In the last 12 months, insiders at Spyre Therapeutics, Inc. ($SYRE) filed 77 transactions with the SEC: 0 open-market purchases totaling $0 and 17 sales totaling $4,250,754. Net insider sentiment: net selling.
Spyre Therapeutics, Inc. operates in the Pharmaceutical preparations industry (Life sciences sector).
Most Active Insiders
- Fairmount Funds Management LLC (Not found) — 10 transactions totaling $10,000,200
- Turtle Cameron (Chief Executive Officer) — 18 transactions totaling $3,074,107
- Burrows Scott L (Chief Financial Officer) — 11 transactions totaling $959,583
- Albers Jeffrey W. (Director) — 3 transactions totaling $257,242
- Hanley Jr. Michael Conick (Chief Business Officer) — 1 transaction totaling $0
View all SEC Filings for Spyre Therapeutics, Inc. (SYRE).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| March 2, 2026 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 5900 | $41.73 | 651,640.0000 | 78,540,164 | 0.90% | 0.01% |
| March 3, 2026 | Burrows Scott L | Chief Financial Officer | M | Common Stock | 2500 | $14.50 | 100,494.0000 | 78,540,164 | 2.55% | 0.00% |
| March 3, 2026 | Burrows Scott L | Chief Financial Officer | S | Common Stock | 2300 | $40.56 | 98,194.0000 | 78,540,164 | 2.29% | 0.00% |
| March 3, 2026 | Burrows Scott L | Chief Financial Officer | S | Common Stock | 200 | $41.66 | 97,994.0000 | 78,540,164 | 0.20% | 0.00% |
| March 3, 2026 | Burrows Scott L | Chief Financial Officer | M | Stock Option (Right to Buy) | 2500 | $0.00 | 402,357.0000 | 78,540,164 | 0.62% | 0.00% |
| March 2, 2026 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 9100 | $42.49 | 642,540.0000 | 78,540,164 | 1.40% | 0.01% |
| Feb. 2, 2026 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 957 | $31.82 | 671,583.0000 | 77,592,130 | 0.14% | 0.00% |
| Feb. 2, 2026 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 14043 | $32.87 | 657,540.0000 | 77,592,130 | 2.09% | 0.02% |
| Jan. 21, 2026 | HENDERSON MICHAEL THOMAS | Director | J | Common Stock | 63227 | $0.00 | 168,606.0000 | 77,592,130 | 60.00% | 0.08% |
| Jan. 9, 2026 | Sloan Sheldon | Chief Medical Officer | A | Stock Option (Right to Buy) | 140000 | $0.00 | 140,000.0000 | 77,592,130 | 9999.99% | 0.18% |
| Jan. 9, 2026 | King-Jones Heidy | See Remarks | A | Stock Option (Right to Buy) | 140000 | $0.00 | 140,000.0000 | 77,592,130 | 9999.99% | 0.18% |
| Jan. 9, 2026 | Burrows Scott L | Chief Financial Officer | A | Stock Option (Right to Buy) | 140000 | $0.00 | 140,000.0000 | 77,592,130 | 9999.99% | 0.18% |
| Jan. 9, 2026 | Turtle Cameron | Chief Executive Officer | A | Stock Option (Right to Buy) | 528000 | $0.00 | 528,000.0000 | 77,592,130 | 9999.99% | 0.68% |
| Jan. 2, 2026 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 100 | $32.39 | 671,907.0000 | 77,592,130 | 0.01% | 0.00% |
| Jan. 2, 2026 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 12709 | $30.47 | 674,198.0000 | 77,592,130 | 1.85% | 0.02% |
| Jan. 2, 2026 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 2191 | $31.79 | 672,007.0000 | 77,592,130 | 0.32% | 0.00% |
| Dec. 1, 2025 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 4005 | $29.83 | 686,907.0000 | 77,592,130 | 0.58% | 0.01% |
| Dec. 1, 2025 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 10995 | $28.73 | 690,912.0000 | 77,592,130 | 1.57% | 0.01% |
| Nov. 3, 2025 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 16845 | $23.66 | 701,907.0000 | 77,592,130 | 2.34% | 0.02% |
| Nov. 3, 2025 | Turtle Cameron | Chief Executive Officer | S | Common Stock | 28155 | $23.13 | 718,752.0000 | 77,592,130 | 3.77% | 0.04% |
| Sept. 2, 2025 | Burrows Scott L | Chief Financial Officer | S | Common Stock | 18428 | $16.26 | 97,994.0000 | 60,275,561 | 15.83% | 0.03% |
| May 29, 2025 | Fairmount Funds Management LLC | Director | A | Stock Option (Right to Buy) | 25000 | $0.00 | 50,000.0000 | 60,275,561 | 100.00% | 0.04% |
