In the last 12 months, insiders at IONIS PHARMACEUTICALS INC ($IONS) filed 986 transactions with the SEC: 3 open-market purchases totaling $658,979 and 289 sales totaling $205,992,773. Net insider sentiment: net selling.
IONIS PHARMACEUTICALS INC operates in the Pharmaceutical preparations industry (Life sciences sector).
Most Active Insiders
- Monia Brett P (Chief Executive Officer) — 90 transactions totaling $70,583,664
- HOUGEN ELIZABETH L (EVP, Finance & CFO) — 51 transactions totaling $38,545,321
- BENNETT C FRANK (EVP, Chief Scientific Officer) — 75 transactions totaling $34,457,425
- O'NEIL PATRICK R. (EVP CLO & General Counsel) — 84 transactions totaling $31,372,515
- Geary Richard S (EVP, Chief Development Officer) — 80 transactions totaling $27,192,545
View all SEC Filings for IONIS PHARMACEUTICALS INC (IONS).
Set Up your own filters →Recent Insider Transactions
| Transaction Date | Insider Name | Title | Transaction Type | Security | Shares | Price | Shares Owned Following | Total Shares Outstanding | % of Owned | % of Outstanding |
|---|---|---|---|---|---|---|---|---|---|---|
| April 1, 2026 | KLEIN JOSEPH III | Director | M | Common Stock | 12000 | $38.06 | 23,114.0000 | 158,964,772 | 107.97% | 0.01% |
| April 1, 2026 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| April 2, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 6193 | $74.05 | 16,348.0000 | 158,964,772 | 27.47% | 0.00% |
| April 1, 2026 | KLEIN JOSEPH III | Director | S | Common Stock | 20105 | $75.50 | 13,330.0000 | 158,964,772 | 60.13% | 0.01% |
| April 1, 2026 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 12000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| April 1, 2026 | KLEIN JOSEPH III | Director | M | Common Stock | 10321 | $41.08 | 33,435.0000 | 158,964,772 | 44.65% | 0.01% |
| April 1, 2026 | KLEIN JOSEPH III | Director | S | Common Stock | 2216 | $75.95 | 11,114.0000 | 158,964,772 | 16.62% | 0.00% |
| March 19, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 5812 | $70.97 | 63,890.0000 | 158,964,772 | 8.34% | 0.00% |
| March 17, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 10172 | $73.21 | 82,660.0000 | 158,964,772 | 10.96% | 0.01% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 9440 | $72.77 | 92,832.0000 | 158,964,772 | 9.23% | 0.01% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 20541 | $37.58 | 307,880.0000 | 158,964,772 | 7.15% | 0.01% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 205608 | $72.38 | 102,272.0000 | 158,964,772 | 66.78% | 0.13% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 33118 | $32.60 | 287,339.0000 | 158,964,772 | 13.03% | 0.02% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 61041 | $56.78 | 254,221.0000 | 158,964,772 | 31.60% | 0.04% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 60299 | $60.89 | 193,180.0000 | 158,964,772 | 45.38% | 0.04% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Non-Qualified Stock Option (right to buy) | 60299 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.04% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Non-Qualified Stock Option (right to buy) | 61041 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.04% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Non-Qualified Stock Option (right to buy) | 20541 | $0.00 | 5,405.0000 | 158,964,772 | 79.17% | 0.01% |
| March 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Non-Qualified Stock Option (right to buy) | 33118 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.02% |
| March 10, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | M | Non-Qualified Stock Option (right to buy) | 4675 | $0.00 | 14,025.0000 | 158,964,772 | 25.00% | 0.00% |
| March 9, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 10148 | $75.25 | 62,211.0000 | 158,964,772 | 14.02% | 0.01% |
| March 9, 2026 | Monia Brett P | Chief Executive Officer | M | Common Stock | 40822 | $60.89 | 295,803.0000 | 158,964,772 | 16.01% | 0.03% |
| March 9, 2026 | Monia Brett P | Chief Executive Officer | M | Common Stock | 73529 | $60.89 | 369,332.0000 | 158,964,772 | 24.86% | 0.05% |
| March 9, 2026 | Monia Brett P | Chief Executive Officer | S | Common Stock | 7382 | $74.11 | 361,950.0000 | 158,964,772 | 2.00% | 0.00% |
| March 9, 2026 | Monia Brett P | Chief Executive Officer | S | Common Stock | 117604 | $75.26 | 244,346.0000 | 158,964,772 | 32.49% | 0.07% |
| March 9, 2026 | Monia Brett P | Chief Executive Officer | S | Common Stock | 1684 | $75.58 | 242,662.0000 | 158,964,772 | 0.69% | 0.00% |
| March 10, 2026 | Monia Brett P | Chief Executive Officer | M | Common Stock | 34103 | $60.89 | 276,765.0000 | 158,964,772 | 14.05% | 0.02% |
| March 10, 2026 | Monia Brett P | Chief Executive Officer | S | Common Stock | 16512 | $75.47 | 260,253.0000 | 158,964,772 | 5.97% | 0.01% |
| March 10, 2026 | Monia Brett P | Chief Executive Officer | S | Common Stock | 17591 | $76.34 | 242,662.0000 | 158,964,772 | 6.76% | 0.01% |
| March 9, 2026 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 40822 | $0.00 | 107,632.0000 | 158,964,772 | 27.50% | 0.03% |
| March 9, 2026 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 73529 | $0.00 | 34,103.0000 | 158,964,772 | 68.32% | 0.05% |
| March 10, 2026 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 34103 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.02% |
| March 10, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | M | Common Stock | 32602 | $46.10 | 48,991.0000 | 158,964,772 | 198.93% | 0.02% |
| March 10, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | S | Common Stock | 21191 | $75.50 | 27,800.0000 | 158,964,772 | 43.25% | 0.01% |
| March 10, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | S | Common Stock | 16086 | $76.30 | 11,714.0000 | 158,964,772 | 57.86% | 0.01% |
| March 10, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | M | Non-Qualified Stock Option (right to buy) | 32602 | $0.00 | 32,601.0000 | 158,964,772 | 50.00% | 0.02% |
| March 10, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | M | Common Stock | 4675 | $34.69 | 16,389.0000 | 158,964,772 | 39.91% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 6951 | $32.60 | 42,262.0000 | 158,964,772 | 19.69% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 385 | $0.00 | 8,877.0000 | 158,964,772 | 4.16% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 3760 | $0.00 | 11,280.0000 | 158,964,772 | 25.00% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 3510 | $0.00 | 5,744.0000 | 158,964,772 | 37.93% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 5500 | $0.00 | 16,500.0000 | 158,964,772 | 25.00% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 6951 | $0.00 | 928.0000 | 158,964,772 | 88.22% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 755 | $80.84 | 22,541.0000 | 158,964,772 | 3.24% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 5030 | $80.00 | 23,296.0000 | 158,964,772 | 17.76% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 14321 | $79.12 | 28,326.0000 | 158,964,772 | 33.58% | 0.01% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 385 | $52.87 | 42,647.0000 | 158,964,772 | 0.91% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 5500 | $34.69 | 35,311.0000 | 158,964,772 | 18.45% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 3760 | $40.85 | 29,811.0000 | 158,964,772 | 14.43% | 0.00% |
| March 3, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 3510 | $37.58 | 26,051.0000 | 158,964,772 | 15.57% | 0.00% |
| March 3, 2026 | Diaz Allene M. | Director | M | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| March 3, 2026 | Diaz Allene M. | Director | M | Non-Qualified Stock Option (right to buy) | 18000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| March 3, 2026 | Diaz Allene M. | Director | M | Non-Qualified Stock Option (right to buy) | 12000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| March 3, 2026 | Diaz Allene M. | Director | S | Common Stock | 1005 | $80.80 | 3,811.0000 | 158,964,772 | 20.87% | 0.00% |
| March 3, 2026 | Diaz Allene M. | Director | S | Common Stock | 14608 | $79.88 | 4,816.0000 | 158,964,772 | 75.21% | 0.01% |
| March 3, 2026 | Diaz Allene M. | Director | S | Common Stock | 39265 | $79.11 | 19,424.0000 | 158,964,772 | 66.90% | 0.02% |
| March 3, 2026 | Diaz Allene M. | Director | M | Common Stock | 18000 | $40.05 | 58,689.0000 | 158,964,772 | 44.24% | 0.01% |
| March 3, 2026 | Diaz Allene M. | Director | M | Common Stock | 12000 | $38.06 | 40,689.0000 | 158,964,772 | 41.83% | 0.01% |
| March 3, 2026 | Diaz Allene M. | Director | M | Common Stock | 10321 | $41.08 | 28,689.0000 | 158,964,772 | 56.19% | 0.01% |
| March 3, 2026 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 4000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.00% |
| March 3, 2026 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 12000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| March 3, 2026 | KLEIN JOSEPH III | Director | S | Common Stock | 1012 | $80.82 | 11,114.0000 | 158,964,772 | 8.35% | 0.00% |
| March 3, 2026 | KLEIN JOSEPH III | Director | S | Common Stock | 6794 | $80.00 | 12,126.0000 | 158,964,772 | 35.91% | 0.00% |
| March 3, 2026 | KLEIN JOSEPH III | Director | S | Common Stock | 13526 | $79.17 | 18,920.0000 | 158,964,772 | 41.69% | 0.01% |
| March 3, 2026 | KLEIN JOSEPH III | Director | M | Common Stock | 4000 | $42.88 | 32,446.0000 | 158,964,772 | 14.06% | 0.00% |
| March 3, 2026 | KLEIN JOSEPH III | Director | M | Common Stock | 12000 | $40.05 | 28,446.0000 | 158,964,772 | 72.97% | 0.01% |
| March 4, 2026 | LOSCALZO JOSEPH | Director | M | Non-Qualified Stock Option (right to buy) | 200 | $0.00 | 10,968.0000 | 158,964,772 | 1.79% | 0.00% |
| March 3, 2026 | LOSCALZO JOSEPH | Director | M | Non-Qualified Stock Option (right to buy) | 832 | $0.00 | 11,168.0000 | 158,964,772 | 6.93% | 0.00% |
| March 4, 2026 | LOSCALZO JOSEPH | Director | S | Common Stock | 200 | $80.00 | 36,330.0000 | 158,964,772 | 0.55% | 0.00% |
| March 4, 2026 | LOSCALZO JOSEPH | Director | M | Common Stock | 200 | $38.06 | 36,530.0000 | 158,964,772 | 0.55% | 0.00% |
| March 3, 2026 | LOSCALZO JOSEPH | Director | S | Common Stock | 832 | $80.33 | 36,330.0000 | 158,964,772 | 2.24% | 0.00% |
| March 3, 2026 | LOSCALZO JOSEPH | Director | M | Common Stock | 832 | $38.06 | 37,162.0000 | 158,964,772 | 2.29% | 0.00% |
| March 4, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 238 | $0.00 | 3,866.0000 | 158,964,772 | 5.80% | 0.00% |
| March 3, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 820 | $0.00 | 4,104.0000 | 158,964,772 | 16.65% | 0.00% |
| March 4, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 201 | $0.00 | 1,769.0000 | 158,964,772 | 10.20% | 0.00% |
| March 3, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 879 | $0.00 | 1,970.0000 | 158,964,772 | 30.85% | 0.00% |
| March 4, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 201 | $80.00 | 45,664.0000 | 158,964,772 | 0.44% | 0.00% |
| March 4, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 201 | $32.60 | 45,865.0000 | 158,964,772 | 0.44% | 0.00% |
| March 4, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 238 | $80.00 | 45,664.0000 | 158,964,772 | 0.52% | 0.00% |
| March 4, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 238 | $56.78 | 45,902.0000 | 158,964,772 | 0.52% | 0.00% |
| March 3, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 36 | $81.01 | 45,664.0000 | 158,964,772 | 0.08% | 0.00% |
| March 3, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 2088 | $80.41 | 45,700.0000 | 158,964,772 | 4.37% | 0.00% |
| March 3, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 879 | $32.60 | 47,788.0000 | 158,964,772 | 1.87% | 0.00% |
| March 3, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 820 | $56.78 | 46,909.0000 | 158,964,772 | 1.78% | 0.00% |
| March 3, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 4096 | $79.36 | 45,664.0000 | 158,964,772 | 8.23% | 0.00% |
| March 3, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 48626 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.03% |
| March 3, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 16463 | $0.00 | 2,406.0000 | 158,964,772 | 87.25% | 0.01% |
| March 3, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 802 | $80.76 | 80,554.0000 | 158,964,772 | 0.99% | 0.00% |
| March 3, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 12687 | $79.88 | 81,356.0000 | 158,964,772 | 13.49% | 0.01% |
| March 3, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 71600 | $79.10 | 94,043.0000 | 158,964,772 | 43.23% | 0.05% |
| March 3, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 48626 | $60.89 | 165,643.0000 | 158,964,772 | 41.55% | 0.03% |
| March 3, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 16463 | $32.60 | 117,017.0000 | 158,964,772 | 16.37% | 0.01% |
| Feb. 27, 2026 | Monia Brett P | Chief Executive Officer | J | Common Stock | 484 | $48.87 | 254,981.0000 | 158,964,772 | 0.19% | 0.00% |
| Feb. 27, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | J | Common Stock | 261 | $48.87 | 100,554.0000 | 158,964,772 | 0.26% | 0.00% |
| Feb. 27, 2026 | Birchler Brian | EVP, Corp and Development Ops | J | Common Stock | 351 | $48.87 | 66,598.0000 | 158,964,772 | 0.53% | 0.00% |
| Feb. 27, 2026 | Swayze Eric | EVP Research | J | Common Stock | 256 | $48.87 | 32,679.0000 | 158,964,772 | 0.79% | 0.00% |
| Feb. 27, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | J | Common Stock | 376 | $48.87 | 72,359.0000 | 158,964,772 | 0.52% | 0.00% |
| Feb. 11, 2026 | PARSHALL B LYNNE | Director | S | Common Stock | 5000 | $82.72 | 56,344.0000 | 158,964,772 | 8.15% | 0.00% |
| Feb. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | J | Common Stock | 0 | $0.00 | 100,293.0000 | 158,964,772 | 0.00% | 0.00% |
| Feb. 13, 2026 | Swayze Eric | EVP Research | S | Common Stock | 6207 | $82.07 | 32,423.0000 | 158,964,772 | 16.07% | 0.00% |
| Feb. 13, 2026 | Swayze Eric | EVP Research | S | Common Stock | 9435 | $81.56 | 38,630.0000 | 158,964,772 | 19.63% | 0.01% |
| Feb. 6, 2026 | Monia Brett P | Chief Executive Officer | S | Common Stock | 29430 | $85.79 | 254,497.0000 | 158,964,772 | 10.37% | 0.02% |
| Feb. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 16463 | $83.03 | 80,293.0000 | 158,964,772 | 17.01% | 0.01% |
| Feb. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 20000 | $82.60 | 80,293.0000 | 158,964,772 | 19.94% | 0.01% |
| Feb. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 16463 | $32.60 | 96,756.0000 | 158,964,772 | 20.50% | 0.01% |
| Feb. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 48626 | $83.03 | 80,293.0000 | 158,964,772 | 37.72% | 0.03% |
| Feb. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 16463 | $0.00 | 2,406.0000 | 158,964,772 | 87.25% | 0.01% |
| Feb. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 48626 | $60.89 | 128,919.0000 | 158,964,772 | 60.56% | 0.03% |
| Feb. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 48626 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.03% |
| Jan. 30, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 6179 | $83.53 | 71,983.0000 | 158,964,772 | 7.91% | 0.00% |
| Jan. 30, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 6179 | $83.45 | 69,702.0000 | 158,964,772 | 8.14% | 0.00% |
| Jan. 29, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Common Stock | 11991 | $0.00 | 75,881.0000 | 158,964,772 | 18.77% | 0.01% |
| Jan. 30, 2026 | Swayze Eric | EVP Research | S | Common Stock | 6179 | $82.93 | 48,065.0000 | 158,964,772 | 11.39% | 0.00% |
| Jan. 29, 2026 | Swayze Eric | EVP Research | A | Common Stock | 11991 | $0.00 | 54,244.0000 | 158,964,772 | 28.38% | 0.01% |
| Jan. 29, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Common Stock | 11991 | $0.00 | 78,162.0000 | 158,964,772 | 18.12% | 0.01% |
| Jan. 29, 2026 | Monia Brett P | Chief Executive Officer | A | Common Stock | 122214 | $0.00 | 346,897.0000 | 158,964,772 | 54.39% | 0.08% |
