In the last 12 months, insiders at Upstream Bio, Inc. ($UPB) filed 56 transactions with the SEC: 5 open-market purchases totaling $48,025,000 and 5 sales totaling $46,571. Net insider sentiment: net buying.
Upstream Bio, Inc. operates in the Pharmaceutical preparations industry (Life sciences sector).
Most Active Insiders
- AI Upstream LLC (Not found) — 5 transactions totaling $19,975,000
- ORBIMED ADVISORS LLC (Director) — 8 transactions totaling $14,025,000
- Chimovits Erez (Director) — 8 transactions totaling $14,025,000
- Sutherland Everett Rand (Chief Executive Officer) — 4 transactions totaling $19,444
- Deykin Aaron (Chief Medical Officer) — 4 transactions totaling $8,305
View all SEC Filings for Upstream Bio, Inc. (UPB).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| March 16, 2026 | Deykin Aaron | Chief Medical Officer | S | Common Stock | 894 | $9.29 | 32,687.0000 | 54,038,591 | 2.66% | 0.00% |
| March 16, 2026 | Sutherland Everett Rand | Chief Executive Officer | S | Common Stock | 2093 | $9.29 | 72,907.0000 | 54,038,591 | 2.79% | 0.00% |
| March 16, 2026 | GRAY MICHAEL | CFO and COO | S | Common Stock | 852 | $9.29 | 29,648.0000 | 54,038,591 | 2.79% | 0.00% |
| March 16, 2026 | Ambrose Allison | General Counsel | S | Common Stock | 475 | $9.29 | 16,525.0000 | 54,038,591 | 2.79% | 0.00% |
| March 16, 2026 | Houghton Adam | Chief Business Officer | S | Common Stock | 699 | $9.29 | 24,301.0000 | 54,038,591 | 2.80% | 0.00% |
| Jan. 2, 2026 | GRAY MICHAEL | CFO and COO | A | Common Stock | 30500 | $0.00 | 30,500.0000 | 54,038,591 | 9999.99% | 0.06% |
| Jan. 2, 2026 | Sutherland Everett Rand | Chief Executive Officer | A | Stock Option (Right to Buy) | 225000 | $0.00 | 225,000.0000 | 54,038,591 | 9999.99% | 0.42% |
| Jan. 2, 2026 | Sutherland Everett Rand | Chief Executive Officer | A | Common Stock | 75000 | $0.00 | 75,000.0000 | 54,038,591 | 9999.99% | 0.14% |
| Jan. 2, 2026 | Houghton Adam | Chief Business Officer | A | Stock Option (Right to Buy) | 75000 | $0.00 | 75,000.0000 | 54,038,591 | 9999.99% | 0.14% |
| Jan. 2, 2026 | Ambrose Allison | General Counsel | A | Stock Option (Right to Buy) | 51000 | $0.00 | 51,000.0000 | 54,038,591 | 9999.99% | 0.09% |
| Jan. 2, 2026 | Houghton Adam | Chief Business Officer | A | Common Stock | 25000 | $0.00 | 25,000.0000 | 54,038,591 | 9999.99% | 0.05% |
| Jan. 2, 2026 | Ambrose Allison | General Counsel | A | Common Stock | 17000 | $0.00 | 17,000.0000 | 54,038,591 | 9999.99% | 0.03% |
| Jan. 2, 2026 | Deykin Aaron | Chief Medical Officer | A | Stock Option (Right to Buy) | 96000 | $0.00 | 96,000.0000 | 54,038,591 | 9999.99% | 0.18% |
| Jan. 2, 2026 | Deykin Aaron | Chief Medical Officer | A | Common Stock | 32000 | $0.00 | 33,581.0000 | 54,038,591 | 2024.04% | 0.06% |
| Jan. 2, 2026 | GRAY MICHAEL | CFO and COO | A | Stock Option (Right to Buy) | 91500 | $0.00 | 91,500.0000 | 54,038,591 | 9999.99% | 0.17% |
| June 10, 2025 | Ruddy Marcella K. | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 53,640,895 | 9999.99% | 0.03% |
| June 10, 2025 | Renaud Ronald C JR | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 53,640,895 | 9999.99% | 0.03% |
| June 10, 2025 | Chimovits Erez | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 53,640,895 | 9999.99% | 0.03% |
| June 10, 2025 | Beckman Daniella | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 53,640,895 | 9999.99% | 0.03% |
| June 10, 2025 | Fleming Harold Edward | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 53,640,895 | 9999.99% | 0.03% |
| June 10, 2025 | Ratcliffe Liam | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 53,640,895 | 9999.99% | 0.03% |
| Feb. 6, 2025 | Sutherland Everett Rand | Chief Executive Officer | A | Stock Option (Right to Buy) | 500000 | $0.00 | 500,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 6, 2025 | GRAY MICHAEL | CFO and COO | A | Stock Option (Right to Buy) | 195000 | $0.00 | 195,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 6, 2025 | Houghton Adam | Chief Business Officer | A | Stock Option (Right to Buy) | 140000 | $0.00 | 140,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 6, 2025 | Deykin Aaron | Chief Medical Officer | A | Stock Option (Right to Buy) | 165000 | $0.00 | 165,000.0000 | 0 | 9999.99% | 0.00% |
