | A | Restricted stock units | 6142 | $0.00 | 6,142.0000 | 73,372,696,000 | 9999.99% | 0.00% |
| March 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 777 | $0.00 | 0.0000 | 73,372,696,000 | 100.00% | 0.00% |
| March 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 2350 | $0.00 | 2,350.0000 | 73,372,696,000 | 50.00% | 0.00% |
| March 3, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 2450 | $0.00 | 4,900.0000 | 73,372,696,000 | 33.33% | 0.00% |
| Feb. 5, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 2272 | $34.39 | 5,437.0000 | 73,372,696,000 | 29.47% | 0.00% |
| Feb. 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 6896 | $0.00 | 0.0000 | 73,372,696,000 | 100.00% | 0.00% |
| Feb. 1, 2025 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 6896 | $0.00 | 7,709.0000 | 73,372,696,000 | 848.22% | 0.00% |
| Jan. 3, 2025 | Milanova Tsveta | Chief Commercial Officer | M | Restricted stock units | 8476 | $0.00 | 8,475.0000 | 73,372,696,000 | 50.00% | 0.00% |
| Jan. 6, 2025 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 2804 | $32.18 | 18,906.0000 | 73,372,696,000 | 12.92% | 0.00% |
| Jan. 3, 2025 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 8476 | $0.00 | 21,710.0000 | 73,372,696,000 | 64.05% | 0.00% |
| Dec. 11, 2024 | Scadden David | Director | M | Stock options (right to buy) | 200 | $0.00 | 29,107.0000 | 73,237,954,000 | 0.68% | 0.00% |
| Dec. 11, 2024 | Scadden David | Director | M | Common stock | 200 | $18.09 | 15,683.0000 | 73,237,954,000 | 1.29% | 0.00% |
| Dec. 11, 2024 | Scadden David | Director | S | Common stock | 200 | $46.28 | 15,483.0000 | 73,237,954,000 | 1.28% | 0.00% |
| Nov. 8, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 772 | $56.09 | 813.0000 | 73,237,954,000 | 48.71% | 0.00% |
| Nov. 8, 2024 | Ballal Rahul D. | Director | M | Common stock | 10000 | $25.99 | 17,992.0000 | 73,237,954,000 | 125.13% | 0.00% |
| Nov. 8, 2024 | Ballal Rahul D. | Director | S | Common stock | 3571 | $57.24 | 14,421.0000 | 73,237,954,000 | 19.85% | 0.00% |
| Nov. 8, 2024 | Ballal Rahul D. | Director | S | Common stock | 4929 | $58.57 | 9,492.0000 | 73,237,954,000 | 34.18% | 0.00% |
| Nov. 8, 2024 | Ballal Rahul D. | Director | S | Common stock | 1500 | $59.21 | 7,992.0000 | 73,237,954,000 | 15.80% | 0.00% |
| Nov. 7, 2024 | Ballal Rahul D. | Director | M | Stock option (right to buy) | 10000 | $0.00 | 27,947.0000 | 73,237,954,000 | 26.35% | 0.00% |
| Nov. 8, 2024 | Ballal Rahul D. | Director | M | Stock option (right to buy) | 10000 | $0.00 | 17,947.0000 | 73,237,954,000 | 35.78% | 0.00% |
| Nov. 7, 2024 | Burns James William | Chief Legal Officer | S | Common stock | 13411 | $52.00 | 24,041.0000 | 73,237,954,000 | 35.81% | 0.00% |
| Nov. 7, 2024 | Burns James William | Chief Legal Officer | S | Common stock | 8341 | $52.56 | 15,700.0000 | 73,237,954,000 | 34.69% | 0.00% |
| Nov. 7, 2024 | Ballal Rahul D. | Director | M | Common stock | 10000 | $25.99 | 17,992.0000 | 73,237,954,000 | 125.13% | 0.00% |
| Nov. 7, 2024 | Ballal Rahul D. | Director | S | Common stock | 8132 | $53.32 | 9,860.0000 | 73,237,954,000 | 45.20% | 0.00% |
| Nov. 7, 2024 | Ballal Rahul D. | Director | S | Common stock | 1868 | $54.41 | 7,992.0000 | 73,237,954,000 | 18.95% | 0.00% |
| Sept. 26, 2024 | Jones Cecilia | Chief Financial Officer | M | Common stock | 7473 | $0.00 | 22,700.0000 | 73,091,490,000 | 49.08% | 0.00% |
| Sept. 26, 2024 | Jones Cecilia | Chief Financial Officer | S | Common stock | 2542 | $49.03 | 20,158.0000 | 73,091,490,000 | 11.20% | 0.00% |
| Sept. 26, 2024 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 7473 | $0.00 | 7,472.0000 | 73,091,490,000 | 50.00% | 0.00% |
| Aug. 11, 2024 | Ballal Rahul D. | Director | M | Common stock | 2302 | $0.00 | 7,992.0000 | 73,091,490,000 | 40.46% | 0.00% |
| Aug. 11, 2024 | Ballal Rahul D. | Director | M | Restricted stock units | 2302 | $0.00 | 2,302.0000 | 73,091,490,000 | 50.00% | 0.00% |
| Aug. 11, 2024 | Smith Cynthia | Director | M | Common stock | 2302 | $0.00 | 7,992.0000 | 73,091,490,000 | 40.46% | 0.00% |
| Aug. 11, 2024 | Smith Cynthia | Director | M | Restricted stock units | 2302 | $0.00 | 2,302.0000 | 73,091,490,000 | 50.00% | 0.00% |
| Aug. 8, 2024 | Goff Brian | Chief Executive Officer | S | Common stock | 11091 | $42.75 | 78,792.0000 | 73,091,490,000 | 12.34% | 0.00% |
| Aug. 8, 2024 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 22691 | $0.00 | 22,691.0000 | 73,091,490,000 | 50.00% | 0.00% |
| Aug. 8, 2024 | Goff Brian | Chief Executive Officer | M | Common stock | 22691 | $0.00 | 89,883.0000 | 73,091,490,000 | 33.77% | 0.00% |
| July 1, 2024 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 3705 | $43.85 | 43,736.0000 | 73,091,490,000 | 7.81% | 0.00% |
| July 1, 2024 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 8375 | $0.00 | 16,749.0000 | 73,091,490,000 | 33.33% | 0.00% |
| July 1, 2024 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 8375 | $0.00 | 47,441.0000 | 73,091,490,000 | 21.44% | 0.00% |