| Jan. 30, 2026 | Monia Brett P | Chief Executive Officer | S | Common Stock | 62970 | $82.72 | 283,927.0000 | 158,964,772 | 18.15% | 0.04% |
| Jan. 29, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Common Stock | 13562 | $0.00 | 139,869.0000 | 158,964,772 | 10.74% | 0.01% |
| Jan. 30, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 6988 | $83.24 | 132,881.0000 | 158,964,772 | 5.00% | 0.00% |
| Jan. 29, 2026 | Birchler Brian | EVP, Corp and Development Ops | A | Common Stock | 11991 | $0.00 | 72,426.0000 | 158,964,772 | 19.84% | 0.01% |
| Jan. 30, 2026 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 6179 | $83.03 | 66,247.0000 | 158,964,772 | 8.53% | 0.00% |
| Jan. 29, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Common Stock | 11421 | $0.00 | 106,178.0000 | 158,964,772 | 12.05% | 0.01% |
| Jan. 30, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 5885 | $82.95 | 100,293.0000 | 158,964,772 | 5.54% | 0.00% |
| Jan. 29, 2026 | Baroldi Joseph | EVP, Chief Business Officer | A | Common Stock | 10278 | $0.00 | 55,481.0000 | 158,964,772 | 22.74% | 0.01% |
| Jan. 30, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 5296 | $82.96 | 50,185.0000 | 158,964,772 | 9.55% | 0.00% |
| Jan. 22, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 3977 | $81.34 | 22,541.0000 | 158,964,772 | 15.00% | 0.00% |
| Jan. 15, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | A | Restricted Stock Unit | 9675 | $0.00 | 37,725.0000 | 158,964,772 | 34.49% | 0.01% |
| Jan. 2, 2026 | Kordasiewicz Holly B. | EVP, Chief Development Officer | A | Non-Qualified Stock Option (right to buy) | 7500 | $0.00 | 16,600.0000 | 158,964,772 | 82.42% | 0.00% |
| Jan. 15, 2026 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 3900 | $0.00 | 68,523.0000 | 158,964,772 | 6.04% | 0.00% |
| Jan. 15, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 2850 | $0.00 | 64,623.0000 | 158,964,772 | 4.22% | 0.00% |
| Jan. 15, 2026 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 9675 | $0.00 | 68,523.0000 | 158,964,772 | 16.44% | 0.01% |
| Jan. 15, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 17037 | $0.00 | 58,848.0000 | 158,964,772 | 22.45% | 0.01% |
| Jan. 15, 2026 | Baroldi Joseph | EVP, Chief Business Officer | A | Performance Restricted Stock Units | 25800 | $0.00 | 77,090.0000 | 158,964,772 | 50.30% | 0.02% |
| Jan. 16, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 1149 | $75.78 | 45,203.0000 | 158,964,772 | 2.48% | 0.00% |
| Jan. 15, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 2850 | $0.00 | 46,352.0000 | 158,964,772 | 6.55% | 0.00% |
| Jan. 16, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 6907 | $75.75 | 45,203.0000 | 158,964,772 | 13.25% | 0.00% |
| Jan. 15, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 17037 | $0.00 | 52,110.0000 | 158,964,772 | 48.58% | 0.01% |
| Jan. 15, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Restricted Stock Unit | 9675 | $0.00 | 27,109.0000 | 158,964,772 | 55.50% | 0.01% |
| Jan. 15, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Restricted Stock Unit | 21055 | $0.00 | 17,434.0000 | 158,964,772 | 54.70% | 0.01% |
| Jan. 15, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Performance Restricted Stock Units | 25800 | $0.00 | 89,282.0000 | 158,964,772 | 40.64% | 0.02% |
| Jan. 16, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 8977 | $75.15 | 94,757.0000 | 158,964,772 | 8.65% | 0.01% |
| Jan. 15, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 21055 | $0.00 | 103,734.0000 | 158,964,772 | 25.47% | 0.01% |
| Jan. 15, 2026 | Birchler Brian | EVP, Corp and Development Ops | A | Restricted Stock Unit | 9675 | $0.00 | 50,801.0000 | 158,964,772 | 23.53% | 0.01% |
| Jan. 15, 2026 | Birchler Brian | EVP, Corp and Development Ops | M | Restricted Stock Unit | 20089 | $0.00 | 41,126.0000 | 158,964,772 | 32.82% | 0.01% |
| Jan. 15, 2026 | Birchler Brian | EVP, Corp and Development Ops | A | Performance Restricted Stock Units | 25800 | $0.00 | 79,138.0000 | 158,964,772 | 48.37% | 0.02% |
| Jan. 16, 2026 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 8480 | $75.11 | 60,435.0000 | 158,964,772 | 12.31% | 0.01% |
| Jan. 15, 2026 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 20089 | $0.00 | 68,915.0000 | 158,964,772 | 41.14% | 0.01% |
| Jan. 15, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | A | Restricted Stock Unit | 9675 | $0.00 | 52,704.0000 | 158,964,772 | 22.48% | 0.01% |
| Jan. 15, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Restricted Stock Unit | 17377 | $0.00 | 43,029.0000 | 158,964,772 | 28.77% | 0.01% |
| Jan. 15, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | A | Performance Restricted Stock Units | 25800 | $0.00 | 47,800.0000 | 158,964,772 | 117.27% | 0.02% |
| Jan. 16, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 8353 | $75.95 | 26,518.0000 | 158,964,772 | 23.95% | 0.01% |
| Jan. 15, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 17377 | $0.00 | 34,871.0000 | 158,964,772 | 99.33% | 0.01% |
| Jan. 15, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Restricted Stock Unit | 12885 | $0.00 | 68,825.0000 | 158,964,772 | 23.03% | 0.01% |
| Jan. 15, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Restricted Stock Unit | 28729 | $0.00 | 55,940.0000 | 158,964,772 | 33.93% | 0.02% |
| Jan. 15, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Performance Restricted Stock Units | 34360 | $0.00 | 120,995.0000 | 158,964,772 | 39.66% | 0.02% |
| Jan. 16, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 12922 | $75.22 | 126,307.0000 | 158,964,772 | 9.28% | 0.01% |
| Jan. 15, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 28729 | $0.00 | 139,229.0000 | 158,964,772 | 26.00% | 0.02% |
| Jan. 15, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | M | Restricted Stock Unit | 7013 | $0.00 | 29,664.0000 | 158,964,772 | 19.12% | 0.00% |
| Jan. 15, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | A | Performance Restricted Stock Units | 25800 | $0.00 | 44,500.0000 | 158,964,772 | 137.97% | 0.02% |
| Jan. 16, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | S | Common Stock | 1823 | $75.96 | 16,389.0000 | 158,964,772 | 10.01% | 0.00% |
| Jan. 15, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | M | Common Stock | 7013 | $0.00 | 18,212.0000 | 158,964,772 | 62.62% | 0.00% |
| Jan. 15, 2026 | Kordasiewicz Holly B. | EVP, Chief Development Officer | A | Restricted Stock Unit | 11250 | $0.00 | 45,730.0000 | 158,964,772 | 32.63% | 0.01% |
| Jan. 15, 2026 | Kordasiewicz Holly B. | EVP, Chief Development Officer | A | Restricted Stock Unit | 13650 | $0.00 | 34,480.0000 | 158,964,772 | 65.53% | 0.01% |
| Jan. 15, 2026 | Kordasiewicz Holly B. | EVP, Chief Development Officer | M | Restricted Stock Unit | 11119 | $0.00 | 20,830.0000 | 158,964,772 | 34.80% | 0.01% |
| Jan. 16, 2026 | Kordasiewicz Holly B. | EVP, Chief Development Officer | S | Common Stock | 4141 | $75.66 | 14,718.0000 | 158,964,772 | 21.96% | 0.00% |
| Jan. 15, 2026 | Kordasiewicz Holly B. | EVP, Chief Development Officer | M | Common Stock | 11119 | $0.00 | 18,859.0000 | 158,964,772 | 143.66% | 0.01% |
| Jan. 15, 2026 | Monia Brett P | Chief Executive Officer | A | Restricted Stock Unit | 42705 | $0.00 | 205,719.0000 | 158,964,772 | 26.20% | 0.03% |
| Jan. 15, 2026 | Monia Brett P | Chief Executive Officer | M | Restricted Stock Unit | 89145 | $0.00 | 163,014.0000 | 158,964,772 | 35.35% | 0.06% |
| Jan. 15, 2026 | Monia Brett P | Chief Executive Officer | A | Performance Restricted Stock Units | 113880 | $0.00 | 744,081.0000 | 158,964,772 | 18.07% | 0.07% |
| Jan. 16, 2026 | Monia Brett P | Chief Executive Officer | S | Common Stock | 44034 | $74.82 | 224,683.0000 | 158,964,772 | 16.39% | 0.03% |
| Jan. 15, 2026 | Monia Brett P | Chief Executive Officer | M | Common Stock | 89145 | $0.00 | 268,717.0000 | 158,964,772 | 49.64% | 0.06% |
| Jan. 15, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Restricted Stock Unit | 9675 | $0.00 | 48,926.0000 | 158,964,772 | 24.65% | 0.01% |
| Jan. 15, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Restricted Stock Unit | 21473 | $0.00 | 39,251.0000 | 158,964,772 | 35.36% | 0.01% |
| Jan. 15, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Performance Restricted Stock Units | 25800 | $0.00 | 90,601.0000 | 158,964,772 | 39.81% | 0.02% |
| Jan. 16, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 9191 | $75.84 | 66,171.0000 | 158,964,772 | 12.20% | 0.01% |
| Jan. 15, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 21473 | $0.00 | 75,362.0000 | 158,964,772 | 39.85% | 0.01% |
| Jan. 15, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Restricted Stock Unit | 9675 | $0.00 | 48,926.0000 | 158,964,772 | 24.65% | 0.01% |
| Jan. 15, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Restricted Stock Unit | 21685 | $0.00 | 39,251.0000 | 158,964,772 | 35.59% | 0.01% |
| Jan. 15, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Performance Restricted Stock Units | 25800 | $0.00 | 91,237.0000 | 158,964,772 | 39.43% | 0.02% |
| Jan. 16, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 9302 | $75.59 | 63,890.0000 | 158,964,772 | 12.71% | 0.01% |
| Jan. 15, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Common Stock | 21685 | $0.00 | 73,192.0000 | 158,964,772 | 42.10% | 0.01% |
| Jan. 15, 2026 | Swayze Eric | EVP Research | A | Restricted Stock Unit | 225 | $0.00 | 49,537.0000 | 158,964,772 | 0.46% | 0.00% |
| Jan. 15, 2026 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 111 | $0.00 | 49,312.0000 | 158,964,772 | 0.22% | 0.00% |
| Jan. 15, 2026 | Swayze Eric | EVP Research | A | Restricted Stock Unit | 9675 | $0.00 | 49,537.0000 | 158,964,772 | 24.27% | 0.01% |
| Jan. 15, 2026 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 21366 | $0.00 | 39,862.0000 | 158,964,772 | 34.90% | 0.01% |
| Jan. 15, 2026 | Swayze Eric | EVP Research | A | Performance Restricted Stock Units | 25800 | $0.00 | 90,282.0000 | 158,964,772 | 40.01% | 0.02% |
| Jan. 16, 2026 | Swayze Eric | EVP Research | S | Common Stock | 49 | $75.97 | 42,253.0000 | 158,964,772 | 0.12% | 0.00% |
| Jan. 15, 2026 | Swayze Eric | EVP Research | M | Common Stock | 111 | $0.00 | 42,302.0000 | 158,964,772 | 0.26% | 0.00% |
| Jan. 16, 2026 | Swayze Eric | EVP Research | S | Common Stock | 9884 | $75.34 | 42,253.0000 | 158,964,772 | 18.96% | 0.01% |
| Jan. 15, 2026 | Swayze Eric | EVP Research | M | Common Stock | 21366 | $0.00 | 52,137.0000 | 158,964,772 | 69.44% | 0.01% |
| Jan. 15, 2026 | YANG MICHAEL J. | Director | M | Restricted Stock Unit | 1930 | $0.00 | 7,150.0000 | 158,964,772 | 21.26% | 0.00% |
| Jan. 15, 2026 | YANG MICHAEL J. | Director | M | Common Stock | 1930 | $0.00 | 7,940.0000 | 158,964,772 | 32.11% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 25545 | $0.00 | 2,971.0000 | 158,964,772 | 89.58% | 0.02% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 25545 | $56.78 | 43,039.0000 | 158,964,772 | 146.02% | 0.02% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 25545 | $85.36 | 17,494.0000 | 158,964,772 | 59.35% | 0.02% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 2101 | $32.60 | 19,595.0000 | 158,964,772 | 12.01% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 2101 | $85.36 | 17,494.0000 | 158,964,772 | 10.72% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 3460 | $32.60 | 20,954.0000 | 158,964,772 | 19.78% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 3460 | $84.62 | 17,494.0000 | 158,964,772 | 16.51% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 3829 | $37.58 | 21,323.0000 | 158,964,772 | 21.89% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 3829 | $84.62 | 17,494.0000 | 158,964,772 | 17.96% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 9264 | $52.87 | 26,758.0000 | 158,964,772 | 52.96% | 0.01% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 9264 | $84.62 | 17,494.0000 | 158,964,772 | 34.62% | 0.01% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 2101 | $0.00 | 11,339.0000 | 158,964,772 | 15.63% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 3460 | $0.00 | 7,879.0000 | 158,964,772 | 30.51% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 3829 | $0.00 | 9,254.0000 | 158,964,772 | 29.27% | 0.00% |
| Jan. 7, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 9264 | $0.00 | 9,262.0000 | 158,964,772 | 50.01% | 0.01% |
| Jan. 2, 2026 | Monia Brett P | Chief Executive Officer | A | Non-Qualified Stock Option (right to buy) | 85410 | $0.00 | 85,410.0000 | 158,964,772 | 9999.99% | 0.05% |
| Jan. 2, 2026 | Kordasiewicz Holly B. | EVP, Chief Development Officer | A | Non-Qualified Stock Option (right to buy) | 9100 | $0.00 | 9,100.0000 | 158,964,772 | 9999.99% | 0.01% |
| Jan. 2, 2026 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 2600 | $0.00 | 21,950.0000 | 158,964,772 | 13.44% | 0.00% |
| Jan. 2, 2026 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 19350 | $0.00 | 21,950.0000 | 158,964,772 | 744.23% | 0.01% |
| Jan. 2, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Non-Qualified Stock Option (right to buy) | 19350 | $0.00 | 19,350.0000 | 158,964,772 | 9999.99% | 0.01% |
| Jan. 2, 2026 | Birchler Brian | EVP, Corp and Development Ops | A | Non-Qualified Stock Option (right to buy) | 19350 | $0.00 | 19,350.0000 | 158,964,772 | 9999.99% | 0.01% |
| Jan. 2, 2026 | Devers Shannon L. | EVP, Chief Human Resources Ofc | A | Non-Qualified Stock Option (right to buy) | 19350 | $0.00 | 19,350.0000 | 158,964,772 | 9999.99% | 0.01% |
| Jan. 2, 2026 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Non-Qualified Stock Option (right to buy) | 25770 | $0.00 | 25,770.0000 | 158,964,772 | 9999.99% | 0.02% |
| Jan. 2, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Non-Qualified Stock Option (right to buy) | 19350 | $0.00 | 19,350.0000 | 158,964,772 | 9999.99% | 0.01% |
| Jan. 2, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Non-Qualified Stock Option (right to buy) | 19350 | $0.00 | 19,350.0000 | 158,964,772 | 9999.99% | 0.01% |
| Jan. 2, 2026 | Swayze Eric | EVP Research | A | Non-Qualified Stock Option (right to buy) | 150 | $0.00 | 19,500.0000 | 158,964,772 | 0.78% | 0.00% |
| Jan. 2, 2026 | Swayze Eric | EVP Research | A | Non-Qualified Stock Option (right to buy) | 19350 | $0.00 | 19,500.0000 | 158,964,772 | 9999.99% | 0.01% |
| Jan. 2, 2026 | Swayze Eric | EVP Research | M | Non-Qualified Stock Option (right to buy) | 18338 | $0.00 | 4,215.0000 | 158,964,772 | 81.31% | 0.01% |
| Jan. 2, 2026 | Swayze Eric | EVP Research | M | Non-Qualified Stock Option (right to buy) | 5125 | $0.00 | 22,553.0000 | 158,964,772 | 18.52% | 0.00% |
| Jan. 2, 2026 | Swayze Eric | EVP Research | S | Common Stock | 18338 | $79.27 | 30,709.0000 | 158,964,772 | 37.39% | 0.01% |
| Jan. 2, 2026 | Swayze Eric | EVP Research | M | Common Stock | 18338 | $60.89 | 49,047.0000 | 158,964,772 | 59.72% | 0.01% |
| Jan. 2, 2026 | Swayze Eric | EVP Research | S | Common Stock | 5125 | $78.57 | 30,709.0000 | 158,964,772 | 14.30% | 0.00% |
| Jan. 2, 2026 | Swayze Eric | EVP Research | M | Common Stock | 5125 | $60.89 | 35,834.0000 | 158,964,772 | 16.69% | 0.00% |
| Jan. 2, 2026 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | A | Non-Qualified Stock Option (right to buy) | 19350 | $0.00 | 19,350.0000 | 158,964,772 | 9999.99% | 0.01% |
| Dec. 1, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 7429 | $81.23 | 52,035.0000 | 158,964,772 | 12.49% | 0.00% |
| Dec. 1, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 20571 | $80.67 | 59,464.0000 | 158,964,772 | 25.70% | 0.01% |
| Nov. 25, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 16777 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 4000 | $0.00 | 4,000.0000 | 158,964,772 | 50.00% | 0.00% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 4000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.00% |