| May 29, 2025 | HENDERSON MICHAEL THOMAS | Director | A | Stock Option (Right to Buy) | 25000 | $0.00 | 25,000.0000 | 60,275,561 | 9999.99% | 0.04% |
| May 29, 2025 | McKenna Mark C. | Director | A | Stock Option (Right to Buy) | 25000 | $0.00 | 25,000.0000 | 60,275,561 | 9999.99% | 0.04% |
| May 29, 2025 | Milligan Sandra | Director | A | Stock Option (Right to Buy) | 25000 | $0.00 | 25,000.0000 | 60,275,561 | 9999.99% | 0.04% |
| May 29, 2025 | Stelzer Laurie | Director | A | Stock Option (Right to Buy) | 25000 | $0.00 | 25,000.0000 | 60,275,561 | 9999.99% | 0.04% |
| May 29, 2025 | Fairmount Funds Management LLC | Director | A | Stock Option (Right to Buy) | 25000 | $0.00 | 50,000.0000 | 60,275,561 | 100.00% | 0.04% |
| May 29, 2025 | Albers Jeffrey W. | Director | A | Stock Option (Right to Buy) | 25000 | $0.00 | 25,000.0000 | 60,275,561 | 9999.99% | 0.04% |
| Jan. 15, 2025 | Sloan Sheldon | Chief Medical Officer | A | Stock Option (Right to Buy) | 95500 | $0.00 | 95,500.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2025 | Burrows Scott L | Chief Financial Officer | A | Stock Option (Right to Buy) | 95500 | $0.00 | 95,500.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2025 | King-Jones Heidy | See Remarks | A | Stock Option (Right to Buy) | 95500 | $0.00 | 95,500.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2025 | Turtle Cameron | Chief Executive Officer | A | Stock Option (Right to Buy) | 370000 | $0.00 | 370,000.0000 | 0 | 9999.99% | 0.00% |
| Jan. 10, 2025 | HENDERSON MICHAEL THOMAS | Director | J | Common Stock | 105379 | $0.00 | 105,379.0000 | 0 | 9999.99% | 0.00% |
| Nov. 6, 2024 | Albers Jeffrey W. | Director | S | Common Stock | 6700 | $36.76 | 27,360.0000 | 0 | 19.67% | 0.00% |
| Oct. 25, 2024 | Albers Jeffrey W. | Director | S | Common Stock | 300 | $36.43 | 34,060.0000 | 0 | 0.87% | 0.00% |
| Oct. 1, 2024 | Sloan Sheldon | Chief Medical Officer | A | Stock Option (Right to Buy) | 400000 | $0.00 | 400,000.0000 | 0 | 9999.99% | 0.00% |
| Sept. 3, 2024 | Burrows Scott L | Chief Financial Officer | S | Common Stock | 18531 | $28.17 | 116,422.0000 | 0 | 13.73% | 0.00% |
| May 14, 2024 | Fairmount Funds Management LLC | Not found | A | Stock Option (Right to Buy) | 11323 | $0.00 | 22,646.0000 | 0 | 100.00% | 0.00% |
| May 14, 2024 | HENDERSON MICHAEL THOMAS | Not found | A | Stock Option (Right to Buy) | 11323 | $0.00 | 11,323.0000 | 0 | 9999.99% | 0.00% |
| May 14, 2024 | Milligan Sandra | Not found | A | Stock Option (Right to Buy) | 21980 | $0.00 | 21,980.0000 | 0 | 9999.99% | 0.00% |
| May 14, 2024 | Albers Jeffrey W. | Not found | A | Stock Option (Right to Buy) | 11323 | $0.00 | 11,323.0000 | 0 | 9999.99% | 0.00% |
| May 14, 2024 | Stelzer Laurie | Not found | A | Stock Option (Right to Buy) | 11323 | $0.00 | 11,323.0000 | 0 | 9999.99% | 0.00% |
| May 14, 2024 | Fairmount Funds Management LLC | Not found | A | Stock Option (Right to Buy) | 11323 | $0.00 | 22,646.0000 | 0 | 100.00% | 0.00% |
| April 25, 2024 | Fairmount Funds Management LLC | Not found | M | Common Stock | 3639680 | $0.00 | 4,830,177.0000 | 0 | 305.73% | 0.00% |
| April 25, 2024 | Fairmount Funds Management LLC | Not found | M | Series A Preferred Stock | 90992 | $0.00 | 346,045.0000 | 0 | 20.82% | 0.00% |
| Feb. 15, 2024 | Turtle Cameron | Chief Executive Officer | A | Common Stock | 400 | $9.82 | 746,907.0000 | 0 | 0.05% | 0.00% |
| Feb. 1, 2024 | McKenna Mark C. | Not found | A | Stock Option (Right to Buy) | 40000 | $0.00 | 40,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 1, 2024 | Burrows Scott L | Chief Financial Officer | A | Stock Option (Right to Buy) | 70000 | $0.00 | 70,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 1, 2024 | Turtle Cameron | Chief Executive Officer | A | Stock Option (Right to Buy) | 277750 | $0.00 | 277,750.0000 | 0 | 9999.99% | 0.00% |
| Feb. 1, 2024 | King-Jones Heidy | See Remarks | A | Stock Option (Right to Buy) | 63000 | $0.00 | 63,000.0000 | 0 | 9999.99% | 0.00% |
