Denali Therapeutics Inc. ($DNLI) Insider Transactions

Last updated: 2026-03-14 11:44 UTC | Total transactions: 139

In the last 12 months, insiders at Denali Therapeutics Inc. ($DNLI) filed 139 transactions with the SEC: 2 open-market purchases totaling $35 and 61 sales totaling $20,599,334. Net insider sentiment: net selling.

Denali Therapeutics Inc. operates in the Biological products, (no disgnostic substances) industry (Life sciences sector).

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Recent Insider Transactions

Transaction Date Insider Name Title Transaction Type Security Shares Price Shares Owned Following Total Shares Outstanding % of Owned % of Outstanding
Jan. 6, 2026 Watts Ryan J. President and CEO S Common Stock 35198 $16.50 2,449,437.0000 172,421,492 1.42% 0.02%
Jan. 6, 2026 Schuth Alexander O. COFO and Secretary S Common Stock 17218 $16.50 806,577.0000 172,421,492 2.09% 0.01%
Jan. 3, 2026 Watts Ryan J. President and CEO A Stock Option (right to buy) 236880 $0.00 236,880.0000 172,421,492 9999.99% 0.14%
Jan. 3, 2026 Schuth Alexander O. COFO and Secretary A Common Stock 57700 $0.00 823,795.0000 172,421,492 7.53% 0.03%
Jan. 3, 2026 Schuth Alexander O. COFO and Secretary A Stock Option (right to buy) 173100 $0.00 173,100.0000 172,421,492 9999.99% 0.10%
Jan. 3, 2026 Watts Ryan J. President and CEO A Common Stock 78960 $0.00 2,484,635.0000 172,421,492 3.28% 0.05%
Dec. 11, 2025 BAKER BROS. ADVISORS LP Not found P $0.01 Prefunded Warrants 2095191 $17.49 25,996,310.0000 172,421,492 8.77% 1.22%
Dec. 11, 2025 BAKER BROS. ADVISORS LP Not found P $0.01 Prefunded Warrants 190523 $17.49 2,335,469.0000 172,421,492 8.88% 0.11%
Nov. 4, 2025 Van Hauwermeiren Timothy Director A Common Stock 10632 $0.00 10,632.0000 172,421,492 9999.99% 0.01%
Nov. 4, 2025 Van Hauwermeiren Timothy Director A Stock Option (right to buy) 31897 $0.00 31,897.0000 172,421,492 9999.99% 0.02%
Sept. 3, 2025 Watts Ryan J. President and CEO G Common Stock 50000 $0.00 2,405,675.0000 164,473,772 2.04% 0.03%
Aug. 12, 2025 Schuth Alexander O. COFO and Secretary S Common Stock 2937 $13.58 766,095.0000 164,473,772 0.38% 0.00%
Aug. 12, 2025 Ho Carole Chief Medical Officer S Common Stock 2937 $13.58 425,610.0000 164,473,772 0.69% 0.00%
Aug. 13, 2025 Ho Carole Chief Medical Officer S Common Stock 806 $14.64 424,804.0000 164,473,772 0.19% 0.00%
Aug. 5, 2025 Ho Carole Chief Medical Officer M Common Stock 44655 $0.68 428,547.0000 164,473,772 11.63% 0.03%
Aug. 5, 2025 Ho Carole Chief Medical Officer M Stock Option (right to buy) 44655 $0.00 62,500.0000 164,473,772 41.67% 0.03%
July 9, 2025 Watts Ryan J. President and CEO M Stock Option (right to buy) 40000 $0.00 20,369.0000 164,473,772 66.26% 0.02%
July 9, 2025 Watts Ryan J. President and CEO M Stock Option (right to buy) 455282 $0.00 622,809.0000 164,473,772 42.23% 0.28%
July 9, 2025 Watts Ryan J. President and CEO M Common Stock 455282 $0.68 2,910,957.0000 164,473,772 18.54% 0.28%
July 9, 2025 Watts Ryan J. President and CEO M Common Stock 40000 $5.28 2,950,957.0000 164,473,772 1.37% 0.02%
July 9, 2025 Watts Ryan J. President and CEO S Common Stock 495282 $15.00 2,455,675.0000 164,473,772 16.78% 0.30%