| June 20, 2024 | CAPELLO JEFFREY D | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Scadden David | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Scadden David | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Schenkein David P | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Schenkein David P | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Owen Catherine E. | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Owen Catherine E. | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Ho Maykin | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Ho Maykin | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Foster-Cheek Kaye I | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Foster-Cheek Kaye I | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Ballal Rahul D. | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Ballal Rahul D. | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | CAPELLO JEFFREY D | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Smith Cynthia | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | Smith Cynthia | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | FOUSE JACQUALYN A | Director | A | Stock options (right to buy) | 11774 | $0.00 | 11,774.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 20, 2024 | FOUSE JACQUALYN A | Director | A | Restricted stock units | 2120 | $0.00 | 2,120.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 13, 2024 | Schenkein David P | Director | M | Restricted stock units | 3388 | $0.00 | 0.0000 | 72,967,922,000 | 100.00% | 0.00% |
| June 13, 2024 | Foster-Cheek Kaye I | Director | M | Common stock | 3388 | $0.00 | 11,112.0000 | 72,967,922,000 | 43.86% | 0.00% |
| June 13, 2024 | Foster-Cheek Kaye I | Director | G | Common stock | 3564 | $0.00 | 7,548.0000 | 72,967,922,000 | 32.07% | 0.00% |
| June 13, 2024 | Schenkein David P | Director | M | Common stock | 3388 | $0.00 | 476,096.0000 | 72,967,922,000 | 0.72% | 0.00% |
| June 13, 2024 | Ho Maykin | Director | M | Restricted stock units | 3388 | $0.00 | 0.0000 | 72,967,922,000 | 100.00% | 0.00% |
| June 13, 2024 | Scadden David | Director | M | Common stock | 3388 | $0.00 | 15,483.0000 | 72,967,922,000 | 28.01% | 0.00% |
| June 13, 2024 | Scadden David | Director | M | Restricted stock units | 3388 | $0.00 | 0.0000 | 72,967,922,000 | 100.00% | 0.00% |
| June 13, 2024 | Owen Catherine E. | Director | M | Common stock | 1976 | $0.00 | 1,976.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 13, 2024 | Owen Catherine E. | Director | M | Restricted stock units | 1976 | $0.00 | 3,953.0000 | 72,967,922,000 | 33.33% | 0.00% |
| June 13, 2024 | CAPELLO JEFFREY D | Director | M | Common stock | 1976 | $0.00 | 1,976.0000 | 72,967,922,000 | 9999.99% | 0.00% |
| June 13, 2024 | CAPELLO JEFFREY D | Director | M | Restricted stock units | 1976 | $0.00 | 3,953.0000 | 72,967,922,000 | 33.33% | 0.00% |
| June 13, 2024 | Foster-Cheek Kaye I | Director | M | Restricted stock units | 3388 | $0.00 | 0.0000 | 72,967,922,000 | 100.00% | 0.00% |
| June 13, 2024 | FOUSE JACQUALYN A | Director | M | Common stock | 3388 | $0.00 | 140,784.0000 | 72,967,922,000 | 2.47% | 0.00% |
| June 13, 2024 | FOUSE JACQUALYN A | Director | M | Restricted stock units | 3388 | $0.00 | 0.0000 | 72,967,922,000 | 100.00% | 0.00% |
| June 13, 2024 | Ballal Rahul D. | Director | M | Common stock | 3388 | $0.00 | 5,690.0000 | 72,967,922,000 | 147.18% | 0.00% |
| June 13, 2024 | Smith Cynthia | Director | M | Common stock | 3388 | $0.00 | 5,690.0000 | 72,967,922,000 | 147.18% | 0.00% |
| June 13, 2024 | Smith Cynthia | Director | M | Restricted stock units | 3388 | $0.00 | 0.0000 | 72,967,922,000 | 100.00% | 0.00% |
| June 13, 2024 | Ballal Rahul D. | Director | M | Restricted stock units | 3388 | $0.00 | 0.0000 | 72,967,922,000 | 100.00% | 0.00% |
| June 13, 2024 | Ho Maykin | Director | M | Common stock | 3388 | $0.00 | 14,912.0000 | 72,967,922,000 | 29.40% | 0.00% |
| June 5, 2024 | Goff Brian | Chief Executive Officer | S | Common stock | 12115 | $48.84 | 67,192.0000 | 72,967,922,000 | 15.28% | 0.00% |
| June 5, 2024 | Goff Brian | Chief Executive Officer | M | Common stock | 25527 | $0.00 | 79,307.0000 | 72,967,922,000 | 47.47% | 0.00% |
| June 5, 2024 | Goff Brian | Chief Executive Officer | M | Performance share units | 25527 | $0.00 | 76,583.0000 | 72,967,922,000 | 25.00% | 0.00% |
| June 3, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 1362 | $44.39 | 1,524.0000 | 72,967,922,000 | 47.19% | 0.00% |
| April 8, 2024 | FOUSE JACQUALYN A | Director | M | Restricted stock units | 15934 | $0.00 | 15,933.0000 | 72,967,922,000 | 50.00% | 0.00% |
| April 10, 2024 | FOUSE JACQUALYN A | Director | S | Common stock | 7791 | $27.55 | 137,396.0000 | 72,967,922,000 | 5.37% | 0.00% |
| April 8, 2024 | FOUSE JACQUALYN A | Director | M | Common stock | 15934 | $0.00 | 145,187.0000 | 72,967,922,000 | 12.33% | 0.00% |
| March 7, 2024 | Foster-Cheek Kaye I | Director | S | Common stock | 1285 | $31.62 | 7,724.0000 | 72,161,489,000 | 14.26% | 0.00% |
| March 5, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 1913 | $31.75 | 2,886.0000 | 72,161,489,000 | 39.86% | 0.00% |
| March 5, 2024 | Foster-Cheek Kaye I | Director | S | Common stock | 300 | $32.21 | 13,424.0000 | 72,161,489,000 | 2.19% | 0.00% |