| Nov. 25, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 16777 | $53.77 | 34,271.0000 | 158,964,772 | 95.90% | 0.01% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 4000 | $0.00 | 8,000.0000 | 158,964,772 | 33.33% | 0.00% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | S | Common Stock | 4000 | $80.00 | 16,446.0000 | 158,964,772 | 19.56% | 0.00% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | M | Common Stock | 4000 | $0.00 | 20,446.0000 | 158,964,772 | 24.32% | 0.00% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | S | Common Stock | 4000 | $80.00 | 16,446.0000 | 158,964,772 | 19.56% | 0.00% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | M | Common Stock | 4000 | $0.00 | 20,446.0000 | 158,964,772 | 24.32% | 0.00% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | M | Common Stock | 4000 | $0.00 | 20,446.0000 | 158,964,772 | 24.32% | 0.00% |
| Nov. 25, 2025 | KLEIN JOSEPH III | Director | S | Common Stock | 4000 | $80.00 | 16,446.0000 | 158,964,772 | 19.56% | 0.00% |
| Nov. 25, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 16777 | $80.91 | 17,494.0000 | 158,964,772 | 48.95% | 0.01% |
| Nov. 18, 2025 | WENDER JOSEPH H | Director | M | Non-Qualified Stock Option (right to buy) | 16000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Nov. 19, 2025 | HERMAN JOAN E | Director | M | Non-Qualified Stock Option (right to buy) | 32000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.02% |
| Nov. 19, 2025 | HERMAN JOAN E | Director | M | Non-Qualified Stock Option (right to buy) | 12000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Nov. 19, 2025 | HERMAN JOAN E | Director | S | Common Stock | 32000 | $72.13 | 46,086.0000 | 158,964,772 | 40.98% | 0.02% |
| Nov. 19, 2025 | HERMAN JOAN E | Director | M | Common Stock | 32000 | $63.90 | 78,086.0000 | 158,964,772 | 69.44% | 0.02% |
| Nov. 19, 2025 | HERMAN JOAN E | Director | S | Common Stock | 12000 | $72.13 | 46,086.0000 | 158,964,772 | 20.66% | 0.01% |
| Nov. 19, 2025 | HERMAN JOAN E | Director | M | Common Stock | 12000 | $40.05 | 58,086.0000 | 158,964,772 | 26.04% | 0.01% |
| Nov. 18, 2025 | WENDER JOSEPH H | Director | M | Common Stock | 16000 | $24.42 | 80,035.0000 | 158,964,772 | 24.99% | 0.01% |
| Nov. 6, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 18300 | $60.89 | 77,957.0000 | 158,964,772 | 30.68% | 0.01% |
| Nov. 6, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 18300 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Nov. 5, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 801 | $0.00 | 18,300.0000 | 158,964,772 | 4.19% | 0.00% |
| Nov. 6, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 14738 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Nov. 5, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 800 | $0.00 | 14,738.0000 | 158,964,772 | 5.15% | 0.00% |
| Nov. 6, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 18300 | $75.42 | 59,657.0000 | 158,964,772 | 23.47% | 0.01% |
| Nov. 6, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 14738 | $76.10 | 59,657.0000 | 158,964,772 | 19.81% | 0.01% |
| Nov. 6, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 14738 | $56.78 | 74,395.0000 | 158,964,772 | 24.70% | 0.01% |
| Nov. 5, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 801 | $75.01 | 59,657.0000 | 158,964,772 | 1.32% | 0.00% |
| Nov. 5, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 801 | $60.89 | 60,458.0000 | 158,964,772 | 1.34% | 0.00% |
| Nov. 5, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 800 | $75.01 | 59,657.0000 | 158,964,772 | 1.32% | 0.00% |
| Nov. 5, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 800 | $56.78 | 60,457.0000 | 158,964,772 | 1.34% | 0.00% |
| Nov. 6, 2025 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 8000 | $76.17 | 48,826.0000 | 158,964,772 | 14.08% | 0.01% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 775 | $60.89 | 60,432.0000 | 158,964,772 | 1.30% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 775 | $75.05 | 59,657.0000 | 158,964,772 | 1.28% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 905 | $56.78 | 60,562.0000 | 158,964,772 | 1.52% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 905 | $75.05 | 59,657.0000 | 158,964,772 | 1.49% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 905 | $0.00 | 15,538.0000 | 158,964,772 | 5.50% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 775 | $0.00 | 19,101.0000 | 158,964,772 | 3.90% | 0.00% |
| Oct. 30, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 2484 | $72.19 | 89,551.0000 | 158,964,772 | 2.70% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 905 | $75.05 | 59,657.0000 | 158,964,772 | 1.49% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 905 | $60.89 | 60,562.0000 | 158,964,772 | 1.52% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 775 | $75.05 | 59,657.0000 | 158,964,772 | 1.28% | 0.00% |
| Oct. 31, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 34664 | $0.00 | 16,443.0000 | 158,964,772 | 67.83% | 0.02% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 775 | $56.78 | 60,432.0000 | 158,964,772 | 1.30% | 0.00% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 775 | $0.00 | 15,668.0000 | 158,964,772 | 4.71% | 0.00% |
| Oct. 31, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 34585 | $0.00 | 19,876.0000 | 158,964,772 | 63.50% | 0.02% |
| Oct. 31, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 34664 | $56.78 | 114,321.0000 | 158,964,772 | 43.52% | 0.02% |
| Oct. 31, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 34585 | $60.89 | 114,242.0000 | 158,964,772 | 43.42% | 0.02% |
| Oct. 31, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 34585 | $75.11 | 79,657.0000 | 158,964,772 | 30.27% | 0.02% |
| Nov. 3, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 905 | $0.00 | 18,971.0000 | 158,964,772 | 4.55% | 0.00% |
| Oct. 31, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 20000 | $75.11 | 59,657.0000 | 158,964,772 | 25.11% | 0.01% |
| Oct. 31, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 34664 | $75.11 | 79,657.0000 | 158,964,772 | 30.32% | 0.02% |
| Oct. 31, 2025 | LOSCALZO JOSEPH | Director | M | Non-Qualified Stock Option (right to buy) | 16000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Oct. 31, 2025 | LOSCALZO JOSEPH | Director | S | Common Stock | 16000 | $75.10 | 36,330.0000 | 158,964,772 | 30.58% | 0.01% |
| Oct. 31, 2025 | LOSCALZO JOSEPH | Director | M | Common Stock | 16000 | $52.22 | 52,330.0000 | 158,964,772 | 44.04% | 0.01% |
| Oct. 31, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 11200 | $75.16 | 64,035.0000 | 158,964,772 | 14.89% | 0.01% |
| Oct. 30, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 5975 | $73.85 | 75,235.0000 | 158,964,772 | 7.36% | 0.00% |
| Oct. 30, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 8341 | $73.16 | 81,210.0000 | 158,964,772 | 9.31% | 0.01% |
| Oct. 14, 2025 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 11475 | $72.03 | 56,826.0000 | 158,964,772 | 16.80% | 0.01% |
| Oct. 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | M | Non-Qualified Stock Option (right to buy) | 12425 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Oct. 14, 2025 | Birchler Brian | EVP, Corp and Development Ops | M | Non-Qualified Stock Option (right to buy) | 11475 | $0.00 | 12,425.0000 | 158,964,772 | 48.01% | 0.01% |
| Oct. 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 12425 | $72.23 | 56,826.0000 | 158,964,772 | 17.94% | 0.01% |
| Oct. 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 12425 | $53.77 | 69,251.0000 | 158,964,772 | 21.86% | 0.01% |
| Oct. 14, 2025 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 11475 | $53.77 | 68,301.0000 | 158,964,772 | 20.19% | 0.01% |
| Oct. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Restricted Stock Unit | 2820 | $0.00 | 60,406.0000 | 158,964,772 | 4.46% | 0.00% |
| Oct. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 6000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.00% |
| Oct. 16, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 1263 | $73.62 | 17,494.0000 | 158,964,772 | 6.73% | 0.00% |
| Oct. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 2820 | $0.00 | 18,757.0000 | 158,964,772 | 17.69% | 0.00% |
| Oct. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 6000 | $72.94 | 15,937.0000 | 158,964,772 | 27.35% | 0.00% |
| Oct. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 6000 | $48.51 | 21,937.0000 | 158,964,772 | 37.65% | 0.00% |
| Oct. 15, 2025 | PARSHALL B LYNNE | Director | S | Common Stock | 5000 | $71.74 | 61,344.0000 | 158,964,772 | 7.54% | 0.00% |
| Oct. 15, 2025 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 125 | $0.00 | 497.0000 | 158,964,772 | 20.10% | 0.00% |
| Oct. 16, 2025 | Swayze Eric | EVP Research | S | Common Stock | 53 | $73.62 | 30,709.0000 | 158,964,772 | 0.17% | 0.00% |
| Oct. 15, 2025 | Swayze Eric | EVP Research | M | Common Stock | 125 | $0.00 | 30,762.0000 | 158,964,772 | 0.41% | 0.00% |
| Oct. 6, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 437 | $69.26 | 179,572.0000 | 158,964,772 | 0.24% | 0.00% |
| Oct. 6, 2025 | Swayze Eric | EVP Research | S | Common Stock | 6849 | $69.02 | 30,637.0000 | 158,964,772 | 18.27% | 0.00% |
| Oct. 6, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 10200 | $52.87 | 67,330.0000 | 158,964,772 | 17.85% | 0.01% |
| Oct. 6, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 10200 | $69.89 | 57,130.0000 | 158,964,772 | 15.15% | 0.01% |
| Oct. 6, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 10200 | $0.00 | 17,000.0000 | 158,964,772 | 37.50% | 0.01% |
| Oct. 6, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 1625 | $69.37 | 33,372.0000 | 158,964,772 | 4.64% | 0.00% |
| Oct. 6, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 3241 | $69.27 | 53,889.0000 | 158,964,772 | 5.67% | 0.00% |
| Oct. 1, 2025 | Swayze Eric | EVP Research | S | Common Stock | 14142 | $66.09 | 37,486.0000 | 158,964,772 | 27.39% | 0.01% |
| Oct. 1, 2025 | Swayze Eric | EVP Research | M | Common Stock | 14142 | $53.77 | 51,628.0000 | 158,964,772 | 37.73% | 0.01% |
| Oct. 1, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 16800 | $65.50 | 92,035.0000 | 158,964,772 | 15.44% | 0.01% |
| Oct. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 30203 | $56.78 | 87,333.0000 | 158,964,772 | 52.87% | 0.02% |
| Oct. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 30203 | $67.69 | 57,130.0000 | 158,964,772 | 34.58% | 0.02% |
| Oct. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 34461 | $60.89 | 91,591.0000 | 158,964,772 | 60.32% | 0.02% |
| Oct. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 34461 | $67.69 | 57,130.0000 | 158,964,772 | 37.62% | 0.02% |
| Oct. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 30203 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.02% |
| Oct. 2, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 15000 | $68.01 | 34,997.0000 | 158,964,772 | 30.00% | 0.01% |
| Oct. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 34461 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.02% |
| Oct. 2, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 15000 | $0.00 | 26,700.0000 | 158,964,772 | 35.97% | 0.01% |
| Oct. 2, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 15000 | $31.80 | 49,997.0000 | 158,964,772 | 42.86% | 0.01% |
| Oct. 2, 2025 | Swayze Eric | EVP Research | M | Non-Qualified Stock Option (right to buy) | 12972 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Oct. 1, 2025 | Swayze Eric | EVP Research | M | Non-Qualified Stock Option (right to buy) | 14142 | $0.00 | 12,972.0000 | 158,964,772 | 52.16% | 0.01% |
| Oct. 2, 2025 | Swayze Eric | EVP Research | S | Common Stock | 12972 | $66.23 | 37,486.0000 | 158,964,772 | 25.71% | 0.01% |
| Oct. 2, 2025 | Swayze Eric | EVP Research | M | Common Stock | 12972 | $53.77 | 50,458.0000 | 158,964,772 | 34.60% | 0.01% |
| Sept. 30, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Non-Qualified Stock Option (right to buy) | 49800 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.03% |
| Sept. 30, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 57900 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.04% |
| Sept. 30, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 57900 | $65.24 | 79,657.0000 | 158,964,772 | 42.09% | 0.04% |
| Sept. 30, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 57900 | $53.77 | 137,557.0000 | 158,964,772 | 72.69% | 0.04% |
| Sept. 30, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 14827 | $0.00 | 30,203.0000 | 158,964,772 | 32.93% | 0.01% |
| Sept. 29, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 10473 | $0.00 | 45,030.0000 | 158,964,772 | 18.87% | 0.01% |
| Sept. 30, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 14827 | $64.68 | 57,130.0000 | 158,964,772 | 20.61% | 0.01% |
| Sept. 30, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 14827 | $56.78 | 71,957.0000 | 158,964,772 | 25.95% | 0.01% |
| Sept. 29, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 10473 | $64.54 | 57,130.0000 | 158,964,772 | 15.49% | 0.01% |
| Sept. 29, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 10473 | $56.78 | 67,603.0000 | 158,964,772 | 18.33% | 0.01% |
| Sept. 30, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 49800 | $65.26 | 110,500.0000 | 158,964,772 | 31.07% | 0.03% |
| Sept. 30, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 49800 | $53.77 | 160,300.0000 | 158,964,772 | 45.07% | 0.03% |
| Sept. 12, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 1700 | $64.58 | 57,130.0000 | 158,964,772 | 2.89% | 0.00% |
| Sept. 12, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 1700 | $0.00 | 55,503.0000 | 158,964,772 | 2.97% | 0.00% |
| Sept. 12, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 1700 | $56.78 | 58,830.0000 | 158,964,772 | 2.98% | 0.00% |
| Sept. 9, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 20000 | $60.89 | 77,130.0000 | 158,964,772 | 35.01% | 0.01% |
| Sept. 9, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 11950 | $0.00 | 41,700.0000 | 158,964,772 | 22.27% | 0.01% |
| Sept. 9, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 11950 | $62.16 | 34,997.0000 | 158,964,772 | 25.45% | 0.01% |
| Sept. 9, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 11950 | $31.80 | 46,947.0000 | 158,964,772 | 34.15% | 0.01% |
| Sept. 9, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 1000 | $64.56 | 57,130.0000 | 158,964,772 | 1.72% | 0.00% |
| Sept. 9, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 20000 | $0.00 | 34,461.0000 | 158,964,772 | 36.72% | 0.01% |
| Sept. 9, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 1000 | $56.78 | 58,130.0000 | 158,964,772 | 1.75% | 0.00% |
| Sept. 9, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 20000 | $64.56 | 57,130.0000 | 158,964,772 | 25.93% | 0.01% |
| Sept. 9, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 1000 | $0.00 | 57,203.0000 | 158,964,772 | 1.72% | 0.00% |
| Sept. 5, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 250 | $0.00 | 53,650.0000 | 158,964,772 | 0.46% | 0.00% |
| Sept. 5, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 250 | $62.00 | 34,997.0000 | 158,964,772 | 0.71% | 0.00% |
| Sept. 5, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 250 | $31.80 | 35,247.0000 | 158,964,772 | 0.71% | 0.00% |
| Sept. 5, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 6000 | $59.60 | 82,679.0000 | 158,964,772 | 6.77% | 0.00% |
| Sept. 3, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 2234 | $37.58 | 18,171.0000 | 158,964,772 | 14.02% | 0.00% |
| Sept. 2, 2025 | Swayze Eric | EVP Research | S | Common Stock | 10000 | $49.22 | 38,616.0000 | 158,964,772 | 20.57% | 0.01% |
| Sept. 2, 2025 | Swayze Eric | EVP Research | S | Common Stock | 1130 | $53.68 | 37,486.0000 | 158,964,772 | 2.93% | 0.00% |
| Sept. 2, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 11200 | $55.04 | 125,635.0000 | 158,964,772 | 8.19% | 0.01% |
| Sept. 2, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 5600 | $57.53 | 120,035.0000 | 158,964,772 | 4.46% | 0.00% |
| Sept. 3, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 11200 | $60.14 | 108,835.0000 | 158,964,772 | 9.33% | 0.01% |