June 3, 2025 BAKER BROS. ADVISORS LP Not found A Common Stock 10565 $0.00 3,415,958.0000 164,473,772 0.31% 0.01%
June 3, 2025 BAKER BROS. ADVISORS LP Not found A Non-Qualified Stock Option (right to buy)uy) 31695 $0.00 31,695.0000 164,473,772 9999.99% 0.02%
June 3, 2025 BAKER BROS. ADVISORS LP Not found A Non- Qualified Stock Option (right to buy) 31695 $0.00 31,695.0000 164,473,772 9999.99% 0.02%
June 3, 2025 Cook Jennifer E. Director A Common Stock 6037 $0.00 26,075.0000 164,473,772 30.13% 0.00%
June 3, 2025 Cook Jennifer E. Director A Stock Option (right to buy) 18111 $0.00 18,111.0000 164,473,772 9999.99% 0.01%
June 3, 2025 FLATLEY JAY T Director A Common Stock 6037 $0.00 352,533.0000 164,473,772 1.74% 0.00%
June 3, 2025 FLATLEY JAY T Director A Stock Option (right to buy) 18111 $0.00 18,111.0000 164,473,772 9999.99% 0.01%
June 3, 2025 Krognes Steve E. Director A Stock Option (right to buy) 18111 $0.00 18,111.0000 164,473,772 9999.99% 0.01%
June 3, 2025 Schenkein David P Director A Common Stock 6037 $0.00 72,721.0000 164,473,772 9.05% 0.00%
June 3, 2025 Schenkein David P Director A Stock Option (right to buy) 18111 $0.00 18,111.0000 164,473,772 9999.99% 0.01%
June 3, 2025 Thornberry Nancy Director A Common Stock 6037 $0.00 24,717.0000 164,473,772 32.32% 0.00%
June 3, 2025 Thornberry Nancy Director A Stock Option (right to buy) 18111 $0.00 18,111.0000 164,473,772 9999.99% 0.01%
June 3, 2025 Tessier-Lavigne Marc Director A Common Stock 6037 $0.00 2,123,445.0000 164,473,772 0.29% 0.00%
June 3, 2025 Tessier-Lavigne Marc Director A Stock Option (right to buy) 18111 $0.00 18,111.0000 164,473,772 9999.99% 0.01%
June 3, 2025 Krognes Steve E. Director A Common Stock 6037 $0.00 813,591.0000 164,473,772 0.75% 0.00%
June 3, 2025 Klein Peter S Director A Stock Option (right to buy) 18111 $0.00 18,111.0000 164,473,772 9999.99% 0.01%
June 3, 2025 Klein Peter S Director A Common Stock 6037 $0.00 27,533.0000 164,473,772 28.08% 0.00%
June 3, 2025 BAKER BROS. ADVISORS LP Not found A Common Stock 10565 $0.00 336,867.0000 164,473,772 3.24% 0.01%
Jan. 6, 2025 Ho Carole Chief Medical Officer S Common Stock 12255 $20.22 386,799.0000 164,473,772 3.07% 0.01%
Jan. 7, 2025 Ho Carole Chief Medical Officer S Common Stock 2907 $20.81 383,892.0000 164,473,772 0.75% 0.00%
Jan. 6, 2025 Schuth Alexander O. COFO and Secretary S Common Stock 12255 $20.22 770,964.0000 164,473,772 1.56% 0.01%
Jan. 7, 2025 Schuth Alexander O. COFO and Secretary S Common Stock 2907 $20.81 768,057.0000 164,473,772 0.38% 0.00%
Jan. 6, 2025 Watts Ryan J. President and CEO S Common Stock 29266 $20.22 2,463,325.0000 164,473,772 1.17% 0.02%
Jan. 7, 2025 Watts Ryan J. President and CEO S Common Stock 7650 $20.81 2,455,675.0000 164,473,772 0.31% 0.00%
Jan. 7, 2025 Krognes Steve E. Director S Common Stock 3339 $20.81 807,554.0000 164,473,772 0.41% 0.00%
Jan. 3, 2025 Ho Carole Chief Medical Officer A Stock Option (right to buy) 162540 $0.00 162,540.0000 164,473,772 9999.99% 0.10%
Jan. 3, 2025 Watts Ryan J. President and CEO A Common Stock 54180 $0.00 2,492,591.0000 164,473,772 2.22% 0.03%
Jan. 3, 2025 Watts Ryan J. President and CEO A Stock Option (right to buy) 162540 $0.00 162,540.0000 164,473,772 9999.99% 0.10%