| March 6, 2024 | Foster-Cheek Kaye I | Director | S | Common stock | 4415 | $31.99 | 9,009.0000 | 72,161,489,000 | 32.89% | 0.00% |
| March 1, 2024 | Goff Brian | Chief Executive Officer | A | Stock options (right to buy) | 195500 | $0.00 | 195,500.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 3834 | $0.00 | 37,708.0000 | 72,161,489,000 | 11.32% | 0.00% |
| March 5, 2024 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1293 | $32.57 | 36,415.0000 | 72,161,489,000 | 3.43% | 0.00% |
| March 1, 2024 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 4000 | $0.00 | 40,415.0000 | 72,161,489,000 | 10.98% | 0.00% |
| March 5, 2024 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1349 | $32.57 | 39,066.0000 | 72,161,489,000 | 3.34% | 0.00% |
| March 1, 2024 | Gheuens Sarah | Chief Medical Officer | A | Restricted stock units | 17000 | $0.00 | 17,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Gheuens Sarah | Chief Medical Officer | A | Stock options (right to buy) | 60000 | $0.00 | 60,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 3834 | $0.00 | 3,833.0000 | 72,161,489,000 | 50.01% | 0.00% |
| March 1, 2024 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 4000 | $0.00 | 8,000.0000 | 72,161,489,000 | 33.33% | 0.00% |
| March 1, 2024 | Jones Cecilia | Chief Financial Officer | M | Common stock | 2000 | $0.00 | 15,512.0000 | 72,161,489,000 | 14.80% | 0.00% |
| March 5, 2024 | Jones Cecilia | Chief Financial Officer | S | Common stock | 672 | $32.57 | 14,840.0000 | 72,161,489,000 | 4.33% | 0.00% |
| March 1, 2024 | Jones Cecilia | Chief Financial Officer | A | Restricted stock units | 17000 | $0.00 | 17,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Jones Cecilia | Chief Financial Officer | A | Stock options (right to buy) | 60000 | $0.00 | 60,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 2000 | $0.00 | 4,000.0000 | 72,161,489,000 | 33.33% | 0.00% |
| March 1, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 777 | $0.00 | 3,663.0000 | 72,161,489,000 | 26.92% | 0.00% |
| March 5, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 295 | $32.57 | 3,368.0000 | 72,161,489,000 | 8.05% | 0.00% |
| March 1, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 2350 | $0.00 | 5,718.0000 | 72,161,489,000 | 69.77% | 0.00% |
| March 5, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 919 | $32.57 | 4,799.0000 | 72,161,489,000 | 16.07% | 0.00% |
| March 1, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | A | Restricted stock units | 7350 | $0.00 | 7,350.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 777 | $0.00 | 777.0000 | 72,161,489,000 | 50.00% | 0.00% |
| March 1, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 2350 | $0.00 | 4,700.0000 | 72,161,489,000 | 33.33% | 0.00% |
| March 1, 2024 | Goff Brian | Chief Executive Officer | M | Common stock | 8500 | $0.00 | 57,936.0000 | 72,161,489,000 | 17.19% | 0.00% |
| March 5, 2024 | Goff Brian | Chief Executive Officer | S | Common stock | 4156 | $32.57 | 53,780.0000 | 72,161,489,000 | 7.17% | 0.00% |
| March 1, 2024 | Goff Brian | Chief Executive Officer | A | Restricted stock units | 54000 | $0.00 | 54,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 8500 | $0.00 | 17,000.0000 | 72,161,489,000 | 33.33% | 0.00% |
| March 1, 2024 | Burns James William | Chief Legal Officer | M | Common stock | 3834 | $0.00 | 35,811.0000 | 72,161,489,000 | 11.99% | 0.00% |
| March 5, 2024 | Burns James William | Chief Legal Officer | S | Common stock | 1293 | $32.57 | 34,518.0000 | 72,161,489,000 | 3.61% | 0.00% |
| March 1, 2024 | Burns James William | Chief Legal Officer | M | Common stock | 4000 | $0.00 | 38,518.0000 | 72,161,489,000 | 11.59% | 0.00% |
| March 5, 2024 | Burns James William | Chief Legal Officer | S | Common stock | 1349 | $32.57 | 37,169.0000 | 72,161,489,000 | 3.50% | 0.00% |
| March 1, 2024 | Burns James William | Chief Legal Officer | A | Restricted stock units | 17000 | $0.00 | 17,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Burns James William | Chief Legal Officer | A | Stock options (right to buy) | 60000 | $0.00 | 60,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Burns James William | Chief Legal Officer | M | Restricted stock units | 3834 | $0.00 | 3,833.0000 | 72,161,489,000 | 50.01% | 0.00% |
| March 1, 2024 | Burns James William | Chief Legal Officer | M | Restricted stock units | 4000 | $0.00 | 8,000.0000 | 72,161,489,000 | 33.33% | 0.00% |
| March 1, 2024 | Milanova Tsveta | Chief Commercial Officer | A | Restricted stock units | 17000 | $0.00 | 17,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| March 1, 2024 | Milanova Tsveta | Chief Commercial Officer | A | Stock options (right to buy) | 60000 | $0.00 | 60,000.0000 | 72,161,489,000 | 9999.99% | 0.00% |
| Feb. 27, 2024 | Schenkein David P | Director | S | Common stock | 11858 | $33.60 | 472,708.0000 | 72,161,489,000 | 2.45% | 0.00% |
| Feb. 27, 2024 | Schenkein David P | Director | M | Common stock | 57471 | $31.64 | 530,179.0000 | 72,161,489,000 | 12.16% | 0.00% |
