SEC Insider Transactions from Manke Isaac.

Last updated: 2026-03-14 11:43 UTC | Total transactions: 16

Manke Isaac has filed 16 insider transactions across 2 companies since March 2024.

Most recent transaction: a grant/award of 5258 shares of OnKure Therapeutics, Inc. ($OKUR) on December 31, 2025.

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Transaction Date Company Ticker Insider Name Title Transaction Type Security Shares Price Shares Owned Following Total Shares Outstanding % of Owned % of Outstanding
Dec. 31, 2025 OnKure Therapeutics, Inc. $OKUR Manke Isaac Not found A Class A Common Stock 5258 $0.00 20,583.0000 13,530,892 34.31% 0.04%
Oct. 23, 2025 Q32 Bio Inc. $QTTB Manke Isaac Not found A Stock Option (Right to Buy) 53521 $0.00 53,521.0000 12,197,615 9999.99% 0.44%
Sept. 30, 2025 OnKure Therapeutics, Inc. $OKUR Manke Isaac Not found A Class A Common Stock 5545 $0.00 15,325.0000 3,447,071 56.70% 0.16%
June 30, 2025 OnKure Therapeutics, Inc. $OKUR Manke Isaac Not found A Class A Common Stock 6311 $0.00 9,780.0000 3,447,071 181.93% 0.18%
May 28, 2025 OnKure Therapeutics, Inc. $OKUR Manke Isaac Not found A Stock Option (right to buy) 7650 $0.00 7,650.0000 3,447,071 9999.99% 0.22%
March 31, 2025 OnKure Therapeutics, Inc. $OKUR Manke Isaac Not found A Class A Common Stock 3469 $0.00 3,469.0000 3,447,071 9999.99% 0.10%
Feb. 24, 2025 Q32 Bio Inc. $QTTB Manke Isaac Not found A Stock Option (Right to Buy) 19008 $0.00 19,008.0000 0 9999.99% 0.00%
Jan. 15, 2025 Q32 Bio Inc. $QTTB Manke Isaac Not found A Stock Option (Right to Buy) 19008 $0.00 19,008.0000 0 9999.99% 0.00%
Feb. 24, 2025 Q32 Bio Inc. $QTTB Manke Isaac Not found D Stock Option (Right to Buy) 12767 $0.00 0.0000 0 100.00% 0.00%
Feb. 24, 2025 Q32 Bio Inc. $QTTB Manke Isaac Not found D Stock Option (Right to Buy) 19008 $0.00 0.0000 0 0.00% 0.00%
Feb. 24, 2025 Q32 Bio Inc. $QTTB Manke Isaac Not found A Stock Option (Right to Buy) 2627 $0.00 2,627.0000 0 9999.99% 0.00%
Feb. 24, 2025 Q32 Bio Inc. $QTTB Manke Isaac Not found D Stock Option (Right to Buy) 2627 $0.00 0.0000 0 100.00% 0.00%
Feb. 24, 2025 Q32 Bio Inc. $QTTB Manke Isaac Not found A Stock Option (Right to Buy) 12767 $0.00 12,767.0000 0 9999.99% 0.00%
Oct. 4, 2024 OnKure Therapeutics, Inc. $OKUR Manke Isaac Not found A Stock Option (right to buy) 15300 $0.00 15,300.0000 316,142 9999.99% 4.84%
April 1, 2024 Q32 Bio Inc. $QTTB Manke Isaac Not found A Stock Option (Right to Buy) 2627 $13.42 2,627.0000 0 9999.99% 0.00%
March 25, 2024 Q32 Bio Inc. $QTTB Manke Isaac Not found A Stock Option (Right to Buy) 12767 $0.00 12,767.0000 0 9999.99% 0.00%