Jan. 3, 2025 Schuth Alexander O. COFO and Secretary A Common Stock 54180 $0.00 783,219.0000 164,473,772 7.43% 0.03%
Jan. 3, 2025 Schuth Alexander O. COFO and Secretary A Stock Option (right to buy) 162540 $0.00 162,540.0000 164,473,772 9999.99% 0.10%
Jan. 3, 2025 Ho Carole Chief Medical Officer A Common Stock 54180 $0.00 399,054.0000 164,473,772 15.71% 0.03%
Dec. 31, 2024 Krognes Steve E. Director S Common Stock 30000 $20.25 810,893.0000 169,456,988 3.57% 0.02%
Jan. 2, 2025 SATO VICKI L Director S Common Stock 3080 $20.91 107,976.0000 164,473,772 2.77% 0.00%
Dec. 27, 2024 Schuth Alexander O. COFO and Secretary M Common Stock 6708 $5.28 729,039.0000 169,456,988 0.93% 0.00%
Dec. 27, 2024 Schuth Alexander O. COFO and Secretary M Stock Option (right to buy) 6708 $0.00 46,671.0000 169,456,988 12.57% 0.00%
Nov. 25, 2024 Ho Carole Chief Medical Officer M Stock Option (right to buy) 17845 $0.00 107,155.0000 169,456,988 14.28% 0.01%
Nov. 25, 2024 Ho Carole Chief Medical Officer M Common Stock 17845 $0.68 344,874.0000 169,456,988 5.46% 0.01%
Nov. 22, 2024 Schuth Alexander O. COFO and Secretary M Common Stock 20516 $0.68 722,331.0000 169,456,988 2.92% 0.01%
Nov. 22, 2024 Schuth Alexander O. COFO and Secretary M Stock Option (right to buy) 20516 $0.00 124,562.0000 169,456,988 14.14% 0.01%
Nov. 11, 2024 Schenkein David P Director M Common Stock 47165 $18.00 126,125.0000 169,456,988 59.73% 0.03%
Nov. 11, 2024 Schenkein David P Director S Common Stock 27129 $32.09 98,996.0000 169,456,988 21.51% 0.02%
Nov. 11, 2024 Schenkein David P Director S Common Stock 32312 $32.87 66,684.0000 169,456,988 32.64% 0.02%
Nov. 11, 2024 Schenkein David P Director M Stock Option (right to buy) 47165 $0.00 0.0000 169,456,988 100.00% 0.03%
Nov. 7, 2024 Schuth Alexander O. COFO and Secretary M Stock Option (right to buy) 15558 $0.00 53,379.0000 169,456,988 22.57% 0.01%
Nov. 7, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 300 $31.29 701,815.0000 169,456,988 0.04% 0.00%
Nov. 7, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 2925 $30.72 702,115.0000 169,456,988 0.41% 0.00%
Nov. 7, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 12333 $29.68 705,040.0000 169,456,988 1.72% 0.01%
Nov. 7, 2024 Schuth Alexander O. COFO and Secretary M Common Stock 15558 $5.28 717,373.0000 169,456,988 2.22% 0.01%
Nov. 7, 2024 SATO VICKI L Director S Common Stock 1020 $30.00 111,056.0000 169,456,988 0.91% 0.00%
Nov. 1, 2024 SATO VICKI L Director S Common Stock 3080 $27.07 112,076.0000 169,456,988 2.67% 0.00%
Oct. 18, 2024 Watts Ryan J. President and CEO M Common Stock 40000 $0.68 2,478,411.0000 169,456,988 1.64% 0.02%
Oct. 18, 2024 Watts Ryan J. President and CEO M Stock Option (right to buy) 40000 $0.00 1,078,091.0000 169,456,988 3.58% 0.02%
Oct. 18, 2024 Watts Ryan J. President and CEO S Common Stock 40000 $27.69 2,438,411.0000 169,456,988 1.61% 0.02%
Sept. 30, 2024 Krognes Steve E. Director S Common Stock 30000 $29.03 840,893.0000 137,370,897 3.44% 0.02%
Sept. 13, 2024 SATO VICKI L Director S Common Stock 1020 $30.00 115,156.0000 137,370,897 0.88% 0.00%
Sept. 3, 2024 SATO VICKI L Director S Common Stock 100 $25.37 116,176.0000 137,370,897 0.09% 0.00%