| Feb. 27, 2024 | Schenkein David P | Director | M | Stock option (right to buy) | 11858 | $0.00 | 57,471.0000 | 72,161,489,000 | 17.10% | 0.00% |
| Feb. 27, 2024 | Schenkein David P | Director | M | Stock option (right to buy) | 57471 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Feb. 27, 2024 | Schenkein David P | Director | S | Common stock | 57471 | $34.89 | 472,708.0000 | 72,161,489,000 | 10.84% | 0.00% |
| Feb. 27, 2024 | Schenkein David P | Director | M | Common stock | 11858 | $31.64 | 484,566.0000 | 72,161,489,000 | 2.51% | 0.00% |
| Feb. 26, 2024 | Schenkein David P | Director | M | Common stock | 20411 | $31.64 | 493,119.0000 | 72,161,489,000 | 4.32% | 0.00% |
| Feb. 23, 2024 | Schenkein David P | Director | M | Stock option (right to buy) | 47731 | $0.00 | 89,740.0000 | 72,161,489,000 | 34.72% | 0.00% |
| Feb. 26, 2024 | Schenkein David P | Director | M | Stock option (right to buy) | 20411 | $0.00 | 69,329.0000 | 72,161,489,000 | 22.74% | 0.00% |
| Feb. 26, 2024 | Schenkein David P | Director | S | Common stock | 20411 | $33.19 | 472,708.0000 | 72,161,489,000 | 4.14% | 0.00% |
| Feb. 23, 2024 | Schenkein David P | Director | M | Common stock | 47731 | $31.64 | 520,439.0000 | 72,161,489,000 | 10.10% | 0.00% |
| Feb. 23, 2024 | Schenkein David P | Director | S | Common stock | 47731 | $33.05 | 472,708.0000 | 72,161,489,000 | 9.17% | 0.00% |
| Feb. 20, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 504 | $26.63 | 2,741.0000 | 72,161,489,000 | 15.53% | 0.00% |
| Feb. 14, 2024 | Burns James William | Chief Legal Officer | S | Common stock | 545 | $25.14 | 31,666.0000 | 72,161,489,000 | 1.69% | 0.00% |
| Feb. 12, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 777 | $0.00 | 3,518.0000 | 72,161,489,000 | 28.35% | 0.00% |
| Feb. 14, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 273 | $25.14 | 3,245.0000 | 72,161,489,000 | 7.76% | 0.00% |
| Feb. 12, 2024 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 777 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Feb. 12, 2024 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 2162 | $0.00 | 34,073.0000 | 72,161,489,000 | 6.78% | 0.00% |
| Feb. 14, 2024 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 642 | $25.14 | 33,431.0000 | 72,161,489,000 | 1.88% | 0.00% |
| Feb. 12, 2024 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 2162 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Feb. 12, 2024 | Burns James William | Chief Legal Officer | M | Common stock | 1833 | $0.00 | 32,211.0000 | 72,161,489,000 | 6.03% | 0.00% |
| Feb. 12, 2024 | Burns James William | Chief Legal Officer | M | Restricted stock units | 1833 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 24, 2024 | Goff Brian | Chief Executive Officer | S | Common stock | 7635 | $21.64 | 49,436.0000 | 72,161,489,000 | 13.38% | 0.00% |
| Jan. 20, 2024 | Milanova Tsveta | Chief Commercial Officer | M | Performance share units | 5448 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 24, 2024 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 1618 | $21.64 | 13,234.0000 | 72,161,489,000 | 10.89% | 0.00% |
| Jan. 20, 2024 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 5448 | $0.00 | 14,852.0000 | 72,161,489,000 | 57.93% | 0.00% |
| Jan. 20, 2024 | Burns James William | Chief Legal Officer | M | Common stock | 5750 | $0.00 | 32,086.0000 | 72,161,489,000 | 21.83% | 0.00% |
| Jan. 24, 2024 | Burns James William | Chief Legal Officer | S | Common stock | 1708 | $21.64 | 30,378.0000 | 72,161,489,000 | 5.32% | 0.00% |
| Jan. 20, 2024 | Burns James William | Chief Legal Officer | M | Performance share units | 5750 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 20, 2024 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 5750 | $0.00 | 33,619.0000 | 72,161,489,000 | 20.63% | 0.00% |
| Jan. 24, 2024 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1708 | $21.64 | 31,911.0000 | 72,161,489,000 | 5.08% | 0.00% |
| Jan. 20, 2024 | Gheuens Sarah | Chief Medical Officer | M | Performance share units | 5750 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 20, 2024 | Jones Cecilia | Chief Financial Officer | M | Common stock | 5380 | $0.00 | 14,955.0000 | 72,161,489,000 | 56.19% | 0.00% |
| Jan. 24, 2024 | Jones Cecilia | Chief Financial Officer | S | Common stock | 1886 | $21.64 | 13,069.0000 | 72,161,489,000 | 12.61% | 0.00% |
| Jan. 20, 2024 | Jones Cecilia | Chief Financial Officer | M | Performance share units | 5380 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 20, 2024 | FOUSE JACQUALYN A | Director | M | Common stock | 23900 | $0.00 | 139,975.0000 | 72,161,489,000 | 20.59% | 0.00% |
| Jan. 24, 2024 | FOUSE JACQUALYN A | Director | S | Common stock | 10722 | $21.64 | 129,253.0000 | 72,161,489,000 | 7.66% | 0.00% |
| Jan. 20, 2024 | FOUSE JACQUALYN A | Director | M | Performance share units | 23900 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 20, 2024 | Goff Brian | Chief Executive Officer | M | Common stock | 17018 | $0.00 | 57,071.0000 | 72,161,489,000 | 42.49% | 0.00% |
| Jan. 20, 2024 | Goff Brian | Chief Executive Officer | M | Performance share units | 17018 | $0.00 | 102,110.0000 | 72,161,489,000 | 14.29% | 0.00% |