| Sept. 2, 2025 | PARSHALL B LYNNE | Director | S | Common Stock | 10750 | $50.42 | 75,594.0000 | 158,964,772 | 12.45% | 0.01% |
| Sept. 2, 2025 | PARSHALL B LYNNE | Director | S | Common Stock | 9250 | $51.49 | 66,344.0000 | 158,964,772 | 12.24% | 0.01% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | M | Common Stock | 102900 | $53.77 | 282,909.0000 | 158,964,772 | 57.16% | 0.06% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 16615 | $59.12 | 266,294.0000 | 158,964,772 | 5.87% | 0.01% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | M | Common Stock | 42030 | $37.58 | 308,324.0000 | 158,964,772 | 15.78% | 0.03% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 127500 | $60.13 | 180,824.0000 | 158,964,772 | 41.35% | 0.08% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | M | Common Stock | 31316 | $32.60 | 212,140.0000 | 158,964,772 | 17.32% | 0.02% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | M | Common Stock | 27568 | $32.60 | 239,708.0000 | 158,964,772 | 13.00% | 0.02% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 59699 | $61.06 | 180,009.0000 | 158,964,772 | 24.90% | 0.04% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 31316 | $0.00 | 67,741.0000 | 158,964,772 | 31.61% | 0.02% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 27568 | $0.00 | 40,173.0000 | 158,964,772 | 40.70% | 0.02% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 42030 | $0.00 | 76,643.0000 | 158,964,772 | 35.42% | 0.03% |
| Sept. 3, 2025 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 102900 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.06% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | M | Common Stock | 16000 | $0.00 | 32,446.0000 | 158,964,772 | 97.29% | 0.01% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | M | Common Stock | 12000 | $0.00 | 44,446.0000 | 158,964,772 | 36.98% | 0.01% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | S | Common Stock | 28000 | $60.00 | 16,446.0000 | 158,964,772 | 63.00% | 0.02% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 12000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 16000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | M | Common Stock | 16000 | $0.00 | 32,446.0000 | 158,964,772 | 97.29% | 0.01% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | M | Common Stock | 12000 | $0.00 | 44,446.0000 | 158,964,772 | 36.98% | 0.01% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | S | Common Stock | 28000 | $60.00 | 16,446.0000 | 158,964,772 | 63.00% | 0.02% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 12000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Sept. 3, 2025 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 16000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Sept. 2, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 10000 | $50.37 | 79,657.0000 | 158,964,772 | 11.15% | 0.01% |
| Sept. 3, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 3162 | $61.02 | 15,009.0000 | 158,964,772 | 17.40% | 0.00% |
| Sept. 3, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 928 | $32.60 | 15,937.0000 | 158,964,772 | 6.18% | 0.00% |
| Sept. 3, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 928 | $0.00 | 13,440.0000 | 158,964,772 | 6.46% | 0.00% |
| Sept. 3, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Non-Qualified Stock Option (right to buy) | 2234 | $0.00 | 13,083.0000 | 158,964,772 | 14.59% | 0.00% |
| Sept. 2, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 11200 | $55.04 | 125,635.0000 | 158,964,772 | 8.19% | 0.01% |
| Sept. 2, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 5600 | $57.53 | 120,035.0000 | 158,964,772 | 4.46% | 0.00% |
| Sept. 3, 2025 | WENDER JOSEPH H | Director | S | Common Stock | 11200 | $60.14 | 108,835.0000 | 158,964,772 | 9.33% | 0.01% |
| Sept. 3, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 2800 | $31.80 | 37,797.0000 | 158,964,772 | 8.00% | 0.00% |
| Sept. 3, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 2800 | $62.01 | 34,997.0000 | 158,964,772 | 7.41% | 0.00% |
| Sept. 3, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 15000 | $31.80 | 49,997.0000 | 158,964,772 | 42.86% | 0.01% |
| Sept. 3, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 30000 | $59.09 | 19,997.0000 | 158,964,772 | 60.00% | 0.02% |
| Sept. 3, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 15000 | $31.80 | 34,997.0000 | 158,964,772 | 75.01% | 0.01% |
| Sept. 3, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 2800 | $0.00 | 83,900.0000 | 158,964,772 | 3.23% | 0.00% |
| Sept. 3, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 15000 | $0.00 | 68,900.0000 | 158,964,772 | 17.88% | 0.01% |
| Sept. 3, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Non-Qualified Stock Option (right to buy) | 15000 | $0.00 | 53,900.0000 | 158,964,772 | 21.77% | 0.01% |
| Sept. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 13050 | $32.60 | 70,180.0000 | 158,964,772 | 22.84% | 0.01% |
| Sept. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 13050 | $54.51 | 57,130.0000 | 158,964,772 | 18.60% | 0.01% |
| Sept. 3, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 14000 | $37.58 | 71,130.0000 | 158,964,772 | 24.51% | 0.01% |
| Sept. 3, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 65475 | $60.89 | 5,655.0000 | 158,964,772 | 92.05% | 0.04% |
| Sept. 3, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 13050 | $32.60 | 18,705.0000 | 158,964,772 | 230.77% | 0.01% |
| Sept. 3, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 11375 | $61.42 | 7,330.0000 | 158,964,772 | 60.81% | 0.01% |
| Sept. 3, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 49800 | $53.77 | 57,130.0000 | 158,964,772 | 679.40% | 0.03% |
| Sept. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 13050 | $0.00 | 17,517.0000 | 158,964,772 | 42.69% | 0.01% |
| Sept. 3, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 13050 | $0.00 | 4,467.0000 | 158,964,772 | 74.50% | 0.01% |
| Sept. 3, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 14000 | $0.00 | 8,942.0000 | 158,964,772 | 61.02% | 0.01% |
| Sept. 3, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 49800 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.03% |
| Sept. 2, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 5000 | $49.14 | 88,679.0000 | 158,964,772 | 5.34% | 0.00% |
| Sept. 3, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 46800 | $53.77 | 135,479.0000 | 158,964,772 | 52.77% | 0.03% |
| Sept. 3, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 33909 | $60.62 | 101,570.0000 | 158,964,772 | 25.03% | 0.02% |
| Sept. 3, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 12891 | $61.50 | 88,679.0000 | 158,964,772 | 12.69% | 0.01% |
| Sept. 3, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 46800 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.03% |
| Sept. 3, 2025 | LOSCALZO JOSEPH | Director | M | Common Stock | 16000 | $24.42 | 52,330.0000 | 158,964,772 | 44.04% | 0.01% |
| Sept. 3, 2025 | LOSCALZO JOSEPH | Director | S | Common Stock | 16000 | $60.15 | 36,330.0000 | 158,964,772 | 30.58% | 0.01% |
| Sept. 3, 2025 | LOSCALZO JOSEPH | Director | M | Non-Qualified Stock Option (right to buy) | 16000 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Sept. 3, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Common Stock | 19658 | $53.77 | 71,165.0000 | 158,964,772 | 38.17% | 0.01% |
| Sept. 3, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 12455 | $60.46 | 58,710.0000 | 158,964,772 | 17.50% | 0.01% |
| Sept. 3, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 7203 | $61.42 | 51,507.0000 | 158,964,772 | 12.27% | 0.00% |
| Sept. 3, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Non-Qualified Stock Option (right to buy) | 19658 | $0.00 | 0.0000 | 158,964,772 | 100.00% | 0.01% |
| Aug. 29, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | J | Common Stock | 331 | $27.71 | 57,130.0000 | 158,964,772 | 0.58% | 0.00% |
| Aug. 29, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | J | Common Stock | 213 | $27.71 | 93,679.0000 | 158,964,772 | 0.23% | 0.00% |
| Aug. 29, 2025 | Birchler Brian | EVP, Corp and Development Ops | J | Common Stock | 166 | $27.71 | 56,826.0000 | 158,964,772 | 0.29% | 0.00% |
| Aug. 29, 2025 | Monia Brett P | Chief Executive Officer | J | Common Stock | 189 | $27.71 | 180,009.0000 | 158,964,772 | 0.11% | 0.00% |
| Aug. 29, 2025 | Geary Richard S | EVP, Chief Development Officer | J | Common Stock | 165 | $27.71 | 89,657.0000 | 158,964,772 | 0.18% | 0.00% |
| Aug. 22, 2025 | Diaz Allene M. | Director | S | Common Stock | 1427 | $42.53 | 18,368.0000 | 158,964,772 | 7.21% | 0.00% |
| Aug. 18, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 10000 | $32.60 | 103,466.0000 | 158,964,772 | 10.70% | 0.01% |
| Aug. 18, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 10000 | $0.00 | 18,869.0000 | 158,964,772 | 34.64% | 0.01% |
| Aug. 18, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 10000 | $43.98 | 93,466.0000 | 158,964,772 | 9.67% | 0.01% |
| Aug. 6, 2025 | PARSHALL B LYNNE | Director | S | Common Stock | 4600 | $41.87 | 86,744.0000 | 158,964,772 | 5.04% | 0.00% |
| Aug. 6, 2025 | PARSHALL B LYNNE | Director | S | Common Stock | 400 | $42.63 | 86,344.0000 | 158,964,772 | 0.46% | 0.00% |
| Aug. 5, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 10000 | $42.86 | 89,492.0000 | 158,964,772 | 10.05% | 0.01% |
| Aug. 4, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 9549 | $42.80 | 51,507.0000 | 158,964,772 | 15.64% | 0.01% |
| July 30, 2025 | Monia Brett P | Chief Executive Officer | M | Common Stock | 2432 | $32.60 | 182,252.0000 | 158,964,772 | 1.35% | 0.00% |
| July 30, 2025 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 2432 | $0.00 | 99,057.0000 | 158,964,772 | 2.40% | 0.00% |
| July 30, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 2432 | $45.00 | 179,820.0000 | 158,964,772 | 1.33% | 0.00% |
| July 15, 2025 | PARSHALL B LYNNE | Director | M | Common Stock | 4079 | $0.00 | 91,344.0000 | 158,964,772 | 4.67% | 0.00% |
| July 15, 2025 | LOSCALZO JOSEPH | Director | M | Common Stock | 4079 | $0.00 | 36,330.0000 | 158,964,772 | 12.65% | 0.00% |
| July 15, 2025 | LOSCALZO JOSEPH | Director | M | Restricted Stock Unit | 4079 | $0.00 | 5,220.0000 | 158,964,772 | 43.86% | 0.00% |
| July 15, 2025 | BERTHELSEN SPENCER R | Director | M | Restricted Stock Unit | 4079 | $0.00 | 5,220.0000 | 158,964,772 | 43.86% | 0.00% |
| July 15, 2025 | BERTHELSEN SPENCER R | Director | M | Common Stock | 4079 | $0.00 | 156,083.0000 | 158,964,772 | 2.68% | 0.00% |
| July 15, 2025 | Diaz Allene M. | Director | M | Restricted Stock Unit | 4079 | $0.00 | 5,220.0000 | 158,964,772 | 43.86% | 0.00% |
| July 15, 2025 | Diaz Allene M. | Director | M | Common Stock | 4079 | $0.00 | 19,795.0000 | 158,964,772 | 25.95% | 0.00% |
| July 15, 2025 | Hayden Michael R | Director | M | Restricted Stock Unit | 4079 | $0.00 | 9,897.0000 | 158,964,772 | 29.19% | 0.00% |
| July 15, 2025 | Hayden Michael R | Director | M | Common Stock | 4079 | $0.00 | 56,298.0000 | 158,964,772 | 7.81% | 0.00% |
| July 15, 2025 | HERMAN JOAN E | Director | M | Restricted Stock Unit | 4079 | $0.00 | 5,220.0000 | 158,964,772 | 43.86% | 0.00% |
| July 15, 2025 | HERMAN JOAN E | Director | M | Common Stock | 4079 | $0.00 | 46,086.0000 | 158,964,772 | 9.71% | 0.00% |
| July 15, 2025 | PARSHALL B LYNNE | Director | M | Restricted Stock Unit | 4079 | $0.00 | 5,220.0000 | 158,964,772 | 43.86% | 0.00% |
| July 15, 2025 | WENDER JOSEPH H | Director | M | Restricted Stock Unit | 4079 | $0.00 | 1,141.0000 | 158,964,772 | 78.14% | 0.00% |
| July 15, 2025 | YANG MICHAEL J. | Director | M | Common Stock | 4079 | $0.00 | 6,010.0000 | 158,964,772 | 211.24% | 0.00% |
| July 15, 2025 | YANG MICHAEL J. | Director | M | Restricted Stock Unit | 4079 | $0.00 | 9,080.0000 | 158,964,772 | 31.00% | 0.00% |
| July 15, 2025 | WENDER JOSEPH H | Director | M | Common Stock | 4079 | $0.00 | 136,835.0000 | 158,964,772 | 3.07% | 0.00% |
| July 11, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 1160 | $41.74 | 179,820.0000 | 158,964,772 | 0.64% | 0.00% |
| July 1, 2025 | LOSCALZO JOSEPH | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| July 1, 2025 | BERTHELSEN SPENCER R | Director | A | Restricted Stock Unit | 5220 | $0.00 | 9,299.0000 | 158,964,772 | 127.97% | 0.00% |
| July 1, 2025 | BERTHELSEN SPENCER R | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| July 1, 2025 | Diaz Allene M. | Director | A | Restricted Stock Unit | 5220 | $0.00 | 9,299.0000 | 158,964,772 | 127.97% | 0.00% |
| July 1, 2025 | Diaz Allene M. | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| July 1, 2025 | Hayden Michael R | Director | A | Restricted Stock Unit | 5220 | $0.00 | 13,976.0000 | 158,964,772 | 59.62% | 0.00% |
| July 1, 2025 | Hayden Michael R | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| July 1, 2025 | HERMAN JOAN E | Director | A | Restricted Stock Unit | 5220 | $0.00 | 9,299.0000 | 158,964,772 | 127.97% | 0.00% |
| July 1, 2025 | HERMAN JOAN E | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| July 1, 2025 | KLEIN JOSEPH III | Director | A | Restricted Stock Unit | 5220 | $0.00 | 13,976.0000 | 158,964,772 | 59.62% | 0.00% |
| July 1, 2025 | KLEIN JOSEPH III | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| July 1, 2025 | LOSCALZO JOSEPH | Director | A | Restricted Stock Unit | 5220 | $0.00 | 9,299.0000 | 158,964,772 | 127.97% | 0.00% |
| July 1, 2025 | YANG MICHAEL J. | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| July 1, 2025 | YANG MICHAEL J. | Director | A | Restricted Stock Unit | 5220 | $0.00 | 13,159.0000 | 158,964,772 | 65.75% | 0.00% |
| July 1, 2025 | PARSHALL B LYNNE | Director | A | Restricted Stock Unit | 5220 | $0.00 | 9,299.0000 | 158,964,772 | 127.97% | 0.00% |
| July 1, 2025 | PARSHALL B LYNNE | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| July 1, 2025 | WENDER JOSEPH H | Director | A | Restricted Stock Unit | 5220 | $0.00 | 9,299.0000 | 158,964,772 | 127.97% | 0.00% |
| July 1, 2025 | WENDER JOSEPH H | Director | A | Non-Qualified Stock Option (right to buy) | 11518 | $0.00 | 11,518.0000 | 158,964,772 | 9999.99% | 0.01% |
| May 1, 2025 | Hayden Michael R | Director | P | Common Stock | 15000 | $31.86 | 52,219.0000 | 158,964,772 | 40.30% | 0.01% |
| April 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 1875 | $0.00 | 57,340.0000 | 158,964,772 | 3.38% | 0.00% |
| April 16, 2025 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 680 | $28.37 | 56,660.0000 | 158,964,772 | 1.19% | 0.00% |
| April 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | M | Restricted Stock Unit | 1875 | $0.00 | 61,215.0000 | 158,964,772 | 2.97% | 0.00% |
| April 15, 2025 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | M | Common Stock | 12226 | $0.00 | 14,215.0000 | 158,964,772 | 614.68% | 0.01% |
| April 16, 2025 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | S | Common Stock | 3016 | $28.36 | 11,199.0000 | 158,964,772 | 21.22% | 0.00% |
| April 15, 2025 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | M | Restricted Stock Unit | 12226 | $0.00 | 36,677.0000 | 158,964,772 | 25.00% | 0.01% |
| April 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 10837 | $0.00 | 38,925.0000 | 158,964,772 | 38.58% | 0.01% |
| April 16, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 3928 | $28.40 | 34,997.0000 | 158,964,772 | 10.09% | 0.00% |
| April 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 10837 | $0.00 | 66,511.0000 | 158,964,772 | 14.01% | 0.01% |
| March 11, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 140 | $32.32 | 180,980.0000 | 158,964,772 | 0.08% | 0.00% |
| Feb. 28, 2025 | Swayze Eric | EVP Research | J | Common Stock | 415 | $28.21 | 48,616.0000 | 158,964,772 | 0.86% | 0.00% |
| Feb. 28, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | J | Common Stock | 554 | $28.21 | 56,799.0000 | 158,964,772 | 0.98% | 0.00% |
| Feb. 28, 2025 | Monia Brett P | Chief Executive Officer | J | Common Stock | 437 | $28.21 | 181,120.0000 | 158,964,772 | 0.24% | 0.00% |