Sept. 3, 2024 SATO VICKI L Director S Common Stock 2980 $24.99 116,276.0000 137,370,897 2.50% 0.00%
Aug. 20, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 2453 $23.79 707,715.0000 137,370,897 0.35% 0.00%
Aug. 20, 2024 Watts Ryan J. President and CEO S Common Stock 2260 $23.79 2,438,411.0000 137,370,897 0.09% 0.00%
Aug. 20, 2024 Krognes Steve E. Director S Common Stock 1727 $23.79 870,893.0000 137,370,897 0.20% 0.00%
Aug. 20, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 3353 $23.54 704,362.0000 137,370,897 0.47% 0.00%
Aug. 21, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 2547 $24.78 701,815.0000 137,370,897 0.36% 0.00%
Aug. 20, 2024 Ho Carole Chief Medical Officer S Common Stock 2453 $23.79 347,034.0000 137,370,897 0.70% 0.00%
Aug. 21, 2024 Ho Carole Chief Medical Officer S Common Stock 14098 $24.41 332,936.0000 137,370,897 4.06% 0.01%
Aug. 21, 2024 Ho Carole Chief Medical Officer S Common Stock 5907 $24.96 327,029.0000 137,370,897 1.77% 0.00%
Aug. 13, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 2272 $22.89 710,168.0000 137,370,897 0.32% 0.00%
Aug. 13, 2024 Ho Carole Chief Medical Officer S Common Stock 2337 $22.89 349,487.0000 137,370,897 0.66% 0.00%
June 13, 2024 Krognes Steve E. Director S Common Stock 688 $21.79 890,836.0000 137,370,897 0.08% 0.00%
July 1, 2024 Krognes Steve E. Director S Common Stock 29900 $22.12 872,720.0000 137,370,897 3.31% 0.02%
July 1, 2024 Krognes Steve E. Director S Common Stock 100 $22.80 872,620.0000 137,370,897 0.01% 0.00%
July 1, 2024 SATO VICKI L Director S Common Stock 2980 $22.12 119,356.0000 137,370,897 2.44% 0.00%
July 1, 2024 SATO VICKI L Director S Common Stock 100 $22.86 119,256.0000 137,370,897 0.08% 0.00%
June 6, 2024 Cook Jennifer E. Director S Common Stock 1458 $21.73 20,038.0000 137,370,897 6.78% 0.00%
May 31, 2024 Schenkein David P Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 FLATLEY JAY T Director A Common Stock 5967 $0.00 346,496.0000 137,370,897 1.75% 0.00%
May 31, 2024 FLATLEY JAY T Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 Harris Erik Director A Common Stock 5967 $0.00 17,052.0000 137,370,897 53.83% 0.00%
May 31, 2024 Thornberry Nancy Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 Klein Peter S Director A Common Stock 5967 $0.00 21,496.0000 137,370,897 38.42% 0.00%
May 31, 2024 Klein Peter S Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 Harris Erik Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 Tessier-Lavigne Marc Director A Common Stock 5967 $0.00 2,117,408.0000 137,370,897 0.28% 0.00%
May 31, 2024 Tessier-Lavigne Marc Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 SATO VICKI L Director A Common Stock 5967 $0.00 122,336.0000 137,370,897 5.13% 0.00%
May 31, 2024 SATO VICKI L Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 Cook Jennifer E. Director A Common Stock 5967 $0.00 21,496.0000 137,370,897 38.42% 0.00%
May 31, 2024 Cook Jennifer E. Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 Schenkein David P Director A Common Stock 5967 $0.00 78,960.0000 137,370,897 8.17% 0.00%
May 31, 2024 Thornberry Nancy Director A Common Stock 5967 $0.00 18,680.0000 137,370,897 46.94% 0.00%