| Dec. 29, 2023 | Fairmount Funds Management LLC | Not found | J | Common Stock | 406038 | $0.00 | 1,190,497.0000 | 0 | 51.76% | 0.00% |
| Dec. 29, 2023 | Fairmount Funds Management LLC | Not found | J | Common Stock | 3435480 | $0.00 | 1,190,497.0000 | 0 | 74.26% | 0.00% |
| Dec. 29, 2023 | Fairmount Funds Management LLC | Not found | J | Common Stock | 406038 | $0.00 | 1,190,497.0000 | 0 | 51.76% | 0.00% |
| Dec. 22, 2023 | Burrows Scott L | Chief Financial Officer | A | Common Stock | 134953 | $0.00 | 134,953.0000 | 0 | 9999.99% | 0.00% |
| Dec. 7, 2023 | Fairmount Funds Management LLC | Not found | A | Series B Preferred Stock | 16667 | $600.00 | 16,667.0000 | 0 | 9999.99% | 0.00% |
| Nov. 24, 2023 | Albers Jeffrey W. | Not found | C | Series A Preferred Stock | 859 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Nov. 22, 2023 | Albers Jeffrey W. | Not found | A | Stock Option (Right to Buy) | 50000 | $0.00 | 50,000.0000 | 0 | 9999.99% | 0.00% |
| Nov. 24, 2023 | Albers Jeffrey W. | Not found | C | Common Stock | 34360 | $0.00 | 34,360.0000 | 0 | 9999.99% | 0.00% |
| Nov. 24, 2023 | Fairmount Funds Management LLC | Not found | C | Series A Preferred Stock | 85887 | $0.00 | 437,037.0000 | 0 | 16.42% | 0.00% |
| Nov. 24, 2023 | Fairmount Funds Management LLC | Not found | C | Common Stock | 3435480 | $0.00 | 3,813,901.0000 | 0 | 907.85% | 0.00% |
| Nov. 24, 2023 | Turtle Cameron | Chief Executive Officer | C | Series A Preferred Stock | 18086 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Nov. 22, 2023 | Turtle Cameron | Chief Executive Officer | A | Stock Option (Right to Buy) | 374000 | $0.00 | 374,000.0000 | 0 | 9999.99% | 0.00% |
| Nov. 24, 2023 | Turtle Cameron | Chief Executive Officer | C | Common Stock | 723440 | $0.00 | 746,507.0000 | 0 | 3136.26% | 0.00% |
| Nov. 22, 2023 | Albers Jeffrey W. | Not found | A | Stock Option (Right to Buy) | 50000 | $0.00 | 50,000.0000 | 0 | 9999.99% | 0.00% |
| Nov. 22, 2023 | Stelzer Laurie | Not found | A | Stock Option (Right to Buy) | 50000 | $0.00 | 50,000.0000 | 0 | 9999.99% | 0.00% |
| Sept. 1, 2023 | Burrows Scott L | Chief Financial Officer | A | Stock Option (Right to Buy) | 10121441 | $0.00 | 10,121,441.0000 | 0 | 9999.99% | 0.00% |
| Sept. 1, 2023 | King-Jones Heidy | See Remarks | A | Stock Option (Right to Buy) | 13495255 | $0.00 | 13,495,255.0000 | 0 | 9999.99% | 0.00% |
| June 22, 2023 | Alspaugh Jonathan | President and CFO | A | Employee Stock Option (right to buy) | 19787969 | $0.00 | 19,787,969.0000 | 0 | 9999.99% | 0.00% |
| June 22, 2023 | Lawton Alison Frances | Director | A | Stock Option (right to buy) | 1950000 | $0.00 | 1,950,000.0000 | 0 | 9999.99% | 0.00% |
| June 22, 2023 | Smith Hunter C | Director | A | Stock Option (right to buy) | 1950000 | $0.00 | 1,950,000.0000 | 0 | 9999.99% | 0.00% |
| June 22, 2023 | Magovcevic-Liebisch Ivana | Director | A | Stock Option (right to buy) | 1950000 | $0.00 | 1,950,000.0000 | 0 | 9999.99% | 0.00% |
| June 22, 2023 | Cox Russell J. | Director | A | Stock Option (right to buy) | 1950000 | $0.00 | 1,950,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 23, 2023 | Alspaugh Jonathan | Chief Financial Officer | A | Employee Stock Option (right to buy) | 640000 | $0.00 | 640,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 23, 2023 | Neuman Linda L | Chief Medical Officer | A | Employee Stock Option (right to buy) | 550000 | $0.00 | 550,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 23, 2023 | Kastenmayer James Paul | General Counsel | A | Employee Stock Option (right to buy) | 500000 | $0.00 | 500,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 23, 2023 | Hanley Jr. Michael Conick | Chief Business Officer | A | Employee Stock Option (right to buy) | 500000 | $0.00 | 500,000.0000 | 0 | 9999.99% | 0.00% |
| Nov. 14, 2022 | Neuman Linda L | Chief Medical Officer | A | Employee Stock Option (right to buy) | 25000 | $0.00 | 25,000.0000 | 0 | 9999.99% | 0.00% |