| Jan. 5, 2024 | Goff Brian | Chief Executive Officer | M | Performance share units | 25527 | $0.00 | 119,128.0000 | 72,161,489,000 | 17.65% | 0.00% |
| Jan. 5, 2024 | Goff Brian | Chief Executive Officer | M | Common stock | 25527 | $0.00 | 52,119.0000 | 72,161,489,000 | 96.00% | 0.00% |
| Jan. 9, 2024 | Goff Brian | Chief Executive Officer | S | Common stock | 12066 | $22.99 | 40,053.0000 | 72,161,489,000 | 23.15% | 0.00% |
| Jan. 5, 2024 | FOUSE JACQUALYN A | Director | M | Common stock | 17500 | $0.00 | 124,466.0000 | 72,161,489,000 | 16.36% | 0.00% |
| Jan. 9, 2024 | FOUSE JACQUALYN A | Director | S | Common stock | 8391 | $22.99 | 116,075.0000 | 72,161,489,000 | 6.74% | 0.00% |
| Jan. 5, 2024 | FOUSE JACQUALYN A | Director | M | Performance share units | 17500 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 5, 2024 | Burns James William | Chief Legal Officer | M | Common stock | 3250 | $0.00 | 27,499.0000 | 72,161,489,000 | 13.40% | 0.00% |
| Jan. 9, 2024 | Burns James William | Chief Legal Officer | S | Common stock | 1163 | $22.99 | 26,336.0000 | 72,161,489,000 | 4.23% | 0.00% |
| Jan. 5, 2024 | Burns James William | Chief Legal Officer | M | Performance share units | 3250 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 5, 2024 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 5000 | $0.00 | 29,658.0000 | 72,161,489,000 | 20.28% | 0.00% |
| Jan. 9, 2024 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1789 | $22.99 | 27,869.0000 | 72,161,489,000 | 6.03% | 0.00% |
| Jan. 5, 2024 | Gheuens Sarah | Chief Medical Officer | M | Performance share units | 5000 | $0.00 | 0.0000 | 72,161,489,000 | 100.00% | 0.00% |
| Jan. 3, 2024 | Milanova Tsveta | Chief Commercial Officer | M | Restricted stock units | 8475 | $0.00 | 16,951.0000 | 72,161,489,000 | 33.33% | 0.00% |
| Jan. 3, 2024 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 8475 | $0.00 | 12,306.0000 | 72,161,489,000 | 221.22% | 0.00% |
| Jan. 5, 2024 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 2902 | $22.32 | 9,404.0000 | 72,161,489,000 | 23.58% | 0.00% |
| Sept. 26, 2023 | Jones Cecilia | Chief Financial Officer | M | Restricted stock units | 7472 | $0.00 | 14,945.0000 | 71,256,118 | 33.33% | 0.01% |
| Sept. 28, 2023 | Jones Cecilia | Chief Financial Officer | S | Common stock | 2179 | $24.79 | 9,575.0000 | 71,256,118 | 18.54% | 0.00% |
| Sept. 26, 2023 | Jones Cecilia | Chief Financial Officer | M | Common stock | 7472 | $0.00 | 11,754.0000 | 71,256,118 | 174.50% | 0.01% |
| Aug. 17, 2023 | Burns James William | Chief Legal Officer | S | Common stock | 6395 | $26.28 | 23,890.0000 | 71,256,118 | 21.12% | 0.01% |
| Aug. 11, 2023 | Ballal Rahul D. | Director | M | Restricted stock units | 2302 | $0.00 | 4,604.0000 | 71,256,118 | 33.33% | 0.00% |
| Aug. 11, 2023 | Smith Cynthia | Director | M | Common stock | 2302 | $0.00 | 2,302.0000 | 71,256,118 | 9999.99% | 0.00% |
| Aug. 11, 2023 | Smith Cynthia | Director | M | Restricted stock units | 2302 | $0.00 | 4,604.0000 | 71,256,118 | 33.33% | 0.00% |
| Aug. 11, 2023 | Ballal Rahul D. | Director | M | Common stock | 2302 | $0.00 | 2,302.0000 | 71,256,118 | 9999.99% | 0.00% |
| Aug. 9, 2023 | Foster-Cheek Kaye I | Director | S | Common stock | 25000 | $25.96 | 13,724.0000 | 71,256,118 | 64.56% | 0.04% |
| Aug. 9, 2023 | Foster-Cheek Kaye I | Director | M | Common stock | 25000 | $18.09 | 38,724.0000 | 71,256,118 | 182.16% | 0.04% |
| Aug. 9, 2023 | Foster-Cheek Kaye I | Director | M | Stock options (right to buy) | 25000 | $0.00 | 4,307.0000 | 71,256,118 | 85.30% | 0.04% |
| Aug. 8, 2023 | Goff Brian | Chief Executive Officer | M | Restricted stock units | 22691 | $0.00 | 45,382.0000 | 71,256,118 | 33.33% | 0.03% |
| Aug. 8, 2023 | Goff Brian | Chief Executive Officer | M | Common stock | 22691 | $0.00 | 36,770.0000 | 71,256,118 | 161.17% | 0.03% |
| Aug. 8, 2023 | Goff Brian | Chief Executive Officer | S | Common stock | 10178 | $25.48 | 26,592.0000 | 71,256,118 | 27.68% | 0.01% |
| Aug. 7, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 2918 | $25.39 | 2,741.0000 | 71,256,118 | 51.56% | 0.00% |
| Aug. 1, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 4150 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.01% |
| Aug. 1, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 1232 | $26.26 | 5,659.0000 | 71,256,118 | 17.88% | 0.00% |
| Aug. 1, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 4150 | $0.00 | 6,891.0000 | 71,256,118 | 151.40% | 0.01% |
| July 1, 2023 | Gheuens Sarah | Chief Medical Officer | A | Restricted stock units | 25124 | $0.00 | 25,124.0000 | 71,256,118 | 9999.99% | 0.04% |
| June 28, 2023 | Goff Brian | Chief Executive Officer | M | Common stock | 25528 | $0.00 | 25,528.0000 | 71,256,118 | 9999.99% | 0.04% |
| June 28, 2023 | Goff Brian | Chief Executive Officer | M | Performance share units | 25528 | $0.00 | 144,655.0000 | 71,256,118 | 15.00% | 0.04% |
| June 28, 2023 | Jones Cecilia | Chief Financial Officer | M | Common stock | 5380 | $0.00 | 5,380.0000 | 71,256,118 | 9999.99% | 0.01% |