| Feb. 6, 2025 | Ambrose Allison | General Counsel | A | Stock Option (Right to Buy) | 25000 | $0.00 | 25,000.0000 | 0 | 9999.99% | 0.00% |
| Dec. 16, 2024 | Ambrose Allison | General Counsel | A | Stock Option (Right to Buy) | 100000 | $0.00 | 100,000.0000 | 0 | 9999.99% | 0.00% |
| Oct. 15, 2024 | ORBIMED ADVISORS LLC | Director | C | Common Stock | 2887833 | $0.00 | 3,894,873.0000 | 0 | 286.76% | 0.00% |
| Oct. 15, 2024 | ORBIMED ADVISORS LLC | Director | P | Common Stock | 660000 | $17.00 | 4,554,873.0000 | 0 | 16.95% | 0.00% |
| Oct. 15, 2024 | ORBIMED ADVISORS LLC | Director | C | Series A redeemable convertible preferred stock | 524500 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | ORBIMED ADVISORS LLC | Director | C | Series A redeemable convertible preferred stock | 2098000 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | ORBIMED ADVISORS LLC | Director | C | Series B redeemable convertible preferred stock | 197456 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | ORBIMED ADVISORS LLC | Director | C | Series B redeemable convertible preferred stock | 789833 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | AI Upstream LLC | Not found | P | Common Stock | 1175000 | $17.00 | 1,175,000.0000 | 0 | 9999.99% | 0.00% |
| Oct. 15, 2024 | AI Upstream LLC | Not found | C | Common Stock | 3147000 | $0.00 | 4,322,000.0000 | 0 | 267.83% | 0.00% |
| Oct. 15, 2024 | AI Upstream LLC | Not found | C | Common Stock | 1172410 | $0.00 | 5,494,410.0000 | 0 | 27.13% | 0.00% |
| Oct. 15, 2024 | AI Upstream LLC | Not found | C | Series A Convertible Preferred Stock | 3147000 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | AI Upstream LLC | Not found | C | Series B Convertible Preferred Stock | 1172410 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | Chimovits Erez | Director | C | Series A redeemable convertible preferred stock | 524500 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | Chimovits Erez | Director | C | Series A redeemable convertible preferred stock | 2098000 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | Chimovits Erez | Director | C | Series B redeemable convertible preferred stock | 197456 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | Chimovits Erez | Director | C | Series B redeemable convertible preferred stock | 789833 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | ORBIMED ADVISORS LLC | Director | C | Common Stock | 721956 | $0.00 | 973,716.0000 | 0 | 286.76% | 0.00% |
| Oct. 15, 2024 | ORBIMED ADVISORS LLC | Director | P | Common Stock | 165000 | $17.00 | 1,138,716.0000 | 0 | 16.95% | 0.00% |
| Oct. 15, 2024 | Chimovits Erez | Director | P | Common Stock | 660000 | $17.00 | 4,554,873.0000 | 0 | 16.95% | 0.00% |
| Oct. 15, 2024 | Chimovits Erez | Director | C | Common Stock | 2887833 | $0.00 | 3,894,873.0000 | 0 | 286.76% | 0.00% |
| Oct. 15, 2024 | Chimovits Erez | Director | P | Common Stock | 165000 | $17.00 | 1,138,716.0000 | 0 | 16.95% | 0.00% |
| Oct. 15, 2024 | Chimovits Erez | Director | C | Common Stock | 721956 | $0.00 | 973,716.0000 | 0 | 286.76% | 0.00% |
| Oct. 15, 2024 | Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | Not found | C | Series B redeemable convertible preferred stock | 852940 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Oct. 15, 2024 | Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | Not found | C | Common Stock | 894733 | $0.00 | 894,733.0000 | 0 | 9999.99% | 0.00% |
| Oct. 10, 2024 | Fleming Harold Edward | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 0 | 9999.99% | 0.00% |
| Oct. 10, 2024 | Renaud Ronald C JR | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 0 | 9999.99% | 0.00% |
| Oct. 10, 2024 | Beckman Daniella | Not found | A | Stock Option (Right to Buy) | 34681 | $0.00 | 34,681.0000 | 0 | 9999.99% | 0.00% |
| Oct. 10, 2024 | Ratcliffe Liam | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 0 | 9999.99% | 0.00% |
| Oct. 10, 2024 | Ruddy Marcella K. | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 0 | 9999.99% | 0.00% |
| Oct. 10, 2024 | Chimovits Erez | Not found | A | Stock Option (Right to Buy) | 17096 | $0.00 | 17,096.0000 | 0 | 9999.99% | 0.00% |