| Feb. 28, 2025 | Geary Richard S | EVP, Chief Development Officer | J | Common Stock | 415 | $28.21 | 99,492.0000 | 158,964,772 | 0.42% | 0.00% |
| Feb. 28, 2025 | Birchler Brian | EVP, Corp and Development Ops | J | Common Stock | 414 | $28.21 | 55,465.0000 | 158,964,772 | 0.75% | 0.00% |
| Feb. 28, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | J | Common Stock | 320 | $28.21 | 93,466.0000 | 158,964,772 | 0.34% | 0.00% |
| Feb. 20, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 1207 | $32.35 | 56,245.0000 | 158,964,772 | 2.10% | 0.00% |
| Feb. 4, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 6165 | $31.62 | 57,452.0000 | 0 | 9.69% | 0.00% |
| Feb. 4, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 38843 | $31.65 | 180,683.0000 | 0 | 17.69% | 0.00% |
| Jan. 30, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Common Stock | 4032 | $0.00 | 62,540.0000 | 0 | 6.89% | 0.00% |
| Jan. 30, 2025 | Swayze Eric | EVP Research | A | Common Stock | 3714 | $0.00 | 49,568.0000 | 0 | 8.10% | 0.00% |
| Jan. 31, 2025 | Swayze Eric | EVP Research | S | Common Stock | 1367 | $32.31 | 48,201.0000 | 0 | 2.76% | 0.00% |
| Jan. 31, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 1484 | $32.20 | 61,056.0000 | 0 | 2.37% | 0.00% |
| Jan. 30, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Common Stock | 3820 | $0.00 | 65,023.0000 | 0 | 6.24% | 0.00% |
| Jan. 31, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 1406 | $32.49 | 63,617.0000 | 0 | 2.16% | 0.00% |
| Jan. 30, 2025 | Monia Brett P | Chief Executive Officer | A | Common Stock | 25372 | $0.00 | 232,768.0000 | 0 | 12.23% | 0.00% |
| Jan. 31, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 13242 | $32.45 | 219,526.0000 | 0 | 5.69% | 0.00% |
| Jan. 30, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Common Stock | 4138 | $0.00 | 112,023.0000 | 0 | 3.84% | 0.00% |
| Jan. 31, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 1523 | $32.44 | 110,500.0000 | 0 | 1.36% | 0.00% |
| Jan. 30, 2025 | Geary Richard S | EVP, Chief Development Officer | A | Common Stock | 3820 | $0.00 | 100,483.0000 | 0 | 3.95% | 0.00% |
| Jan. 31, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 1406 | $32.40 | 99,077.0000 | 0 | 1.40% | 0.00% |
| Jan. 30, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Common Stock | 3607 | $0.00 | 94,473.0000 | 0 | 3.97% | 0.00% |
| Jan. 31, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 1327 | $32.46 | 93,146.0000 | 0 | 1.40% | 0.00% |
| Jan. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Restricted Stock Unit | 12295 | $0.00 | 63,226.0000 | 0 | 16.28% | 0.00% |
| Jan. 16, 2025 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 5400 | $32.70 | 55,051.0000 | 0 | 8.93% | 0.00% |
| Jan. 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | A | Performance Restricted Stock Units | 22000 | $0.00 | 53,338.0000 | 0 | 70.20% | 0.00% |
| Jan. 15, 2025 | Swayze Eric | EVP Research | M | Common Stock | 19111 | $0.00 | 53,008.0000 | 0 | 56.38% | 0.00% |
| Jan. 16, 2025 | Swayze Eric | EVP Research | S | Common Stock | 7154 | $32.84 | 45,854.0000 | 0 | 13.50% | 0.00% |
| Jan. 15, 2025 | Swayze Eric | EVP Research | M | Common Stock | 49 | $0.00 | 45,876.0000 | 0 | 0.11% | 0.00% |
| Jan. 16, 2025 | Swayze Eric | EVP Research | S | Common Stock | 22 | $32.70 | 45,854.0000 | 0 | 0.05% | 0.00% |
| Jan. 15, 2025 | Swayze Eric | EVP Research | A | Performance Restricted Stock Units | 22000 | $0.00 | 64,482.0000 | 0 | 51.79% | 0.00% |
| Jan. 15, 2025 | Swayze Eric | EVP Research | A | Restricted Stock Unit | 33000 | $0.00 | 80,350.0000 | 0 | 69.69% | 0.00% |
| Jan. 15, 2025 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 19111 | $0.00 | 61,239.0000 | 0 | 23.78% | 0.00% |
| Jan. 15, 2025 | Swayze Eric | EVP Research | A | Restricted Stock Unit | 245 | $0.00 | 61,288.0000 | 0 | 0.40% | 0.00% |
| Jan. 15, 2025 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 49 | $0.00 | 61,239.0000 | 0 | 0.08% | 0.00% |
| Jan. 15, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Common Stock | 17372 | $0.00 | 65,031.0000 | 0 | 36.45% | 0.00% |
| Jan. 16, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 6523 | $32.79 | 58,508.0000 | 0 | 10.03% | 0.00% |
| Jan. 15, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Performance Restricted Stock Units | 22000 | $0.00 | 65,437.0000 | 0 | 50.65% | 0.00% |
| Jan. 15, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Restricted Stock Unit | 33000 | $0.00 | 78,308.0000 | 0 | 72.83% | 0.00% |
| Jan. 15, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Restricted Stock Unit | 17372 | $0.00 | 60,936.0000 | 0 | 22.18% | 0.00% |
| Jan. 15, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 19690 | $0.00 | 68,563.0000 | 0 | 40.29% | 0.00% |
| Jan. 16, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 7360 | $32.83 | 61,203.0000 | 0 | 10.73% | 0.00% |
| Jan. 15, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Performance Restricted Stock Units | 22000 | $0.00 | 64,801.0000 | 0 | 51.40% | 0.00% |
| Jan. 15, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Restricted Stock Unit | 33000 | $0.00 | 80,414.0000 | 0 | 69.60% | 0.00% |
| Jan. 15, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Restricted Stock Unit | 19690 | $0.00 | 60,724.0000 | 0 | 24.49% | 0.00% |
| Jan. 15, 2025 | Monia Brett P | Chief Executive Officer | M | Common Stock | 73448 | $0.00 | 240,841.0000 | 0 | 43.88% | 0.00% |
| Jan. 16, 2025 | Monia Brett P | Chief Executive Officer | S | Common Stock | 33445 | $32.63 | 207,396.0000 | 0 | 13.89% | 0.00% |
| Jan. 15, 2025 | Monia Brett P | Chief Executive Officer | A | Performance Restricted Stock Units | 169950 | $0.00 | 630,201.0000 | 0 | 36.93% | 0.00% |
| Jan. 15, 2025 | Monia Brett P | Chief Executive Officer | A | Restricted Stock Unit | 129395 | $0.00 | 325,607.0000 | 0 | 65.95% | 0.00% |
| Jan. 15, 2025 | Monia Brett P | Chief Executive Officer | M | Restricted Stock Unit | 73448 | $0.00 | 252,159.0000 | 0 | 22.56% | 0.00% |
| Jan. 15, 2025 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | A | Performance Restricted Stock Units | 18700 | $0.00 | 18,700.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2025 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | A | Restricted Stock Unit | 28050 | $0.00 | 28,050.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 23887 | $0.00 | 116,755.0000 | 0 | 25.72% | 0.00% |
| Jan. 16, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 8870 | $32.81 | 107,885.0000 | 0 | 7.60% | 0.00% |
| Jan. 15, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Performance Restricted Stock Units | 31000 | $0.00 | 86,635.0000 | 0 | 55.72% | 0.00% |
| Jan. 15, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Restricted Stock Unit | 46500 | $0.00 | 108,556.0000 | 0 | 74.93% | 0.00% |
| Jan. 15, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Restricted Stock Unit | 23887 | $0.00 | 84,669.0000 | 0 | 22.00% | 0.00% |
| Jan. 15, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 18901 | $0.00 | 103,735.0000 | 0 | 22.28% | 0.00% |
| Jan. 16, 2025 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 7072 | $32.86 | 96,663.0000 | 0 | 6.82% | 0.00% |
| Jan. 15, 2025 | Geary Richard S | EVP, Chief Development Officer | A | Performance Restricted Stock Units | 22000 | $0.00 | 64,801.0000 | 0 | 51.40% | 0.00% |
| Jan. 15, 2025 | Geary Richard S | EVP, Chief Development Officer | A | Restricted Stock Unit | 33000 | $0.00 | 79,625.0000 | 0 | 70.78% | 0.00% |
| Jan. 15, 2025 | Geary Richard S | EVP, Chief Development Officer | M | Restricted Stock Unit | 18901 | $0.00 | 60,724.0000 | 0 | 23.74% | 0.00% |
| Jan. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | M | Common Stock | 12295 | $0.00 | 20,204.0000 | 0 | 155.46% | 0.00% |
| Jan. 16, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | S | Common Stock | 4267 | $32.78 | 15,937.0000 | 0 | 21.12% | 0.00% |
| Jan. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | A | Performance Restricted Stock Units | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | A | Restricted Stock Unit | 33000 | $0.00 | 75,521.0000 | 0 | 77.61% | 0.00% |
| Jan. 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 14283 | $0.00 | 60,451.0000 | 0 | 30.94% | 0.00% |
| Jan. 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 2460 | $0.00 | 85,672.0000 | 0 | 2.79% | 0.00% |
| Jan. 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 3750 | $0.00 | 88,132.0000 | 0 | 4.44% | 0.00% |
| Jan. 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 8787 | $0.00 | 85,672.0000 | 0 | 9.30% | 0.00% |
| Jan. 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 33000 | $0.00 | 94,459.0000 | 0 | 53.69% | 0.00% |
| Jan. 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | A | Performance Restricted Stock Units | 22000 | $0.00 | 51,290.0000 | 0 | 75.11% | 0.00% |
| Jan. 16, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 1029 | $32.70 | 28,088.0000 | 0 | 3.53% | 0.00% |
| Jan. 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 2460 | $0.00 | 29,117.0000 | 0 | 9.23% | 0.00% |
| Jan. 16, 2025 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 3401 | $32.70 | 28,088.0000 | 0 | 10.80% | 0.00% |
| Jan. 15, 2025 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 8787 | $0.00 | 31,489.0000 | 0 | 38.71% | 0.00% |
| Jan. 15, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Restricted Stock Unit | 18011 | $0.00 | 38,489.0000 | 0 | 31.88% | 0.00% |
| Jan. 15, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Restricted Stock Unit | 33000 | $0.00 | 56,500.0000 | 0 | 140.43% | 0.00% |
| Jan. 15, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Performance Restricted Stock Units | 22000 | $0.00 | 63,482.0000 | 0 | 53.04% | 0.00% |
| Jan. 16, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 6752 | $32.90 | 90,866.0000 | 0 | 6.92% | 0.00% |
| Jan. 15, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 18011 | $0.00 | 97,618.0000 | 0 | 22.62% | 0.00% |
| Jan. 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | M | Restricted Stock Unit | 14283 | $0.00 | 63,090.0000 | 0 | 18.46% | 0.00% |
| Jan. 15, 2025 | Birchler Brian | EVP, Corp and Development Ops | A | Restricted Stock Unit | 33000 | $0.00 | 77,373.0000 | 0 | 74.37% | 0.00% |
| Jan. 15, 2025 | YANG MICHAEL J. | Director | M | Common Stock | 1931 | $0.00 | 1,931.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2025 | YANG MICHAEL J. | Director | M | Restricted Stock Unit | 1931 | $0.00 | 7,939.0000 | 0 | 19.56% | 0.00% |
| Jan. 2, 2025 | Geary Richard S | EVP, Chief Development Officer | A | Non-Qualified Stock Option (right to buy) | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | Swayze Eric | EVP Research | A | Non-Qualified Stock Option (right to buy) | 163 | $0.00 | 22,163.0000 | 0 | 0.74% | 0.00% |
| Jan. 2, 2025 | Birchler Brian | EVP, Corp and Development Ops | A | Non-Qualified Stock Option (right to buy) | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Non-Qualified Stock Option (right to buy) | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 22000 | $0.00 | 24,500.0000 | 0 | 880.00% | 0.00% |
| Jan. 2, 2025 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 2500 | $0.00 | 24,500.0000 | 0 | 11.36% | 0.00% |
| Jan. 2, 2025 | Swayze Eric | EVP Research | A | Non-Qualified Stock Option (right to buy) | 22000 | $0.00 | 22,163.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Non-Qualified Stock Option (right to buy) | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Non-Qualified Stock Option (right to buy) | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | Monia Brett P | Chief Executive Officer | A | Non-Qualified Stock Option (right to buy) | 86263 | $0.00 | 86,263.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | A | Non-Qualified Stock Option (right to buy) | 18700 | $0.00 | 18,700.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Non-Qualified Stock Option (right to buy) | 31000 | $0.00 | 31,000.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2025 | Devers Shannon L. | EVP, Chief Human Resources Ofc | A | Non-Qualified Stock Option (right to buy) | 22000 | $0.00 | 22,000.0000 | 0 | 9999.99% | 0.00% |
| Dec. 23, 2024 | Hayden Michael R | Director | P | Common Stock | 2500 | $36.20 | 34,719.0000 | 0 | 7.76% | 0.00% |
| Dec. 23, 2024 | Hayden Michael R | Director | P | Common Stock | 2500 | $36.23 | 37,219.0000 | 0 | 7.20% | 0.00% |
| Nov. 12, 2024 | Monia Brett P | Chief Executive Officer | S | Common Stock | 6630 | $38.05 | 167,393.0000 | 0 | 3.81% | 0.00% |
| Nov. 12, 2024 | LOSCALZO JOSEPH | Director | S | Common Stock | 13508 | $37.86 | 32,251.0000 | 0 | 29.52% | 0.00% |
| Nov. 12, 2024 | Swayze Eric | EVP Research | S | Common Stock | 1194 | $37.92 | 33,870.0000 | 0 | 3.41% | 0.00% |
| Oct. 15, 2024 | Swayze Eric | EVP Research | M | Common Stock | 125 | $0.00 | 35,117.0000 | 0 | 0.36% | 0.00% |
| Oct. 15, 2024 | Devers Shannon L. | EVP, Chief Human Resources Ofc | A | Restricted Stock Unit | 11280 | $0.00 | 42,521.0000 | 0 | 36.11% | 0.00% |
| Oct. 15, 2024 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 125 | $0.00 | 426.0000 | 0 | 22.69% | 0.00% |
| Oct. 16, 2024 | Swayze Eric | EVP Research | S | Common Stock | 53 | $38.31 | 35,064.0000 | 0 | 0.15% | 0.00% |
| Sept. 29, 2024 | Devers Shannon L. | EVP, Chief Human Resourses Ofc | A | Non-Qualified Stock Option (right to buy) | 15040 | $0.00 | 15,040.0000 | 0 | 9999.99% | 0.00% |
| Aug. 30, 2024 | Swayze Eric | EVP Research | J | Common Stock | 11 | $38.64 | 34,992.0000 | 0 | 0.03% | 0.00% |
| Aug. 30, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | J | Common Stock | 246 | $38.64 | 48,873.0000 | 0 | 0.51% | 0.00% |
| Aug. 30, 2024 | Monia Brett P | Chief Executive Officer | J | Common Stock | 140 | $38.64 | 174,023.0000 | 0 | 0.08% | 0.00% |
| Aug. 30, 2024 | Geary Richard S | EVP, Chief Development Officer | J | Common Stock | 11 | $38.64 | 84,834.0000 | 0 | 0.01% | 0.00% |
| Aug. 30, 2024 | Birchler Brian | EVP, Corp and Development Ops | J | Common Stock | 12 | $38.64 | 46,168.0000 | 0 | 0.03% | 0.00% |
| Aug. 30, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | J | Common Stock | 177 | $38.64 | 79,607.0000 | 0 | 0.22% | 0.00% |
| Feb. 2, 2024 | Monia Brett P | Chief Executive Officer | S | Common Stock | 23907 | $49.37 | 173,732.0000 | 0 | 12.10% | 0.00% |
| Feb. 2, 2024 | Monia Brett P | Chief Executive Officer | S | Common Stock | 23907 | $49.37 | 173,732.0000 | 0 | 12.10% | 0.00% |
| Feb. 2, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 1885 | $49.52 | 79,047.0000 | 0 | 2.33% | 0.00% |
| Feb. 2, 2024 | Cadoret-Manier Onaiza | EVP,Chf GL Pdt Str & Oper Ofc | S | Common Stock | 2162 | $49.60 | 35,788.0000 | 0 | 5.70% | 0.00% |
| Feb. 2, 2024 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 1995 | $50.04 | 87,300.0000 | 0 | 2.23% | 0.00% |
| Feb. 2, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 2162 | $49.54 | 92,868.0000 | 0 | 2.28% | 0.00% |
| Feb. 2, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 1995 | $49.67 | 48,627.0000 | 0 | 3.94% | 0.00% |
| Feb. 2, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 2106 | $49.59 | 47,659.0000 | 0 | 4.23% | 0.00% |
| Feb. 2, 2024 | Swayze Eric | EVP Research | S | Common Stock | 1940 | $49.56 | 34,291.0000 | 0 | 5.35% | 0.00% |
| Aug. 28, 2024 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 320 | $49.16 | 85,154.0000 | 0 | 0.37% | 0.00% |
| Aug. 29, 2024 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 331 | $49.63 | 84,823.0000 | 0 | 0.39% | 0.00% |
| Aug. 5, 2024 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 2430 | $48.00 | 85,508.0000 | 0 | 2.76% | 0.00% |
| July 15, 2024 | LOSCALZO JOSEPH | Director | M | Restricted Stock Unit | 4677 | $0.00 | 4,079.0000 | 0 | 53.41% | 0.00% |
| July 15, 2024 | BERTHELSEN SPENCER R | Director | M | Common Stock | 4677 | $0.00 | 152,004.0000 | 0 | 3.17% | 0.00% |
| July 15, 2024 | BERTHELSEN SPENCER R | Director | M | Restricted Stock Unit | 4677 | $0.00 | 4,079.0000 | 0 | 53.41% | 0.00% |