| June 30, 2023 | Jones Cecilia | Chief Financial Officer | S | Common stock | 1597 | $28.36 | 3,783.0000 | 71,256,118 | 29.68% | 0.00% |
| June 28, 2023 | Burns James William | Chief Legal Officer | M | Common stock | 5750 | $0.00 | 31,992.0000 | 71,256,118 | 21.91% | 0.01% |
| June 30, 2023 | Burns James William | Chief Legal Officer | S | Common stock | 1707 | $28.36 | 30,285.0000 | 71,256,118 | 5.34% | 0.00% |
| June 28, 2023 | Burns James William | Chief Legal Officer | M | Performance share units | 5750 | $0.00 | 5,750.0000 | 71,256,118 | 50.00% | 0.01% |
| June 28, 2023 | Milanova Tsveta | Chief Commercial Officer | M | Common stock | 5449 | $0.00 | 5,449.0000 | 71,256,118 | 9999.99% | 0.01% |
| June 30, 2023 | Milanova Tsveta | Chief Commercial Officer | S | Common stock | 1618 | $28.36 | 3,831.0000 | 71,256,118 | 29.69% | 0.00% |
| June 28, 2023 | Milanova Tsveta | Chief Commercial Officer | M | Performance share units | 5449 | $0.00 | 5,448.0000 | 71,256,118 | 50.00% | 0.01% |
| June 28, 2023 | FOUSE JACQUALYN A | Director | M | Common stock | 23900 | $0.00 | 117,684.0000 | 71,256,118 | 25.48% | 0.03% |
| June 30, 2023 | FOUSE JACQUALYN A | Director | S | Common stock | 10718 | $28.36 | 106,966.0000 | 71,256,118 | 9.11% | 0.02% |
| June 28, 2023 | Jones Cecilia | Chief Financial Officer | M | Performance share units | 5380 | $0.00 | 5,380.0000 | 71,256,118 | 50.00% | 0.01% |
| June 28, 2023 | FOUSE JACQUALYN A | Director | M | Performance share units | 23900 | $0.00 | 23,900.0000 | 71,256,118 | 50.00% | 0.03% |
| June 28, 2023 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 5750 | $0.00 | 25,866.0000 | 71,256,118 | 28.58% | 0.01% |
| June 30, 2023 | Gheuens Sarah | Chief Medical Officer | S | Common stock | 1707 | $28.36 | 24,159.0000 | 71,256,118 | 6.60% | 0.00% |
| June 28, 2023 | Gheuens Sarah | Chief Medical Officer | M | Performance share units | 5750 | $0.00 | 5,750.0000 | 71,256,118 | 50.00% | 0.01% |
| June 30, 2023 | Goff Brian | Chief Executive Officer | S | Common stock | 11449 | $28.36 | 14,079.0000 | 71,256,118 | 44.85% | 0.02% |
| June 21, 2023 | Ho Maykin | Director | M | Common stock | 4975 | $0.00 | 11,524.0000 | 71,256,118 | 75.97% | 0.01% |
| June 21, 2023 | Scadden David | Director | M | Restricted stock unit | 4975 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.01% |
| June 21, 2023 | Schenkein David P | Director | M | Common stock | 4975 | $0.00 | 472,708.0000 | 71,256,118 | 1.06% | 0.01% |
| June 21, 2023 | Schenkein David P | Director | M | Restricted stock unit | 4975 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.01% |
| June 21, 2023 | Ho Maykin | Director | M | Restricted stock unit | 4975 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.01% |
| June 21, 2023 | Scadden David | Director | M | Common stock | 4975 | $0.00 | 12,095.0000 | 71,256,118 | 69.87% | 0.01% |
| June 21, 2023 | Foster-Cheek Kaye I | Director | M | Restricted stock unit | 4975 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.01% |
| June 21, 2023 | Foster-Cheek Kaye I | Director | M | Common stock | 4975 | $0.00 | 13,724.0000 | 71,256,118 | 56.86% | 0.01% |
| June 13, 2023 | Foster-Cheek Kaye I | Director | A | Stock options (right to buy) | 18958 | $0.00 | 18,958.0000 | 71,256,118 | 9999.99% | 0.03% |
| June 13, 2023 | Owen Catherine E. | Director | A | Restricted stock units | 5929 | $0.00 | 5,929.0000 | 71,256,118 | 9999.99% | 0.01% |
| June 13, 2023 | Owen Catherine E. | Director | A | Stock options (right to buy) | 33177 | $0.00 | 33,177.0000 | 71,256,118 | 9999.99% | 0.05% |
| June 13, 2023 | CAPELLO JEFFREY D | Director | A | Restricted stock units | 5929 | $0.00 | 5,929.0000 | 71,256,118 | 9999.99% | 0.01% |
| June 13, 2023 | CAPELLO JEFFREY D | Director | A | Stock options (right to buy) | 33177 | $0.00 | 33,177.0000 | 71,256,118 | 9999.99% | 0.05% |
| June 13, 2023 | FOUSE JACQUALYN A | Director | A | Restricted stock units | 3388 | $0.00 | 3,388.0000 | 71,256,118 | 9999.99% | 0.00% |
| June 13, 2023 | FOUSE JACQUALYN A | Director | A | Stock options (right to buy) | 18958 | $0.00 | 18,958.0000 | 71,256,118 | 9999.99% | 0.03% |
| June 13, 2023 | Scadden David | Director | A | Restricted stock units | 3388 | $0.00 | 3,388.0000 | 71,256,118 | 9999.99% | 0.00% |
| June 13, 2023 | Scadden David | Director | A | Stock options (right to buy) | 18958 | $0.00 | 18,958.0000 | 71,256,118 | 9999.99% | 0.03% |
| June 13, 2023 | Schenkein David P | Director | A | Restricted stock units | 3388 | $0.00 | 3,388.0000 | 71,256,118 | 9999.99% | 0.00% |
| June 13, 2023 | Schenkein David P | Director | A | Stock options (right to buy) | 18958 | $0.00 | 18,958.0000 | 71,256,118 | 9999.99% | 0.03% |
| June 13, 2023 | Ballal Rahul D. | Director | A | Restricted stock units | 3388 | $0.00 | 3,388.0000 | 71,256,118 | 9999.99% | 0.00% |
| June 13, 2023 | Ballal Rahul D. | Director | A | Stock options (right to buy) | 18958 | $0.00 | 18,958.0000 | 71,256,118 | 9999.99% | 0.03% |
| June 13, 2023 | Ho Maykin | Director | A | Restricted stock units | 3388 | $0.00 | 3,388.0000 | 71,256,118 | 9999.99% | 0.00% |