May 31, 2024 Krognes Steve E. Director A Stock Option (right to buy) 17901 $0.00 17,901.0000 137,370,897 9999.99% 0.01%
May 31, 2024 Krognes Steve E. Director A Common Stock 5967 $0.00 903,308.0000 137,370,897 0.66% 0.00%
May 15, 2024 SATO VICKI L Director S Common Stock 1674 $20.39 116,369.0000 137,370,897 1.42% 0.00%
April 15, 2024 SATO VICKI L Director S Common Stock 1666 $18.29 118,043.0000 137,370,897 1.39% 0.00%
April 1, 2024 Krognes Steve E. Director S Common Stock 92500 $20.50 897,341.0000 137,370,897 9.34% 0.07%
March 29, 2024 Watts Ryan J. President and CEO G Common Stock 40000 $0.00 2,440,671.0000 137,370,897 1.61% 0.03%
March 15, 2024 SATO VICKI L Director S Common Stock 1666 $20.10 119,709.0000 137,370,897 1.37% 0.00%
Feb. 15, 2024 SATO VICKI L Director S Common Stock 1666 $18.37 121,375.0000 137,370,897 1.35% 0.00%
Feb. 14, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 20128 $17.66 711,090.0000 137,370,897 2.75% 0.01%
Feb. 13, 2024 Watts Ryan J. President and CEO S Common Stock 9589 $17.29 2,480,671.0000 137,370,897 0.39% 0.01%
Feb. 13, 2024 Krognes Steve E. Director S Common Stock 2750 $17.29 989,841.0000 137,370,897 0.28% 0.00%
Feb. 13, 2024 Ho Carole Chief Medical Officer S Common Stock 2784 $17.29 353,229.0000 137,370,897 0.78% 0.00%
Feb. 14, 2024 Ho Carole Chief Medical Officer S Common Stock 1405 $17.79 351,824.0000 137,370,897 0.40% 0.00%
Feb. 13, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 2716 $17.29 731,218.0000 137,370,897 0.37% 0.00%
Feb. 8, 2024 Schuth Alexander O. COFO and Secretary M Stock Option (right to buy) 50000 $0.00 145,078.0000 137,370,897 25.63% 0.04%
Feb. 8, 2024 Schuth Alexander O. COFO and Secretary M Common Stock 50000 $0.68 733,934.0000 137,370,897 7.31% 0.04%
Jan. 16, 2024 SATO VICKI L Director S Common Stock 1666 $18.42 123,041.0000 137,370,897 1.34% 0.00%
Jan. 10, 2024 Ho Carole Chief Medical Officer S Common Stock 4668 $19.02 356,013.0000 137,370,897 1.29% 0.00%
Jan. 9, 2024 Watts Ryan J. President and CEO S Common Stock 7818 $19.78 2,490,260.0000 137,370,897 0.31% 0.01%
Jan. 5, 2024 Watts Ryan J. President and CEO S Common Stock 17483 $19.43 2,498,078.0000 137,370,897 0.69% 0.01%
Jan. 5, 2024 Ho Carole Chief Medical Officer S Common Stock 9972 $19.43 360,681.0000 137,370,897 2.69% 0.01%
Jan. 5, 2024 Schuth Alexander O. COFO and Secretary S Common Stock 9972 $19.43 683,934.0000 137,370,897 1.44% 0.01%
Jan. 5, 2024 Krognes Steve E. Director S Common Stock 3208 $19.43 992,591.0000 137,370,897 0.32% 0.00%
Jan. 3, 2024 Schuth Alexander O. COFO and Secretary A Stock Option (right to buy) 161160 $0.00 161,160.0000 137,370,897 9999.99% 0.12%
Jan. 3, 2024 Ho Carole Chief Medical Officer A Stock Option (right to buy) 161160 $0.00 161,160.0000 137,370,897 9999.99% 0.12%
Jan. 3, 2024 Watts Ryan J. President and CEO A Common Stock 89520 $0.00 2,515,561.0000 137,370,897 3.69% 0.07%
Jan. 3, 2024 Watts Ryan J. President and CEO A Stock Option (right to buy) 268560 $0.00 268,560.0000 137,370,897 9999.99% 0.20%
Jan. 3, 2024 Schuth Alexander O. COFO and Secretary A Common Stock 53720 $0.00 693,906.0000 137,370,897 8.39% 0.04%
Jan. 3, 2024 Ho Carole Chief Medical Officer A Common Stock 53720 $0.00 370,653.0000 137,370,897 16.95% 0.04%