| July 15, 2024 | WENDER JOSEPH H | Director | M | Common Stock | 4677 | $0.00 | 132,756.0000 | 0 | 3.65% | 0.00% |
| July 15, 2024 | WENDER JOSEPH H | Director | M | Restricted Stock Unit | 4677 | $0.00 | 4,079.0000 | 0 | 53.41% | 0.00% |
| July 15, 2024 | PARSHALL B LYNNE | Director | M | Common Stock | 4677 | $0.00 | 87,265.0000 | 0 | 5.66% | 0.00% |
| July 15, 2024 | PARSHALL B LYNNE | Director | M | Restricted Stock Unit | 4677 | $0.00 | 4,079.0000 | 0 | 53.41% | 0.00% |
| July 15, 2024 | LOSCALZO JOSEPH | Director | M | Common Stock | 4677 | $0.00 | 45,759.0000 | 0 | 11.38% | 0.00% |
| July 16, 2024 | KLEIN JOSEPH III | Director | M | Common Stock | 12000 | $24.42 | 28,446.0000 | 0 | 72.97% | 0.00% |
| July 16, 2024 | KLEIN JOSEPH III | Director | S | Common Stock | 12000 | $50.00 | 16,446.0000 | 0 | 42.19% | 0.00% |
| July 16, 2024 | KLEIN JOSEPH III | Director | M | Non-Qualified Stock Option (right to buy) | 12000 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| July 15, 2024 | HERMAN JOAN E | Director | M | Common Stock | 4677 | $0.00 | 42,007.0000 | 0 | 12.53% | 0.00% |
| July 15, 2024 | HERMAN JOAN E | Director | M | Restricted Stock Unit | 4677 | $0.00 | 4,079.0000 | 0 | 53.41% | 0.00% |
| July 15, 2024 | Diaz Allene M. | Director | M | Common Stock | 4677 | $0.00 | 17,353.0000 | 0 | 36.90% | 0.00% |
| July 16, 2024 | Diaz Allene M. | Director | S | Common Stock | 900 | $48.94 | 16,453.0000 | 0 | 5.19% | 0.00% |
| July 16, 2024 | Diaz Allene M. | Director | S | Common Stock | 737 | $50.17 | 15,716.0000 | 0 | 4.48% | 0.00% |
| July 15, 2024 | Diaz Allene M. | Director | M | Restricted Stock Unit | 4677 | $0.00 | 4,079.0000 | 0 | 53.41% | 0.00% |
| July 1, 2024 | HERMAN JOAN E | Director | A | Restricted Stock Unit | 4079 | $0.00 | 8,756.0000 | 0 | 87.21% | 0.00% |
| July 1, 2024 | YANG MICHAEL J. | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| July 1, 2024 | BERTHELSEN SPENCER R | Director | A | Restricted Stock Unit | 4079 | $0.00 | 8,756.0000 | 0 | 87.21% | 0.00% |
| July 1, 2024 | KLEIN JOSEPH III | Director | A | Restricted Stock Unit | 4079 | $0.00 | 8,756.0000 | 0 | 87.21% | 0.00% |
| July 1, 2024 | HERMAN JOAN E | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| July 1, 2024 | YANG MICHAEL J. | Director | A | Restricted Stock Unit | 4079 | $0.00 | 9,870.0000 | 0 | 70.44% | 0.00% |
| July 1, 2024 | BERTHELSEN SPENCER R | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| July 1, 2024 | Diaz Allene M. | Director | A | Restricted Stock Unit | 4079 | $0.00 | 8,756.0000 | 0 | 87.21% | 0.00% |
| July 1, 2024 | Diaz Allene M. | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| July 1, 2024 | Hayden Michael R | Director | A | Restricted Stock Unit | 4079 | $0.00 | 8,756.0000 | 0 | 87.21% | 0.00% |
| July 1, 2024 | Hayden Michael R | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| July 1, 2024 | WENDER JOSEPH H | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| July 1, 2024 | WENDER JOSEPH H | Director | A | Restricted Stock Unit | 4079 | $0.00 | 8,756.0000 | 0 | 87.21% | 0.00% |
| July 1, 2024 | PARSHALL B LYNNE | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| July 1, 2024 | PARSHALL B LYNNE | Director | A | Restricted Stock Unit | 4079 | $0.00 | 8,756.0000 | 0 | 87.21% | 0.00% |
| July 1, 2024 | LOSCALZO JOSEPH | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| July 1, 2024 | LOSCALZO JOSEPH | Director | A | Restricted Stock Unit | 4079 | $0.00 | 8,756.0000 | 0 | 87.21% | 0.00% |
| July 1, 2024 | KLEIN JOSEPH III | Director | A | Non-Qualified Stock Option (right to buy) | 10111 | $0.00 | 10,111.0000 | 0 | 9999.99% | 0.00% |
| June 17, 2024 | BERTHELSEN SPENCER R | Director | M | Common Stock | 16000 | $35.53 | 163,327.0000 | 0 | 10.86% | 0.00% |
| June 17, 2024 | BERTHELSEN SPENCER R | Director | S | Common Stock | 16000 | $40.29 | 147,327.0000 | 0 | 9.80% | 0.00% |
| June 17, 2024 | BERTHELSEN SPENCER R | Director | M | Non-Qualified Stock Option (right to buy) | 16000 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| May 9, 2024 | WENDER JOSEPH H | Director | M | Non-Qualified Stock Option (right to buy) | 16000 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| May 9, 2024 | WENDER JOSEPH H | Director | M | Common Stock | 16000 | $35.53 | 128,079.0000 | 0 | 14.28% | 0.00% |
| May 3, 2024 | KLEIN JOSEPH III | Director | S | Common Stock | 1318 | $42.57 | 21,128.0000 | 0 | 5.87% | 0.00% |
| May 3, 2024 | KLEIN JOSEPH III | Director | S | Common Stock | 682 | $42.94 | 20,446.0000 | 0 | 3.23% | 0.00% |
| May 3, 2024 | KLEIN JOSEPH III | Director | S | Common Stock | 1269 | $42.59 | 19,177.0000 | 0 | 6.21% | 0.00% |
| May 3, 2024 | KLEIN JOSEPH III | Director | S | Common Stock | 731 | $42.98 | 18,446.0000 | 0 | 3.81% | 0.00% |
| May 3, 2024 | KLEIN JOSEPH III | Director | S | Common Stock | 1070 | $42.55 | 17,376.0000 | 0 | 5.80% | 0.00% |
| May 3, 2024 | KLEIN JOSEPH III | Director | S | Common Stock | 930 | $42.90 | 16,446.0000 | 0 | 5.35% | 0.00% |
| April 15, 2024 | Birchler Brian | EVP, Corp and Development Ops | M | Restricted Stock Unit | 1875 | $0.00 | 44,373.0000 | 0 | 4.05% | 0.00% |
| April 15, 2024 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 10838 | $0.00 | 53,135.0000 | 0 | 16.94% | 0.00% |
| April 16, 2024 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 905 | $41.66 | 46,156.0000 | 0 | 1.92% | 0.00% |
| April 16, 2024 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 4006 | $41.60 | 21,271.0000 | 0 | 15.85% | 0.00% |
| April 15, 2024 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 10838 | $0.00 | 25,277.0000 | 0 | 75.06% | 0.00% |
| April 15, 2024 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 1875 | $0.00 | 47,061.0000 | 0 | 4.15% | 0.00% |
| Feb. 26, 2024 | Jenne Kyle | EVP, Chf GL Pdt Str Ofcr | A | Non-Qualified Stock Option (right to buy) | 65203 | $0.00 | 65,203.0000 | 0 | 9999.99% | 0.00% |
| Feb. 29, 2024 | Geary Richard S | Officer Level 14 | J | Common Stock | 604 | $34.43 | 87,938.0000 | 0 | 0.69% | 0.00% |
| Feb. 29, 2024 | Birchler Brian | Vice President Level 14 | J | Common Stock | 604 | $34.43 | 45,186.0000 | 0 | 1.35% | 0.00% |
| Feb. 29, 2024 | BENNETT C FRANK | Officer Level 14 | J | Common Stock | 383 | $34.43 | 79,462.0000 | 0 | 0.48% | 0.00% |
| Feb. 29, 2024 | Monia Brett P | CEO Level 15 | J | Common Stock | 538 | $34.43 | 174,289.0000 | 0 | 0.31% | 0.00% |
| Feb. 29, 2024 | Swayze Eric | Officer Level 14 | J | Common Stock | 605 | $34.43 | 35,014.0000 | 0 | 1.76% | 0.00% |
| Feb. 16, 2024 | Monia Brett P | Chief Executive Officer | S | Common Stock | 387 | $44.49 | 173,751.0000 | 0 | 0.22% | 0.00% |
| Feb. 2, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 2071 | $49.59 | 49,812.0000 | 0 | 3.99% | 0.00% |
| Feb. 1, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Common Stock | 3820 | $0.00 | 50,622.0000 | 0 | 8.16% | 0.00% |
| Feb. 2, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 1961 | $49.67 | 48,661.0000 | 0 | 3.87% | 0.00% |
| Feb. 1, 2024 | Monia Brett P | Chief Executive Officer | A | Common Stock | 25372 | $0.00 | 177,223.0000 | 0 | 16.71% | 0.00% |
| Feb. 1, 2024 | Monia Brett P | Chief Executive Officer | A | Common Stock | 20416 | $0.00 | 197,639.0000 | 0 | 11.52% | 0.00% |
| Feb. 2, 2024 | Monia Brett P | Chief Executive Officer | S | Common Stock | 23501 | $49.37 | 174,138.0000 | 0 | 11.89% | 0.00% |
| Feb. 2, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 2125 | $49.54 | 92,905.0000 | 0 | 2.24% | 0.00% |
| Feb. 1, 2024 | Swayze Eric | EVP Research | A | Common Stock | 3715 | $0.00 | 36,316.0000 | 0 | 11.40% | 0.00% |
| Jan. 31, 2024 | Swayze Eric | EVP Research | S | Common Stock | 10773 | $52.00 | 32,601.0000 | 0 | 24.84% | 0.00% |
| Feb. 1, 2024 | Geary Richard S | EVP, Chief Development Officer | A | Common Stock | 3820 | $0.00 | 89,295.0000 | 0 | 4.47% | 0.00% |
| Feb. 1, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Common Stock | 4140 | $0.00 | 95,030.0000 | 0 | 4.55% | 0.00% |
| Feb. 2, 2024 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 1961 | $50.04 | 87,334.0000 | 0 | 2.20% | 0.00% |
| Feb. 1, 2024 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | A | Common Stock | 4140 | $0.00 | 37,950.0000 | 0 | 12.24% | 0.00% |
| Feb. 2, 2024 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | S | Common Stock | 2125 | $49.60 | 35,825.0000 | 0 | 5.60% | 0.00% |
| Feb. 1, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Common Stock | 3609 | $0.00 | 80,932.0000 | 0 | 4.67% | 0.00% |
| Feb. 2, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 1853 | $49.52 | 79,079.0000 | 0 | 2.29% | 0.00% |
| Feb. 2, 2024 | Swayze Eric | EVP Research | S | Common Stock | 1907 | $49.56 | 34,409.0000 | 0 | 5.25% | 0.00% |
| Feb. 1, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Common Stock | 4033 | $0.00 | 51,883.0000 | 0 | 8.43% | 0.00% |
| Jan. 25, 2024 | Monia Brett P | Chief Executive Officer | S | Common Stock | 2285 | $51.75 | 151,851.0000 | 0 | 1.48% | 0.00% |
| Jan. 25, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 6450 | $51.75 | 46,802.0000 | 0 | 12.11% | 0.00% |
| Jan. 16, 2024 | Monia Brett P | Chief Executive Officer | M | Restricted Stock Unit | 68084 | $10.00 | 196,212.0000 | 0 | 25.76% | 0.00% |
| Jan. 16, 2024 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 1353 | $0.00 | 71,007.0000 | 0 | 1.87% | 0.00% |
| Jan. 16, 2024 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 3688 | $0.00 | 71,007.0000 | 0 | 4.94% | 0.00% |
| Jan. 17, 2024 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 564 | $50.42 | 14,439.0000 | 0 | 3.76% | 0.00% |
| Jan. 16, 2024 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 1353 | $0.00 | 15,003.0000 | 0 | 9.91% | 0.00% |
| Jan. 17, 2024 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 1460 | $50.42 | 14,439.0000 | 0 | 9.18% | 0.00% |
| Jan. 16, 2024 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 3688 | $0.00 | 15,899.0000 | 0 | 30.20% | 0.00% |
| Jan. 16, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Restricted Stock Unit | 18314 | $0.00 | 23,500.0000 | 0 | 43.80% | 0.00% |
| Jan. 17, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 6745 | $50.42 | 77,323.0000 | 0 | 8.02% | 0.00% |
| Jan. 16, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 18314 | $0.00 | 84,068.0000 | 0 | 27.85% | 0.00% |
| Jan. 16, 2024 | Geary Richard S | EVP, Chief Development Officer | M | Restricted Stock Unit | 19852 | $0.00 | 46,625.0000 | 0 | 29.86% | 0.00% |
| Jan. 17, 2024 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 7338 | $50.42 | 85,475.0000 | 0 | 7.91% | 0.00% |
| Jan. 16, 2024 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 19852 | $0.00 | 92,813.0000 | 0 | 27.21% | 0.00% |
| Jan. 16, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Restricted Stock Unit | 22487 | $0.00 | 62,056.0000 | 0 | 26.60% | 0.00% |
| Jan. 17, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 8683 | $50.42 | 90,890.0000 | 0 | 8.72% | 0.00% |
| Jan. 16, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 22487 | $0.00 | 99,573.0000 | 0 | 29.17% | 0.00% |
| Jan. 17, 2024 | Monia Brett P | Chief Executive Officer | S | Common Stock | 32059 | $50.42 | 154,136.0000 | 0 | 17.22% | 0.00% |
| Jan. 16, 2024 | Monia Brett P | Chief Executive Officer | M | Common Stock | 68084 | $0.00 | 186,195.0000 | 0 | 57.64% | 0.00% |
| Jan. 16, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Restricted Stock Unit | 15162 | $0.00 | 45,308.0000 | 0 | 25.07% | 0.00% |
| Jan. 17, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 5482 | $50.42 | 47,850.0000 | 0 | 10.28% | 0.00% |
| Jan. 16, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Common Stock | 15162 | $0.00 | 53,332.0000 | 0 | 39.72% | 0.00% |
| Jan. 16, 2024 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 21 | $0.00 | 47,279.0000 | 0 | 0.04% | 0.00% |
| Jan. 16, 2024 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 17069 | $0.00 | 47,279.0000 | 0 | 26.53% | 0.00% |
| Jan. 17, 2024 | Swayze Eric | EVP Research | S | Common Stock | 9 | $50.42 | 43,374.0000 | 0 | 0.02% | 0.00% |
| Jan. 16, 2024 | Swayze Eric | EVP Research | M | Common Stock | 21 | $0.00 | 43,383.0000 | 0 | 0.05% | 0.00% |
| Jan. 17, 2024 | Swayze Eric | EVP Research | S | Common Stock | 6296 | $50.42 | 43,374.0000 | 0 | 12.68% | 0.00% |
| Jan. 16, 2024 | Swayze Eric | EVP Research | M | Common Stock | 17069 | $0.00 | 49,670.0000 | 0 | 52.36% | 0.00% |
| Jan. 16, 2024 | Birchler Brian | EVP, Corp and Development Ops | M | Restricted Stock Unit | 12080 | $0.00 | 46,248.0000 | 0 | 20.71% | 0.00% |
| Jan. 17, 2024 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 4497 | $50.42 | 44,582.0000 | 0 | 9.16% | 0.00% |
| Jan. 16, 2024 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 12080 | $0.00 | 49,079.0000 | 0 | 32.65% | 0.00% |
| Jan. 16, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Restricted Stock Unit | 20641 | $0.00 | 47,414.0000 | 0 | 30.33% | 0.00% |
| Jan. 17, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 7744 | $50.42 | 53,252.0000 | 0 | 12.70% | 0.00% |
| Jan. 16, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 20641 | $0.00 | 60,996.0000 | 0 | 51.15% | 0.00% |
| Jan. 16, 2024 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | M | Restricted Stock Unit | 15062 | $0.00 | 66,997.0000 | 0 | 18.36% | 0.00% |
| Jan. 17, 2024 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | S | Common Stock | 5564 | $50.42 | 33,810.0000 | 0 | 14.13% | 0.00% |
| Jan. 16, 2024 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | M | Common Stock | 15062 | $0.00 | 39,374.0000 | 0 | 61.95% | 0.00% |
| Jan. 12, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Common Stock | 8000 | $32.60 | 46,170.0000 | 0 | 20.96% | 0.00% |
| Jan. 15, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Performance Restricted Stock Units | 17000 | $0.00 | 41,482.0000 | 0 | 69.44% | 0.00% |
| Jan. 15, 2024 | Birchler Brian | EVP, Corp and Development Ops | A | Restricted Stock Unit | 20400 | $0.00 | 58,328.0000 | 0 | 53.79% | 0.00% |
| Jan. 15, 2024 | Birchler Brian | EVP, Corp and Development Ops | A | Performance Restricted Stock Units | 17000 | $0.00 | 31,338.0000 | 0 | 118.57% | 0.00% |
| Jan. 15, 2024 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | A | Restricted Stock Unit | 32400 | $0.00 | 82,059.0000 | 0 | 65.24% | 0.00% |
| Jan. 15, 2024 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | A | Performance Restricted Stock Units | 27000 | $0.00 | 55,635.0000 | 0 | 94.29% | 0.00% |
| Jan. 15, 2024 | Geary Richard S | EVP, Chief Development Officer | A | Restricted Stock Unit | 20400 | $0.00 | 66,477.0000 | 0 | 44.27% | 0.00% |
| Jan. 15, 2024 | Geary Richard S | EVP, Chief Development Officer | A | Performance Restricted Stock Units | 17000 | $0.00 | 42,801.0000 | 0 | 65.89% | 0.00% |
| Jan. 15, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Restricted Stock Unit | 32400 | $0.00 | 84,543.0000 | 0 | 62.14% | 0.00% |
| Jan. 15, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Performance Restricted Stock Units | 27000 | $0.00 | 55,635.0000 | 0 | 94.29% | 0.00% |
| Jan. 15, 2024 | Monia Brett P | Chief Executive Officer | A | Restricted Stock Unit | 87435 | $0.00 | 264,296.0000 | 0 | 49.44% | 0.00% |
| Jan. 15, 2024 | Monia Brett P | Chief Executive Officer | A | Performance Restricted Stock Units | 143550 | $0.00 | 460,251.0000 | 0 | 45.33% | 0.00% |
| Jan. 15, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Restricted Stock Unit | 20400 | $0.00 | 68,055.0000 | 0 | 42.81% | 0.00% |
| Jan. 15, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Performance Restricted Stock Units | 17000 | $0.00 | 42,801.0000 | 0 | 65.89% | 0.00% |
| Jan. 15, 2024 | YANG MICHAEL J. | Director | A | Restricted Stock Unit | 5791 | $0.00 | 5,791.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2024 | Swayze Eric | EVP Research | A | Restricted Stock Unit | 116 | $0.00 | 64,369.0000 | 0 | 0.18% | 0.00% |