| June 13, 2023 | Ho Maykin | Director | A | Stock options (right to buy) | 18958 | $0.00 | 18,958.0000 | 71,256,118 | 9999.99% | 0.03% |
| June 13, 2023 | Smith Cynthia | Director | A | Restricted stock units | 3388 | $0.00 | 3,388.0000 | 71,256,118 | 9999.99% | 0.00% |
| June 13, 2023 | Smith Cynthia | Director | A | Stock options (right to buy) | 18958 | $0.00 | 18,958.0000 | 71,256,118 | 9999.99% | 0.03% |
| June 13, 2023 | Foster-Cheek Kaye I | Director | A | Restricted stock units | 3388 | $0.00 | 3,388.0000 | 71,256,118 | 9999.99% | 0.00% |
| April 12, 2023 | FOUSE JACQUALYN A | Director | F | Common stock | 4731 | $21.35 | 93,784.0000 | 71,256,118 | 4.80% | 0.01% |
| April 8, 2023 | FOUSE JACQUALYN A | Director | M | Common stock | 15933 | $0.00 | 98,515.0000 | 71,256,118 | 19.29% | 0.02% |
| April 8, 2023 | FOUSE JACQUALYN A | Director | M | Restricted stock units | 15933 | $0.00 | 31,867.0000 | 71,256,118 | 33.33% | 0.02% |
| April 3, 2023 | Schenkein David P | Director | S | Common stock | 16363 | $22.85 | 467,733.0000 | 71,256,118 | 3.38% | 0.02% |
| April 3, 2023 | Schenkein David P | Director | M | Common stock | 16363 | $9.05 | 484,096.0000 | 71,256,118 | 3.50% | 0.02% |
| April 3, 2023 | Schenkein David P | Director | M | Stock option (right to buy) | 16363 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.02% |
| March 27, 2023 | Schenkein David P | Director | S | Common stock | 20000 | $22.15 | 467,733.0000 | 71,256,118 | 4.10% | 0.03% |
| March 27, 2023 | Schenkein David P | Director | M | Common stock | 20000 | $9.05 | 487,733.0000 | 71,256,118 | 4.28% | 0.03% |
| March 27, 2023 | Schenkein David P | Director | M | Stock option (right to buy) | 20000 | $0.00 | 16,363.0000 | 71,256,118 | 55.00% | 0.03% |
| March 13, 2023 | Schenkein David P | Director | M | Stock option (right to buy) | 20000 | $0.00 | 36,363.0000 | 71,256,118 | 35.48% | 0.03% |
| March 13, 2023 | Schenkein David P | Director | M | Common stock | 20000 | $9.05 | 487,733.0000 | 71,256,118 | 4.28% | 0.03% |
| March 13, 2023 | Schenkein David P | Director | S | Common stock | 18333 | $22.47 | 469,400.0000 | 71,256,118 | 3.76% | 0.03% |
| March 13, 2023 | Schenkein David P | Director | S | Common stock | 1667 | $22.72 | 467,733.0000 | 71,256,118 | 0.36% | 0.00% |
| March 3, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 504 | $24.29 | 2,741.0000 | 71,256,118 | 15.53% | 0.00% |
| March 1, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | F | Common stock | 273 | $25.31 | 3,245.0000 | 71,256,118 | 7.76% | 0.00% |
| March 1, 2023 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 3833 | $0.00 | 7,667.0000 | 71,256,118 | 33.33% | 0.01% |
| March 1, 2023 | Gheuens Sarah | Chief Medical Officer | A | Stock options (right to buy) | 44000 | $0.00 | 44,000.0000 | 71,256,118 | 9999.99% | 0.06% |
| March 1, 2023 | Gheuens Sarah | Chief Medical Officer | A | Restricted stock units | 12000 | $0.00 | 12,000.0000 | 71,256,118 | 9999.99% | 0.02% |
| March 3, 2023 | Gheuens Sarah | Chief Medical Officer | F | Common stock | 1134 | $25.02 | 20,116.0000 | 71,256,118 | 5.34% | 0.00% |
| March 1, 2023 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 3833 | $0.00 | 21,250.0000 | 71,256,118 | 22.01% | 0.01% |
| March 1, 2023 | Goff Brian | Chief Executive Officer | A | Stock options (right to buy) | 94500 | $0.00 | 94,500.0000 | 71,256,118 | 9999.99% | 0.13% |
| March 1, 2023 | Goff Brian | Chief Executive Officer | A | Restricted stock units | 25500 | $0.00 | 25,500.0000 | 71,256,118 | 9999.99% | 0.04% |
| March 1, 2023 | Burns James William | Chief Legal Officer | M | Restricted stock units | 3833 | $0.00 | 7,667.0000 | 71,256,118 | 33.33% | 0.01% |
| March 1, 2023 | Burns James William | Chief Legal Officer | A | Stock options (right to buy) | 44000 | $0.00 | 44,000.0000 | 71,256,118 | 9999.99% | 0.06% |
| March 1, 2023 | Burns James William | Chief Legal Officer | A | Restricted stock units | 12000 | $0.00 | 12,000.0000 | 71,256,118 | 9999.99% | 0.02% |
| March 3, 2023 | Burns James William | Chief Legal Officer | F | Common stock | 1129 | $25.02 | 26,242.0000 | 71,256,118 | 4.12% | 0.00% |
| March 1, 2023 | Burns James William | Chief Legal Officer | M | Common stock | 3833 | $0.00 | 27,371.0000 | 71,256,118 | 16.28% | 0.01% |
| March 1, 2023 | Jones Cecilia | Chief Financial Officer | A | Stock options (right to buy) | 22000 | $0.00 | 22,000.0000 | 71,256,118 | 9999.99% | 0.03% |
| March 1, 2023 | Jones Cecilia | Chief Financial Officer | A | Restricted stock units | 6000 | $0.00 | 6,000.0000 | 71,256,118 | 9999.99% | 0.01% |
| March 1, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 777 | $0.00 | 1,554.0000 | 71,256,118 | 33.33% | 0.00% |
| March 1, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | A | Restricted stock units | 7050 | $0.00 | 7,050.0000 | 71,256,118 | 9999.99% | 0.01% |
| March 1, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 777 | $0.00 | 3,518.0000 | 71,256,118 | 28.35% | 0.00% |
| Feb. 27, 2023 | Schenkein David P | Director | M | Common stock | 20000 | $9.05 | 487,733.0000 | 71,256,118 | 4.28% | 0.03% |
| Feb. 27, 2023 | Schenkein David P | Director | S | Common stock | 20000 | $25.37 | 467,733.0000 | 71,256,118 | 4.10% | 0.03% |