| Jan. 15, 2024 | Swayze Eric | EVP Research | A | Restricted Stock Unit | 20400 | $0.00 | 64,369.0000 | 0 | 46.40% | 0.00% |
| Jan. 15, 2024 | Swayze Eric | EVP Research | A | Performance Restricted Stock Units | 17000 | $0.00 | 42,482.0000 | 0 | 66.71% | 0.00% |
| Jan. 15, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Restricted Stock Unit | 20400 | $0.00 | 60,470.0000 | 0 | 50.91% | 0.00% |
| Jan. 15, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Performance Restricted Stock Units | 17000 | $0.00 | 43,437.0000 | 0 | 64.30% | 0.00% |
| Jan. 12, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Non-Qualified Stock Option (right to buy) | 8000 | $0.00 | 24,265.0000 | 0 | 24.79% | 0.00% |
| Jan. 12, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 8000 | $53.50 | 38,170.0000 | 0 | 17.33% | 0.00% |
| Jan. 15, 2024 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 2625 | $0.00 | 76,048.0000 | 0 | 3.58% | 0.00% |
| Jan. 15, 2024 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 1800 | $0.00 | 73,423.0000 | 0 | 2.51% | 0.00% |
| Jan. 15, 2024 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 20400 | $0.00 | 76,048.0000 | 0 | 36.66% | 0.00% |
| Jan. 15, 2024 | Baroldi Joseph | EVP, Chief Business Officer | A | Performance Restricted Stock Units | 17000 | $0.00 | 29,290.0000 | 0 | 138.32% | 0.00% |
| Jan. 15, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Restricted Stock Unit | 20400 | $0.00 | 41,814.0000 | 0 | 95.26% | 0.00% |
| Jan. 2, 2024 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | A | Non-Qualified Stock Option (right to buy) | 43200 | $0.00 | 43,200.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2024 | Geary Richard S | EVP, Chief Development Officer | A | Non-Qualified Stock Option (right to buy) | 27200 | $0.00 | 27,200.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2024 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Non-Qualified Stock Option (right to buy) | 43200 | $0.00 | 43,200.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2024 | Monia Brett P | Chief Executive Officer | A | Non-Qualified Stock Option (right to buy) | 116580 | $0.00 | 116,580.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2024 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Non-Qualified Stock Option (right to buy) | 27200 | $0.00 | 27,200.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2024 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Non-Qualified Stock Option (right to buy) | 27200 | $0.00 | 27,200.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2024 | Swayze Eric | EVP Research | A | Non-Qualified Stock Option (right to buy) | 154 | $0.00 | 27,354.0000 | 0 | 0.57% | 0.00% |
| Jan. 2, 2024 | Swayze Eric | EVP Research | A | Non-Qualified Stock Option (right to buy) | 27200 | $0.00 | 27,354.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2024 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 3500 | $0.00 | 30,700.0000 | 0 | 12.87% | 0.00% |
| Jan. 2, 2024 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 27200 | $0.00 | 30,700.0000 | 0 | 777.14% | 0.00% |
| Jan. 2, 2024 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Non-Qualified Stock Option (right to buy) | 27200 | $0.00 | 27,200.0000 | 0 | 9999.99% | 0.00% |
| Jan. 2, 2024 | Birchler Brian | EVP, Corp and Development Ops | A | Non-Qualified Stock Option (right to buy) | 27200 | $0.00 | 27,200.0000 | 0 | 9999.99% | 0.00% |
| Dec. 28, 2023 | Birchler Brian | EVP, Corp and Development Ops | F | Common Stock | 11029 | $50.50 | 36,999.0000 | 0 | 22.96% | 0.00% |
| Dec. 28, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Non-Qualified Stock Option (right to buy) | 45225 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 28, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | F | Common Stock | 43798 | $50.50 | 77,086.0000 | 0 | 36.23% | 0.00% |
| Dec. 28, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 45225 | $47.34 | 120,884.0000 | 0 | 59.77% | 0.00% |
| Dec. 28, 2023 | Swayze Eric | EVP Research | M | Non-Qualified Stock Option (right to buy) | 27100 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 28, 2023 | Swayze Eric | EVP Research | S | Common Stock | 27100 | $50.19 | 32,589.0000 | 0 | 45.40% | 0.00% |
| Dec. 28, 2023 | Swayze Eric | EVP Research | M | Common Stock | 27100 | $47.34 | 59,689.0000 | 0 | 83.16% | 0.00% |
| Dec. 28, 2023 | Birchler Brian | EVP, Corp and Development Ops | M | Non-Qualified Stock Option (right to buy) | 11500 | $0.00 | 15,482.0000 | 0 | 42.62% | 0.00% |
| Dec. 28, 2023 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 11500 | $47.34 | 48,028.0000 | 0 | 31.48% | 0.00% |
| Dec. 28, 2023 | PARSHALL B LYNNE | Director | S | Common Stock | 42525 | $50.19 | 82,588.0000 | 0 | 33.99% | 0.00% |
| Dec. 26, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 20825 | $47.34 | 61,180.0000 | 0 | 51.60% | 0.00% |
| Dec. 26, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 20825 | $51.46 | 40,355.0000 | 0 | 34.04% | 0.00% |
| Dec. 26, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Non-Qualified Stock Option (right to buy) | 20825 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 26, 2023 | PARSHALL B LYNNE | Director | M | Common Stock | 25113 | $47.34 | 107,701.0000 | 0 | 30.41% | 0.00% |
| Dec. 26, 2023 | PARSHALL B LYNNE | Director | S | Common Stock | 25113 | $51.46 | 82,588.0000 | 0 | 23.32% | 0.00% |
| Dec. 27, 2023 | PARSHALL B LYNNE | Director | M | Common Stock | 50000 | $47.34 | 132,588.0000 | 0 | 60.54% | 0.00% |
| Dec. 27, 2023 | PARSHALL B LYNNE | Director | S | Common Stock | 50000 | $50.23 | 82,588.0000 | 0 | 37.71% | 0.00% |
| Dec. 28, 2023 | PARSHALL B LYNNE | Director | M | Common Stock | 42525 | $47.34 | 125,113.0000 | 0 | 51.49% | 0.00% |
| Dec. 26, 2023 | PARSHALL B LYNNE | Director | M | Non-Qualified Stock Option (right to buy) | 25113 | $0.00 | 92,525.0000 | 0 | 21.35% | 0.00% |
| Dec. 27, 2023 | PARSHALL B LYNNE | Director | M | Non-Qualified Stock Option (right to buy) | 50000 | $0.00 | 42,525.0000 | 0 | 54.04% | 0.00% |
| Dec. 28, 2023 | PARSHALL B LYNNE | Director | M | Non-Qualified Stock Option (right to buy) | 42525 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 26, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Common Stock | 25000 | $47.34 | 61,052.0000 | 0 | 69.34% | 0.00% |
| Dec. 26, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 25000 | $51.46 | 36,052.0000 | 0 | 40.95% | 0.00% |
| Dec. 26, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Non-Qualified Stock Option (right to buy) | 25000 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 20, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 6500 | $49.64 | 65,754.0000 | 0 | 9.00% | 0.00% |
| Dec. 20, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 6500 | $47.34 | 72,254.0000 | 0 | 9.89% | 0.00% |
| Dec. 21, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 16113 | $47.34 | 81,867.0000 | 0 | 24.50% | 0.00% |
| Dec. 21, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 16113 | $49.29 | 65,754.0000 | 0 | 19.68% | 0.00% |
| Dec. 20, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 6500 | $0.00 | 16,113.0000 | 0 | 28.74% | 0.00% |
| Dec. 21, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 16113 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 20, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 6500 | $47.34 | 79,461.0000 | 0 | 8.91% | 0.00% |
| Dec. 20, 2023 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 6500 | $49.64 | 72,961.0000 | 0 | 8.18% | 0.00% |
| Dec. 21, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 4112 | $47.34 | 77,073.0000 | 0 | 5.64% | 0.00% |
| Dec. 21, 2023 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 4112 | $49.29 | 72,961.0000 | 0 | 5.34% | 0.00% |
| Dec. 20, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 6500 | $0.00 | 4,112.0000 | 0 | 61.25% | 0.00% |
| Dec. 21, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 4112 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 20, 2023 | Monia Brett P | Chief Executive Officer | M | Common Stock | 6500 | $47.34 | 124,611.0000 | 0 | 5.50% | 0.00% |
| Dec. 20, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 6500 | $49.64 | 118,111.0000 | 0 | 5.22% | 0.00% |
| Dec. 21, 2023 | Monia Brett P | Chief Executive Officer | M | Common Stock | 17500 | $47.34 | 135,611.0000 | 0 | 14.82% | 0.00% |
| Dec. 21, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 17500 | $49.29 | 118,111.0000 | 0 | 12.90% | 0.00% |
| Dec. 20, 2023 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 6500 | $0.00 | 17,500.0000 | 0 | 27.08% | 0.00% |
| Dec. 21, 2023 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 17500 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| Dec. 14, 2023 | Monia Brett P | Chief Executive Officer | M | Common Stock | 14860 | $47.34 | 132,971.0000 | 0 | 12.58% | 0.00% |
| Dec. 14, 2023 | YANG MICHAEL J. | Director | A | Non-Qualified Stock Option (right to buy) | 12356 | $0.00 | 12,356.0000 | 0 | 9999.99% | 0.00% |
| Dec. 14, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 14860 | $49.21 | 118,111.0000 | 0 | 11.18% | 0.00% |
| Dec. 14, 2023 | Monia Brett P | Chief Executive Officer | M | Common Stock | 9140 | $47.34 | 127,251.0000 | 0 | 7.74% | 0.00% |
| Dec. 14, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 9140 | $50.19 | 118,111.0000 | 0 | 7.18% | 0.00% |
| Dec. 14, 2023 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 14860 | $0.00 | 33,140.0000 | 0 | 30.96% | 0.00% |
| Dec. 14, 2023 | Monia Brett P | Chief Executive Officer | M | Non-Qualified Stock Option (right to buy) | 9140 | $0.00 | 24,000.0000 | 0 | 27.58% | 0.00% |
| Dec. 14, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 6571 | $47.34 | 79,532.0000 | 0 | 9.01% | 0.00% |
| Dec. 14, 2023 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 6571 | $49.21 | 72,961.0000 | 0 | 8.26% | 0.00% |
| Dec. 14, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 4042 | $47.34 | 77,003.0000 | 0 | 5.54% | 0.00% |
| Dec. 14, 2023 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 4042 | $50.19 | 72,961.0000 | 0 | 5.25% | 0.00% |
| Dec. 14, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 6571 | $0.00 | 14,654.0000 | 0 | 30.96% | 0.00% |
| Dec. 14, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Non-Qualified Stock Option (right to buy) | 4042 | $0.00 | 10,612.0000 | 0 | 27.58% | 0.00% |
| Dec. 14, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 14002 | $47.34 | 79,756.0000 | 0 | 21.29% | 0.00% |
| Dec. 14, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 14002 | $49.21 | 65,754.0000 | 0 | 17.56% | 0.00% |
| Dec. 14, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 8610 | $47.34 | 74,364.0000 | 0 | 13.09% | 0.00% |
| Dec. 14, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 8610 | $50.19 | 65,754.0000 | 0 | 11.58% | 0.00% |
| Dec. 14, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 14002 | $0.00 | 31,223.0000 | 0 | 30.96% | 0.00% |
| Dec. 14, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Non-Qualified Stock Option (right to buy) | 8610 | $0.00 | 22,613.0000 | 0 | 27.58% | 0.00% |
| Nov. 15, 2023 | KLEIN JOSEPH III | Director | S | Common Stock | 2000 | $50.00 | 22,446.0000 | 0 | 8.18% | 0.00% |
| Oct. 1, 2023 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 2400 | $0.00 | 2,400.0000 | 0 | 9999.99% | 0.00% |
| Oct. 16, 2023 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 125 | $0.00 | 456.0000 | 0 | 21.51% | 0.00% |
| Oct. 16, 2023 | Swayze Eric | EVP Research | M | Common Stock | 125 | $0.00 | 32,641.0000 | 0 | 0.38% | 0.00% |
| Oct. 17, 2023 | Swayze Eric | EVP Research | S | Common Stock | 52 | $47.95 | 32,589.0000 | 0 | 0.16% | 0.00% |
| Oct. 12, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 3770 | $46.00 | 118,111.0000 | 0 | 3.09% | 0.00% |
| Sept. 28, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 4460 | $46.50 | 65,754.0000 | 0 | 6.35% | 0.00% |
| Sept. 26, 2023 | KLEIN JOSEPH III | Director | S | Common Stock | 2000 | $45.13 | 24,446.0000 | 0 | 7.56% | 0.00% |
| Sept. 26, 2023 | PARSHALL B LYNNE | Director | S | Common Stock | 10000 | $45.13 | 82,588.0000 | 0 | 10.80% | 0.00% |
| Aug. 31, 2023 | Geary Richard S | Officer Level 14 | J | Common Stock | 1 | $30.56 | 72,961.0000 | 0 | 0.00% | 0.00% |
| Aug. 31, 2023 | Monia Brett P | CEO Level 15 | J | Common Stock | 157 | $30.56 | 121,881.0000 | 0 | 0.13% | 0.00% |
| Aug. 31, 2023 | BENNETT C FRANK | Officer Level 14 | J | Common Stock | 180 | $30.56 | 70,214.0000 | 0 | 0.26% | 0.00% |
| Aug. 1, 2023 | Diaz Allene M. | Director | S | Common Stock | 657 | $41.05 | 12,676.0000 | 0 | 4.93% | 0.00% |
| July 17, 2023 | HERMAN JOAN E | Director | M | Common Stock | 1777 | $0.00 | 31,997.0000 | 0 | 5.88% | 0.00% |
| July 17, 2023 | BERTHELSEN SPENCER R | Director | M | Restricted Stock Unit | 5333 | $0.00 | 4,677.0000 | 0 | 53.28% | 0.00% |
| July 17, 2023 | BERTHELSEN SPENCER R | Director | M | Restricted Stock Unit | 1777 | $0.00 | 10,010.0000 | 0 | 15.08% | 0.00% |
| July 17, 2023 | BERTHELSEN SPENCER R | Director | M | Common Stock | 5333 | $0.00 | 147,327.0000 | 0 | 3.76% | 0.00% |
| July 17, 2023 | BERTHELSEN SPENCER R | Director | M | Common Stock | 1777 | $0.00 | 141,994.0000 | 0 | 1.27% | 0.00% |
| July 17, 2023 | Diaz Allene M. | Director | M | Restricted Stock Unit | 5333 | $0.00 | 4,677.0000 | 0 | 53.28% | 0.00% |
| July 17, 2023 | Diaz Allene M. | Director | M | Common Stock | 5333 | $0.00 | 13,333.0000 | 0 | 66.66% | 0.00% |
| July 17, 2023 | Hayden Michael R | Director | M | Restricted Stock Unit | 5333 | $0.00 | 4,677.0000 | 0 | 53.28% | 0.00% |
| July 17, 2023 | Hayden Michael R | Director | M | Restricted Stock Unit | 1777 | $0.00 | 10,010.0000 | 0 | 15.08% | 0.00% |
| July 17, 2023 | Hayden Michael R | Director | M | Common Stock | 5333 | $0.00 | 32,219.0000 | 0 | 19.84% | 0.00% |
| July 17, 2023 | Hayden Michael R | Director | M | Common Stock | 1777 | $0.00 | 26,886.0000 | 0 | 7.08% | 0.00% |
| July 17, 2023 | HERMAN JOAN E | Director | M | Restricted Stock Unit | 5333 | $0.00 | 4,677.0000 | 0 | 53.28% | 0.00% |
| July 17, 2023 | HERMAN JOAN E | Director | M | Restricted Stock Unit | 1777 | $0.00 | 10,010.0000 | 0 | 15.08% | 0.00% |
| July 17, 2023 | HERMAN JOAN E | Director | M | Common Stock | 5333 | $0.00 | 37,330.0000 | 0 | 16.67% | 0.00% |
| July 17, 2023 | KLEIN JOSEPH III | Director | M | Restricted Stock Unit | 5333 | $0.00 | 4,677.0000 | 0 | 53.28% | 0.00% |
| July 17, 2023 | KLEIN JOSEPH III | Director | M | Restricted Stock Unit | 1777 | $0.00 | 10,010.0000 | 0 | 15.08% | 0.00% |
| July 18, 2023 | KLEIN JOSEPH III | Director | S | Common Stock | 3555 | $42.00 | 26,446.0000 | 0 | 11.85% | 0.00% |
| July 17, 2023 | KLEIN JOSEPH III | Director | M | Common Stock | 5333 | $0.00 | 30,001.0000 | 0 | 21.62% | 0.00% |
| July 17, 2023 | KLEIN JOSEPH III | Director | M | Common Stock | 1777 | $0.00 | 24,668.0000 | 0 | 7.76% | 0.00% |
| July 17, 2023 | LOSCALZO JOSEPH | Other | M | Restricted Stock Unit | 5333 | $0.00 | 4,677.0000 | 0 | 53.28% | 0.00% |
| July 17, 2023 | LOSCALZO JOSEPH | Other | M | Restricted Stock Unit | 1777 | $0.00 | 10,010.0000 | 0 | 15.08% | 0.00% |
| July 17, 2023 | LOSCALZO JOSEPH | Other | M | Common Stock | 5333 | $0.00 | 41,082.0000 | 0 | 14.92% | 0.00% |
| July 17, 2023 | LOSCALZO JOSEPH | Other | M | Common Stock | 1777 | $0.00 | 35,749.0000 | 0 | 5.23% | 0.00% |
| July 17, 2023 | PARSHALL B LYNNE | Director | M | Restricted Stock Unit | 5333 | $0.00 | 4,677.0000 | 0 | 53.28% | 0.00% |
| July 17, 2023 | PARSHALL B LYNNE | Director | M | Restricted Stock Unit | 1777 | $0.00 | 10,010.0000 | 0 | 15.08% | 0.00% |
| July 17, 2023 | PARSHALL B LYNNE | Director | M | Common Stock | 5333 | $0.00 | 92,588.0000 | 0 | 6.11% | 0.00% |
| July 17, 2023 | PARSHALL B LYNNE | Director | M | Common Stock | 1777 | $0.00 | 87,255.0000 | 0 | 2.08% | 0.00% |
| July 17, 2023 | WENDER JOSEPH H | Director | M | Restricted Stock Unit | 5333 | $0.00 | 4,677.0000 | 0 | 53.28% | 0.00% |