| Feb. 27, 2023 | Schenkein David P | Director | M | Stock option (right to buy) | 20000 | $0.00 | 56,363.0000 | 71,256,118 | 26.19% | 0.03% |
| Feb. 16, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 233 | $27.21 | 2,668.0000 | 71,256,118 | 8.03% | 0.00% |
| Feb. 14, 2023 | FOUSE JACQUALYN A | Director | M | Restricted stock units | 11333 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.02% |
| Feb. 14, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | S | Common stock | 504 | $28.59 | 2,901.0000 | 71,256,118 | 14.80% | 0.00% |
| Feb. 14, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 360 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.00% |
| Feb. 14, 2023 | Burns James William | Chief Legal Officer | M | Common stock | 1738 | $0.00 | 24,147.0000 | 71,256,118 | 7.76% | 0.00% |
| Feb. 16, 2023 | Burns James William | Chief Legal Officer | F | Common stock | 609 | $28.91 | 23,538.0000 | 71,256,118 | 2.52% | 0.00% |
| Feb. 14, 2023 | Burns James William | Chief Legal Officer | M | Restricted stock units | 1738 | $0.00 | 0.0000 | 71,256,118 | 100.00% | 0.00% |
| Feb. 14, 2023 | FOUSE JACQUALYN A | Director | M | Common stock | 11333 | $0.00 | 86,230.0000 | 71,256,118 | 15.13% | 0.02% |
| Feb. 16, 2023 | FOUSE JACQUALYN A | Director | F | Common stock | 3648 | $28.91 | 82,582.0000 | 71,256,118 | 4.23% | 0.01% |
| Feb. 14, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | F | Common stock | 127 | $28.91 | 3,405.0000 | 71,256,118 | 3.60% | 0.00% |
| Feb. 14, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 360 | $0.00 | 3,532.0000 | 71,256,118 | 11.35% | 0.00% |
| Feb. 13, 2023 | Schenkein David P | Director | S | Common stock | 20000 | $28.62 | 467,733.0000 | 71,256,118 | 4.10% | 0.03% |
| Feb. 13, 2023 | Schenkein David P | Director | M | Stock option (right to buy) | 20000 | $0.00 | 76,363.0000 | 71,256,118 | 20.75% | 0.03% |
| Feb. 13, 2023 | Schenkein David P | Director | M | Common stock | 20000 | $9.05 | 487,733.0000 | 71,256,118 | 4.28% | 0.03% |
| Feb. 10, 2023 | Gheuens Sarah | Chief Medical Officer | M | Restricted stock units | 2162 | $0.00 | 2,162.0000 | 71,256,118 | 50.00% | 0.00% |
| Feb. 14, 2023 | Burns James William | Chief Legal Officer | F | Common stock | 643 | $28.44 | 22,409.0000 | 71,256,118 | 2.79% | 0.00% |
| Feb. 10, 2023 | Burns James William | Chief Legal Officer | M | Restricted stock units | 1834 | $0.00 | 1,833.0000 | 71,256,118 | 50.01% | 0.00% |
| Feb. 10, 2023 | Gheuens Sarah | Chief Medical Officer | M | Common stock | 2162 | $0.00 | 17,767.0000 | 71,256,118 | 13.85% | 0.00% |
| Feb. 10, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Restricted stock units | 777 | $0.00 | 777.0000 | 71,256,118 | 50.00% | 0.00% |
| Feb. 1, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | A | Restricted stock units | 6896 | $0.00 | 6,896.0000 | 71,256,118 | 9999.99% | 0.01% |
| Feb. 10, 2023 | Burns James William | Chief Legal Officer | M | Common stock | 1834 | $0.00 | 23,052.0000 | 71,256,118 | 8.64% | 0.00% |
| Feb. 10, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | M | Common stock | 777 | $0.00 | 3,445.0000 | 71,256,118 | 29.12% | 0.00% |
| Feb. 14, 2023 | Gheuens Sarah | Chief Medical Officer | F | Common stock | 758 | $28.44 | 17,009.0000 | 71,256,118 | 4.27% | 0.00% |
| Feb. 14, 2023 | Washburn Theodore James Jr. | Principal Accounting Officer | F | Common stock | 273 | $28.44 | 3,172.0000 | 71,256,118 | 7.92% | 0.00% |
| Sept. 20, 2022 | MARAGANORE JOHN | Director | G | Common stock | 1500 | $0.00 | 28,528.0000 | 70,550,631 | 5.00% | 0.00% |
| Jan. 30, 2023 | Schenkein David P | Director | M | Stock option (right to buy) | 20000 | $0.00 | 96,363.0000 | 71,256,118 | 17.19% | 0.03% |
| Jan. 30, 2023 | Schenkein David P | Director | M | Common stock | 20000 | $9.05 | 487,733.0000 | 71,256,118 | 4.28% | 0.03% |
| Jan. 30, 2023 | Schenkein David P | Director | S | Common stock | 16700 | $29.22 | 471,033.0000 | 71,256,118 | 3.42% | 0.02% |
| Jan. 30, 2023 | Schenkein David P | Director | S | Common stock | 3300 | $29.88 | 467,733.0000 | 71,256,118 | 0.70% | 0.00% |
| Jan. 17, 2023 | Schenkein David P | Director | M | Common stock | 20000 | $9.05 | 487,733.0000 | 71,256,118 | 4.28% | 0.03% |
| Jan. 17, 2023 | Schenkein David P | Director | S | Common stock | 1034 | $29.49 | 467,733.0000 | 71,256,118 | 0.22% | 0.00% |
| Jan. 17, 2023 | Schenkein David P | Director | S | Common stock | 18966 | $28.82 | 468,767.0000 | 71,256,118 | 3.89% | 0.03% |
| Jan. 17, 2023 | Schenkein David P | Director | M | Stock option (right to buy) | 20000 | $0.00 | 116,363.0000 | 71,256,118 | 14.67% | 0.03% |
| Jan. 13, 2023 | Foster-Cheek Kaye I | Director | G | Common stock | 2200 | $0.00 | 8,749.0000 | 71,256,118 | 20.09% | 0.00% |
| Jan. 3, 2023 | Milanova Tsveta | Chief Commercial Officer | A | Stock option (right to buy) | 135682 | $0.00 | 135,682.0000 | 71,256,118 | 9999.99% | 0.19% |
| Jan. 3, 2023 | Milanova Tsveta | Chief Commercial Officer | A | Restricted stock units | 25426 | $0.00 | 25,426.0000 | 71,256,118 | 9999.99% | 0.04% |