| July 17, 2023 | WENDER JOSEPH H | Director | M | Restricted Stock Unit | 1777 | $0.00 | 10,010.0000 | 0 | 15.08% | 0.00% |
| July 17, 2023 | WENDER JOSEPH H | Director | M | Common Stock | 5333 | $0.00 | 112,079.0000 | 0 | 5.00% | 0.00% |
| July 17, 2023 | WENDER JOSEPH H | Director | M | Common Stock | 1777 | $0.00 | 106,746.0000 | 0 | 1.69% | 0.00% |
| July 7, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 18650 | $42.25 | 121,724.0000 | 0 | 13.29% | 0.00% |
| July 3, 2023 | WENDER JOSEPH H | Director | A | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 10,321.0000 | 0 | 9999.99% | 0.00% |
| July 3, 2023 | PARSHALL B LYNNE | Director | A | Restricted Stock Unit | 4677 | $0.00 | 11,787.0000 | 0 | 65.78% | 0.00% |
| July 3, 2023 | LOSCALZO JOSEPH | Other | A | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 10,321.0000 | 0 | 9999.99% | 0.00% |
| July 3, 2023 | LOSCALZO JOSEPH | Other | A | Restricted Stock Unit | 4677 | $0.00 | 11,787.0000 | 0 | 65.78% | 0.00% |
| July 3, 2023 | PARSHALL B LYNNE | Director | A | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 10,321.0000 | 0 | 9999.99% | 0.00% |
| July 3, 2023 | KLEIN JOSEPH III | Director | A | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 10,321.0000 | 0 | 9999.99% | 0.00% |
| July 3, 2023 | KLEIN JOSEPH III | Director | A | Restricted Stock Unit | 4677 | $0.00 | 11,787.0000 | 0 | 65.78% | 0.00% |
| July 3, 2023 | HERMAN JOAN E | Director | A | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 10,321.0000 | 0 | 9999.99% | 0.00% |
| July 3, 2023 | HERMAN JOAN E | Director | A | Restricted Stock Unit | 4677 | $0.00 | 11,787.0000 | 0 | 65.78% | 0.00% |
| July 3, 2023 | Hayden Michael R | Director | A | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 10,321.0000 | 0 | 9999.99% | 0.00% |
| July 3, 2023 | Hayden Michael R | Director | A | Restricted Stock Unit | 4677 | $0.00 | 11,787.0000 | 0 | 65.78% | 0.00% |
| July 3, 2023 | Diaz Allene M. | Director | A | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 10,321.0000 | 0 | 9999.99% | 0.00% |
| July 3, 2023 | Diaz Allene M. | Director | A | Restricted Stock Unit | 4677 | $0.00 | 10,010.0000 | 0 | 87.70% | 0.00% |
| July 3, 2023 | WENDER JOSEPH H | Director | A | Restricted Stock Unit | 4677 | $0.00 | 11,787.0000 | 0 | 65.78% | 0.00% |
| July 3, 2023 | BERTHELSEN SPENCER R | Director | A | Non-Qualified Stock Option (right to buy) | 10321 | $0.00 | 10,321.0000 | 0 | 9999.99% | 0.00% |
| July 3, 2023 | BERTHELSEN SPENCER R | Director | A | Restricted Stock Unit | 4677 | $0.00 | 11,787.0000 | 0 | 65.78% | 0.00% |
| June 20, 2023 | BERTHELSEN SPENCER R | Director | M | Common Stock | 11250 | $28.47 | 140,217.0000 | 0 | 8.72% | 0.00% |
| June 20, 2023 | BERTHELSEN SPENCER R | Director | M | Non-Qualified Stock Option (right to buy) | 11250 | $0.00 | 0.0000 | 0 | 100.00% | 0.00% |
| June 12, 2023 | HERMAN JOAN E | Director | M | Common Stock | 3555 | $0.00 | 30,220.0000 | 0 | 13.33% | 0.00% |
| June 12, 2023 | HERMAN JOAN E | Director | M | Restricted Stock Unit | 3555 | $0.00 | 7,110.0000 | 0 | 33.33% | 0.00% |
| May 24, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 1527 | $41.70 | 40,355.0000 | 0 | 3.65% | 0.00% |
| May 22, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 2301 | $40.13 | 143,004.0000 | 0 | 1.58% | 0.00% |
| May 22, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 2630 | $40.14 | 140,374.0000 | 0 | 1.84% | 0.00% |
| April 17, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | M | Restricted Stock Unit | 5667 | $0.00 | 49,659.0000 | 0 | 10.24% | 0.00% |
| April 17, 2023 | Birchler Brian | EVP, Corp and Development Ops | M | Common Stock | 1875 | $0.00 | 37,200.0000 | 0 | 5.31% | 0.00% |
| April 18, 2023 | Birchler Brian | EVP, Corp and Development Ops | S | Common Stock | 672 | $36.50 | 36,528.0000 | 0 | 1.81% | 0.00% |
| April 17, 2023 | Birchler Brian | EVP, Corp and Development Ops | M | Restricted Stock Unit | 1875 | $0.00 | 27,720.0000 | 0 | 6.34% | 0.00% |
| April 17, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | M | Common Stock | 5667 | $0.00 | 26,894.0000 | 0 | 26.70% | 0.00% |
| April 18, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | S | Common Stock | 2582 | $36.50 | 24,312.0000 | 0 | 9.60% | 0.00% |
| April 17, 2023 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 10838 | $0.00 | 15,302.0000 | 0 | 242.79% | 0.00% |
| April 18, 2023 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 3880 | $36.50 | 11,422.0000 | 0 | 25.36% | 0.00% |
| April 17, 2023 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 10838 | $0.00 | 47,261.0000 | 0 | 18.65% | 0.00% |
| Feb. 28, 2023 | Swayze Eric | EVP Research | J | Common Stock | 575 | $30.52 | 32,516.0000 | 0 | 1.80% | 0.00% |
| Feb. 28, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | J | Common Stock | 301 | $30.52 | 41,882.0000 | 0 | 0.72% | 0.00% |
| Feb. 28, 2023 | Geary Richard S | EVP, Chief Development Officer | J | Common Stock | 575 | $30.52 | 72,960.0000 | 0 | 0.79% | 0.00% |
| Feb. 28, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | J | Common Stock | 163 | $30.52 | 75,659.0000 | 0 | 0.22% | 0.00% |
| Feb. 28, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | J | Common Stock | 383 | $30.52 | 70,034.0000 | 0 | 0.55% | 0.00% |
| Feb. 3, 2023 | Swayze Eric | EVP Research | A | Common Stock | 3715 | $0.00 | 33,756.0000 | 0 | 12.37% | 0.00% |
| Feb. 6, 2023 | Swayze Eric | EVP Research | S | Common Stock | 1815 | $40.79 | 31,941.0000 | 0 | 5.38% | 0.00% |
| Feb. 3, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Common Stock | 4033 | $0.00 | 26,359.0000 | 0 | 18.06% | 0.00% |
| Feb. 6, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 1413 | $40.67 | 24,946.0000 | 0 | 5.36% | 0.00% |
| Feb. 3, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Common Stock | 3822 | $0.00 | 43,501.0000 | 0 | 9.63% | 0.00% |
| Feb. 6, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 1920 | $40.86 | 41,581.0000 | 0 | 4.41% | 0.00% |
| Feb. 3, 2023 | Monia Brett P | Chief Executive Officer | A | Common Stock | 6511 | $0.00 | 127,374.0000 | 0 | 5.39% | 0.00% |
| Feb. 3, 2023 | Monia Brett P | Chief Executive Officer | A | Common Stock | 17210 | $0.00 | 144,584.0000 | 0 | 13.51% | 0.00% |
| Feb. 3, 2023 | Monia Brett P | Chief Executive Officer | A | Common Stock | 25372 | $0.00 | 169,956.0000 | 0 | 17.55% | 0.00% |
| Feb. 6, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 24651 | $40.69 | 145,305.0000 | 0 | 14.50% | 0.00% |
| Feb. 3, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Common Stock | 4140 | $0.00 | 77,575.0000 | 0 | 5.64% | 0.00% |
| Feb. 6, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 2079 | $40.59 | 75,496.0000 | 0 | 2.68% | 0.00% |
| Feb. 3, 2023 | Geary Richard S | EVP, Chief Development Officer | A | Common Stock | 3822 | $0.00 | 74,305.0000 | 0 | 5.42% | 0.00% |
| Feb. 6, 2023 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 1920 | $40.66 | 72,385.0000 | 0 | 2.58% | 0.00% |
| Feb. 3, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | A | Common Stock | 4140 | $0.00 | 22,678.0000 | 0 | 22.33% | 0.00% |
| Feb. 6, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | S | Common Stock | 1451 | $40.66 | 21,227.0000 | 0 | 6.40% | 0.00% |
| Feb. 3, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Common Stock | 3609 | $0.00 | 71,464.0000 | 0 | 5.32% | 0.00% |
| Feb. 6, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 1813 | $40.57 | 69,651.0000 | 0 | 2.54% | 0.00% |
| Jan. 30, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 4500 | $39.42 | 44,179.0000 | 0 | 9.24% | 0.00% |
| Jan. 31, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 4500 | $39.71 | 39,679.0000 | 0 | 10.19% | 0.00% |
| Jan. 17, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Restricted Stock Unit | 23154 | $0.00 | 52,143.0000 | 0 | 30.75% | 0.00% |
| Jan. 17, 2023 | Swayze Eric | EVP Research | M | Common Stock | 15780 | $0.00 | 35,672.0000 | 0 | 79.33% | 0.00% |
| Jan. 18, 2023 | Swayze Eric | EVP Research | S | Common Stock | 5631 | $39.74 | 30,041.0000 | 0 | 15.79% | 0.00% |
| Jan. 17, 2023 | Swayze Eric | EVP Research | M | Restricted Stock Unit | 15780 | $0.00 | 43,397.0000 | 0 | 26.67% | 0.00% |
| Jan. 17, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Common Stock | 13046 | $0.00 | 27,078.0000 | 0 | 92.97% | 0.00% |
| Jan. 18, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | Common Stock | 4752 | $39.57 | 22,326.0000 | 0 | 17.55% | 0.00% |
| Jan. 17, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | Restricted Stock Unit | 13046 | $0.00 | 40,070.0000 | 0 | 24.56% | 0.00% |
| Jan. 17, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Common Stock | 21871 | $0.00 | 56,515.0000 | 0 | 63.13% | 0.00% |
| Jan. 18, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | Common Stock | 7836 | $39.49 | 48,679.0000 | 0 | 13.87% | 0.00% |
| Jan. 17, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | M | Restricted Stock Unit | 21871 | $0.00 | 47,655.0000 | 0 | 31.46% | 0.00% |
| Jan. 17, 2023 | Monia Brett P | Chief Executive Officer | M | Common Stock | 57267 | $0.00 | 145,929.0000 | 0 | 64.59% | 0.00% |
| Jan. 18, 2023 | Monia Brett P | Chief Executive Officer | S | Common Stock | 25066 | $39.49 | 120,863.0000 | 0 | 17.18% | 0.00% |
| Jan. 17, 2023 | Monia Brett P | Chief Executive Officer | M | Restricted Stock Unit | 57267 | $0.00 | 176,861.0000 | 0 | 24.46% | 0.00% |
| Jan. 17, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | M | Common Stock | 23154 | $0.00 | 81,715.0000 | 0 | 39.54% | 0.00% |
| Jan. 18, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | S | Common Stock | 8280 | $39.70 | 73,435.0000 | 0 | 10.13% | 0.00% |
| Jan. 17, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Common Stock | 21983 | $0.00 | 78,356.0000 | 0 | 39.00% | 0.00% |
| Jan. 18, 2023 | Geary Richard S | EVP, Chief Development Officer | S | Common Stock | 7873 | $39.57 | 70,483.0000 | 0 | 10.05% | 0.00% |
| Jan. 17, 2023 | Geary Richard S | EVP, Chief Development Officer | M | Restricted Stock Unit | 21983 | $0.00 | 46,077.0000 | 0 | 32.30% | 0.00% |
| Jan. 17, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | M | Common Stock | 10197 | $0.00 | 22,286.0000 | 0 | 84.35% | 0.00% |
| Jan. 18, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | S | Common Stock | 3748 | $39.55 | 18,538.0000 | 0 | 16.82% | 0.00% |
| Jan. 17, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | M | Restricted Stock Unit | 10197 | $0.00 | 55,326.0000 | 0 | 15.56% | 0.00% |
| Jan. 17, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Common Stock | 19417 | $0.00 | 74,833.0000 | 0 | 35.04% | 0.00% |
| Jan. 18, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | Common Stock | 6978 | $38.89 | 67,855.0000 | 0 | 9.32% | 0.00% |
| Jan. 17, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | M | Restricted Stock Unit | 19417 | $0.00 | 21,414.0000 | 0 | 47.55% | 0.00% |
| Jan. 17, 2023 | Baroldi Joseph | EVP, Chief Business Officer | M | Common Stock | 904 | $0.00 | 4,839.0000 | 0 | 22.97% | 0.00% |
| Jan. 18, 2023 | Baroldi Joseph | EVP, Chief Business Officer | S | Common Stock | 375 | $39.79 | 4,464.0000 | 0 | 7.75% | 0.00% |
| Jan. 17, 2023 | Baroldi Joseph | EVP, Chief Business Officer | M | Restricted Stock Unit | 904 | $0.00 | 3,962.0000 | 0 | 18.58% | 0.00% |
| Jan. 15, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Performance Restricted Stock Units | 13656 | $0.00 | 24,482.0000 | 0 | 126.14% | 0.00% |
| Jan. 15, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Restricted Stock Unit | 16387 | $0.00 | 40,831.0000 | 0 | 67.04% | 0.00% |
| Jan. 15, 2023 | Monia Brett P | Chief Executive Officer | A | Restricted Stock Unit | 89005 | $0.00 | 234,128.0000 | 0 | 61.33% | 0.00% |
| Jan. 17, 2023 | KLEIN JOSEPH III | Director | S | Common Stock | 2000 | $40.00 | 22,891.0000 | 0 | 8.04% | 0.00% |
| Jan. 15, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Performance Restricted Stock Units | 16216 | $0.00 | 28,635.0000 | 0 | 130.57% | 0.00% |
| Jan. 15, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Restricted Stock Unit | 19460 | $0.00 | 75,297.0000 | 0 | 34.85% | 0.00% |
| Jan. 15, 2023 | Geary Richard S | EVP, Chief Development Officer | A | Performance Restricted Stock Units | 14338 | $0.00 | 25,801.0000 | 0 | 125.08% | 0.00% |
| Jan. 15, 2023 | Geary Richard S | EVP, Chief Development Officer | A | Restricted Stock Unit | 17207 | $0.00 | 68,060.0000 | 0 | 33.84% | 0.00% |
| Jan. 15, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | A | Performance Restricted Stock Units | 16216 | $0.00 | 28,635.0000 | 0 | 130.57% | 0.00% |
| Jan. 15, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | A | Restricted Stock Unit | 19460 | $0.00 | 65,523.0000 | 0 | 42.25% | 0.00% |
| Jan. 15, 2023 | Baroldi Joseph | EVP, Chief Business Officer | A | Performance Restricted Stock Units | 12290 | $0.00 | 12,290.0000 | 0 | 9999.99% | 0.00% |
| Jan. 15, 2023 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 14749 | $0.00 | 62,965.0000 | 0 | 30.59% | 0.00% |
| Jan. 15, 2023 | Baroldi Joseph | EVP, Chief Business Officer | A | Restricted Stock Unit | 1800 | $0.00 | 62,965.0000 | 0 | 2.94% | 0.00% |
| Jan. 15, 2023 | Swayze Eric | EVP Research | A | Performance Restricted Stock Units | 14338 | $0.00 | 25,482.0000 | 0 | 128.66% | 0.00% |
| Jan. 15, 2023 | Swayze Eric | EVP Research | A | Restricted Stock Unit | 17207 | $0.00 | 59,758.0000 | 0 | 40.44% | 0.00% |
| Jan. 15, 2023 | Swayze Eric | EVP Research | A | Restricted Stock Unit | 81 | $0.00 | 59,758.0000 | 0 | 0.14% | 0.00% |
| Jan. 15, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Performance Restricted Stock Units | 14338 | $0.00 | 26,437.0000 | 0 | 118.51% | 0.00% |
| Jan. 15, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Restricted Stock Unit | 17207 | $0.00 | 53,116.0000 | 0 | 47.92% | 0.00% |
| Jan. 15, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Performance Restricted Stock Units | 14338 | $0.00 | 25,801.0000 | 0 | 125.08% | 0.00% |
| Jan. 15, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Restricted Stock Unit | 17207 | $0.00 | 69,526.0000 | 0 | 32.89% | 0.00% |
| Jan. 15, 2023 | Monia Brett P | Chief Executive Officer | A | Performance Restricted Stock Units | 146128 | $0.00 | 316,701.0000 | 0 | 85.67% | 0.00% |
| Jan. 3, 2023 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 2400 | $0.00 | 22,065.0000 | 0 | 12.20% | 0.00% |
| Jan. 3, 2023 | Baroldi Joseph | EVP, Chief Business Officer | A | Non-Qualified Stock Option (right to buy) | 19665 | $0.00 | 22,065.0000 | 0 | 819.38% | 0.00% |
| Jan. 3, 2023 | BENNETT C FRANK | EVP, Chief Scientific Officer | A | Non-Qualified Stock Option (right to buy) | 21849 | $0.00 | 21,849.0000 | 0 | 9999.99% | 0.00% |
| Jan. 3, 2023 | O'NEIL PATRICK R. | EVP CLO & General Counsel | A | Non-Qualified Stock Option (right to buy) | 22942 | $0.00 | 22,942.0000 | 0 | 9999.99% | 0.00% |
| Jan. 3, 2023 | Monia Brett P | Chief Executive Officer | A | Non-Qualified Stock Option (right to buy) | 118673 | $0.00 | 118,673.0000 | 0 | 9999.99% | 0.00% |
| Jan. 3, 2023 | HOUGEN ELIZABETH L | EVP, Finance & CFO | A | Non-Qualified Stock Option (right to buy) | 25946 | $0.00 | 25,946.0000 | 0 | 9999.99% | 0.00% |
| Jan. 3, 2023 | Geary Richard S | EVP, Chief Development Officer | A | Non-Qualified Stock Option (right to buy) | 22942 | $0.00 | 22,942.0000 | 0 | 9999.99% | 0.00% |
| Jan. 3, 2023 | Swayze Eric | EVP Research | A | Non-Qualified Stock Option (right to buy) | 22942 | $0.00 | 23,050.0000 | 0 | 9999.99% | 0.00% |
| Jan. 3, 2023 | Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | A | Non-Qualified Stock Option (right to buy) | 25946 | $0.00 | 25,946.0000 | 0 | 9999.99% | 0.00% |
| Jan. 3, 2023 | Swayze Eric | EVP Research | A | Non-Qualified Stock Option (right to buy) | 108 | $0.00 | 23,050.0000 | 0 | 0.47% | 0.00% |
| Jan. 3, 2023 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | A | Non-Qualified Stock Option (right to buy) | 22942 | $0.00 | 22,942.0000 | 0 | 9999.99% | 